|
Match
|
Document |
Document Title |
|
|
US20090270451 |
Piperdine Glycine Transporter Inhibitors
The present invention is directed to piperidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with...
|
|
|
US20090247503 |
5-DEMETHOXYFUMAGILLOL AND DERIVATIVES THEREOF
Provided herein are 5-demethoxyfumagillol and its derivatives. Also provided herein are methods of making the 5-demethoxyfumagillol and derivatives. Also provided herein are biological activities...
|
|
|
US20090233966 |
Analogues of the Azinomycins as Anti-Tumour Agents and as Prodrugs
Compounds of general formula (I) or a salt thereof in which R 1 is preferably an aromatic DNA binding subunit are oxidation-activated prodrugs. The compounds are expected to be converted into an...
|
|
|
US20090198052 |
METHOD FOR PREPARING OPTICALLY ACTIVE PIPERIDINE COMPOUNDS
The present invention relates to a method for preparing a syn-form piperidine compound represented by general formula [I]:
wherein,
bold lines represent bonds in which substituents at...
|
|
|
US20090062342 |
AMINES
The invention relates to novel amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including...
|
|
|
US20090054488 |
Isomigrastatin Analogs In The Treatment Of Cancer
The present invention provides compounds having formula (I): (I) wherein n, R 1 -R 5 , R a -R b , Q, Y 1 and Y 2 are as defined herein; and additionally provides methods for the synthesis...
|
|
|
US20090048227 |
Substituted-1-Phthalazinamines As Vr- 1 Antagonists
Substituted piperidine compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either...
|
|
|
US20090036429 |
Hydroxypiperidine Derivatives and Uses Thereof
Chemical agents, such as derivatives of hydroxypiperidine moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially...
|
|
|
US20080312447 |
Process for Isolation of Crystalline Tacrolimus
The invention is a simple process for separation of tacrolimus and its analogues, ascomycin and tsucubamycin B and preparation of enough pure crystalline tacrolimus. The process takes advantage of...
|
|
|
US20080255345 |
IRNA Agents Targeting CCR5 Expressing Cells And Uses Thereof
The invention relates to iRNA agents that preferably include a modification that targets CC chemokine receptor 5 (CCR5). The invention also relates to methods of making and using such modified iRNA...
|
|
|
US20080194629 |
3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors
The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease...
|
|
|
US20080176841 |
EPOXIDE INHIBITORS OF CYSTEINE PROTEASES
Provided herein are novel epoxide inhibitors of cysteine proteases, compositions comprising the epoxide inhibitors, and packaged pharmaceuticals. Also provided are methods of inhibiting a...
|
|
|
US20080139556 |
FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF
A composition for binding FKBP proteins is disclosed, along with a method of treating conditions associated with neuronal degeneration, wherein said composition comprises a compound of formula I, ...
|
|
|
US20080114030 |
Diarymethyl and related compounds
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , Ar 1 , Ar 2 , E, a, b, c and z are as defined in the specification, or a pharmaceutically...
|
|
|
US20080081824 |
Substituted piperidines as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, Q 1 , R 1 , R 2 , R 3 , R 4 , R 5 ,...
|
|
|
US20080081813 |
Lipid Lowering Biphenylcarboxamides
Biphenylcarboxamide compounds of formula (I)
methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for...
|
|
|
US20080058379 |
Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
Glucopyranosyl-substituted benzonitrile derivatives as defined herein, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the...
|
|
|
US20080051575 |
PHOTOCHROMIC COMPOUNDS
Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other...
|
|
|
US20080045704 |
PHOTOCHROMIC COMPOUNDS
Various non-limiting embodiments disclosed herein relate generally to photochromic compounds, which may be thermally reversible or non-thermally reversible, and articles made therefrom. Other...
|