Matches 1 - 26 out of 26
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US20090286994 Process for Synthesizing Nitramine Compounds  
There is disclosed a process for synthesizing nitrosamine compounds. Specifically, there is disclosed a process for synthesizing N-nitropyrrolidine.
US20090281161 Organic Compounds  
Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially...
US20090264499 Cathepsin C Inhibitors  
A compound of formula (IA) or (IB) and their use in treating inflammatory diseases such as COPD.
US20090264431 NOVEL CATHEPSIN C INHIBITORS AND THEIR USE  
The invention is directed to compounds according to Formula I: wherein R1, R2a, R2b, R2c, R3, and n are defined below, and to pharmaceutically-acceptable salts thereof. They are cathepsin C...
US20090264498 Cathepsin C Inhibitors  
This invention relates to compounds of formula (I) which are useful for treating chronic obstructive pulmonary disease, and the like.
US20090239928 N-Pyrrolidin-3YL-Amide Derivatives As Serotonin and Noradrenalin Re-Uptake Inhibitors  
A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R 1 is H, C 1-6 alkyl, —C(A)D, C 3-8 cycloalkyl, aryl, het, aryl-C 1-4 alkyl or het-C...
US20090239929 N-Pyrrolidin-3-YL-Amide Derivatives As Serotonin and Noradrenalin Re-Uptake Inhibitors  
A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R 1 is H, C 1-6 alkyl, —C(A)D, C 3-8 cycloalkyl, aryl, het, aryl-C 1-4 alkyl or het-C...
US20090239910 Benzenesulfonamide Compounds and Their Use  
The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula I and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 ...
US20090203696 Aryl- and Heteroaryl-Ethyl-Acylguanidine Derivatives, Their Preparation and Their Application in Therapeutics  
Disclosed are compounds according to formula (I): wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical...
US20090088464 Merged ion channel modulating compounds and Uses Thereof  
Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as...
US20090076062 Organic Compounds  
Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions...
US20090068120 AMIDE COMPOUND OR SALT THEREOF, AND BIOFILM INHIBITOR, BIOFILM REMOVER AND DISINFECTANT CONTAINING THE SAME  
The present invention provides a new amide compound and salt thereof that is capable of inhibiting biofilm formation or removing deposited biofilms. The present invention also provides a biofilm...
US20090062373 DEUTERIUM-ENRICHED PF-184298  
The present application describes deuterium-enriched PF-184298, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20090042851 SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF AS ANTAGONISTS OF OREXIN 2 RECEPTORS  
The present invention is directed to a compound of formula (I): wherein Ar 1 , Ar 2 , Ar 3 , R1 and T are as defined herein, its preparation, pharmaceutical composition and uses as orexin 2...
US20090030212 Enantioselective ring-opening of aziridines  
A process for the preparation of a nucleophilic addition product of an aziridine and a nucleophile, the process comprising treating the arizidine with the nucleophile in the presence of a biaryl...
US20080300266 1-(Hetero)Aryl-3-Amino-Pyrrolidine Derivatives for Use as Mglur3 Antagonists  
The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine,...
US20080287523 Pyrrolidin-3-Yl Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease  
The present invention is directed to pyrrolidin-3-yl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the...
US20080262073 Pyrrolic Derivatives with Histone Deacetylase Inhibitory Activity  
The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to...
US20080255205 Multi-cyclic compounds and methods of use  
The present invention relates to compounds of Formulas I and II, wherein B 1 , B 2 , B 3 , B 4 , C 1 , C 2 , ring D, L 1 , L 2 and R 1-4 are defined herein, synthetic intermediates, and...
US20080255371 Method for improving optical purity of 1-benzyl-3-aminopyrolidine and salt for use therein  
The present invention provides a method to improve the optical purity of 1-benzyl-3-aminopyrrolidine having a low optical purity using an inexpensive agent via a simple procedure. The present...
US20080242653 Cyclopropyl amine derivatives  
Compounds of formula (I) wherein R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , and R 5 are defined in the description, are useful in treating conditions or disorders prevented by or ameliorated by...
US20080227826 Inhibitors of Histone Deacetylase  
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
US20080214646 Novel Nsaids Possessing a Nitric Oxide Donor Diazen-1-Ium-1,2-Diolate Moiety  
This invention provides a prodrug that help arthritis patients without increasing cardiovascular and gastrointestinal risk. A novel group of hybrid nitric oxide-releasing non-steroidal...
US20080207908 PROCESSES FOR THE PREPARATION OF PIPERIDINYL-SUBSTITUTED UREA COMPOUNDS  
Disclosed are processes for the synthesis of piperidinyl-substituted urea compounds. This invention further relates to novel intermediates prepared during this synthesis.
US20080139805 Process for producing carbapenem derivative having a 1-alkylpyrrolidine structure  
A process for the preparation of carbapenem-type antibacterial agents involving the following reaction: wherein R 1 is a C 1 -C 3 alkyl group, n is 0, 1 or 2, A is a C 1 -C 3 alkylene group,...
US20080004315 Guanidine Derivatives and Therapeutic Uses Thereof  
Compounds of the formula (I): in which the radicals R and R 1 to R 10 are as defined in the description, processes for the preparation of them, use thereof for the treatment of...
Matches 1 - 26 out of 26