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US20140171376 Light-Sensitive Chimeric GPCR Protein  
A light-sensitive chimeric protein comprising domains from at least two members of the G-protein-coupled-receptor (GPCR) protein super family, which are fused to yield a light-sensitive GPCR...
US20130074201 CANCER-SPECIFIC GENETIC REARRANGEMENTS  
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating cancer characterized by the expression of...
US20110277045 METHODS FOR INCREASING BETA CELL MASS COMPRISING ADMINISTERING A RA770 POLYPEPTIDE  
The present invention discloses polynucleotides which identify and encode DP119, DP444, DP810, DP685, WE474, DP160, RA977, or RA770 as well as novel functions for these proteins of the inventions....
US20120204281 DRG11-RESPONSIVE (DRAGON) GENE FAMILY  
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein....
US20120204280 DRG11-RESPONSIVE (DRAGON) GENE FAMILY  
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein....
US20130219534 Methods for the Treatment and Prevention of Metabolic Disorders  
Described herein are methods for detecting, characterizing, preventing, and treating metabolic diseases, including obesity and obesity-associated disorders such as diabetes.
US20120180151 GENETIC VASECTOMY BY OVEREXPRESSION OF PRM1-EGFP FUSION PROTEIN IN SPERMATIDS  
The present invention provides a genetically-modified non-human animal whose somatic and germ cells contain an exogenous gene encoding a recombinant fusion protein, wherein the presence, and...
US20110296538 IN VIVO QUANTITATIVE SCREENING TEST FOR ANTI-METASTASIS TREATMENT EFFICACY  
The present invention is directed to methods for evaluating the efficacy of a cancer treatment for (i) inhibiting metastasis in a subject, (ii) inhibiting local cancer cell movement, and (iii)...
US20120227120 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
US20110277046 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
US20130139273 Chronic Lymphocytic Leukemia Modeled in Mouse by Targeted miR-29 Expression  
A mouse model and uses there of for detecting, treating, characterizing, and diagnosing various diseases are described.
US20110061119 METHOD OF PRODUCING NON-HUMAN MAMMALS  
A method of producing mutant/targeted non-human mammals, such as mutant mice that does not require production of chimera and permits the introduction of multiple mutations in embryos and, thus,...
US20130247233 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20110214189 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20110185439 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20110287010 Diagnostic methods and markers  
The present invention relates to methods of detecting, monitoring and treating prostate cancer (PRC) OR prostatic intraepithelial neoplasia (PIN) or a predisposition to same. Provided for use in...
US20100333218 TRANSGENIC PROTEINS FROM MULTI-GENE SYSTEMS, METHODS, COMPOSITIONS, USES AND THE LIKE RELATING THERETO  
A non-human transgenic mammalian animal, as described above, contains one or more exogenous double stranded DNA sequence(s) stably integrated into the genome of the animal, which comprises...
US20110265197 Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof  
The present invention provides methods of detecting cancer using biomarkers.
US20150082469 HUMANIZED IL-7 RODENTS  
Genetically modified non-human animals comprising a human or humanized interleukin-7 (IL-7) gene. Cells, embryos, and non-human animals comprising a human or humanized IL-7 gene. Rodents that...
US20130340104 Humanized IL-7 Rodents  
Genetically modified non-human animals comprising a human or humanized interleukin-7 (IL-7) gene. Cells, embryos, and non-human animals comprising a human or humanized IL-7 gene. Rodents that...
US20100333222 KNOCKOUT MICE FOR A P450 GENE CLUSTER  
The invention relates to the generation of mouse models of drug metabolism in which clusters of genes that are involved in drug metabolism have been knocked out. The development of new drugs and...
US20130117873 HUMANIZED IL-6 AND IL-6 RECEPTOR  
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα...
US20110212459 NOVEL PRESENILIN ASSOCIATED MEMBRANE PROTEIN (PAMP) AND USES THEREOF  
Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and...
US20110126299 TRIPLE TRANSGENIC MOUSE MODEL OF AUTOIMMUNE DISEASE AND NF-KAPPA B IN VIVO IMAGING  
The present invention provides for monitoring of NF-κB-associated inflammation in mice undergoing Id-driven autoimmune disease. The mice are triple transgenic mice expressing both Id+ B cells and...
US20130061342 Identification and Enrichment of Cell Subpopulations  
Markers useful for the identification, characterization and, optionally, the enrichment or isolation of tumorigenic cells or cell subpopulations are disclosed.
US20110035814 COOPERATING ONCOGENES IN CANCER  
This invention provides methods of diagnosis, drug screening, and treatment based on the discovery that cIAP1 and Yap are co-amplified oncogenes that cooperate to contribute to oncogenesis and...
US20140338008 ORGAN REGENERATION METHOD UTILIZING iPS CELL AND BLASTOCYST COMPLEMENTATION  
It is revealed that an organ such as pancreas can be regenerated by utilizing a fact that the deficiency of an organ is complemented by injecting an induced pluripotent stem cell (iPS cell) into a...
US20120110686 Cand45 tRNA-Derived Expression System for Gene Modulation  
The present invention relates to systems and methods for modulating gene expression and applications thereof. Provided is a novel expression system to generate RNaseZ and RNA polymerase III...
US20130276156 Multiple Inducible Gene Regulation System  
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
US20110099644 MIG-6 KNOCKOUT MICE AND ELUCIDATION OF ASSOCIATION OF MIG-6 WITH EARLY ONSET DEGENERATIVE JOINT DISEASE AND ROLE AS A TUMOR SUPPRESSOR  
The molecular mechanism underlying degenerative joint disease, also known as osteoarthritis (OA), is not fully understood. Disruption of mitogen inducible gene 6 (Mig-6) in mice by homologous...
US20070011755 Diabetes type 2 animal model  
A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipfl/Pdx 1 promoter. Also disclosed is the use of the model animal for...
US20100306866 Adropin deficient mice and uses thereof  
Mice lacking expression of the Enho gene provide useful tools in the study of the Enho gene and to investigate possible treatments for glucose, lipid and energy metabolism.
US20130072475 COMPOSITIONS AND METHODS FOR THE TREATMENT OF ASTHMA AND ASSOCIATED DISORDERS  
This disclosure provides methods for treating asthma or an associated disorder in a patient in need thereof, by administering to the patient an effective amount of an autophagy inducing agent,...
US20100325747 METHOD OF EXPANDING HUMAN HEPATOCYTES IN VIVO  
Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises...
US20130198879 Humanized Universal Light Chain Mice  
Mice, tissues, cells, and genetic material are provided that comprise a humanized heavy chain immunoglobulin locus, a humanized light chain locus that expresses a universal light chain, and a gene...
US20110307967 TetO-p16 Transgenic Mice  
Mice comprising a human p16 transgene operably linked to an inducible promoter and capable of controlled expression of p16 are provided. Also provided are cells, tissues, and organs obtainable...
US20150257373 MOUSE MODEL AND TREATMENT OF HEREDITARY INCLUSION BODY MYOPATHY  
Disclosed herein are methods of treating HIBM in a subject comprising identifying subject in need thereof; and administering to the subject a compound, or a pharmaceutically acceptable salt,...
US20110059051 Molecular Control of Brown Fat Differentiation and Engergy Expenditure  
The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of Prdm 16 activity or expression. Also provided are methods for preventing or...
US20110247090 Synthetic 5'UTRs, Expression Vectors, and Methods for Increasing Transgene Expression  
The present invention provides synthetic 5′UTRs comprising a first polynucleotide fragment and a second polynucleotide fragment, wherein the first polynucleotide fragment comprises at least one...
US20110288149 Method of protecting against heart failure  
The present invention relates, in general, to heart failure, and, in particular to a method of reducing the risk of heart failure, particularly in patents with established cardiomyopathy.
US20150089679 NON-HUMAN ANIMALS HAVING A HUMANIZED SIGNAL-REGULATORY PROTEIN GENE  
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous...
US20150089680 Human Lambda Light Chain Mice  
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ...
US20130326647 HUMAN LAMBDA LIGHT CHAIN MICE  
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ...
US20120070861 Human Lambda Light Chain Mice  
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ...
US20130024960 OPTIMISED CODING SEQUENCE AND PROMOTER  
An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors...
US20140130194 MICE THAT MAKE VL BINDING PROTEINS  
Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene...
US20140130193 MICE THAT MAKE VL BINDING PROTEINS  
Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene...
US20120096572 Mice That Make VL Binding Proteins  
Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene...
US20120079615 KNOCK-IN MICE WITH INDUCIBLE LOSS OF EOSINOPHILS  
Gene knock-in mice having a targeted insertion of the human diphtheria toxin receptor within the eosinophil peroxidase locus are described. Administering diphtheria toxin to such animals results...
US20140024066 ANIMAL MODEL HAVING PHOTO-ACTIVATABLE MITOCHONDRIA  
An animal model includes a photo-activatable fluorescent protein that can conditionally label the mitochondria throughout the animal or in selective animal cells and tissues, allowing for...