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US20090286772 2-(Phenyl or Heterocyclic)-1H-Phenanthro[9,10-D]Imidazoles  
The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme...
US20090281094 Derivatives of 1--4-methylpiperazine, synthesis process and uses thereof  
The present invention concerns pyrrole compounds, derivatives of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}- 4-methylpiperazine (BM212). The invention concerns the use of the...
US20090281084 PHENYL-1,2,4-OXADIAZOLONE DERIVATIVES WITH PHENYL GROUP, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS  
The invention relates to phenyl-1,2,4-oxadiazolone derivatives with phenyl group and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist...
US20090258857 CHEMICAL COMPOUNDS  
The present invention encompasses compounds of general formula (1) wherein R 1 , M 1 , L 1 and Q are defined as in claim 1 , which are suitable for the treatment of diseases characterised by...
US20090239854 Tetracyclic compounds  
This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles....
US20090227571 Androgen Receptor Modulator Compounds and Methods  
Provided herein are compounds that bind to androgen receptors and modulate the activity and/or the amount of androgen receptors and to methods for making and using such compounds. Also provided are...
US20090216013 Heteroaryl-Ureas and Their Use as Glucokinase Activators  
This invention relates to compounds of formula (I) which are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where...
US20090203903 Thiazolyl mglur5 antagonists and methods for their use  
The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or...
US20090192307 INHIBITORS OF PROTEIN KINASES  
The present invention is directed to a compound having the formula wherein R 1 , R 2 , R 3 , R 4 , G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of...
US20090181956 Hydrazide Compound and Pesticidal Use of the Same  
A hydrazide compound represented by the formula (1): has excellent pesticidal activity.
US20090163708 PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS  
This invention relates to a method of preparing mesylate salts of compounds that inhibit IL-12, IL-23 and/or IL-27 production.
US20090163482 TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR  
This invention is directed to a compound of formula (I), as defined herein, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing a compound of formula (I) a...
US20090163467 New compounds  
The present invention encompasses compounds of general formula (1) wherein R 1 , R 2 , R 4 , X, m, n and p are defined as in claim 1 , which are suitable for the treatment of diseases...
US20090156572 Nitrogen-containing heterocyclic compound and use thereof  
The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B is an aromatic ring...
US20090156571 BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1  
The present invention discloses novel compounds of Formula I: possessing 11 β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention...
US20090143371 ISOXAZOLE-PYRIDINE DERIVATIVES  
The present invention is concerned with isoxazole-pyridine derivatives of formula I wherein X, R 1 to R 6 are as described herein. The compounds are active on the GABA A α5 receptor binding...
US20090143357 HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHK1  
Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as...
US20090137572 2-substituted-4-heteroaryl-pyrimidines useful for the treatment of proliferative disorders  
The present invention relates to selected substituted pyrimidines their preparation, pharmaceutical compositions containing them and their use as inhibitors of one or more protein kinases, and...
US20090093455 QUINOLONE ANALOGS AND METHODS RELATED THERETO  
The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also...
US20090075979 CETP Inhibitors  
Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing...
US20090062531 Arylacetate Derivatives Having Isoxazole Skeleton  
A compound of the formula (I): pharmaceutically acceptable salt or solvate thereof, wherein Y is a group of the formula: wherein Ring A is optionally substituted aryl or optionally...
US20090054642 NOVEL BENZAMIDINE DERIVATIVE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME  
The present invention relates to a novel benzamidine derivative, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The benzamidine derivative of the...
US20090048228 Heterocycle Derivatives As Histone Deacetylase (Hdac) Inhibitors  
The present invention relates to compounds of formula I: or pharmaceutically acceptable salts or tautomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the...
US20090042866 Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control  
The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for...
US20090036434 Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto  
The present invention relates to certain substituted aryl and heteroaryl derivative of Formula (I) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in...
US20090029955 Pyridothienopyrimidine Derivatives  
A pyridothienopyrimidine derivative of formula (I), or the pharmaceutically acceptable salts or N-oxides thereof are disclosed, as well as pharmaceutical compositions comprising said compounds...
US20090018123 Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation  
The present invention concerns recombinant DNA's comprising cDNA of genomic RNA of a Salmonidae alphavirus preceded by a spacer sequence, under the control of a suitable promoter. Said recombinant...
US20090018122 Aryloxy and Arylalkyleneoxy Substituted Imidazoquinolines  
Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods...
US20090005370 ISOXAZOLE-IMIDAZOLE DERIVATIVES  
The present invention is concerned isoxazole-imidazole derivatives having affinity and selectivity for GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing...
US20090005355 Piperidine Compound and Process for Preparing the Same  
The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted...
US20080306055 Heterocyclic Mchr1 Antagonists And Their Use In Therapy  
Compounds of formula I depicted below, pharmaceutical compositions containing them, processes for preparing the compounds, and their use in the treatment of obesity, type II diabetes, metabolic...
US20080280890 HYDROXYLAMINE COMPOUNDS AND METHODS OF THEIR USE  
The present disclosure provides compounds that include hydroxylamines of formula I or II, pharmaceutical compositions, and methods for their use. The methods utilize hydroxylamine compounds and/or...
US20080275021 PYRROLIDINE DERIVATIVES AS DUAL NK1/NK3 RECEPTOR ANTAGONISTS  
The invention relates to pyrrolidine derivatives of formula wherein R 1 , R 2 , R 3 , n, and o are defined in the specification and to pharmaceutically active acid-addition salts thereof....
US20080261944 Indole Derivatives as Antiviral Agents  
The present invention relates to indole compounds of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , A, E and X are as defined herein, and pharmaceutically acceptable salts thereof, useful in the...
US20080255105 Biphenyl Derivatives and Their Use in Treating Hepatitis C  
A compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein: R 1 is a C 1 -C 6 alkyl group or a moiety -A 1 , -L 1 -A 1 , -A 1 -A 1 ′, -L 1...
US20080221088 3,4-Substituted Thiazoles as Ampk Activators  
The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5′-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such...
US20080207607 Heterotricyclic metalloprotease inhibitors  
The present invention relates generally to azatriocyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present...
US20080207606 Novel heterocycles  
Novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts,...
US20080188460 Tricyclic compounds, a process for their preparation and pharmaceutical compositions containing them  
Compounds of formula (I): wherein A represents a 5, 6 or 7-membered (hetero)aromatic or non-aromatic ring, n and n′ represent 0, 1 or 2 X represents an alkylene chain as defined in the...
US20080167297 Pyrimidine Derivatives for Use as Anticancer Agents  
A compound of formula (I), wherein the substituents are as defined in the text for use in inhibiting insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
US20080167288 Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases  
The present invention provides compounds of the formula: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof,...
US20080161278 2-Azetidinyl-4-(1H-Pyrazol-3-Ylamino) Pyrimidines as Inhibitors of Insulin-Like Growth Factor-1 Receptor Activity  
A compound of formula (I): wherein the substituents are as defined in the text for use in inhibiting insulin-like growth factor 1 receptor activity in a warm blooded animal such as man.
US20080160028 SUBSTITUTED PYRIDO [3', 2': 4, 5] THIENO [3, 2-D] PYRIMIDINES AND PYRIDO [3', 2': 4, 5] FURO [3, 2-D] PYRIMIDINES USED AS INHIBITORS OF THE PDE-4 AND/OR THE RELEASE OF TNF-ALPHA  
The invention relates to compounds of general formula (I); 1a, 1 b, 1 c and 1 d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said...
US20080146546 Bicyclic and Tricyclic Heteroaromatic Compounds  
Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X 1 , Y and Z are as defined herein. These compounds bind with high selectivity and/or...
US20080132497 Novel Heterocycles  
This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said...
US20080132487 5-AMINOPYRAZOLE DERIVATIVES AS PESTICIDAL COMPOUNDS  
The invention relates to 5-Aminopyrazole derivatives of formula (I) or salts thereof, a process for their preparation, to compositions thereof and to their use for the control of pests, including...
US20080125418 Benzimidazole derivatives and their use as kdr kinase protein inhibitors  
The invention discloses and claims benzimidazole compounds of formula (I): wherein X is C—R2; Y is C—R2 or C—R3; W and Z are each C—R3; R1 is an optionally substituted aryl, heteroaryl...
US20080125417 CERTAIN PYRIMIDINES, METHOD OF MAKING, AND METHOD OF USE THEREOF  
At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof, is described...
US20080125416 Sigma Receptor Inhibitors  
The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions...
US20080125410 1H-Pyrimido[4,5-b]indole derivatives, their preparation and therapeutic use  
The invention concerns compounds of general formula (I): Wherein n, X, Y, R 1 and R 2 are as defined herein. The invention also concerns a method for preparing the compounds and their...
Matches 1 - 50 out of 64 1 2 >