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US20120258938 Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof  
Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or...
US20090136566 THERAPEUTIC TRITERPENOIDS  
The present invention relates generally to compositions that can be obtained by extraction of birch bark, methods of using such compositions (e.g., methods of medical use, cosmetic use and/or...
US20110172448 PROCESS FOR CARRYING OUT HETEROGENEOUSLY CATALYZED REACTIONS WITH HIGH SELECTIVITY AND YIELD  
A cost effective process is presented for carrying out catalytic, in particular also exothermic, endothermic or autothermal reactions with optimum yield and selectivity. The system used is a...
US20130225789 Polyethylene Glycol Having Hetero Multiple Functional Groups  
Novel PEG multifunctional derivatives. A PEG backbone molecule is covalently attached with at least three different functional groups, either on the same branch arm or on different branch arms.
US20060135800 2-Methylene-19,21-dinor-1alpha-hydroxy-bishomopregnacalciferol  
Compounds of formula I are provided where X1 and X2 are independently selected from H or hydroxy protecting groups. Such compounds may be used in preparing pharmaceutical compositions and are...
US20100160265 7, 8 AND 9-SUBSTITUTED TETRACYCLINE COMPOUNDS  
7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are...
US20080014642 TAGGING REAGENTS AND METHODS FOR HYDROXYLATED COMPOUNDS  
In various aspects, the present teachings provide labeling reagents and sets of labeling reagents for the relative quantitation, absolute quantitation, or both, of hydroxylated compounds...
US20120048285 SUPRAMOLECULAR COMPLEX FLAVOR IMMOBILIZATION AND CONTROLLED RELEASE  
Compositions are provided which contain immobilized flavorants, in the form of supramolecular complexes of flavorant compounds, for flavor delivery. One embodiment relates to the flavorant...
US20110130580 USE OF BUCKYSOME OR CARBON NANOTUBE FOR DRUG DELIVERY  
Compositions and methods for administering a therapeutic agent to a mammal are disclosed. The compositions comprise either (i) vesicles comprising an amphiphilic substituted fullerene, wherein the...
US20130217886 SYNTHESIS OF ENONE INTERMEDIATE  
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary...
US20110112316 TIGECYCLINE CRYSTALLINE FORMS AND PROCESSES FOR PREPARATION THEREOF  
The present invention relates to solid crystalline Tigecycline, and crystalline forms thereof.
US20110257406 FUNCTIONALIZED SUBSTRATE AND USES THEREOF  
The present invention is directed towards proposing ligands of formula: and is also directed towards a substrate at the surface of which is immobilized at least one unit of formula:
US20140200341 Method for the Production of Fluoromethyl Esters of Androstan-17 beta Carboxylic Acids  
Described herein are processes for the preparation of monofluoromethylated organic biologically active compounds, starting from protected intermediates and/or reagents to obtain compounds such as...
US20130065868 ANXIOYTIC MARCGRAVIACEAE COMPOSITIONS CONTAINING BETULINIC ACID, BETULINIC ACID DERIVATIVES, AND METHODS  
Pharmaceutical compositions for preventing or treating anxiety, comprising betulinic acid or derivatives thereof are provided. Methods for preventing or treating anxiety with betulinic acid or...
US20050250749 Helix 12 directed pharmaceutical products  
Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic...
US20060116359 17.Beta-(alpha-hydroxy)-esters of androstanes as intermediates for the preparation of 17.beta-fluorinated-androstane esters  
Process for the preparation of polyhalogenated steroids, in particular of androstanic fluoro derivatives corticosteroids by means of the formation of new androstanic S-hydroxy alkyl or...
US20100130760 PROCESS FOR PREPARING A CRYSTALLINE FORM OF HALOBETASOL PROPIONATE  
The present invention provides a process for preparing a crystalline form of halobetasol propionate, comprising the step of crystallizing halobetasol propionate from absolute ethanol or a mixture...
US20120244294 CROSS-LINKING MOIETY  
A cross-linking moiety having a general formula I: N3—ArF—W, wherein ArF comprises a fluorinated phenyl azide group having at least one non-fluorine substituent that is bulkier than fluorine at a...
US20130035318 C-17 AND C-3 MODIFIED TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY  
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique...
US20140121187 1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT  
Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment...
US20060058271 Methods for screening, studying, and treating dissorders with a component of mercurial toxicity  
The present invention is related to a method, system or process for screening, studying and treating disorders which have a component of mercurial including: autism, autism spectrum disorders,...
US20090023695 METHOD OF MAKING AND USING 7alpha,11beta-DIMETHYL-17beta-HYDROXYESTR-4-EN-3-ONE 17-UNDECANOATE  
Methods of using 7α,11β-dimethyl-17β-hydroxy-4-estren-3-one bucyclate (I) and 7α,11β-dimethyl-17β-hydroxyestr-4-en-3-one 17-undecanoate (II) for various hormonal therapies, dosage forms comprising...
US20100041631 METHODS AND AGENTS FOR TREATING TUBERCULOSIS  
The present invention relates to the treatment of tuberculosis (mycobacterial infections) by the use of KshAB complex inhibitors, or a KstD molecule, or a HsaAB complex, or a HsaC molecule, or a...
US20130053567 METHOD FOR PRODUCING SILYLENOL ETHERS  
The invention relates to a method for producing silyl enol ether compound (3) by reacting ketone or aldehyde compound (1) with allylsilane compound (2) in the presence of a base and 0.00001 to 0.5...
US20130345188 Preparation and Uses of Obeticholic Acid  
The present invention relates to obeticholic acid: or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a...
US20080171728 Efficient Process for Preparing Steroids and Vitamin D Derivatives With the Unnatural Configuration at C20 (20 Alpha-Methyl) from Pregnenolone  
Disclosed herein are methods for preparing steroids and Vitamin D derivatives having the unnatural beta (usually S) configuration at C20, the methods comprising the use of compounds of the...
US20110178317 MEDICINAL APPLICATIONS OF BENZOIC ACID HYDRAZONES SYNTHESIZED ON THE BASIS OF STEROIDAL TIGOGENIN  
Novel benzoic acid hydrazones of 5α-androstan-3,17-dione have been prepared on the basis of steroidal tigogenin of the plant Yucca gloriosa. The hydrazones of the General Formula (I), General...
US20120232266 REDUCTION OF ORGANIC COMPOUNDS WITH LOW AMOUNTS OF HYDROGEN  
The present invention relates to a process for the reaction of a compound with hydrogen wherein the reaction is conducted using a hydrogen-containing gas comprising up to about 10 vol. % hydrogen...
US20050287114 Water-soluble polymeric bone-targeting drug delivery system  
The present invention provides bone-targeting polymeric drug delivery systems based on HPMA and related copolymers and methods of making thereof. The water-soluble bone-targeting polymeric...
US20140356417 MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES  
Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag...
US20110165225 Modified Drugs for Use in Liposomal Nanoparticles  
Drag derivatives are provided herein which are suitable for loading into liposomal nanoparticle carriers. In some preferred aspects, the derivatives comprise a poorly water-soluble drag...
US20100286107 Oligomer-Corticosteroid Conjugates  
The invention provides corticosteroids that are chemically modified by covalent attachment of a water soluble oligomer. A compound of the invention, when administered by any of a number of...
US20080269512 Large Scale Method for the deoxofluorination of ketones  
A method for the deoxofluorination of a ketone for the production of a geminal difluoride compound in an industrial scale comprising the following steps: preparing an educt mixture comprising a...
US20130018026 HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY  
The present invention provides compositions and methods for the targeted delivery, release and/or formation of a drug compound at a target site(s) within the body of an individual, such as a...
US20120157373 ANTIMICROBIAL COMPOUNDS HAVING PROTECTIVE OR THERAPEUTIC LEAVING GROUPS  
Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device...
US20080275016 FULVENE AND FULVALENE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and...
US20140121238 TOTAL SYNTHESIS OF REDOX-ACTIVE 1.4-NAPHTHOQUINONES AND THEIR METABOLITES AND THEIR THERAPEUTIC USE AS ANTIMALARIAL AND SCHISTOMICIDAL AGENTS  
Naphthoquinones, azanaphthoquinones and benxanthones, their process of synthesis and methods of their use as antimalarial or antischistosomal agents.
US20070059239 Process for the preparation of radioactive labeled estradiol  
A method for producing a high yield of an estradiol labeled at the 16-alpha position thereof with a radioactive iodine, especially 123I, for use as an imaging agent. The method includes the step...
US20140309417 PROCESS FOR THE PREPARATION OF STEROL DERIVATIVES  
The present invention relates to a process for the preparation of sterol derivatives comprising the reaction of an α-epoxy compound with an amine in an alcohol comprising 3 to 5 carbon atoms as a...
US20130184447 METAL COORDINATED COMPOSITIONS  
A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moiety an improved performance which can include potency,...
US20100291198 COMPOSITIONS OF PHYTOSTEROLS WITH ENHANCED BIOAVAILABILITY  
A method for preparing porous microparticles containing phytosterol, by preparing a homogeneous melt of phytosterol and a partially water soluble component, cooling the melt to obtain an amorphous...
US20070270566 Chain Extenders  
This invention provides chain extender compositions. These compositions comprise (i) an aromatic primary diamine, and (ii) a component selected from the group consisting of: (a) an aliphatic...
US20110144281 AMPHIPHILIC POLYMERS HAVING A CHOLANE CORE  
The present invention relates to a polymer comprising a cholane core having at least one derivatizable group covalently bonded thereto and a hydrophilic polymer chain covalently bonded to...
US20150112084 PROCESS FOR PREPARATION OF (IS, 3S, 5S)-2-[(2S)-2-AMIN0-2-(3-HYDROXY-l-ADAMANTYL) ACETYL]-2-AZABICYCLO [3.1.0] HEXANE-3-CARBONITRILE  
Provided are novel processes for the preparation of Saxagliptin and novel intermediates employed in the process for preparing Saxagliptin.
US20110046402 NOVEL METHOD AND INTERMEDIATES FOR PREPARING 19-NORSTEROID COMPOUNDS  
The subject of the invention is a method for preparing compounds of general formula (I): in which A, Z, R3 are as defined in the description, and the intermediate compounds for carrying out this...
US20070135395 Novel method for the preparation of intermediates useful for the synthesis fo vitamin d analogues  
The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of...
US20140256970 REACTOR FOR MULTI-STEP RADIOCHEMISTRY  
A stacked reactor vessel provides two separate reaction vessel compartments for performing chemical reactions and is particularly suited to multi-step chemical reactions and for incorporation into...
US20120101070 11a, 12-Derivatives of Tetracycline Compounds  
11a,12-dehydrotetracycline compounds are described.
US20090012319 Process for the preparation 2-substituted-derivatives of estrone and estradiol  
The invention provides a process for the preparation of 2-substituted-derivatives of estrone and estradiol. The invention also provides several novel compounds, which can be intermediates in the...
US20150112089 DEUTERATED BILE ACIDS  
This disclosure relates to deuterated bile acid compositions. A deuterated compound is selected from the disclosed groups of bile acids and their derivatives, analogs and salts. At least one of...