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US20090318442 |
THIAZOLYL-AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM
The present invention relates to substituted thiazolyl- and oxazoyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to...
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US20090312362 |
INHIBITORS OF THE UNFOLDED PROTEIN RESPONSE AND METHODS FOR THEIR USE
Compounds that are inhibitors of the unfolded protein response and endonuclease IRE1 are provided, together with compositions comprising such compounds, and methods for their use in the treatment...
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US20090286767 |
SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES
Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the...
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US20090134784 |
CARBAZOLE-CONTAINING MATERIALS IN PHOSPHORESCENT LIGHT EMITTING DIODES
Carbazole-containing compounds are provided. In particular, the compounds are oligocarbazole-containing compounds having an unsymmetrical structure. The compounds may be useful in organic light...
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US20090117040 |
Novel pharmaceutical and diagnostic compositions for use in the treatment and diagnosis of neurodegenerative diseases or amyloid diseases
The present invention relates to pharmaceutical and diagnostic compositions as well as to the use of the active substances contained therein for preparing a pharmaceutical or a diagnostic...
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US20090093465 |
THERAPEUTIC KINASE MODULATORS
The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity....
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US20090012077 |
Novel Compound - 827
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases,...
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US20080318998 |
Alkyloxy Substituted Thiazoloquinolines and Thiazolonaphthyridines
Thiazoloquinolines and thiazolonaphthyridines with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and...
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US20080114020 |
Difluoro-Substituted Imidazopyridines
The invention provides compounds of the formula (I)
in which the substituents and symbols are as defined in the description. The compounds inhibit the secretion of gastric acid.
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US20080090834 |
SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS
The invention pertains to heteroaromatic compounds of the formula I,
as defined herein, that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said...
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US20080071086 |
METHOD FOR SYNTHESIS OF 8-ALKOXY-9H-ISOTHIAZOLO[5,4-B]QUINOLINE-3,4-DIONES
The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A.
The...
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US20080056987 |
Quinoline derivatives, their preparation, their use, and medicaments comprising them
The present invention relates to a quinoline derivative having the general formula (A)
in which R 1 , R 2 , W, X, Y and Z are indicated in the description and the claims, the use of the...
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US20080039456 |
Rigidified Compounds for Modulating Heparanase Activity
Disclosed are novel rigidified compounds having a rhodanine-like residue and at least one aryl or heteroaryl residue linked to the rhodanine-like residue, whereby a core structure of these...
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