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US20150072962 NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN, 3BETA-25-DIOL, DISULFATE (25HCDS) FOR THERAPY OF METABOLIC DISORDERS, HYPERLIPIDEMIA, DIABETES, FATTY LIVERS DISEASES AND ATHEROSCLEROSIS  
5-cholesten, 3β, 25-diol, disulfate (25HCDS) has been found to be an authentic PPARγ agonist and LXR antagonist, and is used for the therapy of lipid disorders and inflammatory diseases, including...
US20100273749 Method for Treating Dry-Eye Syndrome  
The subject application provides an aqueous composition suitable for use as an artificial tear solution comprising one or more lipids produced by an enzyme of the diacylglycerol acyltransferase 2...
US20050201888 Sterilization process  
A process for the sterilization of a steroid which process comprises heat treating the steroid in the form of a wet mass comprising the steroid, water and an excipient.
US20110082306 BIRCH REDUCTION OF STEROID SUBSTRATES VIA ALKALI METAL - SILICA GEL MATERIALS  
Steroids are well known, medicinal relevant, chemical entities. There are numerous steroids which have fully or partially reduced ‘A’ rings. These fully or partially reduced ‘A’ rings have been...
US20050164998 Steroid extraction process from urine sources  
A process in which urine is optionally filtered to remove solid extraneous matter and optionally treated so as to reduce the phenolic content of the urine to give and the resulting fluid is then...
US20120258941 17-HYDROXY-17-PENTAFLUORETHYL-ESTRA-4,9(10)-DIEN-11-ARYL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THE USE THEREOF FOR TREATING DISEASES  
The invention relates to 17-hydroxy-17-pentafluoroethylestra-4,9(10)-diene 11-aryl derivatives of the formula I with progesterone-antagonising action and to processes for preparation thereof, to...
US20090291933 SOLID STATE FORMS OF A PHARMACEUTICAL  
The invention provides and describes solid state 17α-ethynyl-androst-5-ene-3β,7β,17β-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates...
US20120190661 ANDROGEN COMPOSITION FOR TREATING AN OPTHALMIC CONDITION  
The disclosure provides compositions for treating an ocular condition. The composition comprises a physiologically effective amount of an androgen, wherein the composition is suitable for topical...
US20130288989 NEW USE OF CHEMICAL INGREDIENTS IN CYNOMORIUM AS PHYTOESTROGEN  
Use of chemical ingredients in Cynomorium as phytoestrogen is provided by the present invention. Particularly, use of Cynomorium, extracts of Cynomorium, or at least one ingredient chosen from...
US20150203527 CATIONIC STEROIDAL ANTIMICROBIALS  
Disclosed herein are cationic steroidal antimicrobials (“CSA compounds” or “ceragenins”) and methods of making the same. Particularly advantageous methods are identified for the synthesis of CSA...
US20140309277 LIPIDS, LIPID COMPOSITIONS, AND METHODS OF USING THEM  
Disclosed are formulation and optimization protocols for delivery of therapeutically effective amounts of biologically active agents to liver, tumors, and/or other cells or tissues. Also provided...
US20140100209 TGR5 Modulators and Methods of Use Thereof  
The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases,...
US20120115832 TGR5 Modulators and Methods of Use Thereof  
The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases,...
US20140371469 PHOTOREACTIVE BENZAMIDE PROBES FOR HISTONE DEACETYLASE 2  
The design, modeling, synthesis, biological evaluation, and photoaffinity labeling studies of a series of photoreactive potent and selective HDACs 1 and 2 benzamide based probes are disclosed herein.
US20050165094 Chemical compounds containing a superoxide scavenger and an organic nitrate or nitrite moiety  
Compounds for use in the treatment of heart disease include a superoxide scavenger and an organic nitrate or nitrite moiety. The compounds can be represented by the formula (A)n(B)m, in which A is...
US20110118199 USE OF CNS PENETRATING ANTICANCER COMPOUNDS FOR THE TREATMENT OF PROTOZOAL DISEASES  
The present invention relates to the treatment of protozoal diseases by administering cytotoxic and/or cytostatic compounds, in particular those used in anticancer therapy, to patients. In...
US20130184244 PROCESS FOR PREPARING DELTA-7,9(11) STEROIDS FROM GANODERMA LUCIDUM AND ANALOGS THEREOF  
Processes for preparing lanostane triterpenes from the medicinal mushroom Ganoderma lucidum, and related compounds are described. Compounds, compositions, and methods for treating cancer are also...
US20140273250 METHODS FOR THE SELECTIVE DETECTION OF ALKYNE-PRESENTING MOLECULES AND RELATED COMPOSITIONS AND SYSTEMS  
Provided herein are methods for selectively detecting an alkyne-presenting molecule in a sample and related detection reagents, compositions, methods and systems.
US20110311583 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS  
(A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention...
US20130182202 LIQUID CRYSTAL DISPLAYS AND LIQUID CRYSTALLINE MEDIA WITH HOMEOTROPIC ALIGNMENT  
The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy comprising self-aligning mesogens (SAMs) which effect homeotropic (vertical)...
US20130096097 PHARMACEUTICAL MULTIMERIC PARTICLES, AND MANUFACTURING METHOD FOR SAME  
[Problem] The purpose of the present invention is to provide organic particles containing pharmaceutical particles of which the particles are small and the particle size distribution is narrow,...
US20120045429 Methods and Agent for Modulating the RNA Polymerase II-Histone Surface  
The present invention relates to the identification of an intranucleosomal DNA loop formed during transcription through a nucleosome and use of the same to identify an agent that modulates the RNA...
US20110077225 4-Substituted Tetracyclines and Methods of Use Thereof  
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20110213168 DEUTERATED VITAMIN D COMPOUNDS  
The invention relates to deuterated vitamin D compounds and the process for preparing and synthesizing a class of vitamin D compounds which can be isotopically substituted. These compounds can be...
US20100209536 Methods and Kits for Use in the Treatment and Prevention of Diseases or Conditions of the Immune System or Infectious Diseases  
This invention provides methods of treating and preventing diseases or conditions of the immune system or infectious disease, involving administration of vitamin D and/or one or more antioxidants...
US20130189287 ENZYMATIC CONJUGATION OF POLYPEPTIDES  
The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies,...
US20130018022 PHARMACEUTICAL COMPOSITION INCLUDING A TESTIS EXTRACT AS AN ACTIVE INGREDIENT FOR TREATING AND PREVENTING ANEMIA  
The present invention relates to a pharmaceutical composition including a testis extract serving as an active ingredient for treating and preventing anemia, in which since the testis extract...
US20150140059 NOVEL OXYSTEROL ANALOGUE, OXY149, INDUCES OSTEOGENESIS AND HEDGEHOG SIGNALING AND INHIBITS ADIPOGENESIS  
This invention relates, e.g., to a synthetic compound, Oxy149, having the structure (Formula I) or a bioactive or pharmaceutical composition comprising Oxy149 and a pharmaceutically acceptable...
US20050282787 Synthesis of tetracyclines and analogues thereof  
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary...
US20120077990 Alkene Aziridination  
A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin.
US20120043491 DOPING CAPSULES, COMPOSITE SYSTEMS CONTAINING SAID CAPSULES AND USE THEREOF  
The invention relates to doping capsules which have a substance which displays a decreasing transparency with increasing temperature within a defined temperature range due to physicochemical...
US20060166949 Vitamin d analogues, compositions comprising said analogues and their use  
Compounds according to formula I in which formula R1 and R2, which may be the same or different, represent halogen, (C1-C6)hydrocarbyl, optionally substituted with one or two hydroxyl group or one...
US20110137058 PREPARATION OF PARICALCITOL  
This invention relates to a method for purifying Paricalcitol by reverse phase chromatography. This invention also relates to a purified Paricalcitol prepared by said method. This invention...
US20130131006 METHOD FOR INHIBITING THE INDUCTION OF CELL DEATH BY INHIBITING THE SYNTHESIS OR SECRETION OF AGE-ALBUMIN IN CELLS OF THE MONONUCLEAR PHAGOCYTE SYSTEM  
The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an...
US20130102580 COMPOSITIONS AND METHODS RELATED TO DEOXYCHOLIC ACID AND ITS POLYMORPHS  
Provided herein are polymorphic forms of deoxycholic acid (DCA), improved methods of synthesizing DCA and intermediates thereto, and compositions and fat removal methods employing the DCA as...
US20130053587 Crystallization of 1alpha-Hydroxy-20-Methyl-2-Methylene-19,24,25,26,27-Pentanorvitamin D3  
A method of purifying 1α-hydroxy-20-methyl-2-methylene-19,24,25,26,27-pentanorvita min D3 to obtain 1α-hydroxy-20-methyl-2-methylene-19,24,25,26,27-pentanorvita min D3 in crystalline form. The...
US20120232042 17-HYDROXY-17-PENTAFLUORETHYL-ESTRA-4,9(10)-DIEN-11-ACYLOXYALKYLENE PHENYL DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND USE THEREOF FOR TREATING DISEASES  
The invention relates to 17-hydroxy-13-methyl-17-pentafluoroethyl-11-acyloxyalkylenep henyldodecahydrocyclopenta[a]phenanthren-3-one derivatives of the formula I with progesterone-antagonising...
US20150038443 Transcription Factor Inhibitors and Related Compositions, Formulations and Methods  
The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of...
US20100016597 Method for producing pulverized organic compound particle  
Disclosed is a method for producing pulverized particles of a crystalline organic compound which is poorly water-soluble. Also disclosed is a pulverized organic compound particle produced by such...
US20110207952 CHOLESTEROL EXTRACTION FROM ALGAE AND PREPARATION OF VEGAN VITAMIN D3  
A process for producing vegan vitamin D3 from an algal waste processing stream by saponifying the waste stream to separate out and removing unsaponifiable cholesterol and converting it to vitamin...
US20140017675 ULTRA-HIGH-SENSITIVE ASSAY OF PROTEIN AND NUCLEIC ACID AND KIT, AND NOVEL ENZYME SUBSTRATE  
Provided is a ultra-high-sensitivity assay in which the assay can be made on a commonly used assay apparatus such as an absorptiometer and a plate reader or with naked eyes. The high-sensitivity...
US20080201871 ANTIMICROBIAL COLORANTS  
Quaternary ammonium salts were incorporated into anthraquinone dyes via a stable linkage. The structure of the antimicrobial colorants were characterized by Fourier Transform Infrared (FTIR),...
US20150158903 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF  
Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, wherein Z is a group of the formula (i), (ii), (iii), (iv), or (v), and wherein L1, L2, L3, X1, X2,...
US20130102577 SHIP INHIBITORS AND USES THEREOF  
The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating...
US20140221648 TH17 DIFFERENTIATION MARKERS FOR ACNE AND USES THEREOF  
A method is described for using IL-12R 1/IL-23R, CCR6, BATF, AHR, STAT3, IRF4 crucial actors in Th17 cells differentiation as markers for acne. Also described are method of their use to diagnose...
US20150132228 COMPOSITIONS AND METHODS TO EVALUATE HEPATOBILIARY/GASTROINTESTINAL HEALTH, ENTEROHEPATIC CIRCULATION, AND DRUG INTERACTIONS  
The present invention relates to the synthesis and use of a novel trifluorinated bile acid analogue, that being, CA-sar-TFMA which is useful as an imaging probe, diagnostic agent or contrast agent...
US20070208086 UBIQUINONE ANALOGS AND METHODS OF USE  
New ubiquinone and ubiquinol analogs are disclosed, as well as methods of making and using these compounds.
US20110033561 USE OF PHYTOECDYSONES IN THE PREPARATION OF A COMPOSITION FOR ACTING ON THE METABOLIC SYNDROME  
For reducing the negative effects of the metabolic syndrome on mammal organisms, it is proposed to use phytoecdysones for diminishing the fat body mass in individuals, notably with a weight...
US20140234349 NANOPARTICLES, PROCESS FOR PREPARATION AND USE THEREOF AS CARRIER FOR AMPHIPATIC AND HYDROPHOBIC MOLECULES IN FIELDS OF MEDICINE INCLUDING CANCER TREATMENT AND FOOD RELATED COMPOUNDS  
The present invention regards nanoparticles comprising a sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin, which nanoparticles do not...
US20100204492 PROCESS FOR THE EXTRACTION OF BIOACTIVE LIGNANS WITH HIGH YIELD AND PURITY FROM SESAME OIL  
The present invention provides a process for the extraction and isolation of bioactive lignans with high yield and purity from Sesame oil by sequential extraction, crystallization, and...