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US20090312251 |
Methods of regulating differentiation in mammals
Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation...
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US20090313709 |
Genetically Modified Animal and Use Thereof
The present invention provides a transgenic mouse retaining a DNA that encodes an exogenous GPR40 in an expressible state, wherein (1) the insulin secretion capacity has been increased, and/or (2)...
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US20090311194 |
METHODS AND COMPOSITIONS FOR THE PRODUCTION AND USE OF MAGNETOSOMES
Methods and compositions for using magnetosomes as cellular contrast agents and markers for magnetic resonance imaging are provided. Certain methods involve synthesizing magnetosomes in a cell as...
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US20090307785 |
Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional...
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US20090305384 |
Class II Human Histone Deacetylases, and Uses Related Thereto
The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II...
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US20090297495 |
HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR IMPROVING PAPER STRENGTH
The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides,...
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US20090300777 |
Novel apoptosis inducing factor and method of inducing apoptosis using the same
The purpose of the present invention is to provide a system in which an apoptosis-inducing factor is expressed in an expression promoter-dependent manner, which is not a system wherein a toxin is...
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US20090300782 |
Targeted gene addition in stem cells
The present invention provides methods for adenoassociated virus-mediated site-specific integration of a transgene into a stem cell. Stem cells having a transgene integrated therein, and...
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US20090297438 |
Human Monoclonal Antibodies to Prostate Specific Membrane Antigen (PSMA)
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the...
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US20090288177 |
SGRF GENE-MODIFIED MOUSE
A targeting vector was constructed by replacing exon regions in the SGRF gene with appropriate drug marker genes. This vector was transfected into mouse ES cell lines to obtain chimeric mice, which...
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US20090282496 |
Androgen Receptor Related Methods for Treating Bladder Cancer
Disclosed are compositions and methods for treating bladder cancer.
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US20090276864 |
TRANSGENIC ANIMALS WITH REDUCED MAJOR URINARY PROTEIN PRODUCTION
The present invention relates to a transgenic animal having substantially reduced major urinary protein (uMUP) production. The present invention also relates to methods of producing such animals,...
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US20090276863 |
Protein formulations comprising s1-5
The present inventors discovered that knockout mice whose S1-5 gene function is lost develop age-related diseases or symptoms. Histological analysis in such knockout mice revealed that bone mineral...
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US20090271883 |
ABI1/HSSH3BP1 CONDITIONAL KNOCKOUT MOUSE
Genetically engineered conditional knock-out mice having conditional disruption of the Abi1/Hssh3bp1 gene are disclosed along with methods of making and using same.
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US20090265795 |
Methods of Inhibiting Multiple Cytochrome P450 Genes with siRNA
The present invention relates to siRNAs that are targeted to RNAs encoding two or more enzymes of a subfamily of cytochrome P450 (CYP) enzymes, along with vectors, cells, and kits comprising the...
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US20090260091 |
Methods and animal model for analyzing age-related macular degeneration
Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and...
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US20090253619 |
Novel peptide involved in energy homeostasis
The expression of a mRNA encoding a putative 76 amino acid, secreted protein (“Enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant...
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US20090255002 |
Transgenic Non-Human Animals For Producing Chimeric Antibodies
The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial...
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US20090249501 |
CISD2-Knockout Mice and Uses Thereof
The present invention is related to a Cisd2 knockout mouse with phenotype comprising mitochondrial breakdown and dysfunction, wherein Cisd2 is defined as SEQ ID NO. 1. The present invention is also...
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US20090241207 |
Expression of heterologous genes according to a targeted expression profile
A gene trap vector comprises a DNA construct containing an expression unit of an internal ribosome binding site (IRES) coupled to a heterologous gene sequence; this expression unit is used in gene...
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US20090235372 |
Hairless Immunodeficient Mouse Model
The invention is directed to a hairless, immunodeficient mouse that is homozygous recessive for a hairless (Hr hr ) allele and both B-cell deficient and T-cell deficient. The B-cell and T-cell...
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US20090226375 |
MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOF
The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating...
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US20090228994 |
Antibody Composition-Producing Cell
The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a...
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US20090222932 |
ALZHEIMER'S DISEASE ANIMAL MODEL, METHOD FOR OBTAINING SAME AND USES THEREOF
The invention relates to a transgenic non-human animal which can be used as a non-human animal model for studying Alzheimer's disease (AD) and which is characterized in that: it contains a...
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US20090221492 |
EXPRESSION OF ACTIVE HUMAN FACTOR IX IN MAMMARY TISSUE OF TRANSGENIC ANIMALS
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present...
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US20090222933 |
Human Liver Cancer Cell Line
The present invention relates to a human hepatoma-derived cell line, LH86, liver cell cultures, non-human animal models, artificial livers, liver assist devices, screening assays, and other...
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US20090222934 |
Pre-B Cell Proliferation and Lymphoblastic Leukemia/High-Grade Lymphoma in MIR155 Transgenic Mice
A transgenic non-human animal, such as a mouse, has a genome that include a nucleic acid construct having at least one transcriptional regulatory sequence capable of directing expression in B cells...
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US20090220480 |
CELLULOLYTIC ENZYMES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
The invention provides polypeptides having any cellulolytic activity, e.g., a cellulase activity, a endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a β-xylosidase,...
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US20090217402 |
METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF PEPTIDASES IN MACROPHAGE AND MACROPHAGE-LIKE CELLS
Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects,...
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US20090217404 |
Cell-based RNA interference and related methods and compositions
The invention provides, among other things, methods for performing RNA interference (RNAi) in stem cells (such as embryonic stem cells) and methods for using such stem cells in vivo. The invention...
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US20090217403 |
Means and methods for generating a t cell against an antigen of interest
The invention provides a method for generating a T cell comprising a T cell receptor capable of specifically binding an antigen of interest, comprising: —providing a hematopoietic stem cell...
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US20090217401 |
Human Monoclonal Antibodies To Programmed Death 1(PD-1) And Methods For Treating Cancer Using Anti-PD-1 Antibodies Alone or in Combination with Other Immunotherapeutics
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the...
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US20090210949 |
METHOD OF AMELIORATING SYMPTOM CAUSED BY MOOD DISTURBANCE
The present invention relates to a method for improving symptom of mood disorder or its related disorder comprising a step of allowing Gm1 protein and the like to be excessively present in a brain...
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US20090210956 |
COMPOSITION AND METHOD FOR CLUSTERIN-MEDIATED STEM CELL THERAPY FOR TREATMENT OF ATHEROSCLEROSIS AND HEART FAILURE
Methods and compositions are disclosed for inhibiting, deterring or preventing apoptosis of cardiac myocytes, transplanted stem cells, vascular stem cells, and vascular smooth muscle cells by means...
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US20090210950 |
METHODS FOR SCREENING FOR AGENTS THAT AFFECT DEVELOPMENT
The present invention provides an animal toxicity model that can be used to screen agents that may cause or increase the occurrence of a developmental defect. The invention also provides methods...
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US20090210955 |
SHRNA AND SIRNA EXPRESSION IN A LIVING ORGANISM UNDER CONTROL OF A CODON-OPTIMIZED REPRESSOR GENE
The present invention relates to a biological entity carrying a regulator construct comprising a specific repressor gene and a responder construct comprising at least one segment corresponding to a...
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US20090205062 |
Caspase-9 deficient animals and the use thereof
The invention relates to genetically manipulated animals that are deficient in the expression of Casapse-9, a protein involved in programmed cell death. The invention further relates to methods for...
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US20090202429 |
METHODS FOR TESTING ANTI-THROMBOTIC AGENTS
The invention provides a transgenic non-human animal expressing von Willebrand Factor A1 protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D,...
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US20090193532 |
Genetically Engineered and Phenotyped Mice and Stem Cell Clones for Producing the Same
The current invention relates to genetically engineered mice, cells derived from those mice, and polynucleotides and polypeptides corresponding to genes affected by the engineered mutation. The...
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US20090193533 |
Conditional-Stop Dimerizable Caspase Transgenic Animals
Described are transgenic animals for conditional and inducible cell targeting, that express a dimerizable conditional-STOP caspase 3 transgene.
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US20090187996 |
Ion Channel
The present invention relates to a method of identifying a molecule suitable for the treatment, prophylaxis or alleviation of pain, the method comprising determining whether a candidate molecule is...
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US20090186367 |
DIAGNOSIS OF FERTILITY CONDITIONS USING A SERINE PROTEASE
The present invention relates to a method of diagnosing an infertility condition in a human female subject, the method comprising detecting pregnancy-related serine protease (PRSP) protein in a...
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US20090188001 |
Sucrose Biosensors and Methods of Using the Same
Sucrose biosensors are disclosed, which comprise a sucrose binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy...
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US20090180957 |
IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein...
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US20090183267 |
MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE QPCT-GENE
The present invention provides a knock-out non-human animal, in particular a mouse carrying a Qpct knock-out mutation. The present invention additionally provides the respective cells and cell...
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US20090178153 |
G PROTEIN COUPLED RECEPTORS AND USES THEREOF
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
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US20090172826 |
Model System for TCR (ZETA) Chain Downregulation
The present invention refers to an animal model system which mimics the immunosuppressive environment found in cancer, autoimmune and infectious diseases, as well as in chronic inflammation. In...
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US20090170099 |
Use of Regulatory Sequences for Specific, Transient Expression in Neuronal Determined Cells
The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant...
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US20090165153 |
Modified gene-silencing RNA and uses thereof
Methods and means for efficiently downregulating the expression of any gene of interest in eukaryotic cells and organisms are provided. To this end, the invention provides modified antisense and...
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US20090165150 |
DIRECTED COMPLEMENTATION WITH REMOVABLE GENE OF INTEREST
The invention provides an improved directed complementation method for generating a conditionally tumorigenic mouse cell. In a directed complementation method, the tumorigenicity of a conditionally...
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