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US20090163459 Use of 24-nor-UDCA  
The present invention relates to the use of nor-ursodeoxycholic acid for the manufacture of a drug for the treatment and/or the prevention of liver diseases, preferably chronic liver diseases.
US20090318720 Process for selectively synthesising 3 alpha-hydroxychlormadinone acetate  
The invention relates to a process for synthesising 3α-hydroxychlormadinone acetate.
US20140107196 ANTI-CANCER LEAD MOLECULE  
Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative ‘A’ (Acetyl Plumbagin) has emerged as a lead molecule for testing against estrogen positive breast cancer...
US20100137270 MODULATION OF PROSTAGLANDIN/CYCLOOXYGENASE METABOLIC PATHWAYS  
A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus...
US20110060150 METHOD OF DETECTING FLUORESCENCE  
The invention provides novel anthraquinone compositions that are useful as broad-spectrum quenchers of fluorescence and provides methods for making and using them. The anthraquinone quenchers can...
US20100099141 Method and intermediates for preparing 2-alkoxy and 2-aryloxy estrogen compounds  
The present invention relates to a method for preparing 2-alkoxy and 2-aryloxyestrogen compounds, and the intermediate compounds prepared during the use of this method, which intermediate...
US20120172344 INSULIN-PRODUCING CELL INDUCER, GLUCOSE INTAKE ENHANCER, AND THERAPEUTIC AGENT FOR DIABETES OR DIABETES COMPLICATIONS  
Provided is an insulin-producing cell inducer, an enhancer for glucose intake of muscles, and a therapeutic agent for diabetes or diabetes complications, wherein an active ingredient of those...
US20100204460 NATURAL BRASSINOSTEROIDS FOR USE FOR TREATING HYPERPROLIFERATION, TREATING PROLIFERATIVE DISEASES AND REDUCING ADVERSE EFFECTS OF STEROID DYSFUNCTION IN MAMMALS, PHARMACEUTICAL COMPOSITION AND ITS USE  
The present invention relates to natural brassinosteroids of general formula (I), wherein R is CH2 or O—CH2 group, R2 is hydrogen or hydroxyl, R3 is hydroxyl, R24 is alkyl or alkenyl, which are...
US20100144688 23-Substituted Derivatives of Lupane-type Pentacyclic Triterpenoids  
The present invention comprises small molecule inhibitors of cell proliferative conditions, in particular cancer and conditions associated with cancer. For example, associated malignancies include...
US20120149894 NOVEL CATIONIC LIPIDS WITH VARIOUS HEAD GROUPS FOR OLIGONUCLEOTIDE DELIVERY  
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to...
US20070135375 Sulfamoyl sulfonate prodrugs  
The invention relates to sulfamoyl sulfonate prodrugs of general formula I, a process for their production, pharmaceutical compositions that contain these compounds, and their use for the...
US20090042844 17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS  
Compounds having the structure, their salts or N-oxide derivatives: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic...
US20150166449 Deuterated Idebenone  
The present invention in one embodiment provides a compound of Formula I:(I), or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula I are as defined in the...
US20090105199 OLIGOMERS OF CHOLESTEROL, CHOLESTEROL SULPHATE AND CHOLESTEROL ESTERS AND ALSO DRUGS CONTAINING THESE  
The invention relates to new substances which are derived from cholesterol, cholesterol sulphate and cholesterol esters of a natural, semi-synthetic or synthetic origin in that they represent...
US20100137262 Low Calcemic, Highly Antiproliferative, Analogs of Calcitriol  
The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain...
US20130052178 CHOLESTEROL ESTER FOR REDUCING CHOLESTEROL ABSORPTION  
The present invention relates to a method for reducing cholesterol absorption in an animal comprising administering to the animal a composition comprising an effective amount of at least one...
US20080300223 (20R)-2a-Methyl-19,26,27-Trinor-Vitamin D Analogs  
This invention discloses (20R)-2α-methyl-19,26,27-trinor-vitamin D analogs, and specifically (20R)-2α-methyl-19,26,27-trinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This...
US20050282793 Steroid prodrugs with androgenic action  
This invention relates to steroid prodrugs with androgenic action of general formula (I), in which group Z is bonded to the steroid, pharmaceutical compositions that contain these compounds as...
US20140371190 Farnesoid X receptor modulators  
The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R1, R2, R3, R4, R5, and R6 are as described...
US20100184735 LOCALLY ACTIVE "SOFT" ANTIANDROGENS  
The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or...
US20070015927 New phosphoramidite compounds  
Novel phosphoramidites having various functional groups can be advantageously used as new building blocks to synthesize various oligodeoxyribonucleotides which are useful for the development of a...
US20120283227 (20S)-24-(p-Toluenesulfonyloxy)-25,26,27-Trinorvitamin D3 Analogs and Their Uses  
This invention discloses (20S)-24(p-toluenesulfonyloxy)-25,26,27-trinorvitamin D3 analogs, and especially (20S)-25,26,27-trinor-24-(p-methylphenylsulfonate)-vitamin D3, its biological activities,...
US20110009615 METHOD FOR PRODUCING A STEROID COMPOUND  
An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5β-cholanic acid or ester...
US20070142345 Steroids for cancer treatment  
The present invention relates to novel compounds which are 7α-substituted 17-alkylene-16α-hydroxy steroidal estrogens. This invention specifically relates to estrogen derivatives which contain...
US20130137883 Process for Production of Triterpene Alcohol  
A process for producing triterpene alcohol, comprising sequentially conducting the following steps (A) to (C): (A) subjecting γ-oryzanol to alkaline hydrolysis;(B) mixing the alkaline hydrolysate...
US20110118218 TREATING HYPERTENSION WITH 25-HYDROXYVITAMIN D3  
We disclose the use of optionally in combination with vitamin D3 (cholecalciferol), 25-hydroxyvitamin D3 (cal-cifediol), to treat hypertension. Forms and dosages of a pharmaceutical composition,...
US20050277625 Estriol and estetrol prodrugs  
This invention provides estriol and estetrol prodrugs of general formula (I), in which group Y is bonded to the steroid process for their production, pharmaceutical compositions that contain these...
US20140186442 Topical Minocycline Compositions and Methods of Using the Same  
Topical minocycline compositions with reduced fluorescence are provided. In some instances, the compositions include an amount of a minocycline active agent associated with porous calcium...
US20090023914 Process for preparing drospirenone and intermediate thereof  
The present invention encompasses processes for preparing drospirenone and intermediates thereof.
US20090076206 Additive Mixtures for Agricultural Articles  
An agricultural article made of a composition containing (a) an organic polymer, and (b) an additive mixture comprising the components (b-0) a photosensitizer, (b-I) an organic salt of a...
US20120289723 METHOD FOR PREPARING INDENE DERIVATIVES, AND INTERMEDIATES FOR PREPARATION OF DERIVATIVES  
Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D2 derivative paricalcitol, which is useful as pharmaceutical are efficiently prepared by subjecting a...
US20060014727 Angiogenic compounds and uses thereof  
The invention provides sterol sulphate compounds and compositions that are capable of promoting angiogenesis. The invention also provides methods and uses for these compounds.
US20100064381 Increased Phytosterol Content Through Overexpression of an Acyl-CoA Sterol Acyl-Transferase  
The present invention relates to the use of genetic engineering to produce sterol esters. In certain embodiments, an isolated or recombinant nucleic acid molecule encoding a sterol acyltransferase...
US20080281112 Diamine and polyamic acid derived therefrom for liquid crystal orientation applications  
A diamine includes a structure of formula (I), wherein X and Y are independently a divalence group selected from the group consisting of: —O—, —(C═O)—O—, —O—(C═O)—, —(C═O)—NH—, and —NH—(C═O)—; and...
US20060258598 Alpha-keto carbonyl calpain inhibitors  
The present invention relates to novel α-keto carbonyl calpain inhibitors for the treatment of neurodegenerative diseases and neuromuscular diseases including Duchenne Muscular Dystrophy, Becker...
US20120053356 NOVEL ENERGETIC POLYPHOSPHAZENES  
This invention describes the synthesis and use of novel energetic poly(phosphazene) materials suitable for binding high explosives. These materials may also be used as explosives in their own...
US20080139519 Heat Sterilization of Glucocorticosteroids  
The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a...
US20120214775 Pharmaceutical Salts of 3-O-(3',3'-Dimethylsuccinyl) Betulinic Acid  
Salts of 3-O-(3′,3′-dimethylsuccinyl)Betulinic acid (DSB) are disclosed. Particularly, the preparation, pharmaceutical evaluation, and in vivo bioavailability evaluation of N-methyl-D-glucamine...
US20060111577 Method for preparing 17 alpha-acetoxy-11beta-(4-n,n-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, intermediates thereof, and methods for the preparation of such intermediates  
Methods for the preparation of the 19-norprogesterone of formula I and its intermediates, in crystalline and amorphous forms.
US20050032760 Continuous process for the production of r-rofleponide  
A continuous process for the preparation of 16α,17α[(R)butylidenedioxy]-6α,9α-difluoro-11β,21-dihydroxyp regn-4-ene-3,20-dione (rofleponide) is disclosed.
US20120172339 ANGIOGENIC RESORCINOL DERIVATIVES  
Novel resorcinol derivatives and methods of preparation and use are presented. These compounds can stimulate angiogenesis as a biological function triggered by the activation of one cannabinoid...
US20120115818 SYNTHESIS OF TETRACYCLINES AND INTERMEDIATES THERETO  
Efficient method for preparing the enone intermediate (VII) used in the synthesis of tetracyclines derivatives. In particular, the invention provides a synthesis which allows for substituents at...
US20140179654 ENZYMATIC PROCESS FOR OBTAINING 17 ALPHA- MONOESTERS OF CORTEXOLONE AND/OR ITS 9,11- DEHYDRODERIVATIVES  
The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which...
US20110092472 ENZYMATIC PROCESS FOR OBTAINING 17 ALPHA- MONOESTERS OF CORTEXOLONE AND/OR ITS 9,11- DEHYDRODERIVATIVES  
The present invention refers to a new enzymatic process for obtaining 17α-monoesters of cortexolone and/or its 9,11-dehydroderivatives starting from the corresponding 17α,21-diesters which...
US20080221074 Drug Screen and Treatment Method  
The invention relates to methods identify or characterize compounds that can be used to treat specified clinical disorders such as hyperglycemia and type 2 diabetes. Compounds that can be used in...
US20100152151 TGR5 MODULATORS AND METHODS OF USE THEROF  
The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases,...
US20130225517 Therapeutic Compounds  
The invention provides compounds of formula I: or salts thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I and therapeutic...
US20110165603 SMALL MOLECULE FLUORESCENT SENSORS FOR DETECTION OF POST-TRANSLATIONALMODIFICATIONS AND PROTEIN INTERACTIONS IN BIOASSAYS  
The present invention relates to novel compounds which are capable as acting as fluorescent sensors or which are precursors for these and for the use of these for the assay of biological processes...
US20060182689 Process for separating out at least one organic compound  
Process for separating out at least one organic compound from a substrate containing the said organic compound, comprising a treatment of the substrate with an extraction medium comprising at...
US20130053357 SKIN IRRITATION SUPPRESSANT AND TRANSDERMAL PREPARATION  
Provided is a skin irritation suppressant for transdermal preparations, having a sufficient reduction effect of skin irritation due to a drug. Also provided is a transdermal preparation comprising...