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US20110288111 INHIBITION OF INFLUENZA M2 PROTON CHANNEL  
Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza...
US20130266512 Tetrazine-trans-cyclooctene Ligation for the Rapid Construction of Radionuclide Labeled Probes  
A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ...
US20120280187 FINE METAL PARTICLE-CONTAINING COMPOSITION  
A fine silver particle-containing composition includes a large number of fine silver particles 2 and a coating layer 4 that covers a surface of each silver particle 2. The silver particle 2 is a...
US20100226969 COMPOUNDS FOR INHIBITING PROTEIN AGGREGATION, AND METHODS FOR MAKING AND USING THEM  
The invention provides compositions comprising protein aggregation inhibitors, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for...
US20050282851 Substituted (thiazol-2-yl)-amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes  
Compounds of the formula R—NH—Q (I) provide pharmacological agents which are glucokinase activators and thus may be employed for the treatment of glucokinase mediated conditions. Accordingly, the...
US20120225879 SUBSTITUTED 5-IMINO-1,2,4-THIADIAZOLES THAT CAN BE USED TO TREAT NEURODEGENERATIVE DISEASES  
The present invention is based on the use of a broad family of 5-imino-1,2,4-thiadiazoles as potential new drugs for the treatment of diseases in which PDE7 inhibition is important, specially...
US20140256768 HETEROCYCLIC MOLECULES AS APOPTOSIS INDUCERS  
The present document describes novel compounds which may inhibit the activity of anti-apoptotic proteins such as Bcl-2 family protein members, compositions containing the compounds and methods of...
US20140343260 PET/SPECT AGENTS FOR APPLICATIONS IN BIOMEDICAL IMAGING  
Tracers that can be used for PET or SPECT imaging of the distribution of Pgp are disclosed. The tracers are metalloprobes that can comprise a radioactive metal ion such as 67Ga or 68Ga. Methods of...
US20150024321 NOVEL COMPOUND HAVING AZO SKELETON AND PIGMENT DISPERSANT, PIGMENT COMPOSITION, PIGMENT DISPERSION, AND TONER CONTAINING THE COMPOUND  
To provide an azo compound which improves the dispersibility of an azo pigment in a non-water soluble solvent. The purpose is achieved by an azo compound having a specific structure in which a...
US20140323739 COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT  
The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with...
US20140012011 COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT  
The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with...
US20140235872 NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY  
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with...
US20130178541 NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY  
The instant invention provides for novel catiomc lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with...
US20140228580 METHOD FOR PURIFYING A CRUDE PNPNH COMPOUND  
The present invention relates to a method for purifying a crude PNPNH compound by metalation and re-protonation.
US20110112088 PYRAZOLES FOR THE TREATMENT OF OBESITY AND OTHER CNS DISORDERS  
This invention relates to compounds of the formula: to compositions containing these compounds, and to methods of treatment employing the compounds and compositions.
US20140005244 FAMILY OF POLYAMINE ARYLETHYLAMIDE COMPOUNDS, AND THEIR COSMETIC OR DERMOCOSMETIC USE  
The invention relates to a family of stable polyamine arylethylamide compounds, and to the use of these compounds as agents inhibiting DNA damages induced by by-products of the non-enzymatic...
US20120045390 Composition and Methods for the Diagnosis and Treatment of Tumor  
The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
US20130302248 Imaging Agents for Detecting Neurological Disorders  
Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and...
US20110182812 Imaging Agents for Detecting Neurological Disorders  
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins...
US20140221332 METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF  
Compounds that modulate GluR5 activity and methods of using the same are disclosed.
US20120302555 METHOD OF TREATMENT USING EPROSARTAN  
The disclosed invention relates to a method of treatment of a disorder modulated by blocking angiotensin II (AII) receptors, and particularly selected from the group consisting of hypertension,...
US20100331379 BENZAMIDE GLUCOKINASE ACTIVATORS  
The present invention relates to N-heteroaryl-benzamides, pharmaceutical compositions comprising the same, and methods of using the same. The N-heteroaryl-benzamides are useful in diseases or...
US20110085952 SCRUBBER FOR REMOVING HEAVY METALS FROM GASES  
A wet scrubber for absorbing a heavy metal from a gas stream, a liquor for said wet scrubber, and a power-plant comprising said wet scrubber are described. The wet scrubber has a liquor containing...
US20120027796 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS  
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having...
US20150017718 METHOD FOR INDUCING CARDIAC DIFFERENTIATION OF PLURIPOTENT STEM CELL  
The present invention relates to a method for inducing cardiac differentiation of a pluripotent stem cell, which comprises the steps of (1) culturing a pluripotent stem cell in a medium containing...
US20140274689 N-,C-DISUBSTITUTED AZOLES AND COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS  
Provided herein are new N-,C-disubstituted azoles and derivatives thereof that exhibit nematicidal activity and are useful, for example, in methods for the control of unwanted nematodes.
US20140017722 HEMATOPOIETIC STEM CELL IDENTIFICATION PROBE  
The present invention provides a hematopoietic stem cell identification probe. A hematopoietic stem cell analysis probe containing, as an active ingredient, one or more compounds represented by...
US20150139915 METHODS TO DECREASE SUSCEPTIBILITY TO ASTHMATIC BRONCHOCONSTRICTION  
Methods and compositions are described for reducing airway reactivity and the susceptibility to asthmatic bronchoconstriction that involve increasing sphingolipid content in airways and lungs of a...
US20110015201 HEDGEHOG PATHWAY ANTAGONISTS AND METHODS OF USE  
The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders...
US20110190492 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE  
The invention provides a probe compound useful for early diagnosis of conformation disease, a composition and a kit comprising it for diagnosis for conformation disease, and a medical composition...
US20110301156 Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof to Treat Pain and Other Conditions  
Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds...
US20100310655 Crystal modification A of 1-(2,6-difluorobenzyl)-1 H-1,2,3-triazole-4-carboxamide and dosage forms and formulations thereof  
The invention relates to dosage forms and formulations comprising the novel crystal modification A of the compound I-(2, 6-difluorobenzyl)-I H-I,2,3-triazole-4-carboxamide, wherein crystal...
US20150203875 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1.4-BUTANEDIOL RELATED THERETO  
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol....
US20140058056 MICROORGANISMS AND METHODS FOR ENHANCING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL, AND FOR PRODUCING 1,4-BUTANEDIOL RELATED THERETO  
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol. Such...
US20130053385 METHOD OF COMBATING AND CONTROLLING PESTS  
The use of a compound of formula I wherein the substituents are as defined in claim 1, or compositions containing them in controlling insects, acarines, nematodes or molluscs.
US20110018866 STRUCTURE OF THE FARNESOID X RECEPTOR LIGAND BINDING DOMAIN AND METHODS OF USE THEREFOR  
The present invention provides compositions comprising the ligand binding domain (LBD) of a farnesoid X receptor (FXR) in crystalline form. In alternative embodiments, the LBD of FXR is complexed...
US20130178505 Compounds for the Inhibition of Cellular Proliferation  
Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders,...
US20120034186 INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER  
Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of...
US20080009620 Tricyclic Spacer Systems For Nonlinear Optical Devices  
A compound for spacing nonlinear optical chromophores of the Formula I and the commercially acceptable salts, solvates and hydrates thereof, wherein R1, R2, R3, R4, W, X, Y, Z, Q1, Q2, Q4 and L...
US20110152455 MONOMERS FOR MAKING POLYMERIC CELL CULTURE SURFACE  
N-hydroxysuccinimide acrylate ester monomers are described which provide N-hydroxysuccinimide derivatized monomers for the formation of polymeric cell culture surfaces suitable for culture of...
US20110269764 THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF SYNAPSE FUNCTION  
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that...
US20090030057 Pharmaceutical composition of telmisartan  
The present invention provides a pharmaceutical composition of telmisartan comprising a) a telmisartan compound, b) a surfactant, c) a basic agent, and d) at least one diluent wherein the...
US20140083323 OXIDIZING AGENTS ON PIGMENTS  
Hydrophilic self-cleaning coating compositions and methods to make and use the compositions are disclosed. The compositions include a pigment material made up of an inorganic pigment attached or...
US20130267574 Polymorphic Forms of Asenapine Maleate and Processes for their Preparation  
Are disclosed new crystalline forms of asenapine maleate, useful in the production of pharmaceutical formulations for the treatment of diseases of the central nervous system, in particular...
US20130225836 NOVEL LOW MOLECULAR WEIGHT CYCLIC AMINE CONTAINING CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY  
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with...
US20150023916 ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the...
US20140243367 ANTIVIRAL DRUGS FOR TREATMENT OF ARENAVIRUS INFECTION  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the...
US20110064693 Antiviral Drugs for Treatment of Arenavirus Infection  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the...
US20120203102 AZULENE AND AZAAZULENE SYSTEMS FOR IMAGING, MONITORING AND THERAPY  
This invention is directed to non-benzenoid aromatic compounds. Other aspects include methods of using non-benzenoid aromatic compounds for imaging and phototherapeutic uses thereof. Non-benzenoid...
US20110275657 MELANOCORTIN RECEPTOR MODULATORS, PROCESS FOR PREPARING THEM AND USE THERE IN HUMAN MEDICINE AND COSMETICS  
Melanocortin receptor modulators, processes for preparing them and use thereof in human medicine and cosmetics are described. Melanocortin receptor modulators corresponding to formula (I):...