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US20140301975 Methods for Treating Blood Disorders  
Methods of treating blood disorders are described.
US20150038466 PAIN RELIEF COMPOUNDS  
The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.
US20150057248 BIVALENT AMPA RECEPTOR POSITIVE ALLOSTERIC MODULATORS  
Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.
US20110281927 DEUTERIUM-ENRICHED DORIPENEM  
The present application describes deuterium-enriched doripenem, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20110160270 DEUTERIUM-ENRICHED SDX-101  
The present application describes deuterium-enriched SDX-101, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20110144174 DEUTERIUM-ENRICHED ODANSETRON  
The present application describes deuterium-enriched ondansetron, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20110124704 DEUTERIUM-ENRICHED ATORVASTATIN  
The present application describes deuterium-enriched atorvastatin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20110201709 ISOCYANATE TRIMERISATION CATALYST SYSTEM, A PRECURSOR FORMULATION, A PROCESS FOR TRIMERISING ISOCYANATES, RIGID POLYISOCYANURATE/POLYURETHANE FOAMS MADE THEREFROM, AND A PROCESS FOR MAKING SUCH FOAMS  
The instant invention provides an isocyanate trimerisation catalyst system, a precursor formulation, a process for trimerising isocyanates, rigid foams made therefrom, and a process for making...
US20090143596 Supramolecular Assemblies and Building Blocks  
The present invention generally relates to supramolecular assemblies and their modes of synthesis. The supramolecular assemblies include a 1:8 ratio of a supermolecular polyhedral building block...
US20110207228 ISOBARIC TAGS FOR ANALYTE DETECTION AND QUANTIFICATION  
Isobaric reagents for labeling analytes are provided. The isobaric reagents have facile design and synthesis that allows for differential labeling of an unlimited number of analyte samples.
US20110034521 COMPOUNDS AND METHODS FOR TREATING ZINC MATRIX METALLOPROTEASE DEPENDENT DISEASES  
The present invention provides compounds and methods for treating zinc matrix metalloprotease dependent diseases. In certain embodiments, the compounds of the present invention have the following...
US20130280151 IONIC LIQUID-FUNCTIONALIZED MESOPOROUS SORBENTS AND THEIR USE IN THE CAPTURE OF POLLUTING GASES  
A composite structure for capturing a gaseous electrophilic species, the composite structure comprising mesoporous refractory sorbent particles on which an ionic liquid is covalently attached,...
US20150065504 ANTIVIRAL COMPOUNDS  
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein...
US20150005510 METHOD FOR CONVERSION OF DIAMMONIUM SUCCINATE IN FERMENTATION BROTH TO 2-PYRROLIDONE AND N-METHYLPYRROLIDONE  
This invention relates to a process for preparing 2-pyrrolidone (also called 2-pyrrolidinone) and N-methylpyrrolidone (also called N-methylpyrrolidinone) from diammonium succinate in fermentation...
US20110077327 Puncture Repair Material Recovery System  
A gelling agent, and a method of use for the same, for gelling a puncture repair material, the puncture repair material including a natural rubber latex, a resin emulsion, and an antifreezing...
US20050288351 Azaspiro compounds for the treatment of pain  
This invention relates to azaspiro compounds and their use as medications especially for the treatment of chronic, chronic-phlogistic and/or neuropathic pain. A compound that lends itself...
US20090093472 ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION  
Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also...
US20120184535 COMPOUND, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, A METHOD FOR MODULATING OR REGULATING SERINE/THREONINE KINASES AND A SERINE/THREONINE KINASES MODULATING AGENT  
A compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine and tyrosine kinases and a serine/threonine and...
US20130217137 SYSTEMS AND METHODS FOR PROTEIN MELT ANALYSIS USING DIPYRROMETHENEBORON DIFLUORIDE COMPOUNDS  
According to the present teachings, systems and methods for protein melt analysis are provided that utilizing a dye. In some embodiments, a method comprises preparing a sample by mixing at least...
US20130109686 ISOINDOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS  
The present invention is directed to isoindolone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1...
US20140031403 Solid Forms of Curcumin  
The present invention provides forms of curcumin and the pharmaceutical compositions thereof. The forms of curcumin disclosed herein are curcumin polymorph Form III, curcumin-2-aminobenzimidazole...
US20110120344 SURFACE ACTIVE BLOCKED ISOCYANATES AND COATING COMPOSITIONS THEREOF  
Disclosed herein is a surface active adhesion promoting agent and a coating composition comprising the surface active adhesion promoting agent. The adhesion promoting agent is a blocked isocyanate...
US20130005782 METHOD FOR INTEGRIN LIGAND DISCOVERY  
This invention relates generally to integrin ligand discovery and to a method of integrin ligand discovery base upon induction of ligand-induced epitopes. Such ligands have the potential to be...
US20100069355 Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection  
Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane,...
US20140080787 Method for the Treatment of Neuropathies Associated with Charcot-Marie-Tooth 1A (CMT1A) Disease  
The present invention relates to compositions and methods for the treatment, prevention, and diagnosis of neuropathies due to PMP22 mis-expression in a subject having Charcot-Marie-Tooth disease,...
US20150158849 Solid Salt Forms Of A Pyrrole Substituted 2-indolinone  
The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic...
US20120142749 SOLID SALT FORMS OF A PYRROLE SUBSTITUTED 2-INDOLINONE  
The present invention relates to solid salt forms of the 3-pyrrole substituted 2-indolinone compound 5-[5-fluoro-2-oxo-1, 2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole- 3-carboxylic...
US20110046128 NOVEL COMPOUNDS ADVANTAGEOUS IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS  
A series of novel compounds showing anticonvulsant, chemical countermeasure(s), and analgesic activities is described. Such pharmaceutically active compounds may also show utility in the treatment...
US20140336393 PROCESS FOR PREPARING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR  
The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phe nyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carb...
US20110124869 Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator  
The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phe nyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carb...
US20110106241 COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE  
Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.
US20120302541 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
US20110263519 REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO  
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to...
US20130035315 CRYSTALLIZATION METHOD AND BIOAVAILABILITY  
Preparation and in vitro and in vivo characterization of novel forms of active pharmaceutical ingredients, suitable for pharmaceutical compositions in drug delivery systems for humans.
US20100331552 ACID SALT OF TOLTERODINE HAVING EFFECTIVE STABILITY FOR TRANSDERMAL DRUG DELIVERY SYSTEM  
The present invention relates to an acid salt of tolterodine with superior stabililty and useful as a transdermal drug delivery system. More specifically, the present invention relates to a novel...
US20080219931 Amyloid Imaging as a Surrogate Marker for Efficacy of Anti-Amyloid Therapies  
The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to a patient in need thereof a compound of formula (I) or Formula (II) or...
US20070093539 N-hydroxy-4-(3-pheyl-5-methyl-isoxazole-4-yl)-benzenesulfonate solvates  
The invention relates to new N-hydroxy-4-(3-phenyl-5-methyl-isoxazole-4-yl)-benzenesulfon amide solvates of formula (I). wherein n represents 0 or 1 mol, [solvate] represents water, C1-C4 alcohol,...
US20110092554 1,3,5 TRI-SUBTITUTED BENZENES FOR TREATMENT OF ALZHEIMER'S DISEASE AND OTHER DISORDERS  
The present disclosure relates to novel 1,3,5 tri-substituted benzenes of general formula (I), (II) or (III) and the use of such compounds in the treatment of diseases associated with the...
US20120252853 Positive allosteric modulators of nicotinic acetylcholine receptor  
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The...
US20120083440 METHODS AND COMPOUNDS FOR THE TARGETED DELIVERY OF AGENTS TO BONE FOR INTERACTION THEREWITH  
Bone targeted compounds and methods are provided. Compounds can include a Bone Targeting Portion (RT), having an affinity for bone; a Bone Active Portion (RA) for interacting with and affecting...
US20110256561 LIVER DISEASE MARKER, METHOD AND APPARATUS FOR MEASURING THE SAME, AND METHOD FOR ASSAYING PHARMACEUTICAL PREPARATION  
A normal person (i.e. a control) and liver diseases such as drug induced liver injury, an asymptomatic hepatitis B carrier, an asymptomatic hepatitis C carrier, chronic hepatitis B, chronic...
US20140041062 GENETICALLY ENGINEERED MOUSE MODEL FOR AUTISM SPECTRUM DISORDER HAVING DELETION OF SHANK2 GENE AND USE THEREOF  
The present disclosure relates to an ASD genetically engineered model carrying a deletion of Shank2 gene and having reduced NMDA receptor function. According to the present disclosure, genetically...
US20110104162 Compounds which can be used for the Treatment of Cancers  
The present invention relates to a compound of general formula (I): and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in...
US20150259324 HEPATITIS B ANTIVIRAL AGENTS  
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically...
US20150152073 Hepatitis B Antiviral Agents  
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically...
US20140179665 HEPATITIS B ANTIVIRAL AGENTS  
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically...
US20130251673 HEPATITIS B ANTIVIRAL AGENTS  
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically...
US20150241440 METHODS AND COMPOSITIONS FOR SITE-SPECIFIC LABELING OF PEPTIDES AND PROTEINS  
Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide...
US20120168734 COMPOUND CONTAINING 5-MEMBERED HETEROCYCLES, ORGANIC LIGHT-EMITTING DEVICE USING SAME, AND TERMINAL COMPRISING THE LATTER  
Disclosed are a compound including 5-membered heterocycles, an organic electronic device using the same, and a terminal including the latter.
US20050208125 Substantially pure solid form of the enol tautomer of 3-indolypyruvic acid for use in the treatmetn of central nervous system disturbances  
The enol tautomer of 3-indolylpyruvic acid in stable and pure form, as well as alkali and alkali-earth salts thereof are produced by synthesis process. The enol tautomer comprises only the...