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US20140031401 Modified Release Formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and Methods of Using the Same  
Modified release pharmaceutical compositions (controlled release, sustained release, and/or extended release) of the R-(+) enantiomer of pramipexole (RPPX) and methods of using such compositions...
US20110251379 COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS  
As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating...
US20100215973 MALEIMIDE BASED COMPOUND, COMPOSITION FOR FORMING BOARD, AND BOARD FABRICATED USING THE SAME  
Disclosed is a composition for forming a board. The composition includes a maleimide-based compound including at least three maleimide groups and a liquid crystalline polymer or oligomer. A...
US20150225755 Ergothioneine Production Through Metabolic Engineering  
The present disclosure relates to the production of ergothioneine through either in vitro enzymatic transformations or fermentations using microbials created by metabolic engineering. Also...
US20060178426 Kappa agonists, especialy for the treatment and/or prophylaxis of irritable bowel syndrome  
Compound of the formula (I), in which A, R1, R2, R3, X, Y, m and n have the meaning indicated, are suitable as for the treatment of irritable bowel syndrome.
US20140287011 ARTHROPOD PEST CONTROL COMPOSITION  
Disclosed is an arthropod pest control composition comprising 2-(2,6-difluorophenyl)-4-[4-(1,1-dimethylethyl)-2-ethoxyphen yl]-4,5-dihydrooxazole and an inert carrier, wherein the volume median...
US20110212189 GASTRORETENTIVE ORAL HIGH DOSE ZINC PREPARATIONS  
A sustained-release zinc composition preferably includes potassium bicarbonate. A method of providing zinc to a subject in need of treatment includes administering to the subject an effective...
US20120058144 LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS  
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having...
US20120322769 METHODS OF REDUCING VIRULENCE IN BACTERIA  
A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising...
US20150025068 BISARYLSULFONAMIDES USEFUL IN THE TREATMENT OF INFLAMMATION AND CANCER  
A compound of formula (I), useful for the treatment of cancer, inflammation and inflammatory disorders, and a pharmaceutical composition containing the compound.
US20140303160 Targeting GLI Proteins in Human Cancer by Small Molecules  
The present disclosure provides compositions, pharmaceutical preparations and methods for the diagnosis and treatment of cancers expressing a GLI polypeptide. The disclosed compositions and...
US20110282066 SCREENING METHOD FOR SUBSTANCE USEFUL AS AGENT FOR TREATING PROSTATE CANCER  
[Object] A screening method for a compound which is useful as an agent for treating 17βHSD type 5-related diseases and/or an agent for treating 17βHSD type 5-related cancer such as prostate cancer...
US20120157457 COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION  
The present invention provides compositions and methods for inducing neuronal cell differentiation.
US20150218121 PRODRUGS OF TETRAHYDROCANNABINOL, COMPOSITIONS COMPRISING PRODRUGS OF TETRAHYDROCANNABINOL AND METHODS OF USING THE SAME  
Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the...
US20120289484 PRODRUGS OF TETRAHYDROCANNABINOL, COMPOSITIONS COMPRISING PRODRUGS OF TETRAHYDROCANNABINOL AND METHODS OF USING THE SAME  
Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the...
US20130123485 CATIONIC LIPIDS, METHODS FOR PREPARING THE SAME, AND DELIVERY SYSTEMS HAVING ABILITY TO TRANSITION INTO CELLS COMPRISING THE SAME  
The present invention provides cationic lipids, methods for preparing the same, and delivery systems comprising the same. The present invention can provide cationic lipids which enhance the...
US20140336178 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES  
The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one...
US20130203733 COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES  
The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one...
US20130238118 fD  
The invention disclosed herein relates to methods and means for allocating, allotting, apportioning, dispensing, distributing, preparing, portioning, meting out and/or otherwise providing,...
US20100317703 METHOD FOR INHIBITING BRASSININ OXIDASE  
The present disclosure relates to a method for inhibiting brassinin oxidase comprising treating a pathogen that is producing BO with an effective amount of selected Paldoxin compounds.
US20120129833 CYCLIC KETOENOLS FOR THERAPY  
The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and...
US20130237531 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR  
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
US20130156731 FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEAS  
The present invention relates to novel Fused Tricyclic Compounds, compositions comprising at least one Fused Tricyclic Compound, and methods of using Fused Tricyclic Compounds for treating or...
US20140005181 SMALL MOLECULE ANTAGONISTS OF THE APELIN RECEPTOR FOR THE TREATMENT OF DISEASE  
The present disclosure relates to compounds and methods for treating a disease mediated by apelin.
US20110144172 Crystalline Modifications of Prothioconazole  
There is disclosed a crystalline DMSO solvate of prothioconazole as well as amorphous prothioconazole. Methods for making these solid forms, microbicidal compositions comprising them and uses...
US20150175998 Methods and Kits to Create Protein Substrate˜HECT-Ubiquitin Ligase Pairs  
Methods and kits to use in the isolation and identification of crosslinked protein substrate ubiquitin ligase complexes are disclosed. More specifically the methods and kits disclosed herein...
US20140148498 METHODS AND COMPOSITIONS FOR THE TREATMENT OF MARFAN SYNDROME AND ASSOCIATED DISORDERS  
The instant invention provides methods and compositions for the treatment and prevention of Marfan syndrome and related diseases, disorders and conditions. The invention further provides...
US20130190373 ANGIOTENSIN II RECEPTOR ANTAGONIST FOR THE PREVENTION OR TREATMENT OF SYSTEMIC DISEASES IN CATS  
A pharmaceutical composition for prophylaxis or treatment of systemic diseases in cats, wherein the composition comprising administration of a therapeutically effective amount of angiotensin II...
US20110230442 NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS  
Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors...
US20120029016 Indoles Useful in the Treatment of Inflammation  
There is provided compounds of formula I, wherein ring R1a to R1c, R2a to R2e, and X have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are...
US20130203764 TREATMENT OF CANCER/INHIBITION OF METASTASIS  
Substances and methods are disclosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium...
US20140200226 ANTI-MALARIAL COMPOUNDS FROM MARINE NATURAL PRODUCTS  
Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.
US20100324095 PHARMACEUTICAL COMPOSITION FOR INHIBITING AMYLOID-BETA PROTEIN ACCUMULATION  
The present invention provides: a pharmaceutical composition for inhibiting amyloid-β protein accumulation comprising a compound of the formula (I) or a pharmaceutically acceptable salt thereof as...
US20100144821 COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS  
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative...
US20110165087 TARGETED DELIVERY OF IMAGING PROBES FOR IN VIVO CELLULAR IMAGING  
The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching...
US20110137025 CHEMICAL FRAMEWORK COMPOSITIONS AND METHODS OF USE  
The disclosure provides metal organic frameworks useful for sensing, gas sorption, microelectronics and switches.
US20110207714 SEROTONIN RECEPTOR MODULATORS  
The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases.
US20120288947 FLUORESCENT PROBE COMPOUNDS, PREPARATION METHOD AND APPLICATION THEREOF  
The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission...
US20140107327 METHODS FOR PREPARING DEUTERATED 1,2,3-TRIAZOLES  
This disclosure relates to a method that involves reacting an azide with an alkyne in the presence of deuterated water and a copper-containing catalyst, thereby forming a deuterated 1,2,3-triazole.
US20120214809 Aminoindane Compounds and Use Thereof in Treating Pain  
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by...
US20140255386 MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME  
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is...
US20110245218 Use of Maleimide Salts to Control Phytopathogenic Fungi  
The present invention relates to the use of new and known maleimide salts for controlling phytopathogenic fungi, and also to methods for controlling phytopathogenic fungi in crop protection, in...
US20150126553 BICYCLIC HETEROCYCLES CAPABLE OF MODULATING T-CELL RESPONSES, AND METHODS OF USING SAME  
The present disclosure is directed in part to bicyclic heterocycles, such as a compound represented by formula (I) or (II) as disclosed herein, and their use in treating medical disorders, such as...
US20130287700 COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM  
Subject of the present invention are compounds with high affinity for the Aβ protein, α-synuclein or for Tau-PHF aggregates, which are suitable as preferably fluorescent probes for the in vivo...
US20120046335 SOLID STATES OF ATORVASTATIN POTASSIUM  
Atorvastatin potassium crystalline Forms A, B, E, F, and G are provided. Also provided are methods of preparing atorvastatin potassium crystalline Forms A, B, E, F, and G. Atorvastatin potassium...
US20120165380 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS  
Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an...
US20120035235 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS  
Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an...
US20100331312 MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO  
Amide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical...
US20110009370 METHOD TO ENHANCE TISSUE REGENERATION  
The present invention provides for compositions and methods for modulating tissue growth using tissue growth modulators, which are agents that either enhance or inhibit tissue growth as desired by...
US20140275566 PROCESS FOR DRYING BENDAMUSTINE HYDROCHLORIDE MONOHYDRATE  
Wet bendamustine hydrochloride monohydrate may be dried by a two stage process wherein rapid drying is first carried out to provide a partially dried product, which is then further dried using an...