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US20110295037 |
PROCESSES FOR PREPARING CINACALCET HYDROCHLORIDE AND POLYMORPHIC FORMS THEREOF
The invention relates to cinacalcet hydrochloride, new polymorphic crystalline forms of cinacalcet hydrochloride, amorphous cinacalcet hydrochloride and synthetic processes for their preparation.
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US20090259066 |
Method for preparing prostaglandin F analogue
A method for preparing a prostaglandin F analogue represented by the following formula (I) is disclosed, wherein R1, and are as defined in the specification.
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US20100311728 |
Manipulation of brain CDP-diacylglycerol and uses thereof
Provided herein methods of screening for potential antidepressant compounds effective to increase production of cellular CDP-diacylglycerol and synthesis of inositol phospholipid in...
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US20110145970 |
DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8
The invention relates to novel modulators of the cold menthol receptor TRPM8, to a method for modulating the TRPM8 receptor using said modulators; to the use of the modulators for induction of cold...
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US20120095103 |
COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS
Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70...
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US20120065235 |
COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS
Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70...
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US20110245262 |
COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS
Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70...
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US20090226368 |
Androgen-Receptor (AR) Ligands for Use in the Treatment and Diagnosis of AR-Related Pathologies
The present invention discloses novel compounds and compositions suitable for the treatment of androgen related pathologies. The invention also provides diagnostic compositions for the diagnosis or...
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US20110189090 |
MOLECULAR PROBES FOR IMAGING OF MYELIN
A molecular probe for labeling myelin includes a fluorescent trans-stilbene derivative.
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US20090318564 |
Process for preparing and drying solid rasagiline base
Disclosed is crystalline R(+)-N-propargyl-l-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the...
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US20100331564 |
METHOD FOR PRODUCING URETHANES COMPOSED OF MONO AND DI-FUNCTIONAL AROMATIC AMINES
The object of the invention is to provide a process for preparing urethanes by reacting aromatic amines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate...
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US20120004313 |
CRYSTALLINE FORM VI OF AGOMELATINE, PREPARATION METHOD AND APPLICATION THEREOF
The invention provides a new crystalline form of agomelatine, preparation and use thereof. The X-ray powder diffraction diagram of the agomelatine crystalline form shows main peaks at the...
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US20120209029 |
METHOD FOR PREPARING LARGE-SIZED TITANIUM-SILICALITE MOLECULAR SIEVE AND METHOD FOR PREPARING CYCLOHEXANONE OXIME USING THE MOLECULAR SIEVE
The present invention provides a method for preparing a large-sized titanium-silicalite molecular sieve, and a method for preparing cyclohexanone oxime using the large-sized titanium-silicalite...
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US20110159050 |
AMPHIPHILIC PROTEINS AS MORPHOLOGY MODIFIERS
Disclosed is a process for modifying the morphology and/or polymorphism of an organic substance, which process comprises treating the solid substance, or a solution or dispersion thereof, with one...
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US20110300080 |
ACIDIFIED CHLORITE DISINFECTANT COMPOSITIONS WITH OLEFIN STABILIZERS
A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to...
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US20110086425 |
DELIVERY OF siRNAs
The present invention provides siRNA delivery methods use in vivo or in vitro. The delivery methods include conjugation with delivery peptides and mixing with dendrimers.
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US20090131717 |
COMPOSITION FOR PROTECTING SKIN
Disclosed are a composition for protecting skin and uses thereof. The composition comprises sphingomyelin as an active ingredient and protects the skin by inhibiting skin aging, treating a skin...
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US20120190880 |
METHODS AND COMPOSITIONS FOR PREPARATION OF AMPHETAMINE CONJUGATES AND SALTS THEREOF
The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention...
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US20100266714 |
P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
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US20110158909 |
Cationic Contrast Agents and Methods of Use Thereof
The present invention provides compounds useful as contrast agents, such as for the CT imaging of cartilage tissue. The contrast agents are generally iodinated organic molecules that are positively...
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US20110281952 |
DEUTERIUM-ENRICHED TOLTERODINE
The present application describes deuterium-enriched tolterodine, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20110201690 |
DEUTERIUM-ENRICHED DAPOXETINE
The present application describes deuterium-enriched dapoxetine, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20110130463 |
DEUTERIUM-ENRICHED BUPROPION
The present application describes deuterium-enriched bupropion, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20110118358 |
DEUTERIUM-ENRICHED SALMETEROL
The present application describes deuterium-enriched salmeterol, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20110034521 |
COMPOUNDS AND METHODS FOR TREATING ZINC MATRIX METALLOPROTEASE DEPENDENT DISEASES
The present invention provides compounds and methods for treating zinc matrix metalloprotease dependent diseases. In certain embodiments, the compounds of the present invention have the following...
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US20110046128 |
NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment...
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US20130035508 |
PROCESS FOR THE PREPARATION OF LACOSAMIDE
Present invention relates to an improved and commercial process for the preparation of lacosamide ((R)-2-acetami-do-N-benzyl-3-methoxypropanamide) of formula (I). Present process utilizes high...
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US20110106241 |
COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE
Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.
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US20120302541 |
4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein...
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US20120108667 |
HYDROXY CERAMIDES AND ANALOGS THEREOF AND THEIR USE FOR PREVENTING OR TREATING CANCER
Disclosed herein are compounds, compositions, methods of treatment and synthetic methods for making compounds related to Ceramides and the use of Ceramides.
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US20130029901 |
METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH
Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting...
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US20120083440 |
METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH
Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting...
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US20110104162 |
Compounds which can be used for the Treatment of Cancers
The present invention relates to a compound of general formula (I): and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in...
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US20120016161 |
METHOD FOR PRODUCING OXIME
The present invention provides a method for producing an oxime, comprising the step of an ammoximation reaction of a ketone with an organic peroxide and ammonia in the presence of a catalyst...
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US20130022611 |
METHODS AND COMPOSITIONS FOR MODULATING HEPSIN ACTIVATION OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
The invention provides methods and compositions for modulating hepsin activity and the uPA/plasmin pathway, in particular by regulating pro-uPA activation by hepsin.
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US20110065959 |
Removal of Silica from Water Soluble Compounds by Nanofiltration and Reverse Phase Chromatography
A process for separating soluble silica species such as monomeric silicic acid (or monosilicic acid) and low molecular weight soluble polymeric silica from impure water soluble compounds by...
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US20120264603 |
ATTACHMENT AND RETENTION FORMULATIONS FOR BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS
The invention encompasses formulations for increased attachment and retention systems of biologically active organic compounds and methods for the preparation and use thereof.
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US20110021653 |
HYDROGEL COMPATIBLE TWO-PHOTON INITIATION SYSTEM
A method for creating 3D structures using two-photon direct writing includes mixing a resin having a monomer structure with a solvent to create a resin-solvent mixture. A chromophore initiator is...
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US20110218323 |
PROCESS FOR PREPARING CYCLIC DIAMINES
The present invention relates to a process for preparing a cyclic diamine, comprising the reaction of at least one cyclic alkene with a gas mixture (G) comprising dinitrogen the subsequent...
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US20120095143 |
DISPERSION AND RETRIEVAL OF DE-BUNDLED NANOTUBES
A method for dispersing nanotubes, comprising forming a nanocomposite solution with associated nanotubes and nanoplatelets, mixing a surfactant to the nanocomposite solution, separating the...
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US20120077976 |
CAMPHOR-DERIVED COMPOUNDS, METHOD FOR MANUFACTURING THE SAME, AND APPLICATION THEREOF
Camphor-derived compounds are disclosed, which are represented as the following formula (I): wherein R1, R2, R3, and R4 each are defined as described in the specification. In addition, a method for...
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US20090118457 |
Resorcinol-based mannich base
The invention relates to Mannich bases that can be produced from resorcinol, formaldehyde, and triethylenetetramine and/or tetraethylenepentamine. Also disclosed are a method for the production...
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US20110294741 |
USE OF COMPOUNDS IN THE TREATMENT OF TAU-INDUCED CYTOTOXICITIES
The present invention relates to derivatives of L-Tyrosyl-L-Arginine and the use of said derivatives in the prevention and/or treatment of a tau-induced cytotoxicity.
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US20120277470 |
METHOD FOR PRODUCING TERTIARY AMINE
The present invention provides a method for producing a tertiary amine by using a secondary amine and an alcohol as starting materials to obtain a corresponding tertiary amine. The method of the...
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US20120253071 |
Sterilization of biodegradable hydrogels
The present invention relates to a terminal sterilization process for biodegradable PEG-based insoluble hydrogels using irradiation. The presence of a protective solvent ensures that the hydrogel...
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US20120272868 |
PRODUCTION OF GRAPHENE NANORIBBONS WITH CONTROLLED DIMENSIONS AND CRYSTALLOGRAPHIC ORIENTATION
Graphene particulates, especially graphene nanoribbons (GNRs) and graphene quantum dots Ds and and a high-throughput process for the production of such particulates is provided. The graphene...
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US20110144382 |
ADVANCED CATALYSTS FOR FINE CHEMICAL AND PHARMACEUTICAL APPLICATIONS
A catalyst comprising a plurality of support nanoparticles and a plurality of catalytic nanoparticles. At least one catalytic nanoparticle is bonded to each support nanoparticle. The catalytic...
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US20110263041 |
COMPOSITION FOR MEASURING THE BINDING AFFINITY BETWEEN NUCLEIC ACID AND TEST SUBSTANCE, AND USE THEREOF
In one embodiment of the present invention, a composition is disclosed for measuring a binding affinity between a nucleic acid and a test substance, which contains an organic fluorescent substance...
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US20130089793 |
IONIC LIQUIDS, ELECTROLYTE SOLUTIONS INCLUDING THE IONIC LIQUIDS, AND ENERGY STORAGE DEVICES INCLUDING THE IONIC LIQUIDS
An ionic liquid including a phosphazene compound that has a plurality of phosphorus-nitrogen units and at least one pendant group bonded to each phosphorus atom of the plurality of...
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US20130012502 |
Pharmaceutical or Veterinary Antiviral Compositions
Pharmaceutical or veterinary compositions to prevent or treat viral infections, in particular to prevent or treat influenza A, B and C virus infections.
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