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US20090281127 |
Organic Compounds
A compound of formula (I) and their preparation and use as pharmaceuticals
wherein R 1 , R 2 and R 3 are as defined herein.
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US20090281126 |
Organic Compounds
A compound of formula (I) and their preparation and use as pharmaceuticals
wherein R 1 , R 2 and R 3 are as defined herein.
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US20090275564 |
HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
Provided herein are Aminopurine Compounds having the following structure:
wherein R 1 , R 2 and R 3 are as defined herein, compositions comprising an effective amount of an Aminopurine...
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US20090270427 |
PURINE DERIVATIVES
The present invention relates to compounds of formula 1
or pharmaceutically acceptable salts thereof, wherein
one of R 1 and R 2 is methyl, ethyl or isopropyl, and the other is H;
R 3 and...
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US20090270352 |
Tenofovir Disoproxil Hemi-Fumaric Acid Co-Crystal
The present invention provides a novel crystalline form of Tenofovir disoproxil fumarate (Tenofovir DF), designated Co-crystal TDFA 2:1, methods for the preparation thereof and its use in...
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US20090269846 |
Inhibitors of tyrosine kinase receptor dimerization
The teachings relate to methods of identifying inhibitors of dimerization of tyrosine receptor kinases such as EGFR. The methods comprise providing, on a digital computer, a molecular model...
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US20090258887 |
Novel Carboxylic Acid Derivatives
The present invention is concerned with novel arylalkyl carboxylic acid derivatives, more specifically, with acylates of arylalkyl carboxylic acids with naturally occurring, non-toxic hydroxy,...
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US20090247749 |
SALT FORM AND COCRYSTALS OF ADEFOVIR DIPIVOXIL AND PROCESSES FOR PREPARATION THEREOF
The present invention is directed to novel crystalline forms of adefovir dipivoxil and salts thereof.
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US20090247556 |
Azolopyrimidines as Inhibitors of Cannabinoid 1 Activity
The invention provides compounds of formula (Ia), (Ic), (Ig) and (Ik), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or...
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US20090247538 |
Ortho-Condensed Pyridine and Pyrimidine Derivatives (e.g., Purines) as Protein Kinases Inhibitors
The invention provides a compound for use as a protein kinase B inhibitor, the compound being a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR 5...
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US20090233946 |
FUSED HETEROARYL PYRIDYL AND PHENYL BENZENESUFLONAMIDES AS CCR2 MODULATORS FOR THE TREATMENT OF INFLAMMATION
Compounds are provided that act as potent antagonists of the CCR2 receptor. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the...
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US20090233872 |
Therapeutic Agent for Neurodegenerative Disease
[Problems] To provide a neuronal cell death inhibitor and a therapeutic agent for a neurodegenerative disease, particularly Parkinson's disease. [Means for Solving Problems] It is known that DJ-1...
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US20090209557 |
DIHYDROOROTATE DEHYDROGENASE INHIBITORS WITH SELECTIVE ANTI-MALARIAL ACTIVITY
Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII,
and pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII:
...
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US20090203636 |
Prevention and Treatment of Cancer and Other Diseases
Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of...
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US20090181988 |
Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof
This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases....
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US20090170879 |
6,9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions
Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are...
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US20090156598 |
Imidazolopyrimidine modulators of TRPV1
Certain TRPV1-modulating imidazolopyrimidine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions...
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US20090149649 |
Aromatic hetrocyclic compound, organic light-emitting diode including organic layer comprising the aromatic hetrocyclic compound, and method of manufacturing the organic light-emitting diode
The present invention provides an aromatic heterocyclic compound represented by Formula 1 below, an organic light-emitting diode including an organic layer comprising the aromatic heterocyclic...
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US20090137624 |
Chemical Compounds
This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
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US20090137581 |
Heterocyclic compounds and their uses
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders,...
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US20090124796 |
Nucleobase Having Perfluoroalkyl Group and Process for Producing the Same
Provided is a simple and efficient production process of a nucleobase having a perfluoroalkyl group. A nucleobase (for example, uracils, cytosines, adenines, guanines, hypoxanthines, xanthines, or...
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US20090099213 |
Ortho-Condensed Pyridine and Pyrimidine Derivatives (e.g., Purines) as Protein Kinases Inhibitors
The invention provides a compound for use in the prophylaxis or treatment of a disease state or condition mediated by protein kinase B, the compound having the formula (I): or salts, solvates,...
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US20090099177 |
PYRIDYL COMPOUNDS
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein R 1 , and R 2 , and R 3 are as defined in the specification, a process for the preparation of such compounds,...
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US20090048275 |
SOLID FORMS COMPRISING 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2,4,6-TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-YLAMINO]-CYCLOHEXAN-1-OL, COMPOSITIONS THEREOF, AND USES THEREWITH
Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro-phenylamino)
-9H-purin-2-ylamino]-cyclohexan-1-ol, compositions comprising the solid forms, methods of making the solid forms...
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US20090042890 |
Heteroaryl compounds, compositions thereof, and methods of treatment therewith
Provided herein are Heteroaryl Compounds having the following structure:
wherein R 1 , R 3 , R 4 , L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a...
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US20090042768 |
Purine derivatives and their use for treatment of autoimmune diseases
Compounds useful in the treatment of autoimmune disease are described by the following general formula:
n=0-2 m=0-2 m is not necessarily equal to n;
where R 1 , R 3 ═NH 2 , F, Cl, C 1 -C 4 ...
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US20090030019 |
PURINE DERIVATIVES HAVING, IN PARTICULAR, ANTI-PROLIFERATIVE PROPERTIES, AND THEIR BIOLOGICAL USES
This invention provides 2-, 6, and 9-substituted purine derivatives, particularly 2(1-R hydroxymethylpropylamino)-6-benzylamino-9-isopropyl purine, having, in particular, antiproliferative...
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US20090018055 |
[6,5]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of...
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US20090005400 |
Biologically Active Aphrocallistin Compounds
The subject invention provides novel compositions of biologically active compounds which can advantageously be used in blocking cellular proliferation and/or treatment of cancer.
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US20080280926 |
Phosphodiesterase Inhibitors
The present invention relates to purine derivatives, which can be used as selective phosphodiesterase (PDE) type IV inhibitors. Compounds disclosed herein can be useful in the treatment of asthma,...
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US20080275067 |
Quinazolinones as Inhibitors of Human Phosphatidylinositol 3-Kinase Delta
Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ)...
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US20080261973 |
Sulphonamidoaniline Derivatives Being Janus Kinase Inhibitors
The invention relates to sulphonamidoanilines of formula I,
wherein A is N or CH, W, X, Y and Z are N or CH under the proviso that at least one of the three symbols W, X and Y represent CH, R 1 ...
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US20080214581 |
Purine Derivatives as Agonists of the Adenosine A2a Receptor
A compound of formula (I):
wherein R 1 -R 3 are as defined in the specification, and compositions, combinations, and methods of manufacture, and methods of treatment of inflammatory diseases,...
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US20080214541 |
COMPOSITIONS AND METHODS FOR INDUCING OSTEOGENESIS
The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage.
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US20080207891 |
Methods For Selective N-9 Glycosylation of Purines
A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted...
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US20080207648 |
Organic Compounds
Compounds of formula I
in free or salt form, wherein R 1 , R 2 and R 3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the...
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US20080200483 |
Purine Derivatives for Use as Adenosin A-2A Receptor Agonists
Compounds of formula I
in free or salt form, wherein R 1 , R 2 and R 3 have the meanings as indicated in the specification, are useful for treating conditions mediated by activation of the...
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US20080176872 |
Chemical Compounds
This invention relates to novel compounds having the formula (I); and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
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US20080176840 |
Triazole compounds that modulate Hsp90 activity
The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of...
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US20080161327 |
Substituted 9-Alkyladenines and the Use Thereof
The invention relates to substituted 9-alkyladenines of Formula I: or a pharmaceutically acceptable salt thereof, wherein R 1 -R 6 are defined as set forth in the specification. The invention is...
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US20080161326 |
Novel Sulfone Amide Amide Derivatives
The present invention relates to compounds of the general formula (I):
wherein A, B, C and D each independently are a methine group or a nitrogen atom, said methine group optionally having...
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US20080154038 |
Process for the manufacture of famciclovir using phase-transfer catalysts
The invention relates to a process for the preparation of Famciclovir, which comprises the preparation of a compound of formula (II)
wherein X is a halogen atom by reaction of a compound of...
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US20080139583 |
PHOSPHODIESTERASE 4 INHIBITORS
PDE4 inhibition is achieved by novel compounds of the Formula I:
wherein R 1 and R 2 are as defined herein.
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US20080132526 |
Purine Derivative
The present invention provides a compound of formula (I) and salts and solvates thereof. Compounds of formula (I) are agonists of the adenosine A2 A receptor and are believed to be of potential...
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US20080132525 |
Inhibitors of DNA Methyltransferase
The invention relates to the inhibition of DNA methyltransferase isoforms DNMT1 and DNMT3b2. The invention provides compounds and methods for inhibiting DNMT1 and DNMT3b2.
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US20080125587 |
Synthesis of triazole compounds that modulate HSP90 activity
The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole...
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US20080125446 |
Purine analogs having HSP90-inhibiting activity
Novel purine compounds and tautomers and pharmaceutically acceptable salts thereof are described, as are pharmaceutical compositions comprising the same, complexes comprising the same, e.g., HSP90...
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US20080125426 |
Novel Compounds
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F,...
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US20080119469 |
Novel Compounds
The present invention relates to compounds and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F,...
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US20080119467 |
Purine Derivatives, Compositions Containing Them and Use Thereof
Purine derivatives of formula (IA1) or (IB1), compositions containing them and use thereof as medicinal products, in particular in oncology, are described
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