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US20090258881 |
ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives...
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US20090197915 |
SIGMA RECEPTOR COMPOUNDS
The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the...
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US20090192314 |
PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1YL)-XANTHINES
The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
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US20090171093 |
3'-Fluoro-5'-hydroxythalidomide and derivatives thereof
There are provided a novel 3′-fluoro-5′-hydroxythalidomide derivative and an optically active substance thereof A 3′-fluoro-5′-hydroxythalidomide derivative represented by the general...
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US20090170835 |
ISOINDOLINE DERIVATIVES
Provided is a novel isoindoline compound of the formula (I):
The compound is useful for anesthesia by inducing sedation in a mammal.
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US20090149500 |
POLYMORPHIC FORMS OF 3-(4-AMINO-1-OXO-1,3 DIHYDRO-ISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE
Polymorphic forms of 3-(amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and methods...
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US20090069379 |
DEUTERIUM-ENRICHED LENALIDOMIDE
The present application describes deuterium-enriched lenalidomide, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090069370 |
AZACYCLYLISOQUINOLINONE AND ISOINDOLINONE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS
The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
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US20090062343 |
Polymorphic forms of 3-(4-amino-1-oxo-1, 3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione are disclosed. Compositions comprising the polymorphic forms, methods of making the polymorphic forms and...
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US20090062251 |
Novel Compounds 002
Compounds of Formulae I, or pharmaceutically acceptable salts thereof:
wherein R 1 , R 2 and Y are as defined in the specification as well as salts and pharmaceutical compositions including the...
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US20090048219 |
ORGANIC NITRIC OXIDE DONOR SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE
The invention describes novel organic nitric oxide enhancing salts of nonsteroidal antiinflammatory drugs (NSAIDs) and novel compositions comprising at least one organic nitric oxide enhancing salt...
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US20090042866 |
Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control
The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for...
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US20090042854 |
Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists
The present invention is directed to certain hexahydrpyrrolidinone compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance...
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US20090030014 |
Indole Derivative Having Pgd2 Receptor Antagonist Activity
The present invention creates an indole derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a...
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US20090012055 |
Organic compounds
Novel substituted piperidines of the general formulae (I) and (II)
with the substituent definitions as explained in detail in the description are described. The compounds are suitable in...
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US20090004209 |
4'-O- substituted isoindoline derivatives and compositions comprising and methods of using the same
Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical...
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US20080188478 |
Compounds Useful In Therapy
Compounds of formula (I),
or pharmaceutically acceptable derivatives thereof, wherein:
R 1 represents a group selected from H, CF 3 , and C 1-6 alkyl (optionally substituted by C 1-6 ...
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US20080132496 |
CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
Substituted carboxylic acid amides of general formula
wherein A, B, and R 1 to R 5 are as defined herein, and the tautomers and the salts thereof, particularly the physiologically acceptable...
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US20080119520 |
FUSED BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS
Compounds of formula (I)
are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
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US20080119516 |
2-'4(Phenylamino)-Piperidin-1-Yl!-N-Phenyl-Acetamine Derivatives and Related Compounds as Neuropeptide Y5 (NPY5) Ligands for the Treatment of Obesity
It was an object of the present invention to provide novel compounds that are suitable in particular as active substances in medicaments, preferably in medicaments for the regulation of...
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US20080108809 |
BENZOTHIAZOLE DERIVATIVES WITH ACTIVITY AS ADENOSINE RECEPTOR LIGANDS
The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.
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US20080096876 |
PHENYLALKYNES
Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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US20080085921 |
Stereoisomeric Compounds And Methods For The Treatment Of Gastrointestinal And Central Nervous System Disorders
The subject invention provides stereoisomeric compounds of formula (X):
wherein the variables are as defined herein, and compositions for the safe and effective treatment of various...
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US20080070948 |
BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS
Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M 1 and/or M 4 receptor...
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US20080051432 |
PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS
This invention is directed to derivatives of piperidine-2,6-dione, or their organic or inorganic salts thereof, a methods of synthesis of these derivatives, and their application as active...
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US20080045517 |
6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I):
wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as...
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US20080009628 |
One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols
One-pot condensation-reduction methods for preparing substituted allylic alcohols as well as highly selective extractive methods to separate isomeric alcohols produced in the one-pot...
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