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US20130203777 Identification of Stabilizers of Multimeric Proteins  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are...
US20110294385 ORGANIC BLACK PIGMENTS AND THEIR PREPARATION  
A process for preparing a black colorant, preferably a black pigment, characterized in that a compound of the Formula (I) is reacted with a compound of the Formula (II) in a molar ratio of 1:2, in...
US20140117280 OXYGEN ABSORBER  
An oxygen absorber is provided that contains at least one of compounds each having a particular structure, and the oxygen absorber exhibits an oxygen absorbing capability without a metal contained,...
US20110252507 TRANSGENIC PLANTS USED AS A BIOREACTOR SYSTEM  
The present invention relates generally to the use of plants as bioreactors for the production of molecules having useful properties such as inter alia polymers, metabolites, proteins,...
US20110305770 RELEASABLE POLYMERIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM  
The present invention relates to polymer conjugated releasable lipids and nanoparticle compositions containing the same for the delivery of nucleic acids and methods of modulating gene expression...
US20140242606 PROBE FOR iFRET AND USE THEREOF  
The present invention relates to a probe for iFRET and use thereof. Specifically, the present invention relates to a novel probe for iFRET, a method for preparing the probe for iFRET, a method for...
US20110229581 RELEASABLE CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEMS  
The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the...
US20120190098 FLUOROGENIC COMPOUNDS CONVERTED TO FLUOROPHORES BY PHOTOCHEMICAL OR CHEMICAL MEANS AND THEIR USE IN BIOLOGICAL SYSTEMS  
Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived...
US20110176998 IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS  
The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
US20100292284 Talarazole metabolites  
Novel metabolites of talarazole of formula (I) have been isolated and characterized, wherein R═H, OH, OSO3H or O-gly; R1, ═H, OH, OSO3H, O-gly or =0; and gly=a glucuronate, or a pha...
US20110236310 LABELING COMPOSITION FOR INTRAOCULAR TISSUE, LABELING METHOD OF INTRAOCULAR TISSUE, AND SCREENING METHOD  
The invention provides a labeling composition for an intraocular tissue of a living individual, which specifically labels the intraocular tissue without need of an invasive operation such as...
US20130331368 METHOD OF TREATING HEPATOCELLULAR CARCINOMA  
A therapeutic method for treating hepatocellular carcinoma is disclosed comprising administering to a patient in need of treatment a ruthenium complex salt.
US20110293520 NEW DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES  
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of...
US20120202840 Use of Flubendazole and Vinca Alkaloids for Treatment of Hematological Diseases  
Provided are methods for treating a hematological malignancy comprising administering an effective amount of flubendazole alone or in combination with a vinca alkaloid. Also provided are...
US20110118282 Soluble Guanylate Cyclase Activators  
A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris,...
US20140275112 Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release  
Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating...
US20110262354 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
US20130216630 BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY  
This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials...
US20110307074 BIOMATERIALS FOR USE IN METHODS OF BONE REPLACEMENT THERAPY  
This invention relates to biomaterials, said biomaterials for use in methods to control and/or induce bone growth. Particularly, the invention relates to macroporous calcium phosphate biomaterials...
US20130129628 FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES  
Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processeses using a variety of imaging techniques are provided. The...
US20140093450 PRETARGETING KIT FOR IMAGING OR THERAPY COMPRISING A TRANS-CYCLOOCTENE DIENOPHILE AND A DIENE  
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal...
US20140243509 NEAR INFRARED FLUOROGEN AND FLUORESCENT ACTIVATING PROTEINS FOR IN VIVO IMAGING AND LIVE-CELL BIOSENSING  
Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins,...
US20140213615 Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof  
The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death...
US20130296230 METHOD FOR TREATING MALARIA, METHOD FOR KILLING MALARIA PARASITE, AND USE OF THE METHODS  
A method of the present invention for treating malaria includes the step of administering, to a human or an animal, a therapeutically effective amount of drug for suppressing calcium ion exit from...
US20120088782 LPA RECEPTOR ANTAGONIST  
A compound of the general formula (I): (wherein the symbols are as defined in the description), or a non-toxic salt thereof. This compound engages in LPA receptor bonding and antagonism and hence...
US20090259051 CARVEDILOL PHOSPHATE SESQUIHYDRATE  
The present invention relates a novel crystalline 1-(Carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy) ethyl]amino]-2-propanol phosphate sesquihydrate (Carvedilol dihydrogenphosphate sesquihydrate),...
US20130052205 FLT3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OR THE PREVENTION OF PAIN DISORDERS  
The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.
US20110028522 FULLERENE THERAPIES FOR INFLAMMATION  
Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified...
US20120142935 COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES  
This invention provides a method for preparing a 1,2,3-triazole compound comprising contacting an organic azide with a 2-substituted-1-haloalkyne, in the presence of a copper catalyst and a...
US20130295019 LIGANDS AND METHODS FOR LABELING BIOMOLECULES IN VIVO  
Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods for labeling and/or imaging a biomolecule of interest in a subject or living system.
US20110251196 Modulators of G Protein-Coupled Receptor 88  
The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled...
US20100317712 Estrogen Agonists/Antagonists For Preventing Breast Cancer  
Compounds of this formula are useful for preventing breast cancer.
US20140031231 FORMULATIONS OF CLOMAZONE  
New formulations of clomazone are provided, as well as new methods for making formulations of clomazone. The new formulations provide improved efficacy, decreased volatility, and/or increased...
US20110065766 METHODS OF USE OF ANTIVIRAL COMPOUNDS  
The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel...
US20110065762 METHODS OF USE OF ANTIVIRAL COMPOUNDS  
The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel...
US20110251216 COMPOSITIONS AND METHODS FOR INHIBITING EZH2  
The present invention relates to therapeutic targets for cancer. In particular, the present invention relates to small molecules and nucleic acids that target EZH2 expression in cancer (e.g.,...
US20140221450 Compositions for the treatment of Fragile X syndrome  
The present invention relates to a composition comprising a maxi-K potassium channel opener the use in the treatment of fragile X syndrome. More specifically the present invention relates to a...
US20140179751 Compounds and Compositions That Bind and Stabilize Transthyretin and Their Use for Inhibiting Transthyretin Amyloidosis and Protein-Protein Interactions  
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are...
US20120220610 INHIBITIONS OF GLUTAMINASE C  
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the...
US20120172498 BLACK PIGMENT DISPERSION  
Described is a pigment dispersion which is useful for electrophoretic displays comprising α) a bis-oxodihydro-indolylene-benzodifuranone colorant of the Formula (I) wherein the substituents are ...
US20140296292 METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR  
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include...
US20140163088 COMPOUNDS, COMPOSITION, METHODS, TARGETS FOR CANCER THERAPY  
This invention describes methods and pharmaceutical compositions for combinational cancer treatments that are capable of inducing JNK phosphorylation and induce programmed cell death. It also...
US20140057796 Method for the Diagnosis, Prognosis and Treatment of Breast Cancer Metastasis  
The present invention relates to a method for the diagnosis or the prognosis of metastasis in breast cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample....
US20120065152 PRODRUGS OF GUANFACINE  
Prodrugs of guanfacine, pharmaceutical compositions containing such prodrugs and a method for providing therapeutic benefit in the treatment of ADHD/ODD (attention deficient hyperactivity disorder...
US20120264765 Cyclohexane-1,3-Diones for Use in the Treatment of Amyotrophic Lateral Sclerosis  
The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral...
US20110130349 Compounds and Methods for Treating Toll-Like Receptor 2-Related Diseases and Conditions  
The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation.
US20110178258 Supported Ionic Liquids or Activating Supposrts  
The present invention relates to the covalent anchorage of non-coordinating anions on mineral supports to prepare supported ionic liquids and to their use as activating supports for the...
US20140336230 METHOD OF INCREASING METABOLISM  
The present invention provides a method for increasing metabolism and/or energy expenditure in a subject, e.g., to treat or prevent obesity and/or a related condition and/or the reduce adiposity,...
US20110077581 TARGETED CELLULAR DELIVERY OF NANOPARTICLES  
The various embodiments of the present disclosure relate generally to compositions and methods for the targeted cellular delivery of nanoparticles. More particularly, the various embodiments of the...
US20140243348 COMPOSITIONS AND METHODS FOR TREATING HERPES VIRUSES  
Compositions and methods that are useful for the treatment of herpesvirus infection (including herpes simplex virii) are disclosed. Methods for identifying compounds useful for the treatment of...