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US20140186263 MALEIMIDE-FUNCTIONALIZED GOLD NANOPARTICLES  
A maleimide-functionalized gold nanoparticle is described herein. More specifically, a maleimide-functionalized gold nanoparticle of formula (I): is described, wherein “n” and “m” are integers...
US20100304966 Fungicidal Compounds, Method For the Production Thereof, And Use Thereof To Combat Damaging Fungi, And Agents Comprising The Same  
Compounds of the formula I in which the substituents have the meaning given in the description, processes for preparing these compounds, compositions comprising them and their use for controlling...
US20080132710 ATRASENTAN HYDROCHLORIDE CRYSTALLINE FORM 2  
Atrasentan Hydrochloride Crystalline Form 2, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
US20130274283 PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS  
Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
US20130317047 PHARMACEUTICAL FORMULATIONS AND USE THEREOF IN THE PREVENTION OF STROKE, DIABETES AND/OR CONGESTIVE HEART FAILURE  
The present invention relates to use of an inhibitor of the renin-anglotensin system (RAS) or a pharmaceutically acceptable derivative thereof, such as ramipril or ramiprilat, in the prevention of...
US20130059860 NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS  
The present invention is directed to naphthalene carboxamide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which...
US20140073785 Methods for Forming Protected Organoboronic Acids  
Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks...
US20110201806 Methods for Forming Protected Organoboronic Acids  
Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of building blocks, such as building blocks...
US20090068105 ISATIN ANALOGUES AND USES THEREFOR  
Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues,...
US20140127138 PH-SENSITIVE IMAGING AGENTS  
Composition and method for surface-functionalized SPION-based agents. Such agents can provide highly pH-sensitive MRI contrast in tissue.
US20130338154 MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20130079366 Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction  
Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods...
US20130040944 MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds;...
US20150065498 N-LINKED LACTAM M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS  
The present invention is directed to N-linked lactam compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which...
US20150190351 Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof  
The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful...
US20130338160 Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof  
The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful...
US20130261121 Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof  
The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful...
US20100063127 Antioxidant Properties of Tryptophan from Human Milk  
As tryptophan is not available in sufficient amounts in infant formula or other replacement milks, we describe herein the supplementation of these milks to attain a Trp concentration similar to...
US20140314850 FUNCTIONALIZED NANODIAMONDS AS DELIVERY PLATFORMS FOR NUCLEIC ACIDS  
The present application relates to functionalized nanodiamonds, to complexes comprising a functionalized nanodiamond reversibly bound to a nucleic acid and to compositions comprising such...
US20110263664 Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer  
The disclosure relates to inhibitors of Pim-1 and/or Pim-2 protein kinase, to compositions comprising one or more inhibitors of Pim-1 and/or Pim-2 protein kinase, and to methods for treating cancer.
US20140323540 USE OF A DITHIINO-TETRACARBOXAMIDE FOR THE PROTECTION OF HARVESTED PRODUCTS AGAINST PHYTOPATHOGENIC FUNGI  
The present invention relates to methods for the protection of harvested fruits, cutflowers or vegetables against decay caused by certain storage diseases or disorders expressed in storage...
US20130245018 Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use  
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively...
US20110306611 Transcription factor modulating compounds and methods of use thereof  
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole...
US20110230523 TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF  
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole...
US20130203830 Compounds for Prevention of Cell Injury  
The invention is related to compounds for prevention of cell injury or protection of cells. The compounds are involved in the maintenance or the increase of hydrogen sulphide in cells, which...
US20150182518 CANCER CELL INHIBITORY DRUG AND CANCER STEM-CELL DETECTION PROBE  
An object of the present invention is to provide a cancer cell inhibitory drug, particularly a cancer stem-cell inhibitory drug, or a cancer stem-cell detection probe. The present invention...
US20140364433 SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS  
The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a...
US20140364432 SUBSTITUTED PROLINES / PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS  
The present invention is directed to compounds that modulate the bioactivity of an orexin receptor such as OX1 or OX2, or both; to pharmaceutical compositions and combinations comprising a...
US20060093854 Organometallic complex, light-emitting solid, organic electroluminescent element and organic electroluminescent display  
The object of the present invention is to provide an organic EL element, and the like utilizing the aforementioned organometallic complex that shows phosphorescence light emission and that has...
US20110223666 CYTOPLASM EXPOSURE ADDITIVE AND METHOD FOR EXPOSING PARTICLES DELIVERED INTO CELL TO CYTOPLASM FROM ENDOCYTIC VESICLES IN INTACT CELL  
The present invention relates to a method of exposing particles to cytoplasm comprising introducing particles into a live cell; allowing the live cell to contact a cytoplasm exposure additive...
US20120282338 Extended Release Formulation  
The invention is directed to an extended release formulation comprising pramipexole or a pharmaceutically acceptable salt thereof.
US20110195122 Extended Release Formulation  
The invention is directed to an extended release formulation comprising pramipexole or a pharmaceutically acceptable salt thereof.
US20140199239 Compositions and Methods for in Vivo Imaging  
The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.
US20130158002 POSITIVE ALLOSTERIC MODULATORS OF MGLUR2  
The present invention is directed to 5-substituted 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide and 1,3-dihydro[1,2,5]thiadiazolo[3,4-b]pyridine 2,2,-dioxide derivatives which are potentiators...
US20140308317 Polymeric Compounds And Methods Of Making And Using The Same  
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis,...
US20130065932 PROCESS FOR THE ISOLATION OF ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER  
The present invention relates to two main components, mahanine and mahanimbine (dehydroxy-mahanine) from Murraya koenigii for the treatment of glioblastoma and cervical carcinoma. Mahanimbine...
US20130247989 INERT SOLUTION-PROCESSABLE MOLECULAR CHROMOPHORES FOR ORGANIC ELECTRONIC DEVICES  
Small organic molecule chromophores containing a benzo[c][1,2,5]thiadiazole with an electron-withdrawing substituent W in the 5-position (5BTH), benzo[c][1,2,5]oxadiazole with an...
US20130331566 Phosphine-Ligated Palladium Sulfonate Palladacycles  
Described are palladium precatalysts, and methods of making and using them. The palladium precatalysts show improved stability and improved reactivity in comparison to previously-described...
US20120157641 CURE ACCELERATORS FOR ANAEROBIC CURABLE COMPOSITIONS  
The present invention relates to cure accelerators useful for anaerobic curable compositions, such as adhesives and sealants.
US20120270839 COMPOSITIONS AND METHODS FOR CANCER TREATMENT  
Bromoacetoxycalcidiol (B3CD), which is structurally related to calcidiol, exhibits cytotoxic and apoptotic activity toward cancer cells, including highly aggressive neuroblastoma cells. A series...
US20130190505 Hydrothiolation of Unactivated Alkenes  
The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.
US20110111068 Inhibitors of cognitive decline  
Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or...
US20120289535 DUAL PHASE DRUG RELEASE SYSTEM  
The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure: wherein each occurrence of M is independently a modifier...
US20120004255 DUAL PHASE DRUG RELEASE SYSTEM  
The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure: wherein each occurrence of M is independently a modifier...
US20110053878 ACID-SENSITIVE LINKERS FOR DRUG DELIVERY  
The invention is in general directed to acid-sensitive linkers, and methods of use thereof, such as, for example, in drug delivery methods.
US20140350227 MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME  
The present invention relates to a novel coumarin derivative, to a method for preparing the same, and a multi-fluorescent substance that includes a plurality of the coumarin derivatives and is...
US20130096301 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME  
The present invention is directed to novel synthetic methods for preparing a spiro cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable...
US20150203664 ADDITION-CROSSLINKING SILICONE COMPOSITION WITH LOW COMPRESSION SET  
Polyorganosiloxane compositions which are crosslinkable by means of hydrosilylation have improved compression set due to the incorporation of 3-amino-1,2,4-triazole-5-thiol bonded to silica.
US20140252324 COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME  
Provided is an organic light-emitting diode including a compound of Formula 1 below: wherein a detailed description of a substituent in Formula 1 above is defined as described in the detailed...
US20140225070 COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME  
Provided is an organic light-emitting diode including a compound of Formula 1 below: A detailed description of a substituent in Formula 1 above is defined as described in the detailed description.