Match Document Document Title
US20100303758 Novel Glucocorticoid Receptor Agonists  
This invention relates to novel glucocorticoid receptor agonists of formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical...
US20120108833 PROCESS FOR THE PREPARATION OF PHYTOSTERYL FERULATE  
A method is provided for controlling the operating temperature of a catalytic reactor using a closed-loop system that provides for varying the reactor input and other operating parameters in order...
US20130116407 CONTROLLED RELEASE FROM MACROMOLECULAR CONJUGATES  
The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and...
US20070232579 Nitrated Lipids and Methods of Making and Using Thereof  
Described herein are nitrated lipids and methods of making and using the nitrated lipids.
US20120283201 9-SUBSTITUTED MINOCYCLINE COMPOUNDS  
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20130178449 2-Methylene-20(21)-Dehydro-19,24,25,26,27-Pentanor-Vitamin D Analogs  
This invention discloses 2-methylene-20(21)-dehydro-19,24,25,26,27-pentanor-vitamin D analogs, and specifically 2-methylene-20(21)-dehydro-19,24,25,26,27-pentanor-1α-hydrox yvitamin D3, and...
US20100009941 2-Methylene-20(21)-Dehydro-19-Nor-Vitamin D Analogs  
This invention discloses 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-20(21)-dehydro-19-nor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This...
US20100009940 2-Methylene-(20E)-20(22)-Dehydro-19-Nor-Vitamin D Analogs  
This invention discloses 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(20E)-20(22)-dehydro-19-nor-1α,25-dihydroxyvitam in D3, and pharmaceutical uses...
US20130102573 2-METHYLENE-VITAMIN D ANALOGS AND THEIR USES  
This invention discloses 2-methylene-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-vitamin D3 and (20R)-25-hydroxy-2-methylene-vitamin D3, as well as pharmaceutical uses...
US20100009947 2-Methylene-19,26-Dinor-(20S,22E,25R)-Vitamin D Analogs  
This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses...
US20060166944 4-Aminotetracyclines and methods of use thereof  
The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states,...
US20080287401 Methods for Synthesizing and Purifying Aminoalkyl Tetracycline Compounds  
Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
US20070010504 Polymorphic and amorphous salt forms of squalamine dilactate  
The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More...
US20140058079 DERIVATIVES OF ALLOPREGNANOLONE AND OF EPIALLOPREGNANOLONE AND USES THEREOF FOR TREATING A NEUROPATHOLOGICAL CONDITION  
The présent invention relates to novel neurosteroids, especially derivatives of allopregnanolone and of epiallopregnanolone of formula (I) and the uses thereof as médicament for the treatment of...
US20130102567 3-Desoxy-2-Methylene-Vitamin D Analogs and Their Uses  
This invention discloses 3-desoxy-2-methylene-vitamin D analogs, and specifically (20S)-3-desoxy-1α,25-dihydroxy-2-methylene-vitamin D3 and (20R)-3-desoxy-1α, 25-dihydroxy-2-methylene-vitamin D3...
US20120322775 3-Desoxy-2-Methylene-19-Nor-Vitamin D Analogs and Their Uses  
This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 and...
US20120157418 2-Methylene-19-Nor-Vitamin D Analogs and Their Uses  
This invention discloses 2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-19-nor-vitamin D3 and (20R)-25-hydroxy-2-methylene-19-nor-vitamin D3, as well as...
US20090233889 STABILIZED 1,25-DIHYDROXYVITAMIN D2 AND METHOD OF MAKING SAME  
A stabilized 1,25-dihydroxyvitamin D2 composition which is particularly well suited for pharmaceutical formulations, pharmaceutical formulations of the 1,25-dihydroxyvitamin D2 composition, and a...
US20090099141 COMPOSITIONS AND METHODS FOR TREATING VITAMIN D DEFICIENCIES  
The present invention provides for: (a) an oral dosage of vitamin D3 for humans sufficient to maintain a serum level above a minimally sufficient level and below a toxic level when administered...
US20130172588 CONTINUOUS PHOTOLYTIC PROCESS FOR THE PREPARATION OF VITAMIN D RELATED SUBSTANCES  
The present application provides a novel method for generation of a vitamin D2 compound using a continuous flow photoisomerization reactor. A compound represented by formula I: [structure] as...
US20110184196 Preparation of azide-modified carbon surfaces for coupling to various species  
The invention relates to carbon surfaces modified with one or more azide groups. The invention also relates to methods of modifying carbon surfaces with one or more azide groups.
US20110250537 CHOLATE PHOTOACID GENERATORS AND PHOTORESISTS COMPRISING SAME  
New photoacid generator compounds (“PAGs”) are provided that comprise a cholate moiety and photoresist compositions that comprise such PAG compounds.
US20120071455 6-SUBSTITUTED DEMETHYL-ESTRADIOL DERIVATIVES AS SELECTIVE ER-BETA AGONISTS  
Disclosed herein are 6-substituted 13-demethyl-estradiol derivatives as selective ERβ agonists. Also disclosed is a method for treating pain by administering these 6-substituted...
US20130236540 ORAL DOSAGE FORM OF 25-HYDROXYVITAMIN D  
Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed,...
US20090036693 METHOD OF PURIFYING UBIQUINONE-10  
According to the present invention, a method of purifying ubiquinone-10, which includes separating and removing a substance structurally similar to ubiquinone-10 contained in a starting material...
US20080139830 Preparation of substituted aminoanthraquinones  
Process for preparing substituted aminoanthraquinones by reacting 1,4-di-hydroxyanthraquinone with amines in the presence of dihydro-1,4-dihydroxyanthraquinone and a boric ester.
US20150017093 RADIOLABELED BILE ACIDS AND BILE ACID DERIVATIVES  
The present invention relates in one aspect to radiolabeled compounds comprising the structure of Formula 1. The radiolabeled compounds are preferably bile acids or bile acid derivatives. Further...
US20100034781 Oxysterol Compounds and the Hedgehog Pathway  
This invention relates, for example, to synthetic oxysterols. Also described are methods for using the compounds, including treating subjects in need thereof, and pharmaceutical compositions and...
US20130267721 PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF  
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
US20130190517 PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF  
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
US20110224448 PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF  
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
US20110152552 PREPARATION OF BILE ACIDS AND INTERMEDIATES THEREOF  
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
US20100009946 2-Methylene-19,26-Dinor-(20R,22E,25R)-Vitamin D Analogs  
This invention discloses 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20R,22E,25R)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses...
US20130204019 YIELD-EFFICIENT PROCESS FOR THE PRODUCTION OF HIGHLY PURE 2-METHYL-1, 4-NAPHTHOQUINONE AND ITS DERIVATIVES  
The present invention discloses a process for the production of 2-methyl-1,4-naphthoquinone and its bisulfite adducts, comprising the following steps: a) oxidizing 2-methyl-naphthalene (2-MNA) to...
US20080039642 Practical, Cost-Effective Synthesis of Chloromethylated 1, 4-Benzoquinones  
The present invention relates to a practical and cost-effective method for the synthesis of 5-chloromethylated 2,3-dialkoxy-6-alkyl-1,4-benzoquinones by direct chloromethylation of the...
US20080064668 1,3-Diacylated, 26,27-Alkyl/Haloakyl Vitamin D3 Compounds and Methods of Use Thereof  
The invention provides (1,3)di-acylated vitamin D3 analogs of cholecalciferol, substituted at carbon (20) with methyl or cyclopropyl wherein carbon (16) is a single or double bond, and carbon (23)...
US20100273748 ANTIMICROBIAL THERAPY  
Methods and compositions for modulating gene expression and the innate immune response by 1,25(OH)2 vitamin D3 (1,25D3) are provided. Also provided are methods and compositions for modulating...
US20060241311 Noval polymorphs of atovaquone and process of  
Novel crystalline forms of anti Pneumocystis carinii compound (2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquino ne) commonly known as Atovaquone and methods for producing the same is...
US20150099022 PHYTOECDYSONES FOR USE IN IMPROVING THE MUSCLE QUALITY OF OBESE AND/OR SARCOPENIC MAMMALS  
Phytoecdysones for use in improving muscle quality in obese and/or sarcopenic mammals, preferably, obese mammals subjected to a low-calorie diet. The phytoecdysones are advantageously incorporated...
US20130324752 Crystallization of (20R,22R)-2-Methylene-19-Nor-22-Methyl-1alpha,25-Dihydroxyvitamin D3 and Related Precursors  
Disclosed are methods of purifying the compound (20R,22R)-2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitami n D3 to obtain the compound in crystalline form. The methods typically include the...
US20140227184 C-HALOGEN BOND FORMATION  
Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by...
US20090054388 NOVEL 11 BETA-HYDROXYANDROSTA-4-ENE-3-ONES  
The invention provides 11β-hydroxyandrosta-4-ene-3-one compounds of Formula I, or physiologically acceptable salts or solvates thereof: wherein R4 represents a moiety selected from a group...
US20090137542 Alpha-glucosidase inhibitors from fungal hydroxylation of tibolone and hydroxytibolones  
Sixteen new and one known metabolites were obtained by incubation of tibolone and hydroxytibolones with various fungi. Their structures were elucidated by means of a homo and heteronuclear 2D NMR...
US20110021480 17-beta HSD1 and STS Inhibitors  
Substituted steroid compounds which represent selective inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may represent inhibitors of the steroid sulfatase,...
US20140018332 METHODS OF USE TO ORALLY AND TOPICALLY TREAT ACNE AND OTHER SKIN CONDITIONS BY ADMINISTERING A 19-NOR CONTAINING VITAMIN D ANALOG WITH OR WITHOUT A RETINOID  
Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and,...
US20080027237 Processes for preparations of 9,11-epoxy steroids and intermediates useful therein  
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of 9,11-epoxy steroids.
US20070105828 Novel polymorph form M of mifepristone and process for its preparation  
Mifepristone substantially in polymorph form M is provided. Also provided is a process for the preparation of polymorph form M of mifepristone comprising the steps of (a) dissolving crude...
US20100035793 Modulators  
Use of a composition that modulates a STAT in the manufacture of a medicament for treating or preventing a fibroproliferative disease. The fibroproliferative disease may comprise keloid scarring....
US20080051382 Crystalline Forms of 3-Beta-Amino 17-Methylene Androstane-6-Alpha 7-Beta-Diol Hydrochloride  
The invention relates to novel crystalline forms of 3-beta-amino-17-methylene-androstane-6-alpha,7-beta-diol hydrochloride, referred to as form A, form B and form C, a method for preparing same,...
US20100113378 Compositions and Methods for Treating and Preventing Cancer Using Analogs of Vitamin D  
Disclosed are compositions and methods used to treat and/or prevent cancer and metabolic diseases, such as psoriasis. In one aspect, the present invention pertains to the use of cross-linking...