Matches 1 - 50 out of 69 1 2 >
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US20090318435 PYRAZOLOPYRIDINES AND ANALOGS THEREOF  
Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds,...
US20090306121 AZA-BETA-CARBOLINES AND METHODS OF USING SAME  
Provided are compounds having the general structure according to Formula (I): Further provided are pharmaceutical compositions comprising these compounds. The invention still further provides...
US20090306089 COMPOUNDS  
Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof: (relative chemistry shown) pharmaceutical compositions comprising them, their use in therapy especially against...
US20090298821 HYDROXY AND ALKOXY SUBSTITUTED IH-IMIDAZONAPHTHYRIDINES AND METHODS  
1H-Imidazo[4,5-c]naphthyridin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of...
US20090270443 1-AMINO IMIDAZO-CONTAINING COMPOUNDS AND METHODS  
Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines) with an amino substituent at the 1-position, pharmaceutical compositions containing the compounds and methods of use of...
US20090270376 HETEROCYCLIC JANUS KINASE 3 INHIBITORS  
The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various...
US20090264399 HETEROCYCLIC JANUS KINASE 3 INHIBITORS  
The invention relates to compound of the formula (I) or its salt, wherein —R 1 , —R 2 , —R 3 , —R 4 , —R 5 , -M-, —X— and —Y═ are as defined in the description, their use of as,...
US20090258894 Fused Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes  
The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the...
US20090253734 INHIBITORS OF AKT ACTIVITY  
The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The...
US20090253695 Hydroxyalkyl Substituted Imidazonaphthyridines  
Certain imidazonaphthyridines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods...
US20090240055 Method for 1H-Imidazo[4,5-C] Pyridines and Analogs Thereof  
Methods and intermediates for preparing compounds of the Formulas: (I and X) are disclosed. The methods include a method providing a compound of the Formula: (IV) and converting a compound of...
US20090233936 Fused Aminopiperidines as Dipeptidyl Peptidase-4 Inhibitors for the Treatment or Prevention of Diabetes  
The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the...
US20090232844 IMMUNOPOTENTIATING COMPOUNDS  
The invention provides novel compositions comprising Imidazopyridine compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of...
US20090230857 AROMATIC HETEROCYCLIC COMPOUND, ORGANIC LIGHT EMITTING DIODE COMPRISING ORGANIC LAYER COMPRISING THE SAME AND METHOD OF MANUFACTURING THE ORGANIC LIGHT EMITTING DIODE  
Provided are an aromatic heterocyclic compound represented by Formula 1 below, an organic light emitting diode including the same, and a method of manufacturing the organic light emitting diode: ...
US20090221556 HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS  
1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making...
US20090215736 CASPASE INHIBITORS AND USES THEREOF  
This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R 1 is hydrogen, —CHN 2 , R, CH 2 OR, CH 2 SR, or —CH 2 Y; between R 3 and R 4 represents a...
US20090209764 Process for Preparation of 4-amino-1-isobutyl-1H-Imidazo[4,5-C]-quinoline (Imiquimod)  
A process for the preparation of imiquimod comprising oxidation of 1-Isobutyl- 1 H-imidazo quinoline quinoline (II) afforded 1-Isobutyl-1H-imidazo-[4,5-c]-quinoline-5-N-oxide (III) which is...
US20090182001 Inhibitors of checkpoint kinases  
The instant invention provides for compounds which comprise fused imidazoles that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and...
US20090176822 PYRROLIDINE INHIBITORS OF IAP  
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X 1 , X 2 , Y, R 1 ,...
US20090176821 Amide and Carbamate Derivatives of Alkyl Substituted N-[4-(4-Amino-1H-Imidazo[4,5-C] Quinolin-1-YL)Butyl]Methanesulfonamides and Methods  
Amide and carbamate derivatives of N-[4-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesu lfonamides with an ethyl, methyl, or n-propyl substituent at the 2-position, pharmaceutical...
US20090163533 1-Substituted Pyrazolo (3,4-C) Ring Compounds as Modulators of Cytokine Biosynthesis for the Treatment of Viral Infections and Neoplastic Diseases  
Pyrazolo[3,4-c] ring compounds of Formula (I), e.g., pyrazolo[3,4-c]pyridines, pyrazolo[3,4-c]quinolines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and pyrazolo[3,4-c]naphthyridines,...
US20090131467 Heterocycle Compound, and Production Process and Application Thereof  
The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group...
US20090124611 Pyrazolopyridine-1,4-Diamines and Analogs Thereof  
Pyrazolopyridine-1,4-diamines and analogs thereof, e.g., pyrazolo[3,4-c]pyridine-1,4-diamines, pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, and...
US20090124652 Polymorphs of 1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine Ethane-Sulfonate  
The invention provides various crystalline forms of 1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amin e ethanesulfonate, pharmaceutical compositions, methods of making, and methods of use.
US20090105295 HYDROXYLAMINE SUBSTITUTED IMIDAZOQUINOLINES  
Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with a hydroxylamine substituent at the 2-position, pharmaceutical...
US20090099161 Substituted Imidazoquinolines and Imidazonaphthyridines  
Imidazoquinolines and imidazonaphthyridines with a substituent containing a functional group, e.g., an amide, sulfonamide, urea, or heterocyclyl group, at the 6, 7, 8, or 9-position, pharmaceutical...
US20090082387 DEUTERIUM-ENRICHED NVP-BEZ234  
The present application describes deuterium-enriched NVP-BEZ235, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
US20090069314 Hydroxyalkyl Substituted Imidazoquinoline Compounds and Methods  
Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, and an aryl or heteroaryl substituent at the 7-position, pharmaceutical compositions containing the...
US20090069299 Pyrazolo[3,4-c]Quinolines, Pyrazolo[3,4-c]Naphthyridines, Analogs Thereof, and Methods  
Pyrazolo[3,4-c]quinolines, pyrazolo[4,5-c]naphthyridines, and analogs thereof, eg., 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinolines, and, pharmaceutical compositions containing the compounds,...
US20090062272 IMIDAZOQUINOLINYL SULFONAMIDES  
Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamide compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use...
US20090062328 Oxime and Hydroxylamine Substituted Imidazo[4,5-c] Ring Compounds and Methods  
Imidazo[4,5-c] ring compounds, (e.g. imidazo[4,5-c]pyridines, imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydro imidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridine, and 6,7,8,9-tetrahydro...
US20090054476 A3 Adenosine receptor allosteric modulators  
The present invention relates to allosteric modulation of A 3 adenosine receptor (A 3 AR) and provides for the use of an A 3 adenosine receptor modulator (A 3 RM), for the preparation of...
US20090054399 HIV INTEGRASE INHIBITORS  
Tricyclic compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, R 1 , R 2 and R 3 are defined herein. The compounds are useful for...
US20090042925 OXIME SUBSTITUTED IMIDAZOQUINOLINES  
Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and imidazopyridines) with an oxime substituent at the 2-position, pharmaceutical...
US20090030202 MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENT AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME  
A material for organic electroluminescence devices for use as a host material in combination with at least one phosphorescent metal complex, which comprises a compound having a specific...
US20090030030 ARYLALKENYL AND ARYLALKYNYL SUBSTITUTED IMIDAZOQUINOLINES  
Arylalkenyl and aryalkynyl substituted imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators,...
US20090023720 2-Amino 1H-Imidazo Ring Systems and Methods  
1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the...
US20090018122 Aryloxy and Arylalkyleneoxy Substituted Imidazoquinolines  
Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods...
US20090017489 Methods For Modulating The Development Of Dopamine Neuron By The Dopamine D2 Receptor And Compositions Thereof  
The present invention relates to a composition for modulating the activation of Nurr1, the composition comprising an agonist or an antagonist of a dopamine D2 receptor, methods for modulating the...
US20090005365 THERAPEUTIC PYRAZOLONAPHTHYRIDINE DERIVATIVES  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABA A receptor and negatively modulating the α5...
US20090005376 1-Alkoxy 1H-Imidazo Ring Systems and Methods  
Imidazo-containing compounds (e.g., imidazonaphthyridines, imidazopyridines, imidazoquinolines, and imidazote-trahydroquinolines) with an alkoxy substituent at the 1-position, pharmaceutical...
US20090005566 Method for Making 1-Substituted 1H-Imidazo [4,5-C] Quinolin-4-Amine Compounds and Intermediates Therefor  
The present invention concerns a method for manufacturing 1-substituted 1H imidazo[4,5-c]quinolin-4-amine compounds through their corresponding formamides. The invention also concerns new formamide...
US20080318959 Compounds that Inhibit Hiv Particle Formation  
The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and...
US20080318999 Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators  
The invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R 1 , R 2 , R 3 , A, B, D, m, n, x, and y are defined as described in the...
US20080306048 THERAPEUTIC PYRAZOLOQUINOLINE UREA DERIVATIVES  
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABA A receptor and modulating GABA A , and use of the...
US20080306266 Process for Preparing 2-Methyl-1-(2-Methylpropyl)-1H-Imidazo[4,5-C][1,5]Naphthyridin-4-Amine  
The invention provides various processes for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyrid in-4-amine.
US20080269209 Pyrazoloisoquinoline Derivatives  
New compounds of formula I, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors. (I)
US20080261969 1,4-Dihydropyridine-Fused Heterocycles, Process for Preparing the Same, Use and Compositions Containing Them  
This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment...
US20080262021 1H-Imidazoquinoline Derivatives as Prote In Kinase Inhibitors  
The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprising an imidazoquinoline, especially for...
US20080249310 Process For the Preparation of (2R,3R)-2-Hydroxy-3-Amino-3-Aryl-Propionamide and (2R,3R)-2-Hydroxy-3-Amino-3-Aryl-Propionic Acid Alkyl Ester  
The invention relates to a novel compound (2R,3R)-2-hydroxy-3-amino-3-aryl-propionamide according to formula (1), wherein aryl A represents a substituted or unsubstituted aromatic ring, and to a...
Matches 1 - 50 out of 69 1 2 >