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US20090298841 |
QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS
The present invention relates to novel quinoline compounds having pharmacological activity, to processes for their preparation, to compositions containing them and to their use in the treatment of...
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US20090281109 |
CYSTEINE AND CYSTINE PRODRUGS TO TREAT SCHIZOPHRENIA AND REDUCE DRUG CRAVINGS
The present invention provides cysteine and cystine prodrugs for the treatment of schizophrenia and drug addiction. The invention further encompasses pharmaceutical compositions containing prodrugs...
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US20090270379 |
QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
The present invention is directed to quinolone derivatives, useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and...
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US20090264435 |
Novel Aryl- and Heteroarylpiperazines
Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these...
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US20090258881 |
ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT
The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives...
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US20090221562 |
NOVEL OPIOID ANTAGONISTS
Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.
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US20090221548 |
MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I
wherein R 1a , R 1b , R 1c , Q,...
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US20090216015 |
Base Stable Ionic Liquids
The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of...
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US20090209523 |
Pyrrolo[1,2-A] Pyrazin-1(2H)-One and Pyrrolo[1,2-D][1,2,4]Triazin-1(2H)-One Derivatives as Inhibitors of Poly(Adp-Ribose)Polymerase (Parp)
The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the...
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US20090203904 |
ARYLSULFINATE SALTS IN PHOTOINITIATOR SYSTEMS FOR POLYMERIZATION REACTIONS
Compositions are provided that include an electron donor and a sensitizing compound. More specifically, the electron donor is an arylsulfinate salt. Methods of polymerization are also provided that...
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US20090203672 |
Substituted Sulfonamide Compounds
Substituted sulfonamide compounds corresponding to the formula I′
wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions...
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US20090192146 |
SUBSTITUTED ORGANOSULFUR COMPOUNDS AND METHODS OF USING THEREOF
The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative...
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US20090186899 |
Substituted Sulfonamide Compounds
Substituted sulfonamide compounds corresponding to the formula I
wherein m, n, p, Q, R 1 , R 2 , R 3 , R 4 , X, Y and Z have the respective meanings defined herein, pharmaceutical compositions...
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US20090181945 |
TWO CYCLIC CINNAMIDE COMPOUND
The present invention relates to a novel two cyclic cinnamide compound and a pharmaceutical agent comprising the compound as an active ingredient. The two cyclic cinnamide compound represented by...
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US20090163497 |
Compounds Useful as Antagonists of CCR2
The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and R 1 are defined generally and in subsets herein. Compounds of...
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US20090156465 |
DERIVATIVES OF BETA-AMINO ACID AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS
The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological...
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US20090105264 |
Substituted Nicotinamide Compounds
The present invention relates to a novel class of substituted nicotinamides. These compounds can inhibit histone deacetylase and are suitable for use in selectively inducing terminal...
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US20090099158 |
TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
Certain substituted tetrahydroisoquinoline compounds are histamine H 3 receptor modulators useful in the treatment of histamine H 3 receptor-mediated diseases.
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US20090089939 |
INDOLE-DERIVED STYRYL DYE COMPRISING AN ALKYLENE LINKER, A DYE COMPOSITION COMPRISING THIS DYE, AND A PROCESS FOR LIGHTENING KERATIN MATERIALS USING THIS DYE
The disclosure relates to the dyeing of keratin materials using indole-derived styryl dyes comprising an alkylene linker. Disclosed herein is a dye composition comprising an indole-derived styryl...
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US20090075309 |
Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems
Embodiments of the present disclosure provide for: compositions, BRET systems, kits, and the like.
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US20090075983 |
Novel Diazabicycloalkane Derivatives and Their Medical Use
This invention relates to novel diaza-bicyclo-alkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and...
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US20090062253 |
HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE
The present invention relates to compounds and methods useful as modulators of CB2 for the treatment or prevention of disease states including, but not limited to pain, autoimmune disease,...
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US20090036455 |
ARYLPIPERAZINE DERIVATIVE AND USE THEREOF AS 5-HT1A RECEPTOR LIGANDS
Novel substituted arylpiperazine derivatives with activity as 5-hydroxytryptamine 1A (5-HT 1A ) receptor subtype ligands, to their stereochemical isomers, methods of their preparation, and to their...
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US20090036456 |
3,9-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
This invention relates to novel 3,9-diazabicyclo[3.3.1]nonane derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these...
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US20090018128 |
Compounds
The present invention relates to novel pyrrolopyrazine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which...
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US20090017489 |
Methods For Modulating The Development Of Dopamine Neuron By The Dopamine D2 Receptor And Compositions Thereof
The present invention relates to a composition for modulating the activation of Nurr1, the composition comprising an agonist or an antagonist of a dopamine D2 receptor, methods for modulating the...
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US20090005389 |
2,5 Diaza-Bicyclo [2.2.1] Heptane Derivatives as Calcium Channel Blockers
2,5-diaza-bicyclo[2.2.1]heptane derivatives represented by Formula (I), or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant...
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US20090005388 |
3-Heteroaryl-3,9-Diazabicyclo[3.3.1]Nonane Derivatives as Nicotinic Acetylcholine Receptor Agonists
This invention relates to novel 3,9-diazabicyclo[3.3.1]nonane derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine...
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US20080312240 |
Bicyclic Piperazines as Metabotropic Glutatmate Receptor Antagonists
The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof:
where Ar 1 , A, Hy, R 1 , m and n are as defined in the description. The invention also...
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US20080306077 |
Oxadiazole Derivatives and Their Use as Metabotropic Glutamate Receptor Potentiators 842
Compounds of Formula I:
wherein R 1 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods...
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US20080280912 |
Novel Diazabicycylic Aryl Derivatives and Their Medical Use
This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and...
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US20080200471 |
6' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY
The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I):
wherein R 1 —R 4 A, B, D, E, and G are as defined herein. The disclosure also...
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US20080200470 |
Diaza- or Thiazadione Derivatives With Neuroprotective Activity
The present invention relates to certain derivatives of cycloalkanediones invariably substituted with a chroman-2-yl, 2-quinolyl or —O-phenyl residue which are serotonin (5-hydroxytryptamine,...
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US20080194571 |
Acetylenic Piperazines as Metabotropic Glutamate Receptor Antagonists
The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof:
where Ar 1 , A, B, R 1 , m and n are as defined in the description. The invention also...
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US20080167315 |
Substituted Tetrahydropyrrolopyrazine Compounds and the Use Thereof in the Treatment and/or Inhibition of Pain
Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I:
processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these...
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US20080167288 |
Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases
The present invention provides compounds of the formula:
its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof,...
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US20080161313 |
Diazabicyclononene Derivatives and Use Thereof
The invention relates to a novel 3,9 -diazabicyclα[3.3.1]nonene derivative of formula (I) and the enantiomers thereof and the use thereof as active ingredients in the preparation of...
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US20080161314 |
Novel Diazabicyclic Aryl Derivatives and Their Medical Use
This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and...
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US20080146566 |
Amide Derivatives
The invention concerns a compound of the Formula I (A chemical formula should be inserted here—please see paper copy enclosed herewith) wherein m is 0-2 and each R1 is a group such as hydroxy,...
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US20080103152 |
Novel Diazabicyclononene Derivative
The invention relates to a novel 3,9-diazabicyclo[3.3.1]nonene derivative and the enantiomers thereof and the use thereof as active ingredients in the preparation of pharmaceutical compositions....
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US20080081803 |
Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
The present invention is directed to compounds of the formula I:
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, n and the broken lines are as defined herein which are useful as...
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US20080070919 |
BRIDGED ARYL PIPERAZINES DERIVATIVES USEFUL FOR THE TREATMENT OF CNS, GI-URINARY AND REPRODUCTIVE DISORDERS
The present invention is directed to bridged aryl piperazine derivatives, pharmaceutical compositions containing them and their use in the treatment of depression and related disorders. The...
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