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US20120255046 IN VIVO TRANSDUCTION WITH A CHIMERIC AAV CAPSID PROTEIN  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
US20120204281 DRG11-RESPONSIVE (DRAGON) GENE FAMILY  
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein....
US20120204280 DRG11-RESPONSIVE (DRAGON) GENE FAMILY  
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein....
US20130326646 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING NEUROLOGICAL CONDITIONS  
The present invention relates to the NIPA-1 proteins and nucleic acids encoding the NIPA-1 proteins. The present invention further provides assays for the detection of NIPA-1 polymorphisms and...
US20120180151 GENETIC VASECTOMY BY OVEREXPRESSION OF PRM1-EGFP FUSION PROTEIN IN SPERMATIDS  
The present invention provides a genetically-modified non-human animal whose somatic and germ cells contain an exogenous gene encoding a recombinant fusion protein, wherein the presence, and...
US20110055936 TRANSGENIC MAMALS MODIFIELD IN BRI PROTEIN EXPRESSION  
Provided are non-human mammals comprising a transgenic nucleic acid sequence capable of causing an alteration of expression of Bri2 or Bri3 in the mammal. Also provided are non-human mammals...
US20110179508 ENTEROVIRUS TYPE 71 PROTEIN AND METHOD FOR PRODUCTION  
The invention provides a new type of a capsid protein VP1 of human enterovirus 71, named as MEL701-VP1 and functional/structural variants thereof, which is used for protection against enterovirus....
US20110016544 Methods and compositions for detecting and treating retinal diseases based on metargidin (ADAM-15)  
The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD...
US20110030077 METHODS OF MODULATING THE ORGANIC SOLUTE AND STEROID TRANSPORTER (OSTalpha-OSTbeta) ACTIVITY AND TREATING ASSOCIATED CONDITIONS  
The present invention is directed to methods of modulating bile acid and lipid transport via the organic solute and steroid transporter Ostα-Ostβ. The present invention is further directed to...
US20100325746 Methods and sequences to suppress primate huntington gene expression in vivo  
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These...
US20120151609 Genetically Modified Rat Models for Pain  
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of gene(s) or gene product(s) resulting in altered...
US20100333218 TRANSGENIC PROTEINS FROM MULTI-GENE SYSTEMS, METHODS, COMPOSITIONS, USES AND THE LIKE RELATING THERETO  
A non-human transgenic mammalian animal, as described above, contains one or more exogenous double stranded DNA sequence(s) stably integrated into the genome of the animal, which comprises...
US20110265197 Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof  
The present invention provides methods of detecting cancer using biomarkers.
US20150082469 HUMANIZED IL-7 RODENTS  
Genetically modified non-human animals comprising a human or humanized interleukin-7 (IL-7) gene. Cells, embryos, and non-human animals comprising a human or humanized IL-7 gene. Rodents that...
US20130340104 Humanized IL-7 Rodents  
Genetically modified non-human animals comprising a human or humanized interleukin-7 (IL-7) gene. Cells, embryos, and non-human animals comprising a human or humanized IL-7 gene. Rodents that...
US20100311645 PROTEINS FROM THE WEBS OF NEPHILENGYS CRUENTATA, AVICULARIA JURUENSIS AND PARAWIXIA BISTRIATA SPIDERS ISOLATED FROM BRAZILIAN BIODIVERSITY  
The Present invention relates to molecules isolated from the nucleic acid that encodes spider web proteins or fragments of these or other derivatives of these. The invention also refers to a...
US20120192298 METHOD FOR GENOME EDITING  
The present invention encompasses a method for creating an animal or cell with at least one chromosomal edit. In particular, the invention relates to the use of targeted zinc finger nucleases to...
US20140335063 DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING  
Disclosed herein are methods and compositions for delivery of engineered nucleases and donor molecules into the genome of a cell.
US20110059510 TRANSGENIC RABBITS PRODUCING HUMAN FACTOR VII  
The invention relates to transgenic rabbits that produce human factor VII in their mammary glands. The milk of said transgenic rabbits can be used as a raw material for the production of...
US20110030076 Methods and compositions for targeted cleavage and recombination  
Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an...
US20120084871 NPC1L1 ORTHOLOGUES  
The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.
US20110258715 ORGAN REGENERATION METHOD UTILIZING iPS CELL AND BLASTOCYST COMPLEMENTATION  
It is revealed that an organ such as pancreas can be regenerated by utilizing a fact that the deficiency of an organ is complemented by injecting an induced pluripotent stem cell (iPS cell) into a...
US20120110686 Cand45 tRNA-Derived Expression System for Gene Modulation  
The present invention relates to systems and methods for modulating gene expression and applications thereof. Provided is a novel expression system to generate RNaseZ and RNA polymerase III...
US20130276156 Multiple Inducible Gene Regulation System  
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
US20110016542 CANINE GENOME EDITING WITH ZINC FINGER NUCLEASES  
The present invention provides a genetically modified canine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger...
US20070011755 Diabetes type 2 animal model  
A diabetes type 2 model laboratory animal is disclosed which comprises cells over-expressing GPR40 under the control of the Ipfl/Pdx 1 promoter. Also disclosed is the use of the model animal for...
US20110023141 GENOMIC EDITING OF GENES INVOLVED WITH PARKINSON'S DISEASE  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with Parkinson's disease. In particular, the animals or...
US20130198878 ORGANISMS HOMOZYGOUS FOR TARGETED MODIFICATION  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20110247089 Organisms homozygous for targeted modification  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20140004537 REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A...
US20130326645 METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED TARGETED INTEGRATION OF TRANSGENES  
Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.
US20110023156 FELINE GENOME EDITING WITH ZINC FINGER NUCLEASES  
The present invention provides a genetically modified feline or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger...
US20110023157 EQUINE GENOME EDITING WITH ZINC FINGER NUCLEASES  
The present invention provides a genetically modified equine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger...
US20140165222 HIGH AFFINITY SUMO TRAPS  
The potential use of these “SUMO receptors” to isolate SUMOylated targets has been considered using the SIM sequences of the SUMO-dependent ubiquitin-protein ligase RNF4. RFN4 contains 4 SIM...
US20110318367 NOVEL TARGETS FOR TREATMENT OF HYPERCHOLESTEROLEMIA  
In certain embodiments this invention this invention pertains to the discovery that inhibition of myosin light chain interacting protein (Mylip) can mitigate one or more symptoms of...
US20150128300 METHODS AND COMPOSITIONS FOR GENERATING CONDITIONAL KNOCK-OUT ALLELES  
The disclosure provides methods and compositions for generating conditional knock-out alleles using donor constructs together with sequence-specific nucleases to generate conditional knock-out...
US20130024960 OPTIMISED CODING SEQUENCE AND PROMOTER  
An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors...
US20100319078 Stem Cells Modified to Facilitate Threonine Catabolism  
A mammalian cell comprising a recombinant, functional L-threonine 3-dehydrogenase (EC 1.1.1.103; TDH) gene, methods of making, and methods of use.
US20110023140 RABBIT GENOME EDITING WITH ZINC FINGER NUCLEASES  
The present invention provides a genetically modified rabbit or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger...
US20110203007 ASSAYS OF NEURODEGENERATIVE DISORDERS, INCLUDING FRONTOTEMPORAL DEMENTIA AND AMYOTROPHIC LATERAL SCLEROSIS  
The invention relates to novel assays for the in vivo analysis of neurodegenerative diseases and the use of such assays to discover therapies capable of modulating such diseases.
US20130117870 GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME  
Compositions and methods for use of TALENs to make genetically modified livestock or other animals are set forth. Some of the embodiments of the invention provide for making an founder animal that...
US20140201858 METHODS FOR SITE-SPECIFIC GENETIC MODIFICATION IN STEM CELLS USING XANTHOMONAS TAL NUCLEASES (XTN) FOR THE CREATION OF MODEL ORGANISMS  
The invention relates to organisms and compositions comprising one or more stem cells or one or more embryos, wherein the one or more stem cells or one or more embryos comprise one or more of the...
US20110283375 Transgenic Prothrombin And Related Thrombin Precursors And Transgenics, Methods, Compositions, Uses And The Like Relating Thereto  
The invention provides, among other things, activatable prothrombin, compositions comprising prothrombin, transgenic organisms for making prothrombin, methods for making the transgenic organisms,...
US20110214194 COMPOSITIONS AND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKE RECEPTOR 4 SIGNALING PATHWAY  
Compositions and methods are provided for screening and identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 and a ligand. Methods are provided for...
US20120151613 MUTANTS OF ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID) AND METHODS OF USE  
The invention provides functional mutants of activation-induced cytidine deaminase (AID) protein that have increased activity as compared to a wild-type AID protein. The invention also provides...
US20110023139 GENOMIC EDITING OF GENES INVOLVED IN CARDIOVASCULAR DISEASE  
The present invention provides genetically modified animals and cells comprising edited chromosomal involved in cardiovascular disease. In particular, the animals or cells are generated using a...
US20110023151 GENOME EDITING OF ABC TRANSPORTERS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding ABC transporter proteins. In particular, the animals or cells are generated...
US20150156996 LIVESTOCK WITH GENETICALLY MODIFIED PROLACTIN RECEPTOR  
Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell...
US20130067609 Mammalian Genes Involved in Tularemia and Other Infections  
The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or...
US20110162094 MODIFIED HUMAN FACTOR VII/VIIA AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME  
Modified factors VII/VIIa with a high stability, nucleic acids encoding such modified factors VII/VIIa, and methods of preparing the same.