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US20090293148 |
Improved Methods Controlling Gene Expression
The present invention is in the field of genetics, especially plant genetics, and provides agents capable of controlling gene expression. The present invention specifically provides sequences of...
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US20090285805 |
Binding molecules
The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to...
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US20090276866 |
Production of ungulates, preferably bovines that produce human immunoglobulins
The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1...
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US20090276864 |
TRANSGENIC ANIMALS WITH REDUCED MAJOR URINARY PROTEIN PRODUCTION
The present invention relates to a transgenic animal having substantially reduced major urinary protein (uMUP) production. The present invention also relates to methods of producing such animals,...
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US20090276863 |
Protein formulations comprising s1-5
The present inventors discovered that knockout mice whose S1-5 gene function is lost develop age-related diseases or symptoms. Histological analysis in such knockout mice revealed that bone mineral...
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US20090265798 |
Desaturase genes and uses thereof
The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “Δ5-desaturase”) and at carbon 6 (i.e.,...
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US20090255004 |
G-Protein Coupled Receptor and Uses Therefor
The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the...
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US20090255003 |
Diagnostic and therapeutic target SLC39A11 proteins for neurodegenerative diseases
The present invention discloses a dysregulation of the SLC39A11 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides methods for...
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US20090235370 |
SECRETED LUCIFERASE FOR EX VIVO MONITORING OF IN VIVO PROCESSES
The present invention generally relates to a methods, compositions and assays for real-time monitoring of the progression of a disease, such as a cancer in a subject, by measuring the level of...
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US20090235367 |
Non-human mammal comprising a modified SERCA2 gene and methods, cells, genes, and vectors thereof
The present invention relates to a non-human mammal in which all cells contain genetic modifications in a Ca 2+ handling Serca ATPase gene, more particularly the Serca2 ATPase. Defective Ca 2+ ...
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US20090228999 |
Process of Making Transgenic Mammals That Produce Exogenous Proteins in Milk and Transgenic Mammals Produced Thereby
The invention relates to a non-human transgenic mammal that is useful for the production of a protein of interest that may be toxic to the mammal. The mammal is characterized by the fact that it is...
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US20090228998 |
Induction of exon skipping in eukaryotic cells
The present invention provides a method for at least in part decreasing the production of an aberrant protein in a cell, the cell comprising pre-mRNA comprising exons coding for the protein, by...
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US20090228997 |
Extracellular novel RAGE binding protein ( EN-RAGE) and uses thereof
The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of...
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US20090226375 |
MICRO-RNAs THAT MODULATE SMOOTH MUSCLE PROLIFERATION AND DIFFERENTIATION AND USES THEREOF
The present invention relates to the identification of microRNAs that regulate smooth muscle cell proliferation and differentiation, including the miR-143/miR-145 cluster. Methods of treating...
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US20090222935 |
Transgenic animals and uses thereof
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic...
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US20090222932 |
ALZHEIMER'S DISEASE ANIMAL MODEL, METHOD FOR OBTAINING SAME AND USES THEREOF
The invention relates to a transgenic non-human animal which can be used as a non-human animal model for studying Alzheimer's disease (AD) and which is characterized in that: it contains a...
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US20090221492 |
EXPRESSION OF ACTIVE HUMAN FACTOR IX IN MAMMARY TISSUE OF TRANSGENIC ANIMALS
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present...
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US20090217404 |
Cell-based RNA interference and related methods and compositions
The invention provides, among other things, methods for performing RNA interference (RNAi) in stem cells (such as embryonic stem cells) and methods for using such stem cells in vivo. The invention...
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US20090217403 |
Means and methods for generating a t cell against an antigen of interest
The invention provides a method for generating a T cell comprising a T cell receptor capable of specifically binding an antigen of interest, comprising: —providing a hematopoietic stem cell...
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US20090217400 |
Enzymes, cells and methods for site specific recombination at asymmetric sites
The present invention relates to enzymes, compositions and methods for catalyzing asymmetric recombination of non-palindromic recombination sites in a cell free system, in isolated cells or in...
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US20090215680 |
Inhibitor peptides
The invention concerns peptides useful as MAP kinase/ERK pathway-specific inhibitors relative to a given substrate in a given subcellular compartment.
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US20090214482 |
Transgenic Mammals Expressing Human Preproinsulin
Transgenic mammals which express human preproinsulin, methods and reagents for producing the transgenic mammals, and therapeutic methods of providing patients with insulin and C-peptide using...
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US20090210953 |
Identification of TRPML3 (MCOLN3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone, and/or vasopressin production or release
The present invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals and based thereon high-throughput mammalian...
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US20090205061 |
Taste Receptors Of The T1R Family From Domestic Cat
The present invention relates to the discovery of several genes of the domestic cat ( Felis catus ) associated with taste perception. The invention provides, inter alia, the nucleotide sequence of...
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US20090202429 |
METHODS FOR TESTING ANTI-THROMBOTIC AGENTS
The invention provides a transgenic non-human animal expressing von Willebrand Factor A1 protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D,...
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US20090193533 |
Conditional-Stop Dimerizable Caspase Transgenic Animals
Described are transgenic animals for conditional and inducible cell targeting, that express a dimerizable conditional-STOP caspase 3 transgene.
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US20090193531 |
Methods and compositions for RNA Interference
The present invention provides methods for attenuating gene expression in a cell using gene-targeted double stranded RNA (dsRNA). The dsRNA contains a nucleotide sequence that hybridizes under...
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US20090193530 |
Animals, cells and methods for production of detectably-labeled antibodies
Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least...
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US20090191169 |
Methods for gene transfer to mammals
To provide a transformed hair follicle and a method for transferring a gene to a mammal by means of the transformed hair follicle. The invention provides a method for producing a transformed hair...
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US20090187997 |
Cre-lox based gene knockdown constructs and methods of use thereof
The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo.
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US20090186097 |
Transgenic Ungulates Expressing CTLA4-IG and Uses Thereof
The present invention provides ungulates, including pigs, expressing CTLA4-Ig, as well as tissue, organs, cells and cell lines derived from such animals. Such animals, tissues, organs and cells can...
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US20090180957 |
IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of β-myosin heavy chain (β-MHC) and represses fast skeletal muscle contractile protein...
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US20090178152 |
Use of the Ornithine Transcarbamylase (OTC), as a Marker for Diagnosing Brain Damages
The present invention pertains to the domain of brain diseases, and provides novel markers and methods for diagnosing a brain alteration in an individual, especially in patients suffering from...
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US20090170165 |
METHOD FOR RECOMBINANT PRODUCTION IN CHO CELLS
We describe a Cricetulus griseus cell which is modified, preferably genetically engineered, so that the expression of a heat shock protein is up-regulated compared to a cell which has not been so...
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US20090170099 |
Use of Regulatory Sequences for Specific, Transient Expression in Neuronal Determined Cells
The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant...
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US20090170067 |
Simian tropic, recombinant human immunodeficiency-1 viruses
The present invention relates to a vector for producing recombinant human immunodeficiency virus 1 (HIV-1) that is capable of infecting simian cells and monkeys. The recombinant HIV-1 overcomes...
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US20090165153 |
Modified gene-silencing RNA and uses thereof
Methods and means for efficiently downregulating the expression of any gene of interest in eukaryotic cells and organisms are provided. To this end, the invention provides modified antisense and...
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US20090162848 |
Noxin, a novel stress-induced gene involved in cell cycle and apoptosis
The invention provides for novel noxin polypeptides and nucleic acids from humans, rats, and mice and to related compositions and uses. The invention also provides for the creation of non-human,...
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US20090158450 |
METHOD FOR THE TRANSFER OF EPISOMAL VECTORS INTO ANIMAL CELLS
The present invention refers to a method for the transfer of DNA sequences or exogenous genes into animal sperm cells by means of the use of episomal vectors. The invention also relates to the use...
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US20090155238 |
XYLANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
The invention relates to enzymes having xylanase, mannanase and/or glucanase activity, e.g., catalyzing hydrolysis of internal β-1,4-xylosidic linkages or endo-β-1,4-ghicanase linkages; and/or...
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US20090142266 |
PEPTIDES DERIVED FROM MAUROCALCINE USED AS VECTORS FOR INTRACELLULAR ADDRESSING OF MOLECULES OF INTEREST
Use of a peptide vector for intracellular addressing of a substance of interest, said vector essentially comprising a peptide which is derived from maurocalcine corresponding to the following...
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US20090138978 |
Use of bridge-1 and activators and inhibitors thereof in the treatment of insulin deficiency and diabetes
The present invention is directed to the use of Bridge-1 polynucleotides and Bridge-1 polypeptides, as well as activators and inhibitors of Bridge-1 activity, in the treatment of Bridge-1 mediated...
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US20090133136 |
Inducible SIRNA expression cassette and method of use
An inducible siRNA expression polynucleotide and methods for its use are provided. The expression polynucleotide comprises a bicistronic expression cassette that encodes a repressor and a...
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US20090133133 |
Transgenic Mice for Bioassay of Prions from Deer and Elk with Chronic Wasting Disease
The invention relates to the use of transgenic constructs to produce animal models for the study of chronic wasting disease.
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US20090119787 |
CELL NUCLEAR TRANSFER
The present invention discloses methods for cell nuclear transfer that comprise for example modification of zona pellucida of an oocyte, and/or sectioning of oocytes into several parts. The present...
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US20090113563 |
Probe for detecting nuclear receptor agonist or antagonist and method for screening agonist or antagonist to nuclear receptor with the use of the same
A probe for detecting an agonist or an antagonist to a nuclear receptor, in which, at least, a ligand-recognition site containing a ligand-binding domain of the nuclear receptor is connected with a...
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US20090104177 |
PEPTIDES FOR INHIBITING THE INTERACTION OF PROTEIN KINASE A AND PROTEIN KINASE A ANCHOR PROTEINS
The invention relates to a nucleic acid sequence encoding peptides which inhibit the interaction of protein kinase A (PKA) and protein kinase A anchor proteins (AKAP), to a host organism comprising...
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US20090098134 |
COMPOSITIONS AND METHODS FOR INHIBITING ENDOGENOUS IMMUNOGLOBULIN GENES AND PRODUCING TRANSGENIC HUMAN IDIOTYPE ANTIBODIES
The invention relates to transgenic animals lacking endogenous Ig and capable of producing transgenic antibodies, as well as methods of making the same. The invention further relates to methods for...
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US20090098128 |
NPC1L1 orthologues
The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.
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US20090094709 |
Use of protein phosphatase 2Ce (PP2Ce) having dephosphorylating action on AMPK
A drug includes, RNA interference with protein phosphatase 2Cε (PP2Cε) as an active ingredient. According to the present invention, the activation and deactivation of AMPK can be regulated.
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