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US20090318421 |
Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same,...
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US20090312338 |
Novel Tricyclic Compounds
The invention provides a compound of Formula (I)
pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined...
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US20090311288 |
IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS
The invention proyides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective...
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US20090306089 |
COMPOUNDS
Compounds of Formula (I) or pharmaceutically acceptable salts or N-oxides thereof:
(relative chemistry shown) pharmaceutical compositions comprising them, their use in therapy especially against...
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US20090281080 |
Spirohydantoin Tricyclic CGRP Receptor Antagonists
Compounds of formula I:
(wherein variables A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , B 1 , B 2 , B 3 , B 4 , D 1 , D 2 , E 1 , E 2 , E 3 , E 4 , E 5 , G 1 , G 2 , R 6 , T, U, V, W, X, Y and Z...
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US20090233936 |
Fused Aminopiperidines as Dipeptidyl Peptidase-4 Inhibitors for the Treatment or Prevention of Diabetes
The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the...
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US20090233274 |
DRUG DEVELOPMENT TARGET PROTEIN AND TARGET GENE, AND METHOD OF SCREENING
The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present...
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US20090143361 |
Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10
The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical compositions which comprise these compounds and to the pharmaceutical use of these compounds,...
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US20090143391 |
Aryl and heteroaryl fused imidazo [1,5-a] pyrazines as inhibitors of phosphodiesterase 10
The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these...
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US20090143367 |
ARYL AND HETEROARYL FUSED IMIDAZO[1,5-a]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10
The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these...
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US20090054399 |
HIV INTEGRASE INHIBITORS
Tricyclic compounds of Formula (I) are inhibitors of HIV integrase and inhibitors of HIV replication: wherein bond a, ring A, R 1 , R 2 and R 3 are defined herein. The compounds are useful for...
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US20090042873 |
TRICYCLIC N-HETEROARYL-CARBOXAMIDE DERIVATIVES CONTAINING A BENZIMIDAZOLE UNIT, METHOD FOR PREPARING SAME AND THEIR THERAPEUTIC USE
The invention concerns tricyclic N-heteroarylcarboxamide derivatives containing a benzimidazole unit of general formula (I):
Wherein A, P, Y, R 1 , R 2 and R 3 are as defined herein. The...
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US20080161317 |
Inhibitors of Akt activity
The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The...
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US20080090817 |
Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
The invention provides N-cyclic sulfonamido compounds and salts of Formula I:
wherein A is as described in the specification and R 1 and R 2 combine to form a [3.3.1] or a [3.2.1] ring...
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US20080058315 |
Integrase inhibitors
Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.
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US20080027064 |
Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds,...
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