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US20100317690 TREATMENT OF PROTEIN FOLDING DISORDERS  
Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular,...
US20150141479 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MODERATE TO SEVERE PAIN  
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The...
US20150087628 COMPOSITIONS AND METHODS FOR TREATING CANCER  
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
US20110137025 CHEMICAL FRAMEWORK COMPOSITIONS AND METHODS OF USE  
The disclosure provides metal organic frameworks useful for sensing, gas sorption, microelectronics and switches.
US20120095075 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS  
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having...
US20130211100 Method to Generate Novel Bioactive Molecules  
The present invention describes a method to generate new chemical entities (NCEs) that have well-defined activities such as, but not limited to, anti-bacterial, antifungal and anthelmintic...
US20110195929 COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS  
Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with...
US20140256768 HETEROCYCLIC MOLECULES AS APOPTOSIS INDUCERS  
The present document describes novel compounds which may inhibit the activity of anti-apoptotic proteins such as Bcl-2 family protein members, compositions containing the compounds and methods of...
US20120027796 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS  
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having...
US20120225922 Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration  
The invention includes an amount of (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b] indol-5-yl phenylcarbamate for administering to a subject and also a method of preventing or...
US20130303570 Modulators of Cystic Fibrosis Transmembrane Conductance Regulator  
The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to...
US20120208841 Modulators of Cystic Fibrosis Transmembrane Conductance Regulator  
The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to...
US20080188544 LYOPHILIZED FORMULATIONS OF SALINOSPORAMIDE A  
Lyophilized formulations comprising Salinosporamide A or analogs thereof are provided. In some aspects, lyophilized formulations comprising Salinosporamide A or analogs thereof and bulking agents...
US20110124869 Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator  
The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phe nyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carb...
US20130280305 CATIONIC LIPID  
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl,...
US20130108685 CATIONIC LIPID  
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, alkenyl,...
US20150080576 SUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are amide compounds which can be prepared from certain...
US20120029044 7-AZONIABICYCLO[2.2.1]HEPTANE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF  
Muscarinic acetylcholine receptor antagonists and methods of using them for the treatment of muscarinic acetylcholine receptor-mediated diseases, such as pulmonary diseases, are provided.
US20140271537 DEUTERIUM-ENRICHED ALDEHYDES  
The present invention generally relates to deuterium-enriched aldehydes, compositions comprising deuterium-enriched aldehydes, and methods for slowing the rate of aldehyde autoxidation. In one...
US20130178453 Cannabinoid Agonists  
The present disclosure relates to compounds useful as agonists of the cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the...
US20140221420 CCR5 ANTAGONISTS FOR TREATING HIV  
Compounds that modulate the CCR5 chemokine receptor, pharmaceutical compositions containing them, and uses therefor in the treatment of HIV and related diseases are described.
US20060229353 Substituted heterocycles  
The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.
US20130123285 Compositions and Methods for Targeting A3G:RNA Complexes  
The present invention provides an assay for screening any agent that modulates the ability of A3G to bind with RNA. The invention provides an agent identified by high throughput screening methods...
US20150225342 SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B  
Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the...
US20130178457 CANNABINOID RECEPTOR MODULATORS  
Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the...
US20130261129 CHEMOKINE RECEPTOR ANTAGONISTS  
Disclosed herein are chemokine receptor antagonists of formula (I) wherein R1, R2, and R3 are as defined in the specification. Compositions comprising such compounds; and methods for treating...
US20060160877 2-Heteroaryl carboxamides  
The invention relates to novel 2-heteroaryl carboxamides and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception,...
US20130059898 7-AZONIABICYCLO [2.2.1] HEPTANE DERIVATIVES, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF  
Muscarinic acetylcholine receptor antagonists and methods of using them for the treatment of muscarinic acetyl-choline receptor-mediated diseases, such as pulmonary diseases, are provided.
US20140166987 Disordered Organic Electronic Materials Based on Non-Benzenoid 1,6-Methano[10]Annulene Rings  
Conjugated polymers and small molecules including the nonplanar aromatic 1,6-methano[10]annulene ring structure along with aromatic subunits, such as diketopyrrolopyrrole, and...
US20130116232 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF  
Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of...
US20130200339 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME  
A heterocyclic compound includes a compound represented by Formula 1.
US20130029970 CB Receptor Agonists  
The present disclosure relates to compounds of formula I useful as agonists of cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds...
US20130196960 Cannabinoid Receptor Agonists  
The present disclosure relates to compounds useful as agonists of cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the...
US20110130400 TRPV4 ANTAGONISTS  
The present invention relates to diazabicyclo[2.2.1]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
US20110195986 PYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS  
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1, R4, R5, R3, R3a, W, D,...
US20120010261 CHOLINE AND TROMETHAMINE SALT OF LICOFELONE  
The present invention relates to the choline and tromethamine salt of Licofelone.
US20090069384 THIENOPYRROLES USEFUL IN THE TREATMENT OF INFLAMMATION  
There is provided compounds of formula I: wherein the dotted lines, U5 V5 X1, Y R1, R2 and R4 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds...
US20060287520 Synthesis of salinosporamide A and analogues thereof  
A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors....
US20110155973 IMPROVED, RED COLOUR FILTER COMPOSITION  
A composition, for producing dispersions, thermoplastic masses and/or colour filters, comprising (a) a colourant of formula (1) wherein 20-100 mol % R1 are Br and 80-100 mol % R3 are H, especially...
US20130129811 CATIONIC LIPID  
The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R1 and R2 are, the same or different, each...
US20110021543 HETEROCYCLIC COMPOUNDS AND THEIR USE AS PESTICIDES  
Novel N-aryl substituted heteroindole compounds, processes for their manufacture, veterinary compositions containing such compounds, and methods of controlling ectoparasites are provided. The...
US20150005277 Protein Kinase Inhibitors and Uses Thereof  
The invention is compounds of formula (I), and salts thereof, compositions thereof, and methods of use therefor. In particular, disclosed herein are certain compounds that can be useful for...
US20090247766 Substituted Nitrogen Heterocycles and Synthesis and Uses Thereof  
The invention relates to a nitrogen heterocycle compound of formula 1: Also disclosed are a method of synthesizing the compound and use of the compound for treating various diseases and conditions.
US20150246025 2-PHENYL-5-HETEROCYCLYL-TETRAHYDRO-2H-PYRAN-3-AMINE COMPOUNDS FOR USE IN THE TREATMENT OF DIABETES AND ITS ASSOCIATED DISORDERS  
The present invention relates to novel compounds of the general formula (I) their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically accepted salts, or pro-drugs...
US20100009214 ALPHA-DIKETOPYRROLOPYRROLE PIGMENT, COLORING COMPOSITION CONTAINING THE SAME, AND RED FILM  
An α-diketopyrrolopyrrole pigment characterized by giving an X-ray diffraction spectrum in which the ratio of the peak density (I020) for plane index (020) to the peak intensity (I−141) for plane...
US20150246921 STRONGLY FLUORESCENT HETEROCYCLES AND A METHOD FOR THEIR SYNTHESIS  
This invention provides 1,4-dihydropyrrolo[3,2-b]pyrrole derivatives which can be used as strongly fluorescent compounds and a one-stage method for their synthesis from simple substrates.
US20140288045 COVALENT INHIBITORS OF KRAS G12C  
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated...
US20130197008 3-AMINOCYCLOPENTANECARBOXAMIDES AS CHEMOKINE RECEPTOR AGONISTS  
There is provided a compound of Formula I(a) or I(b): or a pharmaceutically acceptable salt thereof, wherein the various substitutents are defined herein.
US20130196978 ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF  
Alkaloid aminoester compounds which act as muscarinic receptor antagonists are useful for the prevention and/or treatment of a broncho-obstructive or inflammatory diseases.
US20110015248 SUBSTITUTED HETEROCYCLES  
The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.

Matches 1 - 50 out of 248 1 2 3 4 5 >