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US20090305891 |
CYCLOALKYLPHENYL SUBSTITUTED CYCLIC KETOENOLS
The disclosure relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I)
in which
J, X, Y, m and CKE are as defined above, to processes and intermediates for their...
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US20090286796 |
Compounds exhibiting type X sPLA2 inhibiting effect
A compound represented by the general formula:
wherein R 20 is —CH 2 COOH and the like; R 21 is —COCONH 2 and the like; R 22 is C4-C6 alkyl; and the like; R 23 is —CH 2 —R 18 ...
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US20090275585 |
Novel Compounds and Therapeutic Use Thereof for Protein Kinase Inhibition
Novel compound having the following formula:
Also disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of...
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US20090275592 |
Heterocyclic modulators of PKB
The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions...
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US20090270374 |
DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES
Bicyclic nitrogen containing compounds and their use as antibacterials.
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US20090253906 |
ARYL- AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
The compounds of the present invention are represented by the chemical structure found in Formula (I):
wherein:
the carbon atom designated * is in the R or S configuration; and X is a fused...
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US20090197887 |
PIPERAZINYLPIPERIDINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS
The present invention relates to compounds of Formula I:
wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some...
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US20090192175 |
INSECTICIDAL COMPOUNDS
Novel heteroaromatic compounds of formula (I): wherein A 1 , A 2 , A 3 , R 1 , R 2 , G 1 , G 2 , Q 1 and Q 2 are as defined in claim 1 ; or salts or N-oxides thereof. Furthermore, the present...
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US20090163506 |
Urea-compounds active as vanilloid receptor antagonists for the treatment of pain
Certain compounds of formula (I),
or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein R 1 , R 2 , P, P′, n, p, q, r and s are as defined in the specification, a...
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US20090131444 |
Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity
The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their...
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US20090099175 |
Phosphodiesterase 10 inhibitors
The present invention if directed to certain cinnoline compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds and processes for preparing such compounds. The...
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US20090087378 |
Positron Tomography Method and Positron-Emitting Compound to Be Used Therein
It is an objective of the present invention to provide a positron tomography method applicable to the diagnosis of specific brain diseases and to provide a positron-emitting compound for use in the...
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US20090062291 |
PHOSPHODIESTERASE 10 INHIBITORS
The present invention is directed to compounds, useful as PDE10 inhibitors, having the formula
where R 1 , R 2 , R 3 , R 4 , X, Y and Z are as defined herein, pharmaceutical compositions...
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US20090036433 |
Heterocyclic Compounds, their Preparation and their Use as Antibacterials
Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.
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US20090023916 |
TETRAZINE-BASED BIO-ORTHOGONAL COUPLING REAGENTS AND METHODS
Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the...
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US20090012084 |
3-CINNOLINECARBOXAMIDE DERIVATIVES AND THEIR USE FOR TREATING CANCER
The invention relates to chemical compounds of formula (I):
or pharmaceutically acceptable salts thereof which possess CSF-1R kinase inhibitory activity and are accordingly useful for their...
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US20090005390 |
NOVEL QUINUCLIDINE DERIVATIVES AND THEIR USE
This invention relates to novel quinuclidine derivatives and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of...
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US20080308770 |
MONO AND BIS-ESTER DERIVATIVES OF PYRIDINIUM AND QUINOLINIUM COMPOUNDS AS ENVIRONMENTALLY FRIENDLY CORROSION INHIBITORS
A quaternary nitrogen-containing corrosion inhibitor of formula
wherein
is an aromatic, nitrogen-containing ring of 5 to 14 ring atoms, optionally containing an additional N, O or S ring atom...
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US20080287465 |
Cyclic N-Hydroxy Imides as Inhibitors of Flap Endonuclease and Uses Thereof
Acrylic n-hydroxy imides and their use in pharmaceutical compositions and in the inhibition of flap endonuclease are disclosed.
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US20080280911 |
Cinnoline Compounds as Inhibitors of Phosphodiesterase Type IV (Pde4)
There are provided according to the invention novel compounds of formula (I)
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US20080280892 |
Compounds
Tricyclic nitrogen containing compounds and their use as antibacterials.
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US20080269110 |
NON-BASIC MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I. Additionally, the present...
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US20080242655 |
AZA-INDOLYL COMPOUNDS AND METHODS OF USE
The invention relates to azaindolyl compounds of Formula I with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolyl compounds which inhibit MEK kinase activity. The...
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US20080221110 |
Compounds
Tricyclic nitrogen containing compounds and their use as antibacterials
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US20080219922 |
Alzheimer's Disease Imaging Agents
This invention provides compounds and methods of imaging amyloid deposits using radiolabeled compounds. This invention also provides a method of inhibiting the aggregation of amyloid proteins to...
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US20080221107 |
Therapeutic Agents
Compounds of formula (I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and...
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US20080214524 |
FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR
Compounds of formula (I)
are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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US20080188371 |
4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives
The present invention relates to novel 4-biphenyl-substituted pyrazolidine-3,5-dione derivatives of the formula (I)
in which A, D, G, W, X, Y and Z are as defined above, to a plurality of...
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US20080161311 |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I]
wherein each symbol is as defined in the specification, or a pharmaceutically...
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US20080139568 |
Phthalazine Derivatives as Parp Inhibitors
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R 1 , R 2 L 1 , L 2 ,...
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US20080085890 |
Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof
This invention provides compounds of Formula (I), having the structure
where G 1 , G 2 , G 3 , G 4 , A 1 , A 2 , Y 1 , Y 2 , L 1 , Z, e and f are defined herein, or a pharmaceutically...
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US20080081807 |
Arylphenyl-substituted cyclic keto-enols
The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I)
in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl,...
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US20080070918 |
Dihydropyridazine, Tetrahydropyridine, Chromanone, and Dihydronaphthalenone Derivatives
Disclosed are compounds and pharmaceutically acceptable salts of Formula I
wherein A, Q 1 , Q 2 , Q 3 , R 3 , and R 4 are as defined herein. Compounds of Formula I are useful in the...
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US20080064871 |
Production Method of Nitrogen-Containing Fused Ring Compounds
[Problems] The present invention provides a superior production method and a superior purification method of compounds effective for the treatment or prophylaxis of pathology showing involvement of...
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US20080051405 |
Therapeutic Agents
The present invention provides compounds of formula I, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders,...
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US20080039468 |
Novel 3-Phenyltetrahydrocinnolin-5-Ol Derivative and Medicinal Use Thereof
A 3-phenyltetrahydrocinnolin-5-ol derivative represented by the following general formula (1) (wherein Z represents 2-carboxyethyl, 3-dimethylaminopropyl etc.; X represents trifluoromethyl etc.;...
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US20080032988 |
Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds...
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US20080032985 |
4-Substituted Quinoline Derivatives, Method and Intermediates for Their Preparation and Pharmaceutical Compositions Containing Them
The present invention relates to 4-substituted quinoline derivatives of general formula I:
which are active as antimicrobials. The invention also relates to the method and intermediates for...
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US20080027041 |
Pyridizinone derivatives
The present invention provides compounds of formula (I*):
their use as H 3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.
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US20080021217 |
HETEROCYCLIC INHIBITORS OF RHO KINASE
The present invention relates to compounds and methods which may be useful as inhibitors of Rho kinase for the treatment or prevention of disease.
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US20080015193 |
Certain azoles exhibiting ATP-utilizing enzyme inhibitory activity, compositions, and uses thereof
Certain oxazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising...
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