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US20090292125 |
PROCESS FOR PREPARING TETRAHYDROQUINOLINE DERIVATIVES
The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as...
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US20090291950 |
BICYCLIC HETEROARYL INHIBITORS OF PDE4
The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PD E4) for the treatment or prevention of inflammatory diseases and other diseases...
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US20090291940 |
AMINOPYRROLIDINE COMPOUND
Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for...
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US20090270367 |
SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS
The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a...
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US20090247745 |
AMINOQUINOLINE DERIVATIVES AND THEIR USE AS ADENOSINE A3 LIGANDS
The present invention relates to an adenosine A 3 receptor ligand of the general formula (I), within those preferably to the antagonists, including a salt, solvate or isomer (tautomer, desmotrop,...
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US20090233927 |
2-AMINOQUINOLINES
The present invention is concerned with 2-aminoquinoline derivatives of formula I
wherein R 1 and R 2 are as described herein and pharmaceutically acceptable salts thereof, pharmaceutical...
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US20090227628 |
2-AMINOQUINOLINES
The present invention is concerned with 2-aminoquinoline derivatives of formula I
wherein Z, R1, and Ar1 are as defined herein, pharmaceutical compositions containing them, methods for their...
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US20090227627 |
6-SUBSTITUTED-THIO-2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
The present invention is directed to 6-substituted-thio-2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild...
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US20090227626 |
NOVEL POLYQUINOLINE DERIVATIVES AND THERAPEUTIC USE THEREOF
The invention relates to compounds of general formula (I), to the process for the preparation thereof and to the use thereof as a therapeutic agent.
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US20090227584 |
2-AMINOQUINOLINE DERIVATIVES
The present invention is concerned with 2-aminoquinoline derivatives, in particular compounds of formula (I)
wherein R 1 and R 2 are as described herein, pharmaceutical compositions containing...
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US20090227583 |
2-AMINOQUINOLINES
The present invention relates to compounds of formula (I)
wherein A, R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein, pharmaceutical compositions containing them, and methods for their...
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US20090227580 |
Bicyclic derivatives as CETP inhibitors
The present invention relates to novel compounds of formula (I)
or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates...
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US20090227570 |
2-AMINOQUINOLINES
The present invention is concerned with 2-aminoquinoline derivatives of formula I
where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A, and n are as defined in the specification and claims, their use...
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US20090143381 |
MODULATORS OF ATP-BINDING CASSETTE-TRANSPORTERS
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including...
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US20090118329 |
Novel Substituted 2-Amino-4-Phenyldihydroquinolines, Processes for their Preparation, Pharmaceutical Compositions and Methods for Their Use
The invention relates to NHE-3 inhibitor compounds of formula I:
In which R1-R11 are more specifically defined herein. These substituted 2-amino-4-phenyl-dihydroquinolines are useful the...
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US20090118281 |
Amino Alcohol Derivatives And Their Use As Renin Inhibitor
The application relates to novel amino alcohols of the general formula (I) where R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 each have the definitions illustrated in detail in the description, to a...
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US20090099356 |
PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION
The present invention is directed to a process for preparing compounds of formula (I): wherein A, R 1 -R 3 , X, s, t, u, m and Z are defined herein, comprising the step of reacting a reagent of...
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US20090092624 |
Antiinfective Flavononol Compounds and Methods of Use Thereof
The present invention relates in part to antiinfective flavononol compounds represented by formula I:
Another aspect of the invention is a method for treating an infection in a subject by...
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US20090088451 |
QUINOLINES
The present invention relates to 2-aminoquinolines of formula I
wherein R 1 , R 2 and R 3 are as defined in the specification, as 5-HT 5A receptor antagonists, their manufacture,...
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US20090082396 |
5-ARYL-4,5-DIHYDRO-(1H)-PYRAZOLINES AS CANNABINOID CB1 RECEPTOR AGONISTS
The invention is directed to 5-(hetero)aryl-4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB 1 receptor agonists, to pharmaceutical compositions comprising these compounds, to...
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US20090018133 |
Novel Adamantane Derivatives
The invention provides compounds of formula (I), in which m, A, R 1 and Ar have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing...
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US20090012061 |
A Method of Treating Cancer
The present invention relates to a method of treating cellular proliferative diseases, in particular cancer, which comprises administering a modulator of the activity of the mitotic kinesin KSP,...
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US20080318959 |
Compounds that Inhibit Hiv Particle Formation
The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and...
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US20080306110 |
Alkylnitrile Quinolines as Nk-3 Receptor Ligands
Compounds of Formula I
wherein R 1 , A, R 2 , R 3 , R 4 , R 5 , n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical...
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US20080300236 |
QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful...
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US20080293765 |
Alkylsulphonamide Quinolines
Compounds of Formula I
wherein R 1 , A, R 2 , R 3 , R 4 , R 5 , R 8 , n, m, q and r are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical...
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US20080200533 |
Drug or Pharmaceutical Compounds and a Preparation Thereof
The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rate of absorption has become a big challenge in day to day...
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US20080200459 |
TETRAHYDROQUINOLINE CANNABINOID RECEPTOR MODULATORS
The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional...
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US20080194625 |
TETRAHYDROQUINOLINE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
The invention provides for compounds of formula I
wherein the substitutents are as described herein.
Further provided are methods of using such compounds for the treatment of...
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US20080194624 |
2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
The present invention is directed to 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The...
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US20080188462 |
Quinoline Derivatives And Uses Thereof
This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQ R and CQ S malaria parasites. RCQs are hybrid molecules,...
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US20080171765 |
Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents
New aniline or phenol N-mustards linked to DNA-affinity carriers (such as 9-anilinoacridines, acridines and quinolines), aminobenzamides or aminophenol ethers by a urea, carbamic acid, carbanic...
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US20080153799 |
Novel Quinoline-Carbaxamides as Jak3 Kinase Modulators
The present invention relates to novel compounds which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them. A compound of formula (I) or a...
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US20080146567 |
QUINOLINES
The present invention relates to 2-Aminoquinoline derivatives of general formula I
and pharmaceutically-acceptable acid-addition salts thereof, wherein R 1 , R 2 and X are as defined in the...
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US20080125424 |
Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function...
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US20080119515 |
Heterocyclic Kinase Inhibitors: Methods of Use and Synthesis
Inhibitors of kinases, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful...
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US20080096884 |
4-Aminoquinoline-3-Carboxamide Derivatives as Pde4 Inhibitors
Compounds of formula (I)
or pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type IV (PDE4) and are of use in the treatment of inflammatory and/or allergic diseases.
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US20080085901 |
Heteroaryl Substituted Quinolin-4-Ylamine Analogues
Heteroaryl substituted quinolin-4-ylamine analogues of Formula I are provided.
Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are...
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US20080081907 |
2-AMINOQUINOLINE DERIVATIVES
The present invention relates to compounds of the formula (I):
or pharmaceutically acceptable salts thereof,
wherein X, Y, Ar 1 , and Ar 2 are as defined in the specification.
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US20080081822 |
Compounds which Modulate the CB2 Receptor
Compounds of formula (I)
are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating...
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US20080076773 |
Aminopiperidines as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes
The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or...
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US20080064697 |
PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES
This invention is concerned with compounds of the formula
wherein A, R 1 to R 5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the...
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US20080058372 |
Synthesis and antimicrobial activity of novel dicationic ''reversed amidines''
The present invention relates to novel 2,5-bis{[alkyl(or aryl)imino]aminophenyl}furans and thiophenes of the general formula
in which R 1 , R 2 , R 3 and R 4 are each independently selected...
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US20080051423 |
NITROGEN HETEROCYCLE BIARYLS FOR OSTEOPOROSIS AND OTHER DISEASES
Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration...
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US20080045568 |
Novel high affinity quinoline-based kinase ligands
Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and...
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US20080039464 |
Compounds Which Modulate The CB2 Receptor
Compound of formula (I)
are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating...
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US20080021062 |
Alkylsulphonamide Quinolines
Compounds of Formula II
wherein R 1 , A, R 2 , R 3 , R 4 , R 5 , R 8 , n, m and q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical...
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