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US20090299079 |
1-GLYCIDYL-3,3-DINITROAZETIDINE CONTAINING EXPLOSIVE MOIETY AND PREPARATION METHOD THEREOF
Disclosed is a 1-glycidyl-3,3-dinitroazetidine(GDNAZ) of Formula I wherein dinitroazetidine group which is a high energy group having unit structure of explosive moiety is incorporated to a...
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US20090197861 |
INHIBITORS OF INTEGRIN ALPHA2BETA1 WITH MODIFIED UREA MOIETY
Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use....
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US20090163466 |
CYCLIC NITRO COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND USES THEREOF
The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to...
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US20090093644 |
METHODS OF SYNTHESIZING CYCLIC NITRO COMPOUNDS
The present invention provides cyclic nitro compounds, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof...
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US20090082331 |
S1P RECEPTOR MODULATING COMPOUNDS AND USE THEREOF
The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The...
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US20090069287 |
SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS
The invention relates to substituted azacycloalkaπe compounds useful in treating conditions of the Central Nervous System (CNS); a pharmaceutical composition comprising same; a method of treating...
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US20090054396 |
SUBSTITUTED THIOPHENES AND USES THEREOF
This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical salts, compositions and methods of use. These novel compounds provide a treatment or...
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US20090042851 |
SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTAGONISTS OF OREXIN 2 RECEPTORS
The present invention is directed to a compound of formula (I):
wherein Ar 1 , Ar 2 , Ar 3 , R1 and T are as defined herein, its preparation, pharmaceutical composition and uses as orexin 2...
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US20090036423 |
IMMUNOSUPPRESANT COMPOUNDS AND COMPOSITIONS
The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds...
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US20090029947 |
Sphingosine-1-phosphate receptor agonist and antagonist compounds
The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds...
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US20080319206 |
Process for Preparing Protected Amidines
A process for preparing a protected amidine group of formula (I): wherein R 6 represents, for example, C 1-10 alkyl (optionally substituted), aryl, C 1-3 alkylaryl or C 1-3 alkyloxyaryl; which...
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US20080312207 |
Compounds
Compounds of Formula (I) wherein: R1 is methyl; R2 is selected from —C (O) NR4R5, SO2NR4R5, S (O) pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring;...
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US20080287413 |
NEW CRYSTALLINE FORMS
There are provided crystalline forms of the compounds Ph(3-Cl)(5-OCHF 2 )—(R)CH(OH)C(O)-Aze-Pab(OMe) and Ph(3-Cl)(5-OCHF 2 )—(R)CH(OH)C(O)-Aze-Pab(OH), pharmaceutical compositions containing...
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US20080280877 |
Azetidines
The invention relates to EP2 antagonist azetidines of formula (I)
wherein Ar, R 1 , X, and Z are as defined herein, to their use in medicine, particularly in the treatment of endometriosis...
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US20080269190 |
Quaternary ammonium compounds useful as muscarinic receptor antagonists
The invention provides compounds of the formula:
in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R 1-6 , a, Z and Q are as defined in the specification. These...
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US20080242874 |
Direct Aminolysis
In some aspects, the present invention provides a method of preparing a compound of the formula (I) comprising reacting a mesylate compound of the formula (II) by direct aminolysis with a reagent...
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US20080200444 |
SOLUBLE EPOXIDE HYDROLASE INHIBITORS
Disclosed are urea compounds of formula I, stereoisomer, or pharmaceutical acceptable salts thereof, and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the...
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US20080194537 |
Compounds Modifying Apoptosis
The present invention relates to compounds capable of inhibiting binding of the Smac protein to Inhibitors of apoptosis (IAPs). Such compounds are preferably capable of inhibiting IAP and thus may...
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US20080194536 |
Cyanoarylamines
The present invention relates to a compound represented by the following formula:
(I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or a...
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US20080167288 |
Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases
The present invention provides compounds of the formula:
its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof,...
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US20080132480 |
Biphenyloxyacetic Acid Derivatives for the Treatment of Respiratory Disease
The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1 , as useful pharmaceutical compounds for treating respiratory disorders,...
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US20080125409 |
1,5-Diheterocycle-1H-Triazole Derivative
The present invention relates to a compound represented by Formula (I):
wherein Ar 1 , Ar 2 , R 1 and R 2 each represent a substituent,
a salt thereof, or a solvate of the compound or...
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US20080108595 |
INHIBITORS OF CATHEPSIN S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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US20080058304 |
N-hydroxyamide derivatives possessing antibacterial activity
Novel N-hydroxyamide derivatives are disclosed. These N-hydroxyamide derivatives inhibit UPD-3-O—(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase, an enzyme present in gram negative...
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US20080051384 |
ANTIVIRAL AGENTS
Disclosed are compounds and compositions of Formula (I) and their uses for treating Flaviviridae family virus infections.
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US20080045489 |
3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS
Disclosed are novel cyclobutenedione Compounds 1 to 18 comprising a cyclobutenedione ring, a substituted phenyl ring, and a —CH(C 2 H 5 )-furan moiety. The phenyl ring and the —CH(C 2 H 5...
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US20080027036 |
S1P receptor modulating compounds and use thereof
The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with...
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