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US20090281118 |
Selective Ligands for the Neuronal Nicotinic Receptors and Uses Thereof
The present application describes selective ligands of formula (I)
for neuronal nicotinic receptors (NNRs), more specifically for the α4β2 NNR subtype, compositions thereof, and methods of...
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US20090281069 |
ORGANIC COMPOUNDS
The present invention relates to compounds of the formula;
and their use in therapy.
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US20090270421 |
INHIBITORS OF FATTY ACID AMIDE HYDROLASE
Potent inhibitors of fatty acid amide hydrolase (FAAH) are constructed having K i 's below 200 pM and activities 10 2 -10 3 times more potent than the corresponding trifluoromethyl ketones. The...
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US20090270417 |
Organic Compounds
Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially...
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US20090247550 |
3-TRIFLUOROMETHYL-PYRAZINE-2-CARBOXYLIC ACID AMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS
The present invention relates to pyrazine derivatives of the formula
and pharmaceutically acceptable salts thereof, wherein R 1 to R 8 are as defined in the description and claims for use as...
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US20090192172 |
2-Alkyl-Cycloalk(en)yl-Carboxamides
Novel 2-alkylcycloalk(en)ylcarboxamides of the formula (I)
in which
X, s, R 1 , L, R 2 and A are as defined in the description,
a plurality of processes for preparing these compounds...
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US20090156616 |
THERAPEUTIC AGENTS
The present invention relates to compounds of formula (I) and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for...
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US20090143409 |
3-PYRIDINECARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS
The present invention relates to a method of raising HDL cholesterol comprising administering to a patient in need thereof a compound of the formula
wherein A, G, R 1 to R 8 and R 17 are as...
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US20090076032 |
Derivatives of 18Beta-Glycyrrhetinic Acid
The present invention relates to novel derivatives of 18β-glycyrrhetinic acid and methods of synthesising the derivatives. Also included within the scope of the present invention are...
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US20090076031 |
DEUTERIUM-ENRICHED BORTEZOMIB
The present application describes deuterium-enriched bortezomib, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20090022688 |
INHIBITORS OF SERINE PROTEASE, PARTICULARLY HCV NS3-NS4A PROTEASE
The present invention relates to compounds of formula I:
or a pharmaceutically acceptable salt, or mixtures thereof, that inhibit serine protease activity, particularly the activity of hepatitis...
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US20080280873 |
Biaryl Substituted Pyrazinones as Sodium Channel Blockers
Biaryl substituted pyrazinone compounds represented by Formula I, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds,...
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US20080262230 |
Benzyloxypropylamine Derivative
Disclosed is a novel benzyloxypropylamine derivative having an excellent tachykinin receptor antagonistic effect. This compound shows a good transfer into the blood and a long blood half-life in...
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US20080207638 |
Compounds
The present invention relates to compounds of formula (I),
and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various...
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US20080200476 |
ALAPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
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US20080194585 |
Fungicidal Pyrazine Derivatives
Compounds of Formula 1, and their N-oxides and agriculturally suitable salts, are disclosed as useful as fungicides (INSERT FORMULA I HERE) wherein R 1 is NR 4 R 5 , N═CR 19 R 21 , OR 6 , G 1 ...
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US20080176863 |
CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS
The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
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US20080161325 |
1, 3, Diamino-2-Hydroxypropane Pro-Drug Derivatives
The present invention relates to compounds of formula (AA) (I) and (X):
useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the...
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US20080153843 |
SUBSTITUTED SULFONAMIDE COMPOUNDS
Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment...
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US20080132507 |
Hydrazide Derivatives
A compound represented by the following general formula (1) or a salt thereof or a hydrate of the foregoing is safe while exhibiting suitable physicochemical stability, and is useful as therapeutic...
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US20080108632 |
HCV PROTEASE INHIBITORS
This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.
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US20080064872 |
HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY
A novel compound having agonist activity at the S 1 P 3 receptor which is represented by the formula I
wherein
X is selected from the group consisting of CR 3 , N and NO; Y is...
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US20080064708 |
Substituted Pyrazinecarboxylic Acid Anilde Dervatives Or Salts Thereof, Intermediates Of The Same, Pesticides for Agricultural And Horticultural Use, and Usage Thereof
Substituted pyrazinecarboxylic acid anilide derivatives represented by the general formula (I) or salts thereof; intermediates of them; pesticides (such as insecticides and acaricides) for...
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US20080051578 |
SUBSTITUTED BIARYLS, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS
The present invention relates to compounds of general formula (I)
wherein A, B, L, R 1 , R 2 , R 3a and R 3b are defined as in the specification, the tautomers, the enantiomers, the...
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US20080045530 |
Organic Compounds and Their Uses
The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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US20080004290 |
Anti-Cancer Agents
The present invention provides compounds having the structural formula (I):
and methods for the treatment of cancer using compounds of formula (I).
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