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US20090306156 |
PHOSPHODIESTERASE 4 INHIBITORS
Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I:
wherein R 1 , R 2 , and...
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US20090239885 |
Inhibitors of nucleoside phoshorylases and nucleosidases
The present invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT),...
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US20090233969 |
BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general...
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US20090227635 |
THERAPEUTIC COMPOUNDS
Compounds comprising
or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, B, and J are as described. Methods, compositions, and medicaments related thereto...
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US20090215857 |
Therapeutic Pyrrolidines
The present invention provides for compounds of Formula (I),
and pharmaceutically acceptable salts thereof, wherein A, J, Z, and R 20 have any of the values defined therefore in the...
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US20090186834 |
DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS
Various azetidinone, pyrrolidine, imidazolidine, and oxazolidine derivatives are described, as are pharmaceutical compositions containing these compounds and methods of treatment of diseases using...
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US20090182154 |
Combinatorial library approach to iminocyclitols with biological activity
A method of synthesizing stereochemically defined iminocyclitol comprises replacing an intraring oxygen in a cyclic sugar by an intraring imine to form an iminocyclitol, wherein said iminocyclitol...
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US20090162420 |
Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids
The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of...
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US20090118289 |
(Biphenyl) Carboxylic Acids and Derivatives Thereof
The present invention relates to compounds having the general formula (I) with the definitions of A, X, R 1 -R 6 given below, and/or a salt or ester thereof. Furthermore the invention relates to...
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US20090093643 |
Process for Production of Benzyloxypyrrolidine Derivative, and Process for Production of Hydrochloride Salt Powder of Optically Active Benzyloxypyrrolidine Derivative
Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in...
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US20090088464 |
Merged ion channel modulating compounds and Uses Thereof
Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as...
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US20090069335 |
Guanidine-containing compounds useful as muscarinic receptor antagonists
The invention provides compounds of formula I:
or a pharmaceutically acceptable salt thereof, wherein R 1-3 , R 5-7 , a, X, Y, Y′, Y″, and Z are as defined in the specification. These...
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US20090023918 |
PROCESS FOR PREPARING 3-ACYLAMINOBENZOFURAN-2-CARBOXYLIC ACID DERIVATIVE
The present invention provides a process of preparing a compound of the formula [I]:
wherein X is a group of the formula: —N═ or —CH═; R 1 is a hydrogen atom, a halogen atom, a lower...
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US20090012120 |
Synthesis of N-heterocycles, beta-amino acids, and allyl amines via aza-payne mediated reaction of ylides and hydroxy aziridines
An ylide-based aza-Payne rearrangement of 2,3-aziridin- 1 -ols leads to an efficient process for the preparation of pyrrolidines. The aza-Payne rearrangement under the basic reaction conditions...
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US20090005577 |
Method of producing 1-substituted 3-pyrrolates
The instant disclosure is directed to a method of producing crystals of a racemic mixture of a 1-substituted-3-pyrrolate. A method of producing crystals of racemic glycopyrrolate in high purity is...
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US20090005576 |
Production Method of Optically Active Cyclohexane Ether Compounds
The present invention relates to an industrial synthetic method of an optically active cyclohexane ether compound (IIIa) or a salt thereof, which is useful as a pharmaceutical agent, and an...
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US20080306283 |
Process For Production of Aralkyloxypyrrolidine Derivative
The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a...
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US20080161281 |
Amino-Substituted Tricyclic Derivatives and Methods of Use
Compounds of formula (I)
wherein A and B are amine-substituted sidechains, Y 1 and Y 2 form various tricyclic cores, X a and X b are C, CH, or N, as defined herein, and R x is an optional...
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US20080139639 |
Proton Pump Inhibitors
A proton pump inhibitor containing a compound represented by the formula (I)
wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main...
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US20080114051 |
PYRROLIDINE DERIVATIVES AS PROSTAGLANDIN MODULATORS
Substituted pyrrolidine compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful...
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US20080096903 |
SULFAMOYL-CONTAINING DERIVATIVES AND USES THEREOF
Sulfamoyl-containing compounds are disclosed, having utility as inhibitors of disease-related targets, such as Heat Shock Protein 90 (HSP90), and which are useful for treating disorders, e.g.,...
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US20080076818 |
NOVEL PROCESSES FOR THE PREPARATION OF DPP IV INHIBITORS
The present invention relates to novel processes for preparing DPP-IV inhibitors having the structure of formula I,
and pharmaceutically acceptable salt thereof, which are useful for treatment...
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US20080070956 |
Tricyclic aromatic and bis-phenyl sulfinyl derivatives
The present invention provides compounds of the structure:
wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases...
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US20080021005 |
Pegylated Ion Channel Modulating Compounds
This invention is directed to PEGlyated derivatives, drug conjugates and isotopic derivatives of certain ion channel modulating compounds. Pharmaceutical compositions and methods of use of also...
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