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US20110039811 TREATING HYPERGLYCEMIA WITH 25-HYDROXYVITAMIN D3  
We disclose treating hyperglycemia in a human with 25-hydroxyvitamin D3 (calcifediol). Blood glucose is reduced to a level which is closer to normal than baseline. Vitamin D3 (cholecalciferol) may...
US20100086915 DETECTION OF ESR1 AMPLIFICATION IN BREAST CANCER  
The present invention relates to an in-vitro method of identifying a tumor resulting from a proliferative breast disease as responsive to anti-estrogen treatment. Further, the invention relates to...
US20110294151 Fluorescently Labeled Calcium Phosphate Surfaces  
Described herein are substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating. The substrates are useful in culturing and studying the activity of a variety of...
US20140050791 Optimized Synthesis Of Pure, Non-Polymorphic, Crystalline Bile Acids With Defined Particle Size  
The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The inventions further provides a pharmaceutical composition...
US20110239903 MODIFIED PIGMENTS AND METHODS FOR MAKING AND USING THE SAME  
A method of producing a modified pigment by sulfonating a pigment and subsequently oxidizing the pigment. The modified pigment may have sulfonic acid and carboxyl surface modifying groups attached...
US20110152099 BIOACTIVE COMPOUNDS OF ASCOPHYLLUM NODOSUM AND THEIR USE FOR ALLEVIATING SALT-INDUCED STRESS IN PLANTS  
A process for extraction of bioactive organic compounds from alkali extracts of Ascophyllum nodosum. Organic solvent extracts of A. nodosum namely; methanol, chloroform and ethylacetate, were...
US20120190871 TRITERPENOID COMPOSITION OF ANTRODIA CINNAMOMEA, PREPARATION AND ANALYSIS METHOD THEREOF  
Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia cinnamomea using HPLC and NMR, as well...
US20140342998 QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS  
The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions...
US20110257421 7-N-Substituted Phenyl Tetracycline Compounds  
7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
US20110118215 7,8 And 9-Substituted Tetracycline Compounds  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
US20110082305 7-Phenyl-Substituted Tetracycline Compounds  
7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are...
US20090170821 2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs  
This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This...
US20090170820 2-Methylene-(20S,25R)-19,26-Dinor-Vitamin D Analogs  
This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This...
US20090170819 (20R)-23,23-Difluoro-2-Methylene-19-Nor-Bishomopregnacalciferol-Vitamin D Analogs  
This invention discloses (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalcife rol-vitamin D analogs, and specifically (20R)-23,23-difluoro-1...
US20090170818 (20S)-23,23-Difluoro-Methylene-19-Nor-Bishomopregnacalciferol-Vitamin D Analogs  
This invention discloses (20S)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalcife rol-vitamin D analogs, and specifically...
US20080081800 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs  
This invention discloses 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20R,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitam in D3, and pharmaceutical uses...
US20080081799 2-Methylene-(20S,25S)-19,27-Dinor-(22E)-Vitamin D Analogs  
This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitam in D3, and pharmaceutical uses...
US20100035851 AGENT FOR IMPROVING INSULIN RESISTANCE  
To inhibit production of adipocytokines, in particular, adipocytokines that elicit insulin resistance and to prevent onset of pathosis caused by the insulin resistance, or improve the pathosis,...
US20140301967 ANTIMICROBIAL CATIONIC POLYCARBONATES  
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain...
US20120316341 FLUORINATION OF ORGANIC COMPOUNDS  
Methods for fluorinating organic compounds are described herein.
US20140005420 Salts and Polymorphs of a Tetracycline Compound  
Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for...
US20130157988 SUBSTITUTED ANDROST-4-ENE DIONES  
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds...
US20140323748 WATER-SOLUBLE URSODEOXYCHOLIC ACID PRODRUGS  
Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous...
US20130296279 SUBSTITUTED TETRACYCLINES  
The invention in one embodiment is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention is also directed to a composition comprising the compound of...
US20100056488 CORTICOSTEROID CONJUGATES AND USES THEREOF  
The invention features corticosteroids conjugated to either a charged group or a bulky group in a manner that resists in vivo cleavage, the resulting conjugate is a peripherally acting steroid...
US20100069339 NOVEL METHOD OF TREATMENT OF MALE SUB-FERTILITY  
There is provided a method of treatment of male sub-fertility by using a vitamin D compound. Compositions and uses are also provided.
US20050182033 Vitamin D receptor antagonists and their use in treating asthma  
Various compounds such as those having the formula I and XIV where the variables have the values described herein antagonize the vitamin D receptor and are useful in treating conditions such as...
US20130217903 PROCESS FOR PREPARING A CRYSTALLINE FORM OF HALOBETASOL PROPIONATE  
The present invention provides a process for preparing a crystalline form of halobetasol propionate, comprising the step of crystallizing halobetasol propionate from absolute ethanol or a mixture...
US20100233761 ALGAE BIOMASS FRACTIONATION  
A method of fractionating biomass, by permeability conditioning biomass suspended in a pH adjusted solution of at least one water-based polar solvent to form a conditioned biomass, intimately...
US20130196953 GENES FOR BIOSYNTHESIS OF TETRACYCLINE COMPOUNDS AND USES THEREOF  
The invention relates to tetracycline products produced by genetically engineered cells, and to therapeutic methods using such tetracyclines. The present invention is based on the cloning and...
US20100087405 FOOD SUPPLEMENTATION COMPOSITION CONTAINING ONE OR MORE VITAMIN D3 COMPOUNDS AND ONE OR MORE MAGNESIUM SALTS  
Use of one or more vitamin D3 compounds chosen from the group 1-α-hydroxy vitamin D3, 25-hydroxy vitamin D3, 1-α-,25-dihydroxy vitamin D3, in combination with one or more magnesium salts to...
US20120022035 Polymorphic and Amorphous Salt Forms of Squalamine Dilactate  
The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More...
US20090054387 Method for preparing 4-[17beta-methoxy-17alpha-methoxymethyl-3-oxestra-4,9-dien-11beta-yl]benzaldehyde (E)-oxime (asoprisnil)  
The present invention relates to a method for the reliable and reproducible preparation of 4-[17β-methoxy-17α-methoxymethyl-3-oxoestra-4,9-dien-11β-yl] benzaldehyde (E)-oxime (asoprisnil) on the...
US20050222105 Hormone-based nitrogen monoxide donor compounds and use thereof in obstetrics and gynecology  
The invention concerns compounds capable of being fixed on hormone receptors and having a nitrogen monoxide donor group, their use for preventing premature births, increasing cervical-dilatation,...
US20070088007 Method for preparing analogue of vitamin D  
A method for preparing analogues of C1,C24-dihydroxy-vitamin D is disclosed. Especially the method for preparing calcipotriol and tacalcitol from a starting material of Vitamin D2 is disclosed...
US20130144076 WATER-SOLUBLE PHYTOSTEROL DERIVATIVES FOR REDUCING CHOLESTEROL AND PREPARATION THEREOF  
Provided herein is a method of preparing a composition of a phytosterol derivative comprising a phytosterol intermediate coupled to a water-soluble carrier. The method controls the molecular...
US20150064788 RETROVIRAL TRANSDUCTION USING POLOXAMERS  
The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular...
US20120283456 NOVEL ORGANIC/INORGANIC HYBRID SOLID IHM-2-N3 PROVIDED WITH AN AZIDE FUNCTION, AND METHOD FOR MANUFACTURING SAME  
The invention describes a crystallized hybrid solid with an organic-inorganic matrix, of a three-dimensional structure, containing an inorganic network of indium-based metal centers that are...
US20080312193 Substituted Tetracycline Compounds for Treatment of Inflammatory Skin Disorders  
Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.
US20070275939 NUCLEAR SULFATED OXYSTEROL, POTENT REGULATOR OF CHOLESTEROL HOMEOSTASIS, FOR THERAPY OF HYPERCHOLESTEROLEMIA, HYPERLIPIDEMIA, AND ATHEROSCLEROSIS  
The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear steroid metabolite that increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and...
US20090131379 VITAMIN D RECEPTOR ACTIVATORS AND METHODS OF MAKING  
The invention relates to compounds that are vitamin D receptor activators, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such...
US20140051875 CRYSTALLINE FORM OF MAXACALCITOL  
The present invention relates to maxacalcitol hydrate, a new crystalline form of maxacalcitol, with superior technical properties e.g. in the manufacture of crystal suspension formulations, and...
US20140274905 METHODS AND COMPOUNDS FOR CALCIUM ION CHANNEL REGULATION  
The present invention generally relates to methods of modulating Cav1.2 channels and Cav1.2 channel activators.
US20120184515 17-HYDROXY-17-PENTAFLUOROETHYL-ESTRA-4,9(10)-DIENE-11-METHYLENE OXYALKYLENE ARYL DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND USE THEREOF FOR TREATMENT OF DISEASES  
The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-diene-11-methyle neoxyalkylenearyl derivative of the formula I with progesterone-antagonising action and to processes for...
US20070197488 Prodrugs of ERbeta-selective substances, process for their production, and pharmaceutical compositions that contain these compounds  
This invention provides prodrugs of 8β-substituted estratrienes of general formula (I), in which the group Z is bonded to the steroid, process for their production, pharmaceutical compositions...
US20120264722 PHARMACEUTICAL FORMULATIONS AND USES THEREOF IN THE TREATMENT OF FEMALE SEXUAL DYSFUNCTION  
The present invention relates to the use of a combination of a PDE5-inhibitor and testosterone for the preparation of a medicament for the treatment of Female Sexual Dysfunction.
US20110034422 DENDRIMERS FOR SUSTAINED RELEASE OF COMPOUNDS  
Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular...
US20070191323 STABLE CORTICOSTEROID MIXTURES  
A corticosteroid mixture, such as a budesonide solution, is prepared by the active and inactive ingredients of the mixture under oxygen-depleted conditions. The resulting mixture demonstrates...
US20100075937 Patient populations and treatment methods  
The invention provides, inter alia, methods to treat, e.g., hyperglycemia or diabetes patients having two or more of a BMI of at least 28 or 29, a fasting insulin level of at least 4 μU/mL or at...
US20120088745 CHEMICALLY MODIFIED SMALL MOLECULES  
Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein...