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US20130072523 |
ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
Compounds represented by Formula I: (I) or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R1, R2, R2′, R3, R3′, R4, R4′, R5′, R5′m, n, or p are as defined herein, are useful ...
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US20120301430 |
THIOPHENE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
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US20120059170 |
THIOPHENE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
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US20110172238 |
BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, a...
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US20110195932 |
Drug Combinations for the Treatment of Duchenne Muscular Dystrophy
Combinations comprising (or consisting essentially of) one or more compounds of formula (1) with one or more ancillary agents, to processes for preparing the combinations, and to various...
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US20120282629 |
Enhancers of Protein Degradation
The present invention relates to compounds suitable for modulating huntingtin protein processing and useful for treating or preventing huntingtin-related disorders. The invention provides...
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US20120122937 |
METHODS FOR INHIBITING CANCER CELL PROLIFERATION AND INDUCING CANCER CELL APOPTOSIS
Methods and pharmaceutical compositions for treating cancer utilizing compounds characterized by the following structure: and their pharmaceutically acceptable salts.
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US20080299080 |
Thiophene analogues for the treatment or prevention of flavivirus infections
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
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US20110251379 |
COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating...
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US20100215973 |
MALEIMIDE BASED COMPOUND, COMPOSITION FOR FORMING BOARD, AND BOARD FABRICATED USING THE SAME
Disclosed is a composition for forming a board. The composition includes a maleimide-based compound including at least three maleimide groups and a liquid crystalline polymer or oligomer. A prepreg...
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US20060178426 |
Kappa agonists, especialy for the treatment and/or prophylaxis of irritable bowel syndrome
Compound of the formula (I), in which A, R1, R2, R3, X, Y, m and n have the meaning indicated, are suitable as for the treatment of irritable bowel syndrome.
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US20110212189 |
GASTRORETENTIVE ORAL HIGH DOSE ZINC PREPARATIONS
A sustained-release zinc composition preferably includes potassium bicarbonate. A method of providing zinc to a subject in need of treatment includes administering to the subject an effective...
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US20120058144 |
LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having...
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US20120322769 |
METHODS OF REDUCING VIRULENCE IN BACTERIA
A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising...
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US20110282066 |
SCREENING METHOD FOR SUBSTANCE USEFUL AS AGENT FOR TREATING PROSTATE CANCER
[Object] A screening method for a compound which is useful as an agent for treating 17βHSD type 5-related diseases and/or an agent for treating 17βHSD type 5-related cancer such as prostate c...
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US20120157457 |
COMPOSITIONS AND METHODS FOR INDUCING NEURONAL DIFFERENTIATION
The present invention provides compositions and methods for inducing neuronal cell differentiation.
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US20120289484 |
PRODRUGS OF TETRAHYDROCANNABINOL, COMPOSITIONS COMPRISING PRODRUGS OF TETRAHYDROCANNABINOL AND METHODS OF USING THE SAME
Described herein are Δ9-THC prodrugs, methods of making Δ9-THC prodrugs, formulations comprising Δ9-THC prodrugs and methods of using Δ9-THC. One embodiment described herein relates to the tra...
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US20130123485 |
CATIONIC LIPIDS, METHODS FOR PREPARING THE SAME, AND DELIVERY SYSTEMS HAVING ABILITY TO TRANSITION INTO CELLS COMPRISING THE SAME
The present invention provides cationic lipids, methods for preparing the same, and delivery systems comprising the same. The present invention can provide cationic lipids which enhance the...
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US20100317703 |
METHOD FOR INHIBITING BRASSININ OXIDASE
The present disclosure relates to a method for inhibiting brassinin oxidase comprising treating a pathogen that is producing BO with an effective amount of selected Paldoxin compounds.
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US20120129833 |
CYCLIC KETOENOLS FOR THERAPY
The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and t...
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US20110144172 |
Crystalline Modifications of Prothioconazole
There is disclosed a crystalline DMSO solvate of prothioconazole as well as amorphous prothioconazole. Methods for making these solid forms, microbicidal compositions comprising them and uses...
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US20110230442 |
NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS
Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have...
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US20120029016 |
Indoles Useful in the Treatment of Inflammation
There is provided compounds of formula I, wherein ring R1a to R1c, R2a to R2e, and X have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are...
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US20100324095 |
PHARMACEUTICAL COMPOSITION FOR INHIBITING AMYLOID-BETA PROTEIN ACCUMULATION
The present invention provides: a pharmaceutical composition for inhibiting amyloid-β protein accumulation comprising a compound of the formula (I) or a pharmaceutically acceptable salt thereof as ...
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US20100144821 |
COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases...
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US20110165087 |
TARGETED DELIVERY OF IMAGING PROBES FOR IN VIVO CELLULAR IMAGING
The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching...
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US20110137025 |
CHEMICAL FRAMEWORK COMPOSITIONS AND METHODS OF USE
The disclosure provides metal organic frameworks useful for sensing, gas sorption, microelectronics and switches.
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US20110207714 |
SEROTONIN RECEPTOR MODULATORS
The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases.
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US20120288947 |
FLUORESCENT PROBE COMPOUNDS, PREPARATION METHOD AND APPLICATION THEREOF
The present invention discloses a fluorescent probe compound which solved the problem of fluorescence quenching by Pd2+, and its preparation method and use as well. Excitation and emission...
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US20120214809 |
Aminoindane Compounds and Use Thereof in Treating Pain
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by...
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US20110245218 |
Use of Maleimide Salts to Control Phytopathogenic Fungi
The present invention relates to the use of new and known maleimide salts for controlling phytopathogenic fungi, and also to methods for controlling phytopathogenic fungi in crop protection, in the...
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US20120046335 |
SOLID STATES OF ATORVASTATIN POTASSIUM
Atorvastatin potassium crystalline Forms A, B, E, F, and G are provided. Also provided are methods of preparing atorvastatin potassium crystalline Forms A, B, E, F, and G. Atorvastatin potassium...
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US20120165380 |
METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS
Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an...
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US20120035235 |
METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS
Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an...
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US20100331312 |
MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Amide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical compositions...
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US20110009370 |
METHOD TO ENHANCE TISSUE REGENERATION
The present invention provides for compositions and methods for modulating tissue growth using tissue growth modulators, which are agents that either enhance or inhibit tissue growth as desired by...
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US20110034523 |
CRYSTALLINE FORMS OF RUFINAMIDE
Disclosed is a crystalline form of rufinamide selected from: a substantially anhydrous and approximately monosolvated with trifluoroacetic acid crystalline form, hereinafter designated as Form α, ...
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US20100035251 |
BioMarkers for the Progression of Alzheimer's Disease
The genetic polymorphism LRRK2 (leucine-rich repeat kinase 2)-T1602S is significantly associated with conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD), with the patients...
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US20130040947 |
TRKB AGONISTS AND METHODS OF USE
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-di-hydroxyflavone derivative with modified flavone or heterocyclic ring to...
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US20080146640 |
Water-Soluble Prodrugs of Chloramphenicol, Thiamphenicol, and Analogs Thereof
The present invention discloses certain novel prodrugs of chloramphenicol or thiamphenicol, or of an analog of either, including prodrugs of pharmaceutically acceptable salts of chloramphenicol or...
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US20110286922 |
IMAGING AND RADIOTHERAPY METHODS
The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH) and that are suitable for the in vivo imaging of...
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US20110285274 |
ORGANIC MATERIAL AND ORGANIC LIGHT EMITTING DIODE DISPLAY USING SAME
An organic material for an organic light emitting diode (OLED) display, and an OLED display are provided, and the organic material includes an anthracene derivative includes at least deuterium.
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US20130048505 |
PLATING BATH AND METHOD
Copper plating baths containing a leveling agent that is a reaction product of one or more of certain cyclodiaza-compounds with one or more epoxide-containing compounds that deposit copper on the...
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US20120197016 |
SCREENING METHODS OF MODULATING ADRENERGIC RECEPTOR GENE EXPRESSIONS IMPLICATED IN MELANOGENESIS
Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell,...
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US20120088788 |
SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful...
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US20120232063 |
2-Aminoindole Compounds And Methods For The Treatment Of Malaria
The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)—The values and preferred values of the v...
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US20110319398 |
INHIBITION OF YOPS TRANSLOCATION
The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of...
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US20120121536 |
COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION
Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates....
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US20110257130 |
Compositions and Methods for Treatment of Renin-Angiotensin Aldosterone System (RAAS)- Related Disorders
Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related disorder....
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US20110220514 |
Plating bath and method
Copper plating baths containing a leveling agent that is a reaction product of a certain imidazole with a certain epoxide-containing compound that deposit copper on the surface of a conductive...
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