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US20090298816 |
PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE
Compounds of formula (I), wherein the substituents are as defined in claim 1 , and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can...
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US20090298826 |
NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING (SUBSTITUTED PHENYL OR SUBSTITUTED HETEROCYCLIC) CARBONYLOXY LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS
The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator.
The R 1 represents a hydrogen atom or a lower alkyl group; R 2 represents...
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US20090291956 |
SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-b][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME
The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor...
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US20090291948 |
SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE
Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the...
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US20090286776 |
HEXENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF
Compounds of the formula (I): in which R, R 1 , R 2 and R 3 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical...
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US20090270391 |
THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY
An objective of the present invention is to provide compounds having antitumor activity. According to the present invention, there is provided compounds represented by formula (I) and...
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US20090247574 |
3-AMINO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF METABOLIC DISORDERS
The present invention provides novel compounds represented by the general formula (I):
their pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are...
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US20090176829 |
BICYCLIC HETEROARYL COMPOUNDS AS PDE10 INHIBITORS
The invention pertains to tricyclic heteraaryi compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE...
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US20090165858 |
Dye-sensitized photoelectric conversion device
The present invention relates to a photoelectric conversion device sensitized by supporting a methine based dye represented by the following formula (1):
(in the above formula, n represents an...
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US20090156594 |
HETEROCYCLIC KINASE MODULATORS
The present disclosure provides heterocyclic protein kinase modulators and methods of using these compounds to treat diseases mediated by kinase activity.
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US20090149491 |
CARBOCYCLIC OXIME HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS
The present invention discloses compounds of formula I, II, or pharmaceutically acceptable salts, esters, or prodrugs thereof:
which inhibit serine protease activity, particularly the activity...
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US20090128009 |
Materials for organic electroluminescence devices
The present invention relates to novel materials which can be used in organic electronic devices, in particular electroluminescent devices, and are certain derivatives of fused aromatic systems.
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US20090124804 |
Enantioselective process for preparing a substituted alkanoic acid
The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
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US20090124625 |
NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS
The present invention relates to novel compounds of formula (I) wherein W, n, X and W′ are defined in the description; invention compounds are modulators of metabotropic glutamate...
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US20090105266 |
Organic compounds
The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the...
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US20090105232 |
CYCLOHEXYL OR PIPERIDINYL CARBOXAMIDE ANTIBIOTIC DERIVATIVES
The invention relates to antibiotic cyclohexyl or piperidinyl carboximide derivatives of formula (I)
wherein
R 1 represents hydrogen, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, cyano...
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US20090105278 |
Selective inhibitors of human corticosteroid syntheses
The invention relates to compounds for selectively inhibiting human corticosteroid syntheses CYP11B1 and CYP11B2, to the production thereof and to their use for treating hypercortisolism and...
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US20090105271 |
PYRIDYL SULFONAMIDES AS MODULATORS OF ION CHANNELS
The present invention relates to pyridyl sulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds...
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US20090091252 |
BINAPHTHYL COMPOUND AND ORGANIC LIGHT EMITTING ELEMENT USING THE SAME
The present invention provides a novel binaphthyl compound and an organic light emitting element having a good light emitting efficiency and a high durability at a low driving voltage. An organic...
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US20090088452 |
Indole Orexin Receptor Antagonists
The present invention is directed to substituted indole compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric...
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US20090076004 |
Indoles Useful in the Treatment of Inflammation
There is provided compounds of formula (I), wherein X 1 , Q, T, Y, R 1 , R 2 , R 3 , R 4 and R 5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which...
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US20090075985 |
ARYL SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE
Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the...
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US20090076076 |
INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF
The present invention relates to semicarbazone or thiosemicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as...
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US20090069338 |
Method for predicting skin sensitizing activity of compounds
Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions...
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US20090069373 |
Quinoline Acids
This invention relates generally to quinoline-based modulators of Liver X receptors (LXRs) and related methods.
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US20090062279 |
HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS, IN PARTICULAR AS ANTI-ALZHEIMER AGENTS
The invention is related to compound which comprises at least one radical C═Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one...
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US20090054448 |
Amino Acid Derivatives as Histone Deacetylase (HDAC) Inhibitors
The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts or stereoisomers thereof. The compounds of the present invention are inhibitors of histone...
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US20090054402 |
7-SUBSTITUTED INDOLE MCL-1 INHIBITORS
Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein...
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US20090048228 |
Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors
The present invention relates to compounds of formula I:
or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the...
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US20090048298 |
Novel acetyl-CoA Carboxylase (ACC) Inhibitors and their use in Diabetes, Obesity and Metabolic Syndrome
The present invention relates to compounds of formula (I)
which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes,...
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US20090048294 |
HIF-1 ALPHA ACTIVATING AGENT
The present invention relates to a HIF-1α activator containing clioquinol and its derivatives as an active ingredient. Clioquinol and its derivatives of the invention inhibit HIF-1α...
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US20090018163 |
Substituted Heterocyclic Ethers and Their Use in CNS Disorders
The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.
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US20090012074 |
Arylsulfonylmethyl or arylsulfonamide substituted aromatic compounds suitable for treating disorders that respond to modulation of the Dopamine D3 receptor
The present invention relates to aromatic compounds of the formula I
wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R a and...
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US20080308770 |
MONO AND BIS-ESTER DERIVATIVES OF PYRIDINIUM AND QUINOLINIUM COMPOUNDS AS ENVIRONMENTALLY FRIENDLY CORROSION INHIBITORS
A quaternary nitrogen-containing corrosion inhibitor of formula
wherein
is an aromatic, nitrogen-containing ring of 5 to 14 ring atoms, optionally containing an additional N, O or S ring atom...
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US20080306162 |
Treatment of Inflammatory Disorders and Pain
A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines,...
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US20080293764 |
LPA RECEPTOR ANTAGONIST
A compound of the general formula (I):
(wherein the symbols are as defined in the description), or a non-toxic salt thereof. This compound engages in LPA receptor bonding and antagonism and...
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US20080287490 |
Bis-pyridino containing compounds for the use in the treatment of CNS pathologies
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release....
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US20080280849 |
Synergic Combinations Comprising a Quinoline Compound and Other Hiv Infection Therapeutic Agents
The invention relates to a combination comprising a quinoline compound or its sail, according to general formula (I) and at least one HIV infection therapeutic agent selected from the group...
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US20080280769 |
SELECTIVE AND DUAL-ACTION P53/MDM2/MDM4 ANTAGONISTS
A fragment-based strategy, involving “multicomponent reaction chemistry” (MCR), can identify novel chemotypes that disrupt the p53/MDM2 or p53/MDM4 complex employs. This approach uses high...
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US20080275081 |
Novel thrombomodulin expression promoters
It is intended to provide a novel pharmaceutical effect of HMG-COA reductase inhibitors, in particular, (+)-(3R, 5S, 6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-di hydroxy-6-heptenoic...
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US20080275061 |
METHOD FOR CONTROLLING PARTICULAR INSECT PESTS BY APPLYING ANTHRANILAMIDE COMPOUNDS
This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an...
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US20080242698 |
Organic Compounds
The invention relates to novel diamines of the formula
in which all variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their...
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US20080221157 |
Amide Derivatives as Inhibitors of Histone Deacetylase
The present invention relates to ketone derivatives that are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are useful for treating cellular proliferative...
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US20080214822 |
Process For the Preparation of a Leukotriene Antagonist
The present invention relates to a novel process for the preparation of montelukast sodium, a compound of Formula (1b) and precursors thereof. The invention further concerns the free acid of this...
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US20080214455 |
Novel Chemical Compounds
This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with hYAK3 activity.
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US20080207686 |
Peptide Deformylase (Pdf) Inhibitors 4
The present invention relates to compounds of formula (I).
These compounds are a novel type of peptide deformylase (PDF) inhibitors, and are therefore of great interest especially as new...
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US20080207608 |
2-Propene-1-Ones As Hsp 70 Inducers
The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically...
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US20080207635 |
Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders
The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.
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US20080207588 |
Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines
The present invention is concerned with certain novel derivatives of Formula I,
wherein R, R 1 to R 10 are as described in the specification, and at least one CR 5 R 6 , or CR 7 R 8 , or CR 9...
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US20080194584 |
Nitrogen Heteroaromatic Compounds Which Bind To The Active Site Of Protein Kinase Enzymes
Compounds of Formula (I)
or pharmaceutically acceptable salts, hydrates, solvates, geometrical isomers, tautomers, optical isomers, or prodrug forms thereof, wherein X, Y, Z, R1, R2, R3 and R4...
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