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US20090318518 |
INDOLE AND INDOLINE CYCLOPROPYL AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS
The invention is directed to indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic...
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US20090312366 |
NOVEL P2X7R ANTAGONISTS AND THEIR USE
The present application is directed to novel P2X7R antagonists that are indol-3-carboxamide or azaindole-3-carboxamide compounds, pharmaceutical compositions comprising the same and their use for...
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US20090291978 |
Enzyme Inhibitors
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R 1 is a carboxylic acid group (—COOH), or an ester...
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US20090186934 |
Beta Crystalline form of the Arginine Salt of Perindopril, a Process for its Preparation and Pharmaceutical Compositions Containing it.
β-crystalline form of the compound of formula (I):
characterised by its powder X-ray diffraction diagram. Medicinal products containing the same which are useful as inhibitors of angiotensin I...
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US20090181960 |
17BetaHSD TYPE 5 INHIBITOR
To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal...
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US20090162420 |
Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids
The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of...
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US20090124682 |
Indan-Amide Derivatives with Glycogen Phosphorylase Inhibitory Activity
A compound of the formula (1) or a pharmaceutically-acceptable salt: (A chemical formula should be inserted here—please see paper copy enclosed herewith) (1) possess glycogen phosphorylase...
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US20090099248 |
INHIBITORS OF D-AMINO ACID OXIDASE
The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein...
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US20090076004 |
Indoles Useful in the Treatment of Inflammation
There is provided compounds of formula (I), wherein X 1 , Q, T, Y, R 1 , R 2 , R 3 , R 4 and R 5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which...
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US20090069574 |
Process for the synthesis of an ace inhibitor
A process for the synthesis of trandolapril which comprises condensing N-[I-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine N-carboxyanhydride with trans octahydro-1H-indole-2-carboxylic acid in a...
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US20090062363 |
AMIDE DERIVATIVE OR SALT THEREOF
[Problem] To provide a compound which can be used for the prevention and/or treatment of diseases in which 5-HT 2B receptor and 5-HT 7 receptor are concerned, particularly for the treatment of...
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US20090054402 |
7-SUBSTITUTED INDOLE MCL-1 INHIBITORS
Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein...
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US20090043112 |
Process for the Preparation of Enantiomerically Enriched Indoline-2-Carboxylic Acid
The present invention relates to a process for the preparation of an enantiomerically enriched optionally substituted indoline-2-carboxylic acid or a salt thereof, wherein an enantiomerically...
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US20090041722 |
INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD
Indole indane amides which are CB2 agonists are provided which have the structure
wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein, which compounds are useful in treating autoimmune...
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US20090018141 |
KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREWITH
Provided herein are Compounds having the following structure:
wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for...
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US20080318779 |
Fungicidal Composition Containing Acid Amide Derivative
Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the...
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US20080306135 |
Process for the Preparation of Crystalline Perindopril
The present invention relates to a new process for the preparation of crystalline perindopril. The present invention also relates to new alkyl ammonium salts of perindopril and the processes for...
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US20080293802 |
Chemical Compounds
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula (I).
The compounds of the invention are inhibitors of...
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US20080267981 |
Compositions and Methods for Delivery of Antitumor Agents
Methods for treating a neoplastic disease with an antibody-cytotoxin conjugate molecule, methods of synthesizing an antibody-cytotoxin conjugate molecule are provided. Compounds that are useful as...
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US20080255189 |
HEPATITIS C VIRUS INHIBITORS
A compound of the following formula:
in which R 1 , R 2 , R 3 , U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing...
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US20080249155 |
5-Hydroxyindole-3-Carboxylate Derivatives and Uses Thereof
The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof,
...
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US20080221197 |
INDOLE ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS
The present invention provides indole compounds of Formula (I) or (II):
or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables ring A, X 1 ,...
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US20080221194 |
Novel Potassium channel Blockers and Uses Thereof
The invention relates to compounds of Formula (1) for use in modulating potassium channel activity in cells.
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US20080213217 |
Enantiomerically pure phosphoindoles as HIV inhibitors
3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided...
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US20080188472 |
Indole-2-Carboxylic Acid Hydrazides
Compounds of formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes,...
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US20080167306 |
Novel Heteroaryl Derivative
A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic...
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US20080146646 |
N-(Heteroaryl)-1-heteroarylalkyl-1H-indole-2-carboxamide derivatives, preparation and therapeutic use thereof
The invention concerns compounds of general formula (I), wherein n, X 1 , X 2 , X 3 , X 4 , Y and W are as defined herein.
The invention also concerns a method for preparing said compounds and...
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US20080146616 |
Indoles Useful in the Treatment of Inflammation
There is provided a compound of formula (I), wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds...
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US20080139823 |
Process for the Purification of Perindopril
A dicyclohexyamine salt of compound of formula I, namely perindopril, having an X-ray powder diffraction pattern with characteristic peaks (2θ): 8.462, 10.624, 18.693, 9.424, 17.272, 14.177,...
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US20080119465 |
Novel Indoline Compounds
Sulfonylindoline compounds of formula I,
wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
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US20080114034 |
1H-Indole-3-Carboxylic Acid Derivatives And Their Use As Ppar Agonists
Compounds of the formula (1): in which A, R 1 , R 2 and R 3 are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of...
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US20080108819 |
Novel indole derivatives and their use as medicament
The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
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US20080038276 |
INHIBITORS OF PLASMA KALLIKREIN
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease...
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US20080027124 |
3-SUBSTITUTED-5- AND 6-AMINOALKYL INDOLE-2-CARBOXYLIC ACID AMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I
The present invention discloses and claims compounds of formula (I) and formula (II)
as inhibitors of human casein kinase Iε, and methods of using said compounds of formula (I) and formula...
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US20080004241 |
Bicyclic compositions and methods for modulating a kinase cascade
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
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