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US20130052131 NANOPARTICLES, METHODS OF MAKING NANOPARTICLES, AND METHODS OF USE  
Embodiments of the present disclosure, in one aspect, relate to a nanoparticle, methods of imaging a tumor, method of imaging a disease, method of treating a condition, disease, or related...
US20060233862 Process for the preparation of a fat composition containing sterol esters a product obtained by said process and the use thereof  
A method for preparing a fat composition by reacting a sterol raw material with a triglyceride raw material to create the fat composition.
US20070037992 Method for the purification of crude diacerein by means of toluene  
A method to purify crude diacerein via the use of toluene which consists of: dissolving crude diacerein in about 13 times the volume of dry diacerein of a 1:1 acetone/water mixture; adjusting the...
US20150218079 BENZOQUINONE DERIVATIVES FOR TREATING OXIDATIVE STRESS DISORDERS  
Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders,...
US20080227760 Method of Extracting Ginsengnoside Rg2m, Pharmaceutical Composition Including Ginsengnoside Rg2, and Uses Thereof  
The present invention provides a method of extracting ginsenoside Rg2, which is applied to mass production. The method of the present invention employs gradient salting-out instead of conventional...
US20130041166 PROCESS FOR THE PREPARATION OF DIENOGEST SUBSTANTIALLY FREE OF IMPURITIES  
The present invention provides novel process for preparation and purification of dienogest (I). The present invention provides dienogest (I) substantially free of impurities.
US20120252772 Cucurbitane-Triterpenoid Compounds, Pharmaceutical Composition, Use and Preparation Method Thereof  
Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid...
US20110224183 16, 17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SLECTIVE ESTROGENIC ACTIVITY  
The invention discloses a steroid compound having the formula (1): wherein dotted bonds represent optional double bonds; R6 is H, ═CH2, or —CH3, or —CH2—CH3; R7 is H, C1-4-alkyl, C2-5 alkenyl or...
US20090302284 Reversibly Thermochromic Compositions  
The present invention pertains to a reversibly thermochromic system comprising a substituted or an unsubstituted 6,11-dihydroxy-naphthacene-5,12-dione and a base and to a reversibly thermochromic...
US20060281710 17SS-HSD1 and STS inhibitors  
The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may...
US20100267684 USE OF BIOLOGICAL SURFACTANT AS ANTI-INFLAMMATORY AGENT AND TISSUE PRESERVATIVE SOLUTION  
The present invention relates to a use of a biological surfactant as an anti-inflammatory agent and a tissue preservative solution. More particularly, the present invention is directed to an...
US20150239926 ASYMMETRIC IONIZABLE CATIONIC LIPID FOR RNA DELIVERY  
What is described is a compound of formula I wherein R1 consists of a linear or branched alkyl consisting of 1-18 carbons, an alkenyl or alkynyl consisting of 2 to 12 carbons, or a cholesteryl;R2...
US20050090675 Process for preparing highly pure androstane 17-beta-carboxylic acids and 17-beta-carbothioic acid fluoromethyl esters thereof  
The present invention relates to an oxidation process for preparing the androstane 17-β-carboxylic acid of general formula (I) with a high purity degree by oxidative demolition of the carbon atom...
US20120302530 23-HYDROXY-BETULINIC ACID DERIVATIVES, PREPARATION METHODS AND USES THEREOF  
The present invention discloses 23-hydroxyl-betulinic acid derivatives, including 3-oxo-23-hydroxyl-betulinic acid, 3-oxo-23-hydroxyl-dihydrobetulinic acid, and 23-hydroxyl-dihydrobetulinic acid....
US20150132388 COMPLEXES OF FULVESTRANT AND ITS DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM  
The present invention relates to pharmaceutically acceptable complex formulae comprising complexes of Fulvestrant, or a salt, or derivatives thereof and complexation agents and pharmaceutically...
US20140206657 BILE ACID ANALOG TGR5 AGONISTS  
Provided herein are bile acid analogues and derivatives, methods of synthesizing bile acid analogues and derivatives and their use in treating diabetes and liver disease.
US20100113401 METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS  
Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
US20150027483 TRI-AROMATIC AZOMETHINE DIRECT DYES COMPRISING AT LEAST ONE UNIT DERIVED FROM RESORCINOL, DYEING COMPOSITION, METHOD AND USE  
The present invention relates to azomethine-type direct dyes with a tri-aromatic unit having the following formula (I): and their use for colouring keratin fibres, particularly human keratin...
US20050245465 Compounds for treating Alzheimer's disease and for inhibiting beta-amyloid peptitde production  
The present invention provides compositions and methods for treating and preventing Alzheimer's disease by administering to a subject an effective amount of a dammarane or ginsenoside compound....
US20110224447 Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids  
The instant invention provides for novel lipid nanoparticles and novel lipid nanoparticle components (specifically cationic lipids) that are useful for the delivery of nucleic acids, specifically...
US20120090995 DEVICE FOR DETECTING AN ANALYTE  
Devices for detecting an analyte comprising a redox active analyte sensitive material on a working electrode and computer assisted signal acquisition and processing.
US20100081638 COMPOSITIONS COMPRISING AN EXTRACT OF TIARELLA POLYPHYLLA OR COMPOUNDS ISOLATED THEREFROM FOR PREVENTING AND TREATING CANCER DISEASES  
The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof,...
US20140274971 Systems and Methods of Using Chemically Bound Antibiotics Activated by Infections  
Methods, devices and systems are disclosed for chemically bonding antibiotics to selected substrate materials which are not dissolved in normal physiological processes so that high local...
US20120065179 PRODRUG COMPRISING BETA-KETO CARBOXYLIC ACID, BETA-KETO CARBOXYLIC ACID SALT OR BETA-KETO CARBOXYLIC ACID ESTER FOR DRUG DELIVERY  
There is provided a prodrug of a pharmaceutically active agent, such prodrug comprising a beta-keto carboxylic acid, a beta-keto carboxylic acid salt or a beta-keto carboxylic acid ester...
US20130324749 Crystallization of (20R) and (20S) Analogs of 2-Methylene-19-Nor-24-Dimethyl-1alpha,25-Dihydroxyvitamin D3  
Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to obtain the (20R) and (20S) analogs in crystalline form. The method...
US20140171645 ELECTROPHILIC ALKYLATING REAGENTS, THEIR PREPARATION AND USE  
The present invention provides electrophilic alkylating reagents of formula II, wherein is an aryl group, R2 is an alkyl group, R3 is a substituted phenyl group, wherein the number of substituents...
US20150166598 Steroids as Agonists for FXR  
The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula...
US20140024631 Steroids as Agonists for FXR  
The invention relates to compounds of formula (I): wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula...
US20070010602 Nigrosine dye and process for producing the same  
A non-pyrophoric nigrosine dye and a method of production thereof. A nigrosine dye wherein B−A≦0.04% by weight if, in analysis using a gas chromatograph apparatus equipped with a glass-made sample...
US20120259007 ANTICOAGULANT COMPOUNDS AND THEIR USE  
According to the invention there is provided a compound of formula (I): wherein R1, R2, R3 and n have meanings given in the description, or a pharmaceutically acceptable solvate, salt or prodrug...
US20070135400 Estradiol derivatives  
Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the...
US20150210620 PROCESS FOR THE PREPARATION OF VITAMIN K2  
Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2...
US20140296546 METHOD FOR PRODUCING 30-HALOGENATED BETULINIC ACID  
The invention discloses a method for producing 30-halogenated betulinic acid. Betulin is used as a raw material and selectively oxidized and halogenated to generate 30-betulinic acid, and the...
US20090209773 Method and device for purifying high melting organic raw products or compund mixtures by means of fractionated melting crystallisation from solvent mixtures  
This invention relates to a method and a device for purifying and/or separating preferably high melting organic raw products or compound mixtures containing, in particular, high melting and/or...
US20130281419 Therapeutic Uses for an Aminosterol Compound  
A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically...
US20070149491 Compounds useful for treating neurodegenerative disorders  
As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating...
US20120022025 CRYSTALLINE FORM C OF TIGECYCLINE DIHYDROCHLORIDE AND METHODS FOR ITS PREPARATION  
The present invention relates to crystalline form C of Tigecycline dihydrochloride and to methods for the preparation of the same. Furthermore the present invention relates to the use of...
US20050026889 17Afla,21-dihydroxypregnene esters as antiandrogenic agents  
17α,21-Dihydroxypregna-4,9-diene-3,20-dione and 17α,21-dihydroxypregna-4-ene-3,20-dione 17 and/or 21 esters of having remarkable antiandrogenic activity, and the processes for the preparation thereof.
US20120184611 SELENOQUINONE-DERIVED ACTIVE ORGANOMETALLIC COMPLEXES, METHODS FOR SYNTHESIZING SAME, AND USES THEREOF  
The present invention relates to the synthesis of novel biologically active selenoquinone-derived organometallic complexes, and to the uses thereof in the context of preventing or treating cancer.
US20060122153 Antineoplastic ether lipid compounds with modifications at the sn-2 carbon  
Ether lipid compounds of formula (I), Pharmaceutically-acceptable salts, prodrugs or isomers thereof are provided, where the variables are as defined herein. The compounds of the invention have...
US20120244462 METHOD FOR PREPARING ALIZARIN DERIVATIVE COMPOUND, NOVEL ALIZARIN DERIVATIVE COMPOUND, SURFACE MODIFICATION METHOD, PHOTOELECTRIC CONVERSION FILM, PHOTOELECTRIC CONVERSION ELEMENT, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR  
The present invention provides a novel alizarin derivative compound and a simplified and low cost method for preparing an alizarin derivative compound including: obtaining a compound represented...
US20050222097 Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity  
Sterol derivatives of formula (I) and a method for the production of the compounds, a medicament using one of the compounds and a pharmaceutical composition comprising the medicament.
US20100197647 COMPOUNDS THAT INHIBIT OESTRONE SULPHATASE; COMPOSITIONS THEREOF; AND METHODS EMPLOYING THE SAME  
Disclosed and claimed are compounds suitable for use as an inhibitor of oestrone sulphatase in a subject in need thereof, as well as compositions containing such compounds and methods for using...
US20090275766 PROCESS FOR THE PREPARATION OF TIGECYCLINE IN THE AMORPHOUS FORM  
The invention relates to processes for the preparation of tigecycline (I): a wide spectrum antibiotic belonging to the tetracycline family, in stable amorphous form, by freeze-drying, antisolvent...
US20070244334 Processes and intermediates for preparing steric compounds  
This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R1, R′1 and R2 are defined herein and the compound...
US20100168451 PREPARATIVE METHOD OF DIHYDROCUCURBITACIN F-25-O-ACETATE AND THE USE THEREOF IN THE MANUFACTURE OF MEDICAMENTS FOR TREATING CANCERS  
A method for producing dihydrocucurbitacin F-25-0-acetate consisting of the steps as followed: percolating radix hemsleyae using acetone as solvents to obtain extract; eluting the extract in...
US20110009654 11B-FLUORO-3-ACETOXYESTRA-3,5-DIEN-17-ONE AND METHOD FOR THE PRODUCTION THEREOF  
The present invention relates to 11β-fluoro-3-acetoxyestra-3,5-dien-17-one as a suitable intermediate in the preparation of 11-fluoro-substituted steroids and to the process for preparation...
US20050032763 Process for the synthesis of high purity D-(17a)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-one oxime  
The invention relates to a process for the synthesis of d-(17α)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-ene-20-yn-3-o ne-oxime (also known as norelgestromin) via acetylation of d-norgestrel at...
US20100247439 DENDRITIC NANO-ANTIOXIDANTS  
Provided are dendritic nano-antioxidant compounds according to Formula I, which may further comprise active agents covalently or non-covalently attached. Further provided are compositions...
US20110263555 TGR5 Modulators and Methods of Use Thereof  
The invention relates to compounds of Formula (A): (A) or a salt, solvate, hydrate, or amino acid conjugate thereof. The compounds of formula A are TGR5 modulators useful for the prevention and...