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US20110269689 HIGH PENETRATION COMPOSITIONS AND THEIR APPLICATIONS  
High penetration compositions (HPC) of a parent compound, which are capable of crossing biological barriers with high penetration efficiency. The HPCs are capable of being converted to parent...
US20110319368 Once daily formulations of tetracyclines  
Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent...
US20130143848 USE OF MEGESTROL ACETATE FOR IMPROVING HEART FUNCTION AND THE TREATMENT OF HEART INSUFFICIENCY  
The present invention relates to improving the heart function, the survival and/or the treatment of heart insufficiency using megestrol acetate (Megace®; MA) in patients with heart insufficiency...
US20140243509 NEAR INFRARED FLUOROGEN AND FLUORESCENT ACTIVATING PROTEINS FOR IN VIVO IMAGING AND LIVE-CELL BIOSENSING  
Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins,...
US20150005269 Treatment of Heart Failure and Sudden Cardiac Death  
A method of reducing heart failure or preventing sudden cardiac death in a subject in need thereof is carried out by administering a composition comprising a compound that increases cellular level...
US20110257268 Reduction of Sterols and Other Compounds from Oils  
A process for the removal of sterols, specifically cholesterol, from a triglyceride oil, preferably a marine triglyceride oil, said process comprising contacting an oil with an adsorbent,...
US20130261094 TUNABLE, BIODEGRADABLE LINKER MOLECULES FOR TRANSIENT CONJUGATION OF COMPONENTS IN DRUG DELIVERY SYSTEMS, AND DRUG DELIVERY SYSTEMS PREPARED THEREWITH  
The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems...
US20130072464 PROGESTERONE RECEPTOR ANTAGONISTS  
The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of formula I with progesterone-antagonizing action and methods of production thereof, use thereof for...
US20060166955 Production process for 16-dehydropregnenoneol and its analogs  
The present invention relates to a clean process for the degradation of steroidal sapogenin to produce 16-dehydropregnenolone and its analogs. The pure or the crude pseudo steroidal sapogenin,...
US20130150336 Methods For Reducing Superoxide Anions in Eukaryotic Organisms  
Provided are methods and compositions for reducing superoxide anions such that a prophylactic or therapeutic effect against conditions associated with excess oxidative stress achieved. The...
US20110130375 NEW NO-RELEASING STEROIDS FOR THE TREATMENT OF RETINA AND MACULA LUTEA DISEASES  
The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof The compounds are useful for treating diabetic macular edema, diabetic...
US20110237811 STABILIZED STEROID COMPOSITION AND METHOD FOR ITS PREPARATION  
Stabilized, 17-substituted hydrocortisone containing compositions and methods of manufacture are disclosed. Isomerization of the hydrocortisone component of topical steroid compositions is...
US20130245253 Conjugated Neuroactive Steroid Compositions And Methods Of Use  
The present disclosure provides modified neuroactive steroids. The modified neuroactive steroids may comprise, consist of, or consist essentially of a therapeutic agent and/or a modifying moiety....
US20110027776 KITS AND METHODS FOR ASSESSING ANTIOXIDANT REQUIREMENT OF A HUMAN  
The invention relates to kits and methods for assessing the desirability of supplementing the diet of a human with reduced coenzyme Q (CoQH2). The methods involve assessing occurrence in the...
US20150175651 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF  
Described herein are neuroactive steroids of the Formula (1) or a pharmaceutically acceptable salt, solvate, stereoisomer, tautomer, and/or isotopic variant thereof. Such compounds are envisioned,...
US20140179658 METHODS AND COMPOSITIONS FOR STIMULATION AND ENHANCEMENT OF REGENERATION OF TISSUES  
Methods and pharmaceutical compositions are provided for enhancing or stimulating regeneration of a tissue in a subject. In one aspect, the invention provides a method including administering to a...
US20150203441 CHOLATE AND DEOXYCHOLATE-BASED AMPHIPHILES FOR MEMBRANE PROTEIN MANIPULATION  
Disclosed are compounds and methods for manipulating proteins in general and membrane proteins in particular. The compounds can be prepared from cholic acid, deoxycholic acid, lithocholic acid, or...
US20140200200 Antagonists of CB1 Receptor  
The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders;...
US20150190340 EYE DROP WITH DIFLUPREDNATE FOR MACULAR EDEMA TREATMENT  
The present invention aims to provide an eye drop for treating macular edema. The present invention provides an eye drop for treating macular edema, which contains difluprednate as an active...
US20110212935 COMPOSITIONS AND TREATMENT METHODS-4  
The invention relates to the use of compounds to ameliorate or treat an condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used...
US20130345184 PHARMACEUTICAL SOLID STATE FORMS-2  
The invention provides and describes solid state 17α-ethynyl-5α-androstane-3α,17β-diol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of...
US20100317628 MicroRNA Modulators and Method for Identifying and Using the Same  
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is...
US20150166597 POLYMORPHIC FORMS OF A STEROID-LIKE COMPOUND AND METHODS FOR THE PREPARATION AND USE THEREOF  
Provided herein are multiple solid forms of a defined steroid-like compound, and methods for the preparation and use thereof. In one aspect, there is provided a crystalline form of said...
US20120101052 15-THIA STEROID COMPOUNDS AND COMPOSITIONS  
The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the...
US20110218162 15-THIA STEROID COMPOUNDS AND COMPOSITIONS  
The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the...
US20130203712 METHODS FOR INHIBITING MUSCLE ATROPHY  
In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a...
US20150030541 NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES  
The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a...
US20130066086 NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES  
The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a...
US20120028290 Compositions and Methods for Labeling and Imaging Phospholipids  
The present invention provides a method to label phospholipids in vivo based on the metabolic incorporation of an alkynyl- or azido-labeled metabolic precursor into phospholipids. The resulting...
US20130078358 STIGMASTEROL-RICH PHYTOSTEROL COMPOSITION AND USE  
A stigmasterol-rich phytosterol composition is prepared wherein the composition comprises at least 50% stigmasterol, based on the total weight of phytosterols, no more than 1000 ppm water, no more...
US20110201585 The Use of Oestrogen Applied to the Penis to Reduce HIV Infections  
A method of reducing or inhibiting the risk of infection from sexually transmitted viral infections (STIs), such as HIV and HPV, comprising the topical administration of oestrogenic compounds,...
US20110312929 TREATMENT OF VAGINAL ATROPHY IN WOMEN WITH CARDIOVASCULAR PATHOLOGY RISK  
The present invention relates to the use of estriol in the preparation of a pharmaceutical formulation for vaginal administration with the capacity to self-limit the absorption of estriol, for the...
US20140349979 STABILIZED MODIFIED RELEASE VITAMIN D FORMULATION AND METHOD OF ADMINISTERING SAME  
A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic...
US20080306285 Heat-Labile Prodrugs  
Disclosed herein are heat-labile prodrugs, their preparation and uses.
US20130238118 fD  
The invention disclosed herein relates to methods and means for allocating, allotting, apportioning, dispensing, distributing, preparing, portioning, meting out and/or otherwise providing,...
US20120015913 Formulations of 14-EPI-Analogues of Vitamin D  
The present invention provides new formulations of 14-epi-analogues of vitamin D, such as inecalcitol, providing improved absorption profile.
US20110098260 Steroid Compounds and Formulations  
The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological...
US20140107357 TIGECYCLINE CRYSTALLINE HYDRATE AND PREPARATION METHOD THEREFOR AND USE THEREOF  
Provided are a Tigecycline crystalline hydrate, and a preparation method therefor and use thereof. The crystalline hydrate has high stability for storage, and is used for the manufacture of a...
US20120238488 COMPOUNDS AND METHODS FOR TREATING NEOPLASIA  
The invention features compounds, pharmaceutical compositions and methods useful for the treatment of neoplasia. In particular embodiments, the compounds of the invention are useful for the...
US20120126107 Enhanced Sensitivity for Analysis of Carbonyl Containing Compounds Using Mass Spectrometry  
The present disclosure provides methods and composition involving increased sensitivity of compounds using mass spectrometry. In one embodiment, a method of increasing the sensitivity for...
US20130345455 METHODS OF PREPARING PHARMACEUTICAL SOLID STATE FORMS  
The invention provides and describes solid state 17α-ethynyl-5α-androstane-3α,17β-diol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of...
US20130225663 LIPID DELIVERY FORMULATIONS  
The invention provides formulations that contain an immunogenic or immunostimulatory cargo, delivery moiety and/or lipid, and a lipid that functions to reduce or prevent induction in a subject of...
US20140255386 MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME  
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is...
US20130023498 MicroRNA Modulators and Method for Identifying and Using the Same  
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is...
US20130143850 METHODS AND COMPOSITIONS FOR STIMULATING REEPITHELIALISATION DURING WOUND HEALING  
The present invention relates to methods and compositions for stimulating reepithelialisation during wound healing. More particularly, the present invention relates to a mmeralocorticoid receptor...
US20100305341 PRODUCTION OF STEROLS IN OLEAGINOUS YEAST AND FUNGI  
The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable...
US20120033164 LIQUID CRYSTAL DISPLAY DEVICE AND BLUE COLOR FILTER THEREOF  
A liquid crystal display device includes a white light emitting diode backlight module for supplying white light, a plurality of red sub-pixels, a plurality of green sub-pixels and a plurality of...
US20130209565 POSOLOGY AND ADMINISTRATION OF GLUCOCORTICOID BASED COMPOSITIONS  
The present invention relates to an improved method of administration of glucocorticoid based compositions in glucocorticoid replacement therapies enabling an objectively based regimen for...
US20120226050 POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS  
The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of...
US20150246037 TREATMENT FOR NEURODEGENERATION  
Provided is a method of treating and/or preventing Wolfram Syndrome (WS)-related neurodegeneration (i.e. of Wolfram Syndrome-Associated Neuronal Degeneration), by increasing the expression and/or...