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US20120071670 METHOD FOR PRODUCING OF ULTRA-CLEAN AND HIGH-PURITY N-METHYL PYRROLIDONE  
The present invention provides a method for producing of ultra-clean and high-purity N-methyl pyrrolidone through using industrial grade N-methyl pyrrolidone as raw material. After the...
US20140121246 GPR120 RECEPTOR AGONISTS AND USES THEREOF  
GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
US20130131351 GPR120 RECEPTOR AGONISTS AND USES THEREOF  
GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
US20130109734 GPR120 RECEPTOR AGONISTS AND USES THEREOF  
GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
US20110313003 GPR120 RECEPTOR AGONISTS AND USES THEREOF  
GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
US20150090963 ORGANIC COMPOUNDS AND ORGANIC LIGHT-EMITTING DEVICES INCLUDING THE SAME  
An organic compound represented by Formula 1 is disclosed. An organic light-emitting device including the organic compound is also disclosed.
US20140179753 COMPOUNDS FROM ANTRODIA CINNAMOMEA AND USE THEREOF  
The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or...
US20130225649 COMPOUNDS FROM ANTRODIA CINNAMOMEA AND USE THEREOF  
The present invention relates to compounds from Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) or...
US20150191491 PREPARATION METHOD OF ZEOLITIC IMIDAZOLATE FRAMEWORK-90 IN WATER-BASED SYSTEM  
The present invention provides a preparation method of Zeolitic Imidazolate Framework-90 (ZIF-90) in water-based system, which uses pure water as a solvent, and the reaction is carried out at room...
US20150158879 Novel indazoles for the treatment and prophylaxis of respiratory syncytial virus infection  
The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R7, A1, A2 and A3 are as described herein, compositions including the compounds and methods of using...
US20130289284 RENEWABLE MODIFIED NATURAL COMPOUNDS  
Provided are modified natural compounds that are produced, at least in part, from (A) at least one epoxidized and/or maleated natural fatty acid, or epoxidized and/or maleated natural oil, and (B)...
US20110245308 SUBSTITUTED BENZYL AND PHENYLSULFONYL TRIAZOLONES, AND USE THEREOF  
The present application relates to new, substituted benzyl-1,2,4-triazolones and phenylsulfonyl-1,2,4-triazolones, to processes for preparing them, to their use alone or in combinations for the...
US20130023571 N- ( 4-PERFLUOROALKYL-PHENYL) -4-TRIAZOLYL-BENZAMIDES AS INSECTICIDES  
The present invention relates to novel triazole-substituted benzamide derivatives, to processes and intermediates for preparing them, to methods of using them to control insect, acarine, nematode...
US20130244267 COMPOSITIONS AND METHODS FOR QUADRICYCLANE MODIFICATION OF BIOMOLECULES  
The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low...
US20150133510 TERTIARY AMINES FOR USE IN THE TREATMENT OF CARDIAC DISORDERS  
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate...
US20110311582 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS  
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention formula (I) provides...
US20110319287 MODULATOR ASSAY  
The present invention relates inter alia to methods for identifying modulators of tumour necrosis factor (TNF) signalling. In one aspect, the method involves identifying an agent that modulates a...
US20110077272 PULMONARY FORMULATIONS OF TRIPTANS  
A pharmaceutical composition includes triptans, such as sumatriptan, and may be used in therapy. The composition may be administered via the inhaled route.
US20120316193 PROTEOSTASIS REGULATORS  
The present invention is directed to compounds having the Formulae (Ia-Ie), (II), (IIIa-IIId), (IVa-IVc), (Va-Vb), (VIa-VIe), (VII), (VIIIa-VIIIc), and (IX), pharmaceutically acceptable salts,...
US20130090479 THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES  
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of...
US20120015998 PHOTOTHERAPY METHODS AND DEVICES COMPRISING EMISSIVE ARYL-HETEROARYL COMPOUNDS  
Disclosed herein are compounds represented by a formula: R1—Ar1—X—Ar2—Ar3-Het, wherein R1, Ar1, X, Ar2, Ar3, and Het are described herein. Compositions and light-emitting devices related thereto...
US20140142117 REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF  
The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various...
US20130281455 Phenylpyri(mi)dinylazoles  
Phenylpyri(mi)dinylazoles of the formula [I-a] and [I-b], wherein the symbols have the meanings stated in the description, and agrochemically active salts thereof and the use thereof for the...
US20110118211 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME  
Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure wherein is a heteroaryl ring; R4 is...
US20130217888 PROCESS FOR PREPARING BENDAMUS TINE HYDROCHLORIDE MONOHYDRATE  
The present invention provide processes for the preparation of Bendamustine hydrochloride monohydrate of formula (I) The present application also provides a process of purification of Bendamustine...
US20120172408 ACTIVE INGREDIENT COMPRISING INDOCYANINE GREEN AND/OR INFRACYANINE GREEN  
The present invention relates to an active ingredient including indocyanine green and/or infracyanine green for use in treating dental or periodontal infectious diseases under irradiation with...
US20130023539 PYRROLIDINE OR THIAZOLIDINE CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS AS AGONISTS OF G-PROTEIN COUPLED RECEPTOR 43 (GPR43)  
The present invention is directed to novel compounds of formula (I) and their use in treating and/or preventing metabolic diseases.
US20100324071 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME  
Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure where Q is and R1, R2, R3,...
US20150259334 BENZISOXAZOLES  
The present invention relates to compounds of general formula whereinAr1/Ar2 are phenyl or a 5 or 6-membered heteroaryl;R1/R2 is hydrogen, halogen, lower alkyl, CF3 or lower alkoxy; n,m are 1 or...
US20130261311 BIOTIN STANNANE FOR HPLC-FREE RADIOIODINATION  
The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include...
US20070299064 Pesticidal Heterocyclic Dihaloallyl Compounds  
The invention relates to compounds of formula wherein Het, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R2, R3, R4, k and m are as defined hereinabove, and, where applicable, to possible E/Z...
US20140256782 Opsin-Binding Ligands, Compositions and Methods of Use  
Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult...
US20150030540 Imaging agents for detecting neurological dysfunction  
Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective...
US20130072471 Inhibitors of Ion Channels  
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly,...
US20150239838 Compounds for Treatment of Complement Mediated Disorders  
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof are provided. The...
US20080249316 CRYSTALLINE FORMS OF [3-(4- -PHENOXY)-PROPYL]-DIETHYL-AMINE  
The present invention relates to crystalline forms of [3-(4-{2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1H-imidazol-4 -yl}-phenoxy)-propyl]-diethylamine (“COMPOUND I”) useful in the treatment of RAGE...
US20080178763 Poly(oxyalkylene)ated Colorants and Their Use as Fluorescent Security Taggants  
Certain poly(oxyalkylene) colorants are disclosed along with method of preparation thereof. A method of using these colorants as fluorescent security taggants is also disclosed.
US20110054180 Magnetic Nanoparticle-Supported Glutathione as a Sustainable Organocatalyst  
This invention relates to the use of nano-organocatalysts, and, more specifically, to the use of magnetic nanomaterial-supported organocatalysts. It is an object of the present invention to...
US20150025042 Compounds For Treating Proliferative Disorders  
Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variables are as defined in the claims, and methods of using compounds of the invention...
US20150048332 AMINE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME  
An amine-based compound is represented by Formula 1 below: wherein Z11 to Z24, R1 to R4 and Ar1 are as indicated in the specification. An organic light-emitting diode includes the amine-based...
US20140294851 CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE  
Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.
US20130012502 Pharmaceutical or Veterinary Antiviral Compositions  
Pharmaceutical or veterinary compositions to prevent or treat viral infections, in particular to prevent or treat influenza A, B and C virus infections.
US20140255696 Biotin-Decorated Fluorescent Silica Nanoparticles With Aggregation-Induced Emission for Tumor Cell Targeting and Long-Term Tumor Cell Tracking  
Fluorescent silica nanoparticles with aggregation induced emission characteristics as well as methods for attaching biotin thereto for tumor cell targeting and long-term cell tracking....
US20100297556 Coating compositions suitable for use with an overcoated photoresist  
Organic coating compositions, particularly antireflective coating compositions, are provided that comprise that comprise a diene/dienophile reaction product. Preferred compositions of the...
US20120178774 TOLL-LIKE RECEPTOR MODULATORS AND USES THEREOF  
The present invention provides a compound selected from the group consisting of: where n, m, X1, X2, X3, X4, R1, R2, R3, R11, R12, Y1, Y2, Y3, Y4, and Y5 are those defined herein. Some aspects of...
US20150158852 INDUSTRIAL METHOD FOR THE PREPARATON OF HIGH-PURITY METHIOZOLIN  
Provided is an industrial method for the preparation of [5-{(2,6-difluorobenzyloxy)methyl}-4,5-dihydro-5-methyl-3-(3 -methylthiophene-2-yl)-isoxazole](common name: methiozolin) represented by...
US20090075985 ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE  
Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the...
US20130095502 REAGENTS AND METHODS FOR PHOSPHORYLATION/DEPHOSPHORYLATION ANALYSES  
Disclosed herein are reagents that include a moiety that includes a metal such as titanium and that readily binds to phosphorylated molecules the reagents also include at least one moiety that...
US20150152064 METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION  
Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods...
US20120148534 METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION  
Briefly described, embodiments of this disclosure include compounds, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods...