AcclaimIP-ad

Match Document Document Title
US20080039435 Novel Steroid Agonist For Fxr  
The invention relates to a FXR agonist of formula (I) and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.
US20110152208 Use of Compounds Extracted from Momordica Charantia L. in the Manufacture of Medicaments for Prevention and Treatment of Diabetes and Obesity  
The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation...
US20140100419 ACTIVE VITAMIN D OR ANALOGS THEREOF FOR USE IN IN VIVO OR IN VITRO FERTILIZATION  
The present invention relates to methods for improving the ability of spermatozoa to fertilize an egg in vitro and/or vivo, said method comprising providing a medium comprising active vitamin D...
US20110015295 ADDITIVE MIXTURES FOR AGRICULTURAL ARTICLES  
Disclosed are 2,6-bis[octadecyloxy]anthraquinone, 1-(4,6-bis[dibutylamino]-[1,3,5]-triazin-2-ylamino)-anthraqu inone, 2-(4,6-bis[dibutylamino]-[1,3,5]-triazin-2-ylaminoyanthraqui none,...
US20130102779 Substituted Tetracycline Compounds  
The present invention pertains to tetracycline compounds of formula (VIIa): R5*, R5*′, R7r*, and R9m* are defined herein. These tetracycline compounds can be used to treat tetracycline...
US20110086822 Substituted Tetracycline Compounds  
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20090082317 LOW-CALCEMIC 16,23-DIENE 25-OXIME ANALOGS OF 1ALPHA,25-DIHYDROXY VITAMIN D3  
The present invention provides novel 16,23-diene 25-oxime ether analogs of 1,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of...
US20100255117 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER  
The instant invention provides methods and compositions for the treatment of cancer.
US20110178052 9-ALPHA ESTRATRIENE DERIVATIVES AS ER-BETA SELECTIVE LIGANDS FOR THE PREVENTION AND TREATMENT OF INTESTINAL CANCER  
Use of 9α-estra-1,3,5(10)-triene derivatives of formula (I) for the prevention and treatment of intestinal cancer, in particular adenoma and adenocarcinoma of the duodenum, ileum, colon, and rectum.
US20050288262 3, 10, and 12a Substituted tetracycline compounds  
The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20100305072 Substituted Tetracycline Compounds  
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20150126483 PREPARATIONS OF HYDROPHOBIC THERAPEUTIC AGENTS, METHODS OF MANUFACTURE AND USE THEREOF  
The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or...
US20100093685 NITRIC OXIDE RELEASING STEROIDS  
The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof R-(Z)a-Rx (I) wherein R is the corticosteroid...
US20080161586 PROCESS FOR RECOVERING STEROLS FROM A CRUDE SOURCE CONTAINING STEROL ESTERS  
A process of obtaining sterols suitable for human consumption from a crude wood pulping source containing sterol esters is disclosed. The sterols are obtained at high yield and purity. In...
US20100298585 METHOD FOR SYNTHESIS OF DIENOGEST FROM ESTRONE-3-METHYLETHER  
A method for the synthesis of dienogest from 3-methoxy-estra-1,3,5-trien-17-one includes the steps of a) reacting 3-methoxy-estra-1,3,5-trien-17-one with alcohol in the presence of an acid in an...
US20140135298 MUTATION MIMICKING COMPOUNDS THAT BIND TO THE KINASE DOMAIN OF EGFR  
This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders...
US20140179637 METHODS AND COMPOUNDS TO INHIBIT ENVELOPED VIRUS RELEASE  
A compound having an antiviral activity for inhibiting release of an enveloped virus from a cell is disclosed, including methods of inhibiting release of an enveloped virus from a cell. The...
US20100273894 TREATMENT OF LEBER'S HEREDITARY OPTIC NEUROPATHY AND DOMINANT OPTIC ATROPHY WITH TOCOTRIENOL QUINONES  
The present invention relates to methods of treating Leber's hereditary optic neuropathy and dominant optic atrophy with tocotrienol quinones, including alpha-tocotrienol quinone, in order to...
US20050137174 Prodrugs of 9-aminomethyl tetracycline compounds  
The invention pertains to prodrugs of 9-aminomethyl substituted tetracycline compounds, methods of using the compounds, and pharmaceutical compositions containing them.
US20140107089 STRUCTURAL MODIFICATION OF 19-NORPROGESTERONE I: 17-ALPHA-SUBSTITUTED-11-BETA-SUBSTITUTED-4-ARYL AND 21-SUBSTITUTED 19-NORPREGNADIENEDIONE AS NEW ANTIPROGESTATIONAL AGENTS  
Disclosed are compounds having the general formula: wherein R1-R4 and X are as defined herein, pharmaceutical compositions including such compounds, and a method of treating a patient involving...
US20110295025 PROCESS FOR THE PREPARATION OF CHOLYL-L-LYSINE  
A process for the preparation of cholyl-L-lysine comprising the steps of: —(a) reacting N-ε-CBZ-cholyl-L-lysine with a hydrogen source in the presence of a catalyst in a solvent comprising one or...
US20080200440 Progesterone receptor antagonists  
The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
US20060275880 Selective enzymatic esterfication and solvolysis of epimeric vitamin D analog and separation and epimerization of the epimers  
Since the C-24 of the vitamin D derivatives having C-24 hydroxyl branch is a chiral center, there are two epimers, i.e. C-24R hydroxyl and C-24S hydroxyl, that can be found. However, only the...
US20090181936 Diene and Triene Compounds and Formulations  
The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in...
US20070238889 PROCESS FOR PREPARING DC-CHOLESTEROL  
Processes for preparing 3β-[N-(N′,N′-dimethylaminoethane)-carbamoyl]cholesterol (“DC-cholesterol”) and its salts.
US20110184197 EFFECTIVE HYDROGENATION PROCESS  
The invention relates to an effective process for producing plant stanol by hydrogenating plant sterol in an organic solvent at a hydrogen pressure of 1-200 bar in the presence of a hydrogenation...
US20110086088 Compositions and methods for treatment of mammalian skin  
Compositions useful for treatment of a wide range of skin disorders including: pre-cancerous lesions, keratotic lesions, superficial basal cell carcinomae; squamous cell carcinomae; malignant...
US20070249574 Stanol composition and the use thereof  
A stanol composition containing in addition to sitostanol as the main component, also a substantial amount of at least 10% campestanol has been found to effectively lower serum cholesterol levels...
US20090099140 20-Alkyl, Gemini Vitamin D3 Compounds and Methods of Use Thereof  
The invention provides 20-alkyl Gemini vitamin D3 compounds, methods for using the compounds to treat vitamin D3 associated states and pharmaceutical compositions containing the compounds.
US20050059641 Compositions and methods for treating and preventing cancer using analogs of vitamin D  
Disclosed are compositions and methods used to treat and/or prevent cancer and metabolic diseases, such as psoriasis. In one aspect, the present invention pertains to the use of cross-linking...
US20090137828 Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol  
The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes allylic and olefin oxidation, de-carbonylation, carbonyl reduction, fluoride...
US20140031319 METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS  
Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
US20120077791 NOVEL CRYSTALLINE FORM OF ANTIPROGESTIN CDB-4124  
The present invention relates to novel crystalline Form A of 17α-acetoxy-21-methoxy-11β-[4-N,N-dimethylaminophenyl]-19-no rpregna-4,9-diene-3,20-dione, (also known as CDB-4124) and methods for the...
US20110034429 5a-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR  
Disclosed are compounds such as 5α-androstane-3,6,17-trione, formulations comprising said compounds, and methods of use thereof to stimulate endogenous testosterone production and improve athletic...
US20100009943 2-Methylene-(22E)-25-(1-Methylene-Hexyl)-26,27-Cyclo-22-Dehydro-19-Nor-Vitamin D Analogs  
This invention discloses 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehy dro-19-nor-vitamin D analogs, and specifically...
US20150190534 COMPOUNDS FOR USE AS POSITRON EMISSION IMAGING AGENTS  
The present invention relates generally to compounds according to formula I that bind more specifically to mutated androgen receptors than to the wild type androgen receptors and therefore are...
US20140296510 Method for preparing ulipristal acetate and key intermediate thereof  
A method as well as new intermediates for preparing Ulipristal acetate (a compound I) and a method for preparing the new intermediates are provided. The intermediate in a constitutional formula IV...
US20110014641 METHOD FOR MEASURING AROMATASE ACTIVITY  
The present invention relates to compounds useful for measuring aromatase activity. The invention further provides methods for measuring aromatase activity and for screening test agents which...
US20070066579 5-androsten-3beta-ol steroid intermediates and processs for their preparation  
The present invention provides 5-androsten-3β-ol steroid intermediates and processes for their preparation.
US20120329737 HYBRID MOLECULES MADE OF LIPIDS AND LIPID-ANALOGOUS COMPOUNDS AND USE THEREOF AS PHARMACEUTICAL OR COSMETIC PREPARATION  
The invention relates to hybrid molecules made of two lipids or lipid-analogous compounds which are linked to each other via their lipophilic end. The hybrid molecules thereby have at least one...
US20100280252 POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS  
The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of...
US20120101271 DIAMINE SYNTHESIS VIA CATALYTIC C-H AMINATION OF AZIDES  
Selective intramolecular C—H amination via metalloradical activation of azides: synthesis of 1,3-diamines under neutral and nonoxidative conditions. One aspect of the present invention is the...
US20130211069 PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS  
The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess...
US20100273761 NUCLEAR SULFATED OXYSTEROL, POTENT REGULATOR OF LIPID HOMEOSTASIS, FOR THERAPY OF HYPERCHOLESTEROLEMIA, HYPERTRIGLYCERIDES, FATTY LIVER DISEASES, AND ATHEROSCLEROSIS  
The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an...
US20090093448 19-NOR-PROGESTERONE FOR CONTRACEPTION  
The invention relates to compounds of the general formula (I) to a method for the production thereof, to pharmaceutical, cosmetic compositions or dosage forms which contain these compounds, and to...
US20140094464 QUINONE COMPOUNDS FOR TREATING APE1 MEDIATED DISEASES  
The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and...
US20130303502 Preparations of Hydrophobic Therapeutic Agents, Methods of Manufacture and Use Thereof  
The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone, pharmaceutical compositions (e.g., topical or intranasal...
US20140179638 9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUNDS  
The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a...
US20070032461 1,3 Aclyated 24-keto-vitamin d3 compounds and methods of use thereof  
The invention provides 1,3 acylated, 24-keto vitamin D3 compounds of formula I: wherein: X1 and X1 are each independently H2 or ═CH2, provided X1 and X1 are not both ═CH2; R1 and R2 are each...
US20100331292 SUBSTITUTED 16,17-ANNELLATED STERIOD COMPOUNDS FOR USE IN WOMENS HEALTHCARE  
The present invention relates to substituted steroid compounds having the formula Wherein R1 is H or halogen; R2 is H, (1C-4C)alkyl, (1C-4C)acyl, glucuronyl or sulfamoyl; R3 is H or halogen; R4 is...