|
Match
|
Document |
Document Title |
|
|
US20090291974 |
BOSENTAN SALTS
Stable acid addition salts of bosentan useful for the purification of bosentan base; the salts are in solid state and the starting acid has a pKa lower than 3.
|
|
|
US20090281125 |
Heterocyclic Compounds Useful in Treating Diseases and Conditions
The present invention relates to compounds of formula (I)
and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such...
|
|
|
US20090264447 |
Pyrimidine compounds for combating pathogenic fungi and cancer
The present invention relates to the use of pyrimidine compounds of formula I
wherein the variables have the meanings stated in the claims and in the description, for combating pathogenic fungi,...
|
|
|
US20090263472 |
ENDOTHELIN RECEPTOR ANTAGONIST DERIVATIVES
Endothelin receptor antagonist nitroderivatives of general formula (I):
having an improved pharmacological activity compared with their parent compounds. They can be employed for treating or...
|
|
|
US20090233918 |
2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof:
wherein R 2 represents a hydrogen or the like; R 3 represents methyl...
|
|
|
US20090197901 |
VARIOLIN DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS
Variolin derivatives of formula (5) are provided, wherein the substituent groups defined by X 2 , R 1 , R 2 , R 3 , R 6 , R 7 , and R 12 are each independently selected from the group consisting...
|
|
|
US20090192146 |
SUBSTITUTED ORGANOSULFUR COMPOUNDS AND METHODS OF USING THEREOF
The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative...
|
|
|
US20090156811 |
Process for the Preparation of Bosentan
A process for the preparation of 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-[
2,2′]bipyrimidinyl-4-yl]-benzenesulfonamide, bosentan, comprising the reaction of a compound of...
|
|
|
US20090111795 |
Multimers of Heterocyclic Compounds and Their Use
A compound of formula (I): M-L-M, wherein L is a linker and each M is independently a group of formula (II): is useful in therapy, e.g. of respiratory diseases.
|
|
|
US20090105268 |
Dihydropyrimidone Multimers and Their Use as Human Neutrophil, Elastase Inhibitors
A compound of formula M-L-M (I) wherein L is a linker and each M is independently a group of formula (II) is useful in therapy, e.g. of respiratory diseases.
|
|
|
US20090099194 |
CXCR4 Antagonists Including Diazine And Triazine Structures For The Treatment Of Medical Disorders
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
|
|
|
US20090088490 |
TWO-PHOTON ABSORPTION RECORDING MATERIAL CONTAINING DYE HAVING POLYMERIZABLE GROUP
A simultaneous two-photon absorption three-dimensional recording material includes at least one kind of dye having at least one polymerizable group.
|
|
|
US20090082379 |
Novel Cyclic Urea Derivatives, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors
Compounds of formula (I):
wherein Ra, Rb, R, X 1 and X 2 are as defined in the disclosure, pharmaceutical compositions comprising said compounds, processes for making and methods of using the...
|
|
|
US20090075188 |
AZO COMPOUND, CURABLE COMPOSITION, COLOR FILTER, AND METHOD OF PRODUCING THE SAME
This invention provides an azo compound represented by Formula (I), Formula (II), or Formula (III):
wherein R 1 and R 2 each independently represent a hydrogen atom or a substituent; D 1 and...
|
|
|
US20090074825 |
COLORANTS BASED N-HALAMINES COMPOSITIONS AND METHOD OF MAKING AND USING
The present invention includes methods, articles, compositions and colorant dyes and pigments that include biocidal N-halamine dye composition having two or more heterocyclic ring structures...
|
|
|
US20090069351 |
DEUTERIUM-ENRICHED BOSENTAN
The present application describes deuterium-enriched bosentan, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
|
|
|
US20090054466 |
Leukotriene B4 Inhibitors
Provided herein are compounds of the formula (I):
as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
|
|
|
US20090029994 |
Trisubstituted amine compound
The present invention relates to a compound of the general formula (1):
wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an...
|
|
|
US20090023738 |
DIAMINOPYRIMIDINES AS MODULATORS OF THE EP2 RECEPTOR
The present invention relates to diaminopyrimidines of the general formula I, process for their preparation, and the use thereof for the manufacture of pharmaceutical compositions for the treatment...
|
|
|
US20090005403 |
Alkinyl-Oxypyrimidines Used in the Form of Pesticides
The invention relates to compounds of the formula (I),
in which
A, R 1 , R 2 , R 3 and R 4 are as defined in the description, to processes and intermediates for their preparation and to...
|
|
|
US20090005394 |
Endothelin receptor antagonists
This invention relates to novel endothelin receptor antagonists, derivatives, acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides compositions...
|
|
|
US20080318987 |
METHODS FOR MODULATING BONE FORMATION AND MINERALIZATION
Methods and compositions for modulating bone formation and mineralization are described.
|
|
|
US20080293940 |
Amide Derivative and Medicine
The present invention is directed to an amide derivative having excellent BCR-ABL tyrosine kinase inhibitory activity, or a salt thereof. The present invention provides an amide derivative...
|
|
|
US20080287475 |
4-(3-Aminopyrazole) Pyrimidine Derivatives for Use as Tyrosine Kinase Inhibitors in the Treatment of Cancer
This invention relates to novel compounds having the formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
|
|
|
US20080269266 |
NOVEL COMPOUNDS 747
There is provided novel pyrimidine derivatives of formula (I)
or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their...
|
|
|
US20080242687 |
SUBSTITUTED PYRIMIDINES
Disclosed herein are substituted pyrimidine-based endothelin modulators of Formula I, processes of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
|
|
|
US20080234223 |
N4 MODIFICATIONS OF PYRIMIDINE ANALOGS AND USES THEREOF
The present invention relates to N4 carboxylester or ester derivatives of pyrimidine analogs with increased stability, solubility, and bioavailability. Also disclosed are methods of using these...
|
|
|
US20080227782 |
PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS
This invention is directed to a compound of formula (I):
wherein R 1 , R 2 , R 3 and L 1 are as defined herein, a pharmaceutical composition comprising the compound, and the use of the...
|
|
|
US20080220286 |
Dinaphthyl ethylene derivativce, process for preparing it, film prepared from it, and OLED including the film
The present invention relates to a dinaphthyl ethylene derivative of formula (I), a process for preparing it, a film prepared from it useful in the manufacure of an organic light emitting device...
|
|
|
US20080214544 |
Substituted heterocycles and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as c-met mediated diseases and/or HGF mediated diseases. The invention encompasses novel compounds, analogs,...
|
|
|
US20080194545 |
ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE
The present invention is directed to compounds of formula I, pharmaceutical compositions comprising the compounds, and methods for making and using the inventive compounds.
|
|
|
US20080160244 |
Dye and recording media utilizing the same
The invention provides dyes for optical disc recoding media, having the general formula:
wherein m, n is independently selected from integers 0-3; X represents oxygen, sulfur, C—R 1 , or N—R...
|
|
|
US20080146571 |
O-LINKED PYRIMIDIN-4-AMINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE TO TREAT CANCER
O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
|
|
|
US20080139534 |
Bisbenzamidines and bisbenzamidoximes for the treatment of human African trypanosomiasis
Disclosed are bisbenzamidine and bisbenzamidoxime compounds useful for treatment of treatment of trypanosomiasis. The compounds disclosed are useful for treating mammals infected with parasitic...
|
|
|
US20080125440 |
TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY
The present invention relates to tyrosine kinase inhibitors that contain a zinc-binding moiety and their use in the treatment of tyrosine related diseases and disorders such as cancer. The said...
|
|
|
US20080070894 |
Novel Substituted Imidazole Derivative
The present invention relates to a compound represented by Formula [I] or a pharmaceutically acceptable salt or ester thereof:
wherein:
X 1 , X 2 , X 3 , and X 4 , which may be...
|
|
|
US20080070093 |
Development and characterization of novel proton conducting aromatic polyether type copolymers bearing main and side chain pyridine groups
Featured are novel heterocycle substituted hydroquinones, aromatic copolymers and homopolymers bearing main and side chain polar pyridine units. These polymers exhibit good mechanical properties,...
|
|
|
US20080025904 |
Compound and Method for the Selective Extraction of Higher Fullerenes from Mixtures of Fullerenes
A compound of formula I
and a corresponding method for the extraction of high-order fullerenes from a carbonaceous mixture including at least one solid-liquid extraction.
|
|
|
US20080027037 |
Cyclic compounds
1. A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof,
wherein X is ═CH— or ═N—, Y is —NH—, —NR 4 —, —S—, —O—, —CH═N—,...
|