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US20090275556 |
Aryl sulfonamides useful as inhibitors of chemokine receptor activity
The present invention provides compounds of general formula I:
or a pharmaceutically acceptable salt thereof, wherein R 1 , X, Z, R 2 , X 1 , Ar, n, R 3 and R 4 are defined generally and in...
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US20090275064 |
Methods to identify therapeutic agents
As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic...
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US20090264533 |
Methods and Compositions for Modulating RHO-Mediated Gene Transcription
The present invention is directed to methods and compositions methods and compositions for determining and inhibiting gene transcription in mammalian cells. The invention relates to novel...
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US20090247627 |
AMINO- AND AMIDO-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
The invention provides amino- and amido-aminotetralin compounds of formula (I):
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , and n are defined in the specification, or a...
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US20090234154 |
Process for the preparation of tamsulosin and intermediates thereof
A process for producing tamsulosin of formula I
and pharmaceutically acceptable addition salts, thereof comprises the steps of:
a) Reacting compound...
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US20090233909 |
Sulfonamide compounds as cysteine protease inhibitors
The present invention is directed to compounds of formula (I) that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases...
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US20090227571 |
Androgen Receptor Modulator Compounds and Methods
Provided herein are compounds that bind to androgen receptors and modulate the activity and/or the amount of androgen receptors and to methods for making and using such compounds. Also provided are...
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US20090170950 |
Inhibitors Of Neurotrypsin
The invention relates to a method for determining whether a compound is a neurotrypsin inhibitor, characterized in that the compound is incubated together with neurotrypsin, a variant thereof or a...
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US20090163487 |
N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
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US20090137844 |
Crystallization process
The invention relates to a process for the production of tamsulosin hydrochloride crystals where the crystal size distribution is controlled by controlling the temperature where hydrochloric acid...
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US20090137681 |
Sirtuin Inhibiting Compounds
Provided herein are compositions and methods for treating or preventing cancer and autoimmune diseases. Compositions comprise a sirtuin inhibitory compound that decreases the activity of a sirtuin,...
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US20090124828 |
Unsaturated Sulfides, Sulfones, Sulfoxides and Sulfonamides Synthesis
α,β-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I:
wherein Ar 1 , Ar 2 , X, n, * and R are as defined herein, are prepared by dehydration of β-hydroxy...
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US20090105309 |
Medicinal Compounds
Compounds of formula (I):
and salts, solvates, and physiologically functional derivatives thereof, useful for the prophylaxis or treatment of a clinical condition for which a selective β 2...
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US20090105168 |
Use Of HDAC And/Or DNMT Inhibitors For Treatment Of Ischemic Injury
The present invention provides methods of ameliorating or reducing the extent of ischemic injury, reperfusion injury, and myocardial infarction, by administering an inhibitor of histone deacetylase...
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US20090099187 |
Novel 8-Sulfonyl-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5HT6 Receptor
The present invention relates to new compounds of formula (I), wherein R 1 to R 12 , P, X, Q and n are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their...
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US20090093525 |
Cyclopropyl aryl amide derivatives and uses thereof
Compounds of the formula:
wherein Ar 1 , Ar 2 , R 1 and R 2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
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US20080319225 |
Method of Preparation of (R)-(-)-5(2-Aminopropyl)-2-Methoxybenzenesulfonamide
A method of preparation of (R)-(−)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide of formula I and its use for production tamsulosin. A protective group is introduced to...
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US20080318996 |
6-Amino(Aza)Indane Compounds Suitable for Treating Disorders that Respond to Modulation of the Dopamine D3 Receptor
The present invention relates to 6-amino(aza)indane compound of the formula (I) Wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R...
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US20080312328 |
DEUTERIUM-ENRICHED TAMSULOSIN
The present application describes deuterium-enriched tamsulosin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20080299674 |
Novel Isonitrile Compound, Its Method Of Manufacture, A Marine Fouling Organism Larva Fluorescent, And A Method Of Detecting This Marine Fouling Organism Larva Using Said Marker
Novel isonitrile compounds represented by the general formula F-A-NC, their method of manufacture, a marine fouling organism larva fluorescent marker having at least one of these compounds as an...
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US20080262089 |
Process for the Preparation of Tamsulosin
The invention includes an improved process for producing tamsulosin comprising reacting 5-(2-aminopropyl)-2-methoxybenzenesulfonamide with 2-(o-ethoxyphenoxy)ethyl bromide in an organic phosphite...
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US20080255169 |
Sulphonamide Derivatives
The invention relates to sulphonamide derivatives of formula (I),
where
R C is optionally substituted 4-6-membered heterocyclic ring containing one or more N atoms, or R C forms together with...
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US20080207701 |
OPIOID RECEPTOR ANTAGONISTS
A compound of the formula (I) wherein the variables X 1 , X 2 , B, D, R 1 to R 7 including R 3′ , p, y, q, and z, are as defined or a pharmaceutically acceptable salt, solvate, enantiomer,...
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US20080207584 |
Compound Having S1P Receptor Binding Potency and Use Thereof
Provided are: a compound represented by formula (I):
(wherein ring A and ring D each represent a cyclic group which may have a substituent(s); E and G each represent a bond or a spacer having 1...
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US20080119555 |
Aryl Alkyl Sulfonamides As Therapeutic Agents For The Treatment Of Bone Conditions
The present invention pertains to certain aryl alkyl sulfonamides and derivatives thereof which, inter alia, inhibit osteoclast survival, formation, and/or activity; and/or inhibit bone resorption,...
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US20080090788 |
Chemical Compounds
Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as a Nuclear Factor-kB (NF-kB) inhibitor
wherein:
A has the...
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US20080063678 |
Novel 2-Cyano-3(Halo)Alkoxy-Benzenesulfonamide Compounds for Combating Animal Pests
The invention relates to 2-cyano-3-(halo)alkoxy-benzenesulfonamide compounds I
where the variables Alk and R 1 to R 5 are as defined in claim 1, and/or to their agriculturally useful...
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US20080058302 |
Sulfamoyl Benzamides and Methods of Their Use
Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the...
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US20080051416 |
Novel Compounds
The present invention is directed to novel compounds of formula (I):
or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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US20080033208 |
Process for Manufacturing Optically Pure (R) or (S)-5-(2-Aminopropyl)-2-Methoxybenzene Sulfonamide
The invention relates to an improved process for the manufacture of enantiomerically pure R-(+) or S-(+)-5-(2-amino-propyl)-2-methoxybenzene sulfonamide by resolution of...
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US20080033207 |
Preparation of R-5- (2-(2-Ethoxyphenoxyetylamino) -2-Methoxybenzen-Sulphonamide Hydrochloride of High Chemical
In the present invention, the process for the preparation of tamsulosin hydrochloride and subsequent purification with thermal crystallisation to provide essentially pure tamsulosin hydrochloride...
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US20080027073 |
Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals...
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