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US20130022629 Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof  
Disclosed are an assay to identify modulators of the PD-1:PD-L pathway and PD-1:PD-L pathway modulators, e.g., compounds and pharmaceutical compositions thereof. Methods for treating diseases...
US20140243322 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME  
Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on...
US20110275645 Small Molecules for Inhibition of Protein Kinases  
The invention provides compounds that inhibit protein kinases, prodrugs of the compounds, intermediates and methods of synthesizing the compounds and/or prodrugs, pharmaceutical compositions...
US20120122849 PKM2 MODULATORS FOR USE IN THE TREATMENT OF CANCER  
Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the...
US20150011512 TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS  
The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome...
US20120190639 TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS  
The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome...
US20120020881 Triaryl-sulphonium compounds, kit and methods for labeling positron emitting isotopes  
This invention relates to novel compounds suitable for labeling by positron emitting isotopes, such as 18F, 11C, 13N and 15O, through appropriate labeling reagents, such as 18F reagents and methods...
US20110172417 Heterogeneous Copper Nanocatalyst and Manufacturing Methods Thereof  
This invention relates to a heterogeneous copper nanocatalyst composed of copper nanoparticles immobilized on a boehmite support, a method of preparing the same, and the use thereof. The copper...
US20140249193 MODULATORS OF MITOCHONDRIAL PROTEIN IMPORT  
The present invention provides compounds that modulate protein translocation in mitochondria, compositions thereof, and methods of identifying, making and using these.
US20150087628 COMPOSITIONS AND METHODS FOR TREATING CANCER  
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
US20140155415 BENZODIOXEPINE AND BENZODIOXINE COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES  
The present invention relates to compounds of formula I or II, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention...
US20120289496 NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES  
The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of...
US20130296453 FUNCTIONALIZED NANOPARTICLES  
The present invention discloses functionalized nanoparticles comprising on the surface a covalently bound radical of the formula (I) wherein the nanoparticles are SiO2, Al2O3 or mixed SiO2 and...
US20130261133 Therapeutic Compounds for Protozoal and Microbial Infections and Cancer  
The compounds of the invention exhibit antiprotozoal, antimicrobial, and anticancer properties that are useful for the treatment or prevention of infections or cancer in a patient (e.g., a human)....
US20120009142 METHODS FOR TREATING HEPATITIS C  
In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one...
US20130203777 Identification of Stabilizers of Multimeric Proteins  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are...
US20110294385 ORGANIC BLACK PIGMENTS AND THEIR PREPARATION  
A process for preparing a black colorant, preferably a black pigment, characterized in that a compound of the Formula (I) is reacted with a compound of the Formula (II) in a molar ratio of 1:2, in...
US20140117280 OXYGEN ABSORBER  
An oxygen absorber is provided that contains at least one of compounds each having a particular structure, and the oxygen absorber exhibits an oxygen absorbing capability without a metal contained,...
US20110252507 TRANSGENIC PLANTS USED AS A BIOREACTOR SYSTEM  
The present invention relates generally to the use of plants as bioreactors for the production of molecules having useful properties such as inter alia polymers, metabolites, proteins,...
US20110305770 RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM  
The present invention relates to polymer conjugated releasable lipids and nanoparticle compositions containing the same for the delivery of nucleic acids and methods of modulating gene expression...
US20140242606 PROBE FOR iFRET AND USE THEREOF  
The present invention relates to a probe for iFRET and use thereof. Specifically, the present invention relates to a novel probe for iFRET, a method for preparing the probe for iFRET, a method for...
US20110229581 RELEASABLE CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS  
The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the...
US20120190098 FLUOROGENIC COMPOUNDS CONVERTED TO FLUOROPHORES BY PHOTOCHEMICAL OR CHEMICAL MEANS AND THEIR USE IN BIOLOGICAL SYSTEMS  
Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived...
US20110176998 IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS  
The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
US20100292284 Talarazole metabolites  
Novel metabolites of talarazole of formula (I) have been isolated and characterized, wherein R═H, OH, OSO3H or O-gly; R1, ═H, OH, OSO3H, O-gly or =0; and gly=a glucuronate, or a pha...
US20110236310 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD  
The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as...
US20130331368 METHOD OF TREATING HEPATOCELLULAR CARCINOMA  
A therapeutic method for treating hepatocellular carcinoma is disclosed comprising administering to a patient in need of treatment a ruthenium complex salt.
US20110293520 NEW DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES  
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of...
US20120202840 Use of Flubendazole and Vinca Alkaloids for Treatment of Hematological Diseases  
Provided are methods for treating a hematological malignancy comprising administering an effective amount of flubendazole alone or in combination with a vinca alkaloid. Also provided are...
US20110118282 Soluble Guanylate Cyclase Activators  
A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris,...
US20140275112 Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release  
Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating...
US20110262354 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
US20140356322 Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase  
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are...
US20130216630 BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY  
This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials...
US20110307074 BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY  
This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials...
US20130129628 FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES  
Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processeses using a variety of imaging techniques are provided. The...
US20150133551 Lipids That Increase Insulin Sensitivity And Methods Of Using The Same  
The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including d...
US20140093450 PRETARGETING KIT FOR IMAGING OR THERAPY COMPRISING A TRANS-CYCLOOCTENE DIENOPHILE AND A DIENE  
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal...
US20140243509 NEAR INFRARED FLUOROGEN AND FLUORESCENT ACTIVATING PROTEINS FOR IN VIVO IMAGING AND LIVE-CELL BIOSENSING  
Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins,...
US20140213615 Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof  
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death...
US20150064123 HIGH ENERGY VISIBLE LIGHT FILTER SYSTEMS WITH YELLOWNESS INDEX VALUES  
The present invention relates to ophthalmic and non-ophthalmic systems with blue light filtering and Yellowness Index ranges. UV and IR filtering are also included. Industrial applications are also...
US20150057166 METHOD FOR ANALYZING THE THREE DIMENSIONAL STRUCTURE OF A GPCR  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled...
US20130296230 METHOD FOR TREATING MALARIA, METHOD FOR KILLING MALARIA PARASITE, AND USE OF THE METHODS  
A method of the present invention for treating malaria includes the step of administering, to a human or an animal, a therapeutically effective amount of drug for suppressing calcium ion exit from...
US20120088782 LPA RECEPTOR ANTAGONIST  
A compound of the general formula (I): (wherein the symbols are as defined in the description), or a non-toxic salt thereof. This compound engages in LPA receptor bonding and antagonism and hence...
US20090259051 CARVEDILOL PHOSPHATE SESQUIHYDRATE  
The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate),...
US20150072396 Compounds and Methods for Conjugation of Biomolecules  
Low-copper click chemistry, 1.3-dipolar cycloadditions, and Staudinger ligations for modifying biomolecules is provided. Compositions, methods, and kits relating to low-copper click chemistry,...
US20150005352 REACTIVE OXYGEN SPECIES-BASED PRODRUGS  
Provided herein are ROS-sensitive prodrug compositions and methods of treating ROS-associated diseases by administering the ROS-sensitive prodrug compositions.
US20130052205 FLT3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OR THE PREVENTION OF PAIN DISORDERS  
The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.
US20110028522 FULLERENE THERAPIES FOR INFLAMMATION  
Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified...
US20120142935 COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES  
This invention provides a method for preparing a 1,2,3-triazole compound comprising contacting an organic azide with a 2-substituted-1-haloalkyne, in the presence of a copper catalyst and a...