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US20110034523 CRYSTALLINE FORMS OF RUFINAMIDE  
Disclosed is a crystalline form of rufinamide selected from: a substantially anhydrous and approximately monosolvated with trifluoroacetic acid crystalline form, hereinafter designated as Form α,...
US20100035251 BioMarkers for the Progression of Alzheimer's Disease  
The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients...
US20140093960 CELL DIFFERENTIATION INDUCER AND DIFFERENTIATION INDUCING METHOD  
The objective of the present invention is to provide a cell differentiation inducer which is a low-molecular compound, which can be chemically synthesized easily and which can efficiently induce a...
US20130178506 ISOXAZOLE TREATMENTS FOR DIABETES  
The present invention relates to compounds and methods for inducing synthesis and secretion of insulin from pancreatic beta cells. The methods may take place in vitro, ex vivo such as in isolates...
US20130190324 TOPICAL OCULAR DRUG DELIVERY  
The present invention provides compositions and methods for increasing the delivery (i.e., bioavailability) of a compound to an ocular cell. Such compositions and methods can be used to treat an...
US20140105918 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS  
The present invention relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample....
US20140288050 MODULATORS OF OPIOID RECEPTORS AND METHODS OF USE THEREOF  
Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain,...
US20150158908 SMAC Mimetic for Treating Myelodysplastic Syndromes  
A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
US20130225832 PROCESS FOR THE RESOLUTION OF MEDETOMIDINE AND RECOVERY OF THE UNWANTED ENANTIOMER  
A new and efficient process to obtain Medetomidine enantiomers, a selective and potent α2-receptor agonist, is presented. Such process comprises a resolution step and a racemisation reaction, to...
US20150079625 NAPHTHALENE-BASED TWO-PHOTON FLUORESCENT PROBES, PREPARATION METHOD AND USE THEREOF  
The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned...
US20130040947 TRKB AGONISTS AND METHODS OF USE  
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-di-hydroxyflavone derivative with modified flavone or heterocyclic ring...
US20080146640 Water-Soluble Prodrugs of Chloramphenicol, Thiamphenicol, and Analogs Thereof  
The present invention discloses certain novel prodrugs of chloramphenicol or thiamphenicol, or of an analog of either, including prodrugs of pharmaceutically acceptable salts of chloramphenicol or...
US20110286922 IMAGING AND RADIOTHERAPY METHODS  
The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of...
US20150152506 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LUNG CANCER METASTASIS  
The present invention relates to a method for the diagnosis or the prognosis of metastasis in lung cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample....
US20140142065 METHOD OF USING BINUCLEAR GOLD (I) COMPOUNDS FOR CANCER TREATMENT  
Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as...
US20110285274 ORGANIC MATERIAL AND ORGANIC LIGHT EMITTING DIODE DISPLAY USING SAME  
An organic material for an organic light emitting diode (OLED) display, and an OLED display are provided, and the organic material includes an anthracene derivative includes at least deuterium.
US20150031892 SPHINGOLIPID METABOLITE MIMETICS  
Sphingolipid metabolite mimetics and methods of synthesizing them are provided. The sphingolipid metabolite mimetics are shown to be effective at inducing apoptosis in various types of tumor...
US20130130289 COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H  
The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox...
US20140076036 DABIGATRAN ETEXILATE AND RELATED SUBSTANCES, PROCESSES AND COMPOSITIONS, AND USE OF THE SUBSTANCES AS REFERENCE STANDARDS AND MARKERS  
The present invention relates to dabigatran etexilate and related substances and use of the substances as reference standards and markers. There are also provided processes of detecting the...
US20130048505 PLATING BATH AND METHOD  
Copper plating baths containing a leveling agent that is a reaction product of one or more of certain cyclodiaza-compounds with one or more epoxide-containing compounds that deposit copper on the...
US20120197016 SCREENING METHODS OF MODULATING ADRENERGIC RECEPTOR GENE EXPRESSIONS IMPLICATED IN MELANOGENESIS  
Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a...
US20150236353 FABRICATION AND FUNCTIONALIZATION OF A PURE NON-NOBLE METAL CATALYST STRUCTURE SHOWING TIME STABILITY FOR LARGE SCALE APPLICATIONS  
A pure and crystalline single-crystal nitrogen-functionalized graphene nano-flake powder comprising from 2 atomic % to at least 35 atomic % of total functionalized nitrogen within the graphene...
US20120088788 SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS  
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore...
US20150051260 METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS  
Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
US20150133442 METHODS AND COMPOSITIONS FOR THE INHIBITION OF PIN1  
The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
US20150045389 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR  
The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in...
US20120232063 2-Aminoindole Compounds And Methods For The Treatment Of Malaria  
The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the...
US20110319398 INHIBITION OF YOPS TRANSLOCATION  
The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of...
US20140378888 (BACTERIO)CHLOROPHYLL PHOTOSENSITIZERS FOR TREATMENT OF EYE DISEASES AND DISORDERS  
An ophthalmic composition is provided, comprising chlorophyll or bacteriochlorophyll compounds for photodynamic treatment (PDT) of diseases, disorders and conditions associated with corneal or...
US20120121536 COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION  
Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates....
US20130344165 JAB1 INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO  
This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting...
US20110257130 Compositions and Methods for Treatment of Renin-Angiotensin Aldosterone System (RAAS)- Related Disorders  
Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related...
US20150053211 Cleaning and safe mouth guard solution  
An aqueous oral spray designed to treat mouth guards against bacterial infection comprising: 1. A naturally derived di-basic amino acid derivative,2. A natural sweetener which inhibits the...
US20130143910 Fructose-1,6-biphosphatases as new targets for diagnosing and treating breast cancer brain metastasis  
A method and composition for treating cancer cells that targets fructose-1,6-biphosphataseenzymes (FBPs, type 1 and type 2) and/or their respective pathways. In one embodiment, inhibitors of FBPs...
US20110220514 Plating bath and method  
Copper plating baths containing a leveling agent that is a reaction product of a certain imidazole with a certain epoxide-containing compound that deposit copper on the surface of a conductive...
US20110220512 Plating bath and method  
Copper plating baths containing a leveling agent that is a reaction product of a certain imidazole with a certain epoxide-containing compound that deposit copper on the surface of a conductive...
US20120041178 Coenzyme Q10 Nanoparticles, Preparation Method Thereof and Composition Containing Said Nanoparticles  
Provided are a coenzyme Q10 nanoparticle, a method of preparing the same and a composition having the nanoparticle. According to the present invention, Coenzyme Q10 may be dissolved in only a...
US20120329841 TREATING CANCER WITH DESTHIAZOLYL RITONAVIR  
Treatment of cancer includes administering a compound of formula I, for example desritonavir, to a subject. In particular, treatment of breast cancer is described.
US20140051729 COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS  
Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent....
US20110220513 Plating bath and method  
Copper plating baths containing a leveling agent that is a reaction product of a certain benzimidazole with a certain epoxide-containing compound that deposit copper on the surface of a conductive...
US20120226050 POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS  
The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of...
US20130123513 Adhesive Compositions for Bonding Composites  
The present invention relates to a non-thermosetting composition made by reacting epichlorohydrin and a primary amine, to the use of that composition for making thermosetting (curable) adhesives...
US20110300149 LJUNGAN VIRUS  
The present invention relates to a new group of Ljungan viruses, proteins expressed by the viruses, antibodies to the viruses and proteins, vaccines against the viruses, diagnostic kits for...
US20120209009 SYNTHETIC ROUTE TO ABCD-PORPHYRINS  
A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under...
US20110306774 SYNTHETIC ROUTE TO ABCD-PORPHYRINS  
A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under...
US20110195934 AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS  
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable faints thereof according to wherein all of the variables are defined herein.
US20130023402 Preparation of Functionalized Zeolitic Frameworks  
The disclosure provides zeolitic frameworks for gas separation, gas storage, catalysis and sensors. More particularly the disclosure provides zeolitic frameworks (ZIFs). The ZIF of the disclosure...
US20120053150 N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS  
The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions...
US20120283248 COMPOSITION AND METHOD FOR TREATING COGNITIVE IMPAIRMENTS IN DOWN SYNDROM SUBJECTS  
Compounds having inverse agonist functional selectivity for GABAA receptors containing the α5 subunit for use as a medicament in the treatment of cognitive impairments in subjects suffering from...
US20140275189 Methods for Modulating Bacterial Virulence and Related Compounds  
The present invention relates to compounds and methods for the treatment of bacterial infections. The compounds and methods involve the disruption of the QseC signaling pathway which modulates the...