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US20140072624 UNIT DOSE FORM FOR ORAL ADMINISTRATION  
Formulations and unit dose forms of TH-302 and other hypoxia activated prodrugs suitable for oral administration are useful for treating cancer.
US20150174104 SYSTEMS AND METHODS TO TREAT PAIN LOCALLY  
Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting...
US20110263553 STEROID ANALOGUES FOR NEUROPROTECTION  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
US20130190340 Small-Molecule-Targeted Protein Degradation  
Certain aspects of the invention relate to compounds, compositions and methods that are useful for treating or preventing a disease in a subject by enhancing the degradation of a protein. In other...
US20140073604 Ladder-Frame Polyether Conjugates  
Disclosed are compounds that are conjugates of ladder frame polyether compounds and biologically active compounds or research compounds, pharmaceutical formulations comprising the conjugates, and...
US20120077778 Ladder-Frame Polyether Conjugates  
Disclosed are compounds that are conjugates of ladder frame polyether compounds and biologically active compounds or research compounds, pharmaceutical formulations comprising the conjugates, and...
US20120277420 REFINED ROUTES TO CHLORIN BUILDING BLOCKS  
A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing...
US20110158930 METHOD FOR TREATMENT OF IRRITABLE BOWEL SYNDROME  
A method for treatment of a patient suffering from irritable bowel syndrome with diarrhea or mixed irritable bowel syndrome, which comprises administering to the patient a therapeutically...
US20100317690 TREATMENT OF PROTEIN FOLDING DISORDERS  
Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular,...
US20110034495 Method of Modulating Stress-Activated Protein Kinase System  
A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 2-position by a carbonyl- or sulfonyl-linked pyrrolidin-1-yl or related moiety, being inhibitors of p38 MAP kinase, are...
US20130210024 COMBINATION TREATMENT OF CANCER  
The present technology relates to a method of treating cancer by sensitizing human tumours to DNA damaging therapies through activating FBXO32 expression. Transactivation of FBXO32 through the...
US20110112037 CRYSTAL STRUCTURE  
The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the...
US20130096165 COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by...
US20110172278 COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by...
US20130245077 CRYSTALLINE FORMS OF FEBUXOSTAT  
New forms of Febuxostat have bean, prepared and characterized. These forms are useful for examples in the chronic management of hyperuricemia in patients with gout.
US20120264703 Methods And Compositions For The Treatment Of Anxiety Disorders, Including Post Traumatic Stress Disorder (PTSD) And Related Central Nervous System (CNS) Disorders.  
The present invention provides novel methods and formulations for treating anxiety disorders, including Post Traumatic Stress Disorder, in human subjects employing coordinate treatment using α and...
US20140088313 SUBSTITUTED INDOLOCARBAZOLES  
A substituted indolocarbazole comprising at least one optionally substituted thienyl.
US20120184556 SUBSTITUTED ENZOIMIDAZOLESULFONAMIDES AND SUBSTITUTED INDOLESULFONAMIDES AS MGLUR4 POTENTIATORS  
Disclosed are substituted benzoimidazolesulfonamides and substituted indolesulfonamides as mGluR4 potentiators.
US20120157689 SUBSTITUTED INDOLOCARBAZOLES  
A substituted indolocarbazole comprising at least one optionally substituted thienyl.
US20140000807 ACCELERATORS FOR TWO STEP ADHESIVE SYSTEMS  
Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators in primers for two step adhesive systems are provided.
US20120237561 INJECTABLE FORMULATIONS CONTAINING ASENAPINE AND METHOD OF TREATMENT USING SAME  
The present invention provides a formulation comprising asenapine hemipamoate suspended particles, which formulation can be administered via a Depot provided by an IM injection of the formulation,...
US20130216475 METHODS AND COMPOSITIONS FOR PROTEIN LABELLING  
A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
US20150119364 BORON-CONTAINING SMALL MOLECULES  
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to...
US20120219538 STABILIZED PROTEIN FORMULATIONS AND USE THEREOF  
The present invention is directed to stable protein formulations, related methods and uses thereof. In particular, the invention relates to a method of stabilizing therapeutic proteins in aqueous...
US20150216880 INDUCING LACTATION IN NURSING FEMALES  
A topical cream applied to a nipple of a lactating female induces lactation. The cream comprises a base cream having from about 0.5% to about 10%, by volume, of a steroid, based upon the total...
US20130324409 CONTROL OF PLANT STRESS TOLERANCE, WATER USE EFFICIENCY AND GENE EXPRESSION USING NOVEL ABA RECEPTOR PROTEINS AND SYNTHETIC AGONISTS  
The present invention provides methods of regulating plant stress tolerance.
US20110318345 NASAL DELIVERY  
substances and the nasal administration thereof, in particular as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, in particular the posterior region of...
US20130197044 METHODS OF TREATING HEPATORENAL SYNDROME AND HEPATIC ENCEPHALOPATHY WITH THROMBOXANE-A2 RECEPTOR ANTAGONISTS  
The present invention is directed to methods of treating hepatorenal syndrome by administration of a therapeutically effective amount of a thromboxane A2 receptor antagonist to a patient in need...
US20130178504 CRYSTALLINE FORMS OF FEBUXOSTAT  
New forms of Febuxostat have been prepared and characterized. These forms are useful, for example, in the chronic management of hyperuricemia in patients with gout.
US20100317702 CRYSTALLINE FORM OF FEBUXOSTAT  
New forms of Febuxostat have been prepared and characterized. These forms are useful, for example, in the chronic management of hyperuricemia in patients with gout.
US20150166472 NOVEL SIGMA RECEPTOR LIGANDS AND METHODS OF MODULATING CELLULAR PROTEIN HOMEOSTASIS USING SAME  
The present invention includes compounds useful in preventing, treating or ameliorating Sigma-related disorders or diseases. The compounds of the invention can modulate cellular protein...
US20150045401 PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE  
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through...
US20100311800 ANGIOTENSIN II RECEPTOR ANTAGONISTS  
The present invention relates to nitrooxyderivatives of angiotensin II receptor antagonists.
US20140296531 Novel semi-synthetic small molecules for the treatment parasitic disease  
Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African...
US20110086818 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS  
The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while...
US20130288331 PEPTIDOMIMETIC COMPOUNDS AND RELATED METHODS  
Provided herein are compounds and methods of using same for the perturbation and/or inhibition of protein-protein interactions. Also provided herein is a data mining method useful for the...
US20150119435 COMPOUNDS USEFUL FOR PROMOTING PROTEIN DEGRADATION AND METHODS USING SAME  
The present invention includes compounds that act as degraders of a target protein, wherein degradation is independent of the class of the target protein or its localization. In certain...
US20140336234 CHLOROPHYLL c CONTAINING DEGRANULATION SUPPRESSOR  
Degranulation suppressors are provided that are effective against allergic disease and osteoarthritis. The degranulation suppressors contain chlorophyll c.
US20120064181 P2X3 Receptor Antagonists for Treatment of Pain  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
US20120015052 P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
US20110003822 P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
US20130116292 NEURORESTORATION WITH R(+) PRAMIPEXOLE  
Formulations and methods of use thereof for restoring neuronal, muscular (cardiac and striated) and/or retinal tissue function in children and adults afflicted with chronic neurodegenerative...
US20110218222 NEURORESTORATION WITH R(+) PRAMIPEXOLE  
Formulations and methods of use thereof for restoring neuronal, muscular (cardiac and striated) and/or retinal tissue function in children and adults afflicted with chronic neurodegenerative...
US20110319630 POROUS REACTIVE FRAMEWORK  
This disclosure relates to porous frameworks for gas separation, sensing and drug/biomolecule delivery. More particularly, the disclosure relates to reactive porous frameworks for functionalization.
US20150141479 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MODERATE TO SEVERE PAIN  
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The...
US20120322978 CROSSLINKING REAGENTS, METHODS, AND COMPOSITIONS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS  
The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of protein-protein interactions in vivo...
US20150150855 METHOD OF IMPROVING LIVER FUNCTION  
The present disclosure relates generally to the use of methazolamide in therapy. The disclosure further relates to treating liver dysfunction, or improving liver function, in a patient.
US20130224114 Translocator Protein Ligands  
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the...
US20110044898 TRANSLOCATOR PROTEIN LIGANDS  
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the...
US20150094267 SUCCINIMIDE-ACTIVATED NITROXYL COMPOUNDS AND METHODS FOR THE USE THEREOF FOR NITROXYLATION OF PROTEINS  
The present invention relates to succinimide-activated nitroxyl compounds and methods for the synthesis of such compounds. The present invention also relates to the use of succinimide-activated...