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US20060211669 Synthesis of estetrol via estrone derived steroids  
A process is provided for the making of estetrol starting from a 3-A-oxy-estra 1,3,5(10),15-tetraen-17-one, wherein A is a C1-C5 alkyl group, preferably a methyl group, or a C7-C12 benzylic group,...
US20150231155 ONAPRISTONE POLYMORPHIC FORMS AND METHODS OF USE  
Polymorphic forms of onapristone and methods of making and using such polymorphic forms are provided. Crystalline polymorphic forms can be characterized by their X-ray powder diffraction patterns...
US20140271819 ONAPRISTONE POLYMORPHIC FORMS AND METHODS OF USE  
Polymorphic forms of onapristone and methods of making and using such polymorphic forms are provided. Crystalline polymorphic forms can be characterized by their X-ray powder diffraction patterns...
US20050137409 Processes for preparing benzoquinones and hydroquinones  
A process for the preparation of benzoquinones and hydroquinones includes oxidizing an aromatic hydroxy compound with oxygen or an oxygen containing gas, a copper containing catalyst, and...
US20070265231 Hydrazide Compounds for Combating Animal Pests  
The present invention relates to new hydrazide compounds which are useful for combating animal pests, in particular insects, arachnids and nematodes and to the salts thereof. The invention also...
US20050176778 Isoprenyl derivatives and their use in the title treatment and prevention of osteoporosis and cardiovascular calcification  
A non-toxic biologically active compound is provided having the following general formula (I): wherein n is an integer from 1 to 14, preferably from 2 to 4, and R is an organic moiety, preferably...
US20120238767 ANTIOXIDANT INFLAMMATION MODULATORS: NOVEL DERIVATIVES OF OLEANOLIC ACID  
Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and...
US20110092467 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds  
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates...
US20120165300 DIASTEREOMERS OF 2-METHYLENE-19-NOR-22-METHYL-1ALPHA,25-DIHYDROXYVITAMIN D3  
Compounds of formula I are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
US20110237557 DIASTEREOMERS OF 2-METHYLENE-19-NOR-22-METHYL-1ALPHA,25-DIHYDROXYVITAMIN D3  
Compounds of formula I are provided where X1, X2, and X3 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
US20120309728 NEW STEROID INHIBITORS OF PGP FOR USE FOR INHIBITING MULTIDRUG RESISTANCE  
The present invention relates to a compound of formula (I) for its use for reversing or inhibiting multidrug resistance.
US20070232576 Sulfated molecular umbrellas as anti-HIV and anti-HSV agents  
A chemical genus of sulfated cholestanes attached to an oligomer through amide or ester bonds is disclosed. The compounds are useful as anti human immunodeficiency virus (HIV) and anti-herpes...
US20050227950 2-alkylidene-18,19-dinor-vitamin D compounds  
2-alkylidene-18,19-dinor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by low...
US20140057886 Bile Acid Derivatives as FXR Ligands for the Prevention or Treatment of FXR-Mediated Diseases or Conditions  
The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy,the hydroxyl group in position 7 is in the alpha or beta position;and pharmaceutically acceptable...
US20120283234 Bile Acid Derivatives As FXR Ligands For The Prevention Or Treatment Of FXR-Mediated Diseases Or Conditions  
The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy,the hydroxyl group in position 7 is in the alpha or beta position;and pharmaceutically acceptable...
US20100234334 NITRIC OXIDE RELEASING STEROIDS  
The invention relates to nitrooxyderivative of corticosteriods of general formula (I) and pharmaceutical acceptable salts or stereoisomers thereof wherein R is the corticosteriod residue of...
US20140011992 SYNTHESIS OF ABIRATERONE AND RELATED COMPOUNDS  
The present invention relates to processes for obtaining abiraterone and derivatives thereof, such as abiraterone acetate, by means of a Suzuki coupling through a steroid borate of general formula...
US20070129558 Monohalogenovinyl vitamin d derivative compounds  
New vitamin D derivative compounds containing a monohalovinyl moiety at position C-20 are described. A process for obtaining the new compounds, consisting of reacting an aldehyde precursor with a...
US20110124844 Selective and Specific Preparation of Discrete Peg Compounds  
Aspects of the present invention are directed to novel methods for making discrete polyethylene compounds selectively and specifically to a predetermined number of ethylene oxide units. Methods...
US20070149489 Preparation of paricalcitol  
The present invention is directed to a novel process for preparing Paricalcitol wherein Paricalcitol, dissolved in a solvent, is precipitated from a concentrated or seeded solution.
US20090324489 Wortmannin conjugates and uses thereof  
The invention features conjugates of wortmannin, and wortmannin derivatives, and their use as inhibitors of PI3-kinase activity in treating cancer, inflammatory diseases, and C. albicans infections.
US20140243539 Process for the Production of Estetrol  
The present invention relates to a process for the preparation of a compound of formula (I), hydrates or solvates thereof.
US20110082302 Process for Producing Oseltamivir Phosphate and Intermediate Compound  
Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a...
US20080262251 Process For the Recovery of Sterols From Organic Material  
A process for recovering sterols from organic material containing sterols and sterol derivatives. In a first step (a) the organic material is reacted with at least one of polyols, polyamines,...
US20060149045 Steroid compounds with anti-tumor activity  
The present invention relates to novel steroid compounds of Formula (IB) having anti-tumor activity. The present invention also relates to a method for the preparation of said steroid compounds....
US20140206655 (22E)-2-METHYLENE-22-DEHYDRO-1ALPHA,24,25-TRIHYDROXY-19-NOR-VITAMIN D3 ANALOGS  
Disclosed are (22E)-2-methylene-22-dehydro-1,24,25-trihydroxy-19-nor-vitam in D3 compounds, their biological activities, and various pharmaceutical uses for these compounds. Particularly disclosed...
US20080206820 Labeling Methods with Oxygen Isotopes  
The present invention provides methods for labeling One or two oxygen atom(s) in a carboxyl group of a carboxyl-containing compound with an oxygen isotope selected from oxygen-17 (17O) or...
US20150232489 Functionalisable Polysilylated Organosilane Precursors  
The present invention concerns a funtionalisable polysilylated organosilane precursors with formula (I): in which: Z1 represents a moiety with formula (a) and Z2 represents a moiety with formula...
US20150141679 METHODS FOR THE PURIFICATION OF DEOXYCHOLIC ACID  
Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are provided. Also, provided are processes for...
US20130123523 METHODS FOR THE PREPARATION OF ETONOGESTREL AND DESOGESTREL  
Described herein is a process for the synthesis of etonogestrel and desogestrel and intermediates used to form etonogestrel and desogestrel.
US20100172844 ALBUMIN BINDING MOLECULES AND USES THEREOF  
The invention relates to portable albumin binders, which are useful for improving the pharmacokinetic properties of diagnostic or therapeutic agents, in particular increasing the blood...
US20060014973 Processes for the preparation of 16beta-alkoxy, 17alpha-hydroxy steroids and steroidal 16beta, 17alpha-diols from 16alpha, 17alpha-epoxy steroids  
The present invention provides processes for the preparation of 16β-alkoxy, 17α-hydroxy steroids via the reaction of a 16α,17α-epoxy steroid with an appropriate alcohol in the presence of base....
US20140323456 ESTERS OF DCPLA AND METHODS OF TREATMENT USING THE SAME  
The present disclosure relates to esters of 8-[2-(2-pentyl-cyclopropylmethyl)cyclopropyl]-octanoic acid (“DCPLA”). The disclosure further relates to compositions, kits, and methods for treatment...
US20110288288 Process for the preparation of 17-0-vinyl- triflates as intermediates  
A compound of formula (I) or a pharmaceutically-acceptable salt thereof, may be made by a process including a triflating step by which a ketone of formula (II) is converted into a triflate of...
US20070149490 PROCESS FOR THE EXTRACTION OF BETULINIC ACID  
Disclosed are large-scale industrial processes for obtaining highly pure betulinic acid from ground plane bark. Betulinic acid is 3β-hydroxy-lup-20(29)-ene-28-oic acid of formula
US20100210654 NOVEL P2Y12 RECEPTOR ANTAGONISTS  
The present invention relates to novel P2Y12 receptor antagonists useful for treating, alleviating and/or preventing diseases and disorders related to P2Y12 receptor function as well as...
US20120149667 PHARMACEUTICAL COMPOSITIONS FOR TREATING IBD  
A stable and/or synergistic pharmaceutical composition including: a) predinisolone metasulfobenzoate (PMSB) or its acceptable salts, preferably prednisolone metasulfobenzoate sodium and b) 5-ASA,...
US20110144363 PROCESS FOR OBTAINING 17-SPIROLACTONES IN STERIODS  
The invention relates to processes for obtaining steroids with a spirolactone group in position 17, particularly to industrially obtaining 6β,7β;...
US20100041906 METHOD FOR THE PRECIPITATION OF ORGANIC COMPOUNDS  
The present invention concerns a method for the controlled precipitation of organic compounds giving crystals with a very small average size and a very narrow size distribution.
US20120258929 AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT PEPTIDYL-DIPEPTIDASE A ACTIVITY  
The present invention provides an agent that modulates physiological condition of pests, wherein the agent has an ability to modulate the activity of an insect peptidyl-dipeptidase A; a method for...
US20090258847 Cholanic Acid Amides  
4-(3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phena nthren-17-yl)-pentanoic acid amides wherein the nitrogen of the amide group is substituted by a sulfonylaminocarbonyl-(C1-4)-alkyl...
US20140303385 ASYMMETRIC SYNTHESIS OF ORGANIC COMPOUNDS  
The present invention provides processes for the production of chiral compounds in a stereoisomeric excess. The present processes involve reacting a hydrometallated alkene compound with a compound...
US20090118164 METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH  
Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting...
US20100120736 Mineralocorticoid Receptor Antagonists  
Compounds of the formula (I) are provided having a steroid skeleton and substitution characteristics in the A and B rings of the steroid skeleton effective for mineralocorticoid receptor...
US20070167420 Process for preparing a crystalline form of halobetasol propionate  
The present invention provides a process for preparing a crystalline form of halobetasol propionate, comprising the step of crystallizing halobetasol propionate from absolute ethanol or a mixture...
US20100092386 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI  
The present invention relates to a novel delivery system for delivering therapeutic agents into living cells, and more particularly, to novel chemical moieties that are designed capable of...
US20110236311 RADIOLABELLING METHODS  
The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a...
US20070093458 Preparation of paricalcitol and crystalline forms thereof  
The present invention is directed to a novel process for preparing Paricalcitol wherein Paricalcitol, dissolved in a solvent, is precipitated from a concentrated or seeded solution. The present...
US20100190756 3, 10, AND 12a SUBSTITUTED TETRACYCLINE COMPOUNDS  
The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20100160263 7,9-SUBSTITUTED TETRACYCLINE COMPOUNDS  
The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as...