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US20090280483 |
Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors
The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of...
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US20090221824 |
ENANTIOSELECTIVE PROCESS
A process for the production of compounds comprising the enantioselective hydrogenation of 2-substituted acrylic acid derivatives.
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US20090203747 |
NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE
The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a...
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US20090137817 |
SPATIALLY-DEFINED MACROCYCLIC COMPOUNDS USEFUL FOR DRUG DISCOVERY
Novel spatially-defined macrocyclic compounds containing specific conformational control elements are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle...
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US20090011975 |
TARGETED BONE MARROW PROTECTION AGENTS
The invention provides a method of inhibiting cell death in a mammal. The method comprises administering to a mammal an effective amount of a composition comprising a cell protection factor...
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US20080312085 |
Pesticidal Compositions
The present invention relates to 1-(Azolin-2-yl)-amino-alkane compounds, which are useful for combating insects, arachnids and nematodes. The present invention also relates to a method for...
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US20080300285 |
Chemical Compounds
The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i), formula (ii), formula (iii) Y is O, S(O) m , NR 3 , CR 5 R 6 , CR 5 R 6 —CR 7 R 8 , O—CR 7 R 8 , S(O) m —CR...
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US20080300266 |
1-(Hetero)Aryl-3-Amino-Pyrrolidine Derivatives for Use as Mglur3 Antagonists
The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine,...
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US20080242654 |
NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS
The present application relates to thiazolylidene containing compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , L 2 and A are as defined in the specification. Compositions comprising such...
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US20080227783 |
5-Substituted Thiazol-2-Yl Amino Compounds and Compositions as Protein Kinase Inhibitors
The invention provides 5-substituted thiazol-2-yl amino compounds of Formula (I): pharmaceutical compositions comprising such compounds and the use of such compounds for the treatment or prevention...
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US20080221082 |
Ligands of Integrin Receptors
The invention relates to the use of cyclic compounds as ligands of integrin receptors, in particular as ligands of the α V β 3 integrin receptor, the novel compounds themselves, their use, and...
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US20080200371 |
THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES
Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit...
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US20080182837 |
NEW CHEMICAL COMPOUNDS
The present invention encompasses compounds of general formula (1)
wherein the groups R 2 to R 4 , L, Q and n are defined as in claim 1 , which are suitable for the treatment of diseases...
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US20080182993 |
Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
4-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-N-methyl-2-th
iazolemethanamine which is an intermediate.
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US20080171734 |
CHEMICAL COMPOUNDS
The invention relates to a novel group of compounds of Formula (I) or a salt thereof:
wherein R 1 , A and HET-1 are as described in the specification, which may be useful in the treatment or...
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US20080153883 |
NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS AND USES THEREOF
The present invention relates to thiazolidinylidene containing compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and X are as defined in the specification, compositions...
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US20080146797 |
PROCESS FOR SYNTHESIZING HETEROCYCLIC COMPOUNDS
The invention provides the process illustrated in scheme 1 for synthesizing heterocyclic compounds of formula I.
In the process, an isothiocyanate of formula II is initially reacted with a...
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US20080125471 |
Water-Soluble Tetrazolium Salts
Thiazolyl tetrazolium salts with increased solubility in aqueous solutions have alkylammonium alkoxy substituents, preferably trimethyl ammonium propoxy groups substituents, on phenyl rings...
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US20080119454 |
Aryl carbonyl derivatives as therapeutic agents
This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where...
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US20080119455 |
Aryl carbonyl derivatives as therapeutic agents
This invention relates to aryl carbonyl derivatives which are activators of glucokinase which may be useful for the management, treatment, control, or adjunct treatment of diseases, where...
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US20080096938 |
Chemical compounds
The invention provides compounds formula I, their preparation, and their use as pharmaceutically active immunosuppressive agents for the treatment of autoimmune disorders, organ transplant...
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US20080070929 |
THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE
The invention relates to a series of thiazoline and oxazoline derivatives, compositions thereof, and methods of treating conditions and disorders using such compounds.
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US20080058380 |
ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
The invention relates to a compound corresponding to the general formula (I):
wherein, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 5′ and R 6 are as defined herein. More specifically, this...
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US20080039466 |
2-(3-Substituted-Aryl) Amino-4-Aryl-Thiazoles As Tyrosine Kinase Inhibitors
The present invention relates to novel compounds selected from 2-(3substitutedaryl)amino-4-aryl-thiazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain...
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US20080027067 |
Heterocyclic derivatives as modulators of ion channels
The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the...
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US20080015202 |
Thiazole Derivatives Having Vap-1 Inhibitory Activity
A compound of the formula (I):
U-V-W-X-Y-Z (I)
wherein U is lower alkyl;
V...
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