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US20140235439 3,5-DISUBSTITUTED-4,5-DIHYDRO-1,2,4-OXADIAZOLES AND COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS  
Provided herein are new 3,5-disubstituted-4,5-dihydro-1,2,4-oxadiazoles that exhibit nematicidal activity and are useful, for example, in compositions and methods for the control of unwanted...
US20120052110 METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING  
Provided herein are compositions and methods that inhibit expression of Adam12 gene products, such as ADAM12 mRNA and/or ADAM12 polypeptides, as a therapeutic approach for the treatment of, or...
US20120264802 PHOTOSENSITIZERS FOR TARGETED PHOTODYNAMIC THERAPY  
The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.
US20110282067 ZEOLITIC IMIDAZOLATE FRAMEWORKS FOR KINETIC SEPARATION OF PROPANE AND PROPENE  
Zeolitic Imidazolate Frameworks (ZIFs) characterized by organic ligands consisting of imidazole ligands that are either essentially all 2-chloroimidazole ligands or essentially all...
US20130069010 MODULAR SUPRAMOLECULAR APPROACH FOR CO-CRYSTALLIZATION OF DONORS AND ACCEPTORS INTO ORDERED NETWORKS  
Organic charge-transfer (CT) co-crystals in a mixed stack system are disclosed, wherein a donor molecule (D) and an acceptor molecule (A) occupy alternating positions (DADADA) along the CT axis. A...
US20110152339 FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION  
The invention provides methods for the treatment of cancer in a subject comprising administering a dansyl-carbazole compound.
US20110212999 TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS  
This invention relates to novel triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention...
US20140066426 FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES  
The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these...
US20120171125 Methods for Enhancing the Cognitive Function  
A compound having an affinity to a SV2 protein for the treatment of a condition associated with enhancement or improvement of the cognitive ability or to counteract cognitive decline of a mammal....
US20120222557 IONIC LIQUIDS COMPRISING HETERAROMATIC ANIONS  
Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally...
US20130317013 EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF  
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are...
US20110288080 Nitrofuran Compounds for the Treatment of Cancer and Angiogenesis  
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The...
US20130256228 USE OF NOVEL DRAW SOLUTES AND COMBINATIONS THEREOF TO IMPROVE PERFORMANCE OF A FORWARD OSMOSIS SYSTEM AND PROCESS  
This disclosure describes draw solution compositions for FO processes which increase the available membrane area for permeation and are also amenable to reconcentration with standard techniques,...
US20110244016 MEDICAL IMPLANT HAVING A COATING COMPOSED OF OR CONTAINING AT LEAST ONE ACTIVE SUBSTANCE  
One embodiment of the invention relates to a medical implant whose surface is completely or partially covered by a coating composed of at least one active substance or containing at least one...
US20150232392 METHOD FOR SYNTHESIZING RADIOPHARMACEUTICALS USING A CARTRIDGE  
The present invention relates to a method for synthesizing a radiopharmaceutical using a cartridge, which makes it possible to carry out several steps of reaction required for synthesizing a...
US20110071142 IDENTIFICATION AND USE OF SMALL MOLECULES TO MODULATE TRANSCRIPTION FACTOR FUNCTION AND TO TREAT TRANSCRIPTION FACTOR ASSOCIATED DISEASES  
The present invention relates to methods of identifying small molecule candidate agents capable of modulating transcription factor function such that the function/expression of a target...
US20110294785 INFLUENZA A VIRUS INHIBITION  
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza...
US20130211100 Method to Generate Novel Bioactive Molecules  
The present invention describes a method to generate new chemical entities (NCEs) that have well-defined activities such as, but not limited to, anti-bacterial, antifungal and anthelmintic...
US20130046099 Thiadiazole Which can be used as a Vulcanization Accelerator and Method for Obtaining Same  
A thiadiazole of formula (I):
US20120046336 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION  
This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam,...
US20140155371 MULTICOMPONENT CRYSTALLINE SYSTEM OF EZETIMIBE AND PROLINE  
Provided is a crystalline composition comprising a mixture of a compound of formula 1 (Ezetimibe) and proline or proline derivatives, or a hydrate/solvate thereof, as well as a process for...
US20130158091 POLYMORPHS OF SAXAGLIPTIN HYDROCHLORIDE AND PROCESSES FOR PREPARING THEM  
The invention provides polymorphs of Saxagliptin hydrochloride, processes for preparing polymorphs of Saxagliptin hydrochloride, and pharmaceutical compositions of polymorphs of Saxagliptin...
US20120083517 POLYMORPHS OF SAXAGLIPTIN HYDROCHLORIDE AND PROCESSES FOR PREPARING THEM  
The invention provides polymorphs of Saxagliptin hydrochloride, processes for preparing polymorphs of Saxagliptin hydrochloride, and pharmaceutical compositions of polymorphs of Saxagliptin...
US20120245213 HUMAN TYPE I TASTE RECEPTOR SUBUNIT 3 MODULATORS AND METHODS OF USING SAME  
Methods and compositions are provided for modulating the activity of human type I taste receptor subunit 3 (hT1R3). Such materials and methods are useful for the screening and preparation of...
US20130118399 METHODS AND SYSTEMS RELATING TO THE SELECTION OF SUBSTRATES COMPRISING CRYSTALLINE TEMPLATES FOR THE CONTROLLED CRYSTALLIZATION OF MOLECULAR SPECIES  
The present invention generally relates to methods and systems relating to the selection of substrates comprising crystalline templates for the controlled crystallization of molecular species. In...
US20110195929 COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS  
Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with...
US20110178141 Thiazoliums and Their Use for Treating Protein Aging Associated Diseases  
The present invention relates to a composition of a thiazolium compound of formula I or a solvate thereof, wherein the definitions of groups in the formula I are as those given in the claims:
US20100168053 ORAL DELIVERY SYSTEM FOR METHYLCOBALAMIN TO TREAT DISORDERS  
A method of treating a disorder by lollipop administering methylcobalamin, with or without folinic acid by direct delivery to the trigeminal nerve. The disorders addressed are: a) attention...
US20150252005 Method of Synthesizing Organic Molecules  
A method of synthesizing organic molecules is provided, wherein the method comprises providing an electrophilic educt, providing an ionic liquid comprising a carbanion, and synthesizing the...
US20120136161 Method of Synthesizing Organic Molecules  
A method of synthesizing organic molecules is provided, wherein the method comprises providing an electrophilic educt, providing an ionic liquid comprising a carbanion, and synthesizing the...
US20130225469 HARD SURFACE CLEANERS BASED ON COMPOSITIONS DERIVED FROM NATURAL OIL METATHESIS  
Aqueous hard surface cleaner compositions derived from metathesized natural oil feedstocks are disclosed. In one aspect, the compositions comprise at least one anionic surfactant derived from a...
US20130158082 METHODS OF MANAGING BLOOD SUGAR LEVELS AND COMPOSITIONS RELATED THERETO  
The disclosure relates to methods of managing blood sugar levels and compositions related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diabetes,...
US20140315968 Substituted 2-Imidazolidinones and 2-Imidazolones and Their Use in the Treatment of Cancer  
Compounds of formula (I) wherein R1, R4, R8, X and Y as defined herein are provided as useful for the inhibition of certain types of cancer cells, amongst others, breast cancer cells, or for the...
US20110257222 COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES  
The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the...
US20110171736 FLUORESCENT ISOTOPE TAGS AND THEIR METHOD OF USE  
The present invention provides novel reactive fluorescent compounds that incorporate stable isotopic (deuterium, 13-carbon, 15-nitrogen, 18-oxygen) substitutions. The invention includes the use of...
US20110166361 CRYSTALLINE FORMS OF [3-(4- -PHENOXY)-PROPYL]-DIETHYL-AMINE  
The present invention relates to crystalline forms of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 -yl}-phenoxy)-propyl]-diethylamine (“COMPOUND I”) useful in the treatment of RAGE...
US20150110809 MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS)  
Embodiments of the invention are directed to compounds that inhibit an activity of EP AC proteins and methods of using the same. The inventors have developed a sensitive and robust high throughput...
US20120077752 COMPOSITION FOR IMPROVING BRAIN FUNCTION AND METHOD FOR IMPROVING BRAIN FUNCTION  
The present invention provides a composition which may be ingested orally in a small dose for the purpose of improving brain function, and a method for improving brain function. The present...
US20100022596 EPOTHILONE ANALOGUES  
The invention relates to analogues of epothilones, uses and methods of making the same.
US20120132564 PROCESS FOR REMOVING ORGANIC ACIDS FROM CRUDE OIL AND CRUDE OIL DISTILLATES  
The present invention relates to a process for the removal of organic acids, particularly naphthenic acids, from crude oils and crude oil distillates by use of a supported basic ionic liquid in a...
US20140296209 COMPOUNDS AND METHODS FOR TREATMENT OF HYPERTENSION  
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2B antagonists. The compounds may also bind...
US20140359794 BODIPY STRUCTURE FLUORESCENCE PROBES FOR DIVERSE BIOLOGICAL APPLICATIONS  
The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: (I), or a pharmaceutically acceptable salt thereof. The...
US20140073803 RADIOTRACER PRECURSOR AND METHOD FOR PREPARING THE SAME  
A precursor SnBZM for a dopamine receptor radiotracer and a method for preparing the same are revealed. The precursor includes a tributyltin group (Bu3Sn) that is easy to be replaced. Thus a...
US20130165560 Modified Fillers And Elastomeric Composites Comprising Same  
Modified fillers are described which have adsorbed and/or attached chemical groups, such as a triazole and/or pyrazole thereon. Other modified fillers are also described. Elastomeric compositions...
US20070190359 Metal complexes of cyclometallated imidazo[1,2-ƒ]phenanthridine and diimidazo[1,2-a:1',2'-c]quinazoline ligands and isoelectronic and benzannulated analogs thereof  
Compounds comprising phosphorescent metal complexes comprising cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1′,2′-c]quinazoline ligands, or isoelectronic or benzannulated...
US20150225417 THERAPEUTIC AGENT FOR MOTOR DISORDERS  
Provided are an agent for the treatment and/or prophylaxis of a movement disorder, the agent for the treatment and/or prophylaxis wherein the movement disorder is extrapyramidal syndrome, the...
US20120101101 THERAPEUTIC AGENT FOR MOTOR DISORDERS  
Provided are an agent for the treatment and/or prophylaxis of a movement disorder, the agent for the treatment and/or prophylaxis wherein the movement disorder is extrapyramidal syndrome, the...
US20120071528 METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA  
The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.
US20060009512 5-ht 1b/1d receptor agonists for the treatment of headache resulting from administering an endothelin receptor antagonist  
The use of a 5-HT1B/1D receptor agonist in the treatment or prevention of headache that results from administering an endothelin receptor antagonist; and the combination, comprising an endothelin...
US20110021584 Methods and Assays for Detecting and Treating Hypoglycemia  
Methods for regulating glucagon release and of treating hypoglycemia, and for screening drug candidates for treating hypoglycemia. The methods are useful for treating diabetes mellitus and...