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US20130143880 POSITIVE ALLOSTERIC MODULATORS OF MGLUR2  
The present invention is directed to benzimidazolone derivatives which are positive allosteric modulators of the mGluR2 receptor, useful in the treatment or prevention of neurological and...
US20110028736 Zofenopril Calcium  
The present invention relates to zofenopril calcium form A substantially free of other forms of zofenopril calcium and to zofenopril calcium having a chemical purity of more than 98.5%. The...
US20100197760 DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION  
The present invention provides compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and more...
US20100179211 DISUBSTITUTED PHENYLPYRROLIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION  
The present invention relates to the use of compounds which increase extracellular levels of catecholamines, dopamine and norepinephrine, in cerebral cortical areas of the mammalian brain, and...
US20140309174 HEMIASTERLIN DERIVATIVES AND USES THEREOF IN THE TREATMENT OF CANCER  
The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1-R7,...
US20100305120 COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY  
Compounds of formula (I): wherein X, L1, R1, L2, R2, R3, and R4 are as defined herein, are useful in the treatment or prophylaxis of Duchenne muscular dystrophy, Becker muscular dystrophy, or...
US20100324044 METABOTROPIC GLUTAMATE RECEPTOR ISOXAZOLE LIGANDS AND THEIR USE AS POTENTIATORS  
Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and...
US20100317662 Metabotropic Glutamate Receptor Isoxazole Ligands and Their Use as Potentiators - 286  
Compounds in accord with Formula I: wherein R1, R2, R3 and R4 are as defined in the specification, pharmaceutically acceptable salts, methods of making, pharmaceutical compositions containing and...
US20100298392 Isoindoline Derivatives For The Treatment Of Arrhythmias  
There is provided compounds of formula I, wherein R1 to R7 have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and...
US20110060097 Dihalogen Indolocarbazole Monomers and Poly (Indolocarbazoles)  
Monomers and polymers based on dihalogen indolocarbazole and poly(indolocarbazoles), and methods of making such and using the same are described, as well as organic electronic devices...
US20150065711 Discrete PEG Constructs  
Disclosed are linear discrete PEG constructs, which can be created and produced in a precise and reproducible way. Key to being able to do these things, where x in the discrete PEGx can vary from...
US20130143916 COMPOUND LIBRARIES MADE THROUGH PHOSPHINE-CATALYZED ANNULATION/TEBBE/DIELS-ALDER REACTIONS  
A method for producing libraries of structurally and stereochemically diverse molecules that can be screened for biological or chemical activity. A library of 91 heterocyclic compounds composed of...
US20130129812 NOVEL COMPOSITIONS AND METHODS FOR TREATING CANCER  
Provided herein are methods and compositions inter alia for treating diseases, including hyperproliferative diseases, migraine headaches, and depression.
US20110014250 INHIBITORS OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE FOR STIMULATING PIGMENTATION OF THE SKIN OR SKIN APPENDAGES  
Inhibitors of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), for example tetrazole, styrylpyrazole, phenylfuran, phenylthiophene, phenylpyrrazole, pyrazolecarboxamide, 2-thioacetamide and azo...
US20090069569 CYCLOADDITION OF AZIDES AND ALKYNES  
This invention provides a process which comprises contacting, in a reaction zone, at least one organic azide, at least one alkyne, and at least one N-heterocyclic carbene copper compound in which...
US20110003955 Imide Oligomer And Polyimide Resin Obtained By Thermal Curing Thereof  
To provide an imide oligomer, excellent in thermal moldability, having excellent heat resistance as a thermally-cured polyimide resin, and that is obtainable easily and inexpensively. An imide...
US20130137740 COMBRETASTATIN ANALOGS FOR USE IN THE TREATMENT OF CANCER  
The present invention relates to specific analogs of combretastatin, in particular the compounds of formula (I) as described and defined herein, and pharmaceutical compositions comprising the...
US20130028872 COMPOSITION AND METHOD FOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS  
Described are methods for inducing differentiation of a human embryonic stem cell or a population of human embryonic stem cells toward a cell or population of cells characteristic of the...
US20100324008 PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING  
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are...
US20120252792 METHODS AND COMPOSITIONS FOR MODULATING RHO-MEDIATED GENE TRANSCRIPTION  
The invention provides methods, compositions, and kits for the inhibition of members of the Rho GTPase family. Specifically, the invention provides methods, compositions and kits for the...
US20140200257 PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY  
The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.
US20130345279 NOVEL POLYMORPHS OF AZABICYCLOHEXANE  
The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph...
US20120136038 Novel Polymorphs Of Azabicyclohexane  
The invention provides polymorphic crystalline forms of acid addition salts of (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph...
US20110243843 FLUORESCENT SILICA NANOPARTICLES FOR DETECTING LYMPH NODE AND THE IDENTIFICATION METHOD OF LYMPH NODE USING THEREOF  
The present invention relates to fluorescent silica nanoparticles for detecting lymph node and identification method of lymph node using thereof. The functionalized silica nanoparticles containing...
US20110091382 NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION  
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective...
US20110046378 Novel Imaging Agents for Detecting Neurological Dysfunction  
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective...
US20130005702 PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS  
The invention provides compounds of the formula (I) having protein kinase B inhibiting activity: Also provided are pharmaceutical compositions containing the compounds, methods for preparing the...
US20130116293 High-Throughput Methods for Determining Pharmacological Levels of Plasma D-Serine  
Described herein are high-throughput methods of monitoring D-serine levels in plasma. The assay involves the use of strong cation solid phase extraction (SPE) to isolate D-serine from plasma,...
US20150252035 ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION AND ITCH  
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof....
US20110288083 METHOD OF TREATING CANCER BY INHIBITION OF PROTEIN KINASE-LIKE ENDOPLASMIC RETICULUM PROTEIN KINASE  
The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first...
US20090233975 Hair resiliency/body improver and hair cosmetic  
A hair resiliency and body improver comprising as the active ingredient thereof one or more types of compounds selected from the group consisting of 2-aminothiazole derivatives represented by the...
US20100016610 FRICTIONLESS MOLECULAR ROTARY MOTORS  
A rotaxane consisting of a cucurbituril and an uncharged guest molecule, having low or null affinity therebetween is provided as well as processes for providing the same. Various uses as energy...
US20120035149 Prokineticin Receptor Antagonists And Uses Thereof  
Contemplated compounds, compositions, and methods of prokineticin antagonists are presented where a prokineticin antagonist is used in the treatment and prevention of various conditions and...
US20140221286 SODIUM CHANNEL BLOCKERS REDUCE GLUCAGON SECRETION  
It is discovered that sodium-channel blockers inhibit the secretion of glucagon from pancreatic alpha cells. The present disclosure, based on such discoveries, provides compositions and methods...
US20150210656 HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
US20140221666 HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
US20130023543 HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
US20130023542 HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
US20120077975 HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHOD OF USE  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
US20120077853 HUMAN PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE  
The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to...
US20140252327 AMINE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME  
Provided are an amine-based compound and an organic light-emitting diode including the same. The amine-based compound is represented by Formula 1 or Formula 2 below:
US20130189287 ENZYMATIC CONJUGATION OF POLYPEPTIDES  
The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies,...
US20110059937 IL-8 RECEPTOR ANTAGONISTS  
This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
US20150168415 COMPOUNDS AND METHODS FOR ANALYSIS AND SYNTHESIS OF SACCHARIDE COMPOUNDS  
Provided is an isotope-labelled compound having a general formula IIa′, S-Y′-BIM, wherein S is a sugar moiety, Y′ is an isotope-containing sensor moiety and BIM is a benzimidazole. The compound...
US20070232648 MODULATORS OF THE GLUCOCORTICOID RECEPTOR AND METHOD  
Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such...
US20100324301 SULFENAMIDE, VULCANIZATION ACCELERATOR CONTAINING THE SULFENAMIDE FOR RUBBER, AND PROCESS FOR PRODUCING THE VULCANIZATION ACCELERATOR  
A sulfenamide vulcanization accelerator is provided that acts satisfactorily slowly on a vulcanization reaction, produces no carcinogenic nitrosamine, and is free from environmental hygiene...
US20140308666 DEVELOPMENT OF NOVEL DETERGENTS FOR USE IN PCR SYSTEMS  
This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for...
US20120322066 Development of Novel Detergents for Use in PCR Systems  
This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for...
US20110155996 BISTABLE CARBAZOLE COMPOUNDS  
Bistable carbazole compounds of formula (I) are described, wherein M is Fe, Co, Ru or Os, preferably Fe, useful as basic functional units for computing systems based on the QCA (Quantum Cellular...
US20150197543 Treatment of Autism Spectrum Disorders Using Glycyl-L-2-Methylprolyl-L-Glutamic Acid  
This invention provides compounds, compositions and methods for treating Autism Spectrum Disorders (ASD) using glycyl-2-methylprolyl-glutamic acid (G-2-MePE) and analogs thereof. Autism Spectrum...