|
Match
|
Document |
Document Title |
|
|
US20090306130 |
NOVEL TETRAHYDRO-ISOQUINOLINES
The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic...
|
|
|
US20090298869 |
Crystalline pharmaceutical and methods of preparation and use thereof
Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses...
|
|
|
US20090291949 |
SUBSTITUTE ISOQUINOLINES USEFUL IN THE TREATMENT OF DISEASES SUCH AS CANCER AND ATHEROSCLEROSIS
A compound of Formula (I):
or a salt or solvate thereof, wherein:
One of R 1 and R 2 is H and the other represents —NHCONHR 4 , wherein R 4 represents
a phenyl or naphthyl...
|
|
|
US20090291978 |
Enzyme Inhibitors
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers, wherein R 1 is a carboxylic acid group (—COOH), or an ester...
|
|
|
US20090275607 |
Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof
A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain...
|
|
|
US20090270414 |
2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
The invention relates to novel tetrahydro-1H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects...
|
|
|
US20090264462 |
KAPPA OPIOID RECEPTOR LIGANDS
Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease...
|
|
|
US20090233930 |
Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
|
|
|
US20090221829 |
3,4-Dihydroisoquinolinium Salt Derivatives
The present invention relates to 3,4-dihydroisoquinolinium salt derivatives. More specifically, the present invention relates to 3,4-dihydroisoquinolinium salt derivatives of the following chemical...
|
|
|
US20090203710 |
Novel piperidine derivative
Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty...
|
|
|
US20090171090 |
METHOD FOR PRODUCING BENZAZEPINONE
It is an object of the present invention to provide 2-iminocarboxylic acid derivatives, and a practically suitable industrial method for producing benzazepinones in a short process under mild...
|
|
|
US20090163718 |
PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES
The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula
wherein R 2 , R 3 and R 4 are each independently selected from the...
|
|
|
US20090143372 |
CHEMICAL COMPOUNDS
The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I:
where R1, R2, R3, U and V are defined below and to...
|
|
|
US20090126125 |
STYRYL TETRAHYDROQUINOLINIUM THIOL/DISULFIDE DYE COMPOUND AND METHOD FOR LIGHTENING KERATIN MATERIALS USING THE SAME
The present disclosure relates to the dyeing of keratin materials using thiol/disulfide styryl tetrahydroquinolinium fluorescent dyes. Disclosed herein is a dye composition comprising a...
|
|
|
US20090105231 |
AMIDE DERIVATIVES AS ROCK INHIBITORS
This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical...
|
|
|
US20090099221 |
PYRIDYL-AND PYRIMIDINYL-SUBSTITUTED PYRROLE-, THIOPHENE-AND FURANE-DERIVATIVES AS KINASE INHIBITORS
The present invention provides compounds of the formula (I), or the pharmaceutically acceptable salts thereof, wherein G, W, R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the specification....
|
|
|
US20090099158 |
TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
Certain substituted tetrahydroisoquinoline compounds are histamine H 3 receptor modulators useful in the treatment of histamine H 3 receptor-mediated diseases.
|
|
|
US20090075978 |
SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS
The present invention relates to substituted propiolic acid amides, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.
|
|
|
US20090018145 |
Compositions and their use as anti-tumor agents
The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of...
|
|
|
US20090012117 |
Bicyclic derivatives as modulators of ion channels
Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
|
|
|
US20080318923 |
1,3-Dihydro-2H-Indole-2-One Compound and Pyrrolidine-2-One Compound Fused With Aromatic Heterocycle
It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug...
|
|
|
US20080312445 |
Novel Crystalline Forms Of Nelfinavir Mesylate
The present invention provides novel crystalline forms of Nelfinavir mesylate, Form-A, Form-B, Form-C, Form-D and the process for their preparation without the use of any special equipment such as...
|
|
|
US20080293684 |
Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors
The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of...
|
|
|
US20080293718 |
Novel 2-Amino-Imidazole-4-One Compounds and Their Use in the Manufacture of a Medicament to Be Used in the Treatment of Cognitive Impairment, Alzheimer's Disease, Neurodegeneration and Dementia
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a...
|
|
|
US20080287489 |
Ophthalmic compositions for treating ocular hypertension
This invention relates to potent potassium channel blocker compounds of Formula I or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraocular...
|
|
|
US20080269197 |
AROMATIC SULFONES AND THEIR MEDICAL USE
The invention provides compounds of formula (I):
wherein A and B represent the groups —(CH 2 ) m — and —(CH 2 ) n — respectively; R 1 represents hydrogen or C 1-6 alkyl; R 2 represents...
|
|
|
US20080262231 |
Processes for Preparing Morphinans and Intermediates Thereof
The present invention is directed to processes for the synthesis of morphinans. In particular, a process for cyclizing a β,γ-bicyclic ketone compound to form a nordihydrothebainone product using...
|
|
|
US20080242861 |
Synthesis of amino-protected cyclohexane-1,4-diyldimethanamine and its derivatives
This invention relates to methods of preparing the compounds of formula (V):
Each variable in this formula is defined in the specification.
|
|
|
US20080234274 |
Novel Compounds
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F,...
|
|
|
US20080234254 |
Inhibitors of Histone Deacetylase
The present invention relates to a benzamide derivative comprising a head, spacer and cap group wherein the spacer includes a benzene ring substituted with an additional spacer and wherein the...
|
|
|
US20080221086 |
Novel Inhibitors of Glutaminyl Cyclase
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy,
or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all...
|
|
|
US20080200501 |
NOVEL CANNABINOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION
The present invention relates to novel cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptor modulators, and uses thereof for treating diseases,...
|
|
|
US20080176849 |
DEACETYLASE INHIBITORS
The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
|
|
|
US20080176896 |
Modulators of cellular adhesion
The present invention provides compounds having formula (I):
and pharmaceutically acceptable derivatives thereof, wherein R 1 -R 4 , n, p, A, B, D, E, L and AR 1 are as described...
|
|
|
US20080166332 |
Methods of Treatment of Amyloidosis Using Subsituted Ethanolcyclicamine Aspartyl Protease Inhibitors
The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and...
|
|
|
US20080119511 |
Benzo-fused compounds for use in treating metabolic disorders
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:
where the definitions of the variables
...
|
|
|
US20080119459 |
Trifluoromethylbenzamide Derivatives and Therapeutic Uses Thereof
Compounds of the formula (I), in which the radicals R 1 to R 3 and AR are as defined in the description, processes for the preparation thereof, the use thereof in the treatment of cardiovascular...
|
|
|
US20080113975 |
THIOUREA COMPOUNDS
This invention relates to thiourea compounds of formula (I) shown below:
Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus...
|
|
|
US20080108653 |
TRIPEPTIDYL PEPTIDASE INHIBITORS
The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as...
|
|
|
US20080096883 |
Trifluoromethyl substituted benzamides as kinase inhibitors
The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals,...
|
|
|
US20080096869 |
ADAMANTYL ACETAMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS
the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R 1 and R 2 each independently...
|
|
|
US20080096916 |
Drugs And Prodrugs Useful The Treatment Of Energy Balance In Ruminants
The use of a compound of formula (I) an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug, in the manufacture of a...
|
|
|
US20080090816 |
ANTI-INFECTIVE BIARYL COMPOUNDS
Compounds represented by the formula
where R 1 , R 2 , R 3 , R 4 , R 5 , and Q are as defined herein, exhibit activity against infectious pathogens.
|
|
|
US20080085893 |
MATRIX METALLOPROTEASE INHIBITORS
The present invention relates to compounds of Formula I,
wherein R1, R2, R3, R4, R5, R6, and R7 are defined in the specification. In addition, the present invention relates to methods treating...
|
|
|
US20080070935 |
Isoquinoline, Quinazoline and Phthalazine Derivatives
Disclosed are compounds and pharmaceutically acceptable salts of Formula I
wherein R 0 , R 5 , R 6 , R 7 , n, Q 1 -Q 5 , Y, and X 1 -X 3 are as defined herein. Compounds of Formula I are...
|
|
|
US20080021031 |
SELENOPHENE COMPOUNDS
This invention relates to selenophene compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor...
|