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US20090291945 |
CYSTEINE PROTEASE INHIBITORS
To provide a compound having an excellent cysteine protease inhibitory effect, and to provide a drug for treatment or prevention of the disease selected from the group consisting of osteoporosis,...
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US20090203681 |
NOVEL N-(2-AMINO-PHENYL)-AMIDE DERIVATIVES
The present invention provides novel compounds of the general formula (I)
and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments...
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US20090181943 |
Inhibitors of Histone Deacetylase
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I)
and N-oxides,...
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US20080306054 |
Pharmaceutical Compounds
The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I):
or salts, tautomers, solvates and N-oxides thereof; wherein R 1 is hydroxy or hydrogen;...
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US20080255105 |
Biphenyl Derivatives and Their Use in Treating Hepatitis C
A compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein: R 1 is a C 1 -C 6 alkyl group or a moiety -A 1 , -L 1 -A 1 , -A 1 -A 1 ′, -L 1...
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US20080194536 |
Cyanoarylamines
The present invention relates to a compound represented by the following formula:
(I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or a...
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US20080176838 |
Dpp-IV Inhibitors
The invention relates to compounds of formula (I)
wherein R 1-9 , Z, n, X, A, and R b have the meaning as cited in the description and the claims. Said compounds are useful as DPP-IV...
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US20080113976 |
N-ALKYLATED DIAMINOPROPANE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis,...
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US20080108595 |
INHIBITORS OF CATHEPSIN S
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at...
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US20080090782 |
Materials and methods to potentiate cancer treatment
Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA...
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US20080064687 |
Novel thiourea derivatives and the pharmaceutical compositions containing the same
The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the...
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US20080004258 |
BUTYL AND BUTYNYL BENZYL AMINE COMPOUNDS
Certain substituted butyl and butynyl benzyl amine compounds are histamine H 3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H 3 receptor- and/or...
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