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US20050256093 Branched polyamine steroid derivatives  
Novel compounds comprising a steroid backbone coupled to a branched polyamine according to formula I are provided. The compounds show antimicrobial activity and may be used in the treatment and...
US20080125407 METHOD FOR PREPARATION OF FLUTICASONE PROPIONATE  
Taught is a method for preparing S-fluoromethyl-6α,9α-difluoro-11β-hydroxy-16α-methyl-17α-pro pionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate (fluticasone propionate). The present method is...
US20090017003 THIOSULFONATE ANTI-INFLAMMATORY AGENTS  
The present invention relates to novel thiosulfonates derivatives. The present invention also provides methods for preventing, treating and/or reducing inflammation-associated diseases in the...
US20100234624 USE OF 20(S)-PROTOPANAXADIOL IN MANUFACTURE OF ANTIDEPRESSANTS  
The invention provides the novel use of 20(S)-protopanaxadiol in the preparation of medicaments for the treatment of depressive psychiatric disorders. The pharmacological test results indicated...
US20080064888 PROCESS FOR THE PREPARATION OF CHOLANIC ACIDS  
A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.
US20090036638 Contrast Dyes for Inkjet Lithographic Printing Plates  
A contrast dye for preparing a lithographic printing plate includes at least one A, D, and B group wherein A represents a phosphorous containing group capable of reacting with the surface of a...
US20140046021 SELF-MAGNETIC METAL-SALEN COMPLEX COMPOUND  
The molecular structures of metal-salen complexes which exerts pharmacological effects are clarified and the metal-salen complexes having such molecular structures and their derivatives are...
US20100130451 SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF  
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary...
US20090291467 Near Infrared Fluorophore for the Selective Labelling of Membranes in Cells  
The present invention relates to anthraquinone derivatives which act as a fluorophore, to a process for producing said anthraquinone derivatives and their use as fluorophores for staining...
US20070292967 Assay for Ligands of the Ecdysone Receptor  
The present invention provides an ecdysteroid derivative in which a fluorescent moiety is attached to an ecdysteroid moiety by derivatisation of a hydroxyl group on the alkyl side chain of the...
US20100174101 Process for the manufacture of 7-alpha-[9-(4,4,5,5,5-penta fluoropentylsulphinyl) nonyl]estra-1,3,5-(10)- triene-3,17-beta-diol  
The present invention provides a novel multi-step process for the manufacturing Fulvestrant, which is economical and convenient to operate at commercial scale, and requires only simple...
US20100286105 METHODS OF TREATING HYPERANDROGENISM AND CONDITIONS ASSOCIATED THEREWITH BY ADMINISTERING A FATTY ACID ESTER OF AN ESTROGEN OR AN ESTROGEN DERIVATIVE  
Compositions and methods for treating hyperandrogenism and conditions associated therewith, including polycystic ovary syndrome are disclosed. The invention is directed to methods for treating...
US20110269974 Polymer Derivatives  
The invention provides water-soluble compounds that include a polymer and at least one terminal azide or acetylene moiety. Also provided are highly efficient methods for the selective modification...
US20100240029 Cholesterol-Regulating Complex of SIRT1 and LXR and Methods of Use  
A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRT1 forms a complex with LXR bound to an LXR element. Methods of forming the complex, identifying an agent...
US20100048887 COMPOUNDS INCLUDING AN ANTI-INFLAMMATORY PHARMACORE AND METHODS OF USE  
This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and...
US20130102650 ANTIMICROBIAL COMPOUNDS OF 1,4-NAPHTOQUINONE STRUCTURE  
The present invention relates to a compound having formula (I) wherein: R1 is chosen from the group consisting of: phenyl group, possibly substituted, —CH2—C6H4—R′1 group, R′1 being chosen from...
US20070244335 Isolation of tetracycline derivatives  
Provided is a process for the isolation of tetracycline derivatives.
US20150247090 MONOMER, LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY DEVICE, AND PRODUCTION METHOD FOR LIQUID CRYSTAL DISPLAY DEVICE  
The present invention provides a liquid crystal composition for forming a polymer layer capable of keeping high voltage holding ratio. The liquid crystal composition in an aspect of the present...
US20150252373 Alkynyl-Derivatized Cap Analogs, Preparation and Uses Thereof  
Alkynyl-derivatized cap analogs, alkynyl-modified capped RNA, 1,4-disubstituted triazole-derivatized capped RNA, methods of preparation, methods of isolation, and uses thereof are provided. The...
US20130102655 ALKYNYL-DERIVATIZED CAP ANALOGS, PREPARATION AND USES THEREOF  
Alkynyl-derivatized cap analogs, alkynyl-modified capped RNA, 1,4-disubstituted triazole-derivatized capped RNA, methods of preparation, methods of isolation, and uses thereof are provided. The...
US20080317662 Molten Salts, Method of Their Production and Process for Generating Hydrogen Peroxide  
A molten salt and process for preparing a molten salt or hydrogen peroxide uses ionic hydroquinones or hydroquinone derivatives as O2 reduction catalysts.
US20110237504 DELIVERY AGENTS FOR ENHANCING MUCOSAL ABSORPTION OF THERAPEUTIC AGENTS  
A delivery agent for delivering a biologically active agent to a warm-blooded animal includes a hydrophobic moiety covalently bonded to a hydrophilic moiety. The hydrophobic moiety can include...
US20060167290 Method of separating ergosterol  
The present invention provides a method of separating ergosterol from a solution containing ergosterol in water-insoluble organic solvent, comprising supplying water to the solution and...
US20150105362 SYNTHESIS OF ESTETROL VIA ESTRONE DERIVED STEROIDS  
A process is provided for the making of estetrol starting from a 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is an C1-C5 alkyl group, preferably a methyl group, or a C7-C12 benzylic...
US20060074255 3-Methyl-20-epi-vitamin D derivatives  
The object of the present invention is to synthesize vitamin D derivatives in which the 3-position is substituted with methyl and the steric configuration at the 20-position is epimerized. The...
US20100179337 PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF  
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
US20100145083 PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF  
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
US20080287404 High Purity 17Alpha-Cyanomethyl-17Beta-Hydroxy-Estra-4,9-Diene-3- One and Process For the Syntheses Thereof  
The invention relates to a new process for the synthesis of high purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from...
US20060281717 11a, 12-derivatives of tetracycline compounds  
11a, 12-dehydrotetracycline compounds are described.
US20150031875 COMBINED SYNTHESIS ROUTE FOR DESOGESTREL AND ETONOGESTREL  
The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.
US20070135392 Apoptosis promoters  
Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl-1 protein are disclosed.
US20080306292 Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid  
Provided are syntheses of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid, (S)-Pregabalin via a chiral intermediate of the following formula 4 wherein Ar is a C6-10 aromatic group, R is a straight...
US20130274460 Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses  
The invention provides electrophilic monohalomethylating reagents, methods for their preparation and methods for preparation of monohalomethylated biologically active compounds using such...
US20080015374 METHOD FOR THE SYNTHESIS AND ISOLATION OF PHYTOSTEROL ESTERS  
A process for the synthesis and isolation of phytosterol esters is described, wherein an alkali metal borohydride is used to reductively bleach tocoquinones and other chromophores in phytosterol...
US20120165553 IMMUNOSTIMULANT  
[Problem to be Solved] An immunostimulant highly safe and administrable for a long period of time as well as a pharmaceutical composition containing the immunostimulant as an active ingredient and...
US20120115819 Pentacycline Compounds  
The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein....
US20110233048 PHOTOBASE GENERATOR  
There is intended to provide the novel compounds which generate a base easily when irradiated with long wavelength light (active energy rays), a photobase generator containing the compounds and a...
US20060111332 Process and intermediates to prepare17beta-hydroxy-7alpha-methyl-19-nor-17alpha-pregn -5(10)-en-20-yn-3-one  
The present invention is a process for the preparation of 17β-hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one (17α-ethynyl-17β-hydroxy-7α-methyl-5(10)-estren-3-one, tibolone) of formula 1,...
US20110152544 PROCESS FOR THE PREPARATION 2-SUBSTITUTED DERIVATIVES OF ESTRONE AND ESTRADIOL  
The invention provides a process for the preparation of 2-substituted-derivatives of estrone and estradiol comprising i) the preparation of a compound of general formula (II) by reacting a...
US20130261259 GENETICALLY ENCODED INITIATOR FOR POLYMER GROWTH FROM PROTEINS  
This invention pertains to methods for producing homogeneous recombinant proteins that contain polymer initiators at defined sites. The unnatural amino acid, 4-(2′-bromoisobutyramido)phenylalanine...
US20100145070 ANTI-CANCER COMPOUND AND MANUFACTURING METHOD THEREOF  
Anti-cancer compounds and manufacturing methods thereof are disclosed. The anti-cancer compounds are 1,8-diamidoanthraquinone derivatives with amino compounds. The manufacturing method includes...
US20060004214 Methods for preparing 1,1,1-tris(4-hydroxyphenyl)alkanes  
A method for preparing 1,1,1,-tris(4-hydroxyphenyl)alkanes generally comprises reacting a mixture of an aromatic hydroxy compound and a ketone in the presence of at least one sulfonic acid...
US20110319644 PROCESS FOR PRODUCTION OF 1-HYDROXY-19-NORCYCLOVITAMIN D DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION  
A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The...
US20120302534 DERIVATIVES OF BETULIN  
The present invention relates to a compound characterized by the following Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X, and Y are as described herein. Compounds...
US20100204191 Function-Selective Vitamin D Receptor Agonist  
The present invention provides a VDR ligand which does not induce hypercalcemia that is an adverse reaction of a vitamin D3 preparation; and a composition which comprises lithocholic acid...
US20080167283 Nandrolone 17 Beta-Carbonates  
Disclosed are compounds of the formula (I) wherein R is C1-C30 alkyl, which may be optionally further substituted with one or more C5-C8 cycloalkyl groups, or a C5-C12 cycloalkyl, which may be...
US20100240630 COMPOUNDS AND THERAPEUTIC USES THEREOF  
The invention relates to compounds, pharmaceutical compositions and methods useful for treating viral infection.
US20100113400 9-Aminomethyl Substituted Minocycline Compounds  
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20110087037 SYNTHESIS OF RING B ABEO-STEROLS AS NOVEL INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS  
Novel 3β-hydroxy-Δ5-steroid analogs possessing a contracted cyclopentane B-ring provide good inhibitory activity against Mycobacterium tuberculosis. The 5(6→7)abeo-sterol nucleus present in...
US20150005487 SORBENT COMPRISING ON ITS SURFACE A CATIONIC OR PROTONIZABLE ALIPHATIC RESIDUE FOR THE PURIFICATION OF ORGANIC MOLECULES  
The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent...