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US20090281079 |
Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis
This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or...
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US20090275569 |
Benzotriazine Inhibitors of Kinases
The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various...
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US20090270374 |
DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES
Bicyclic nitrogen containing compounds and their use as antibacterials.
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US20090253704 |
PYRROLOTRIAZINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
The present invention discloses pyrrolotriazinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I:
The compounds are useful in treating and/or...
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US20090247531 |
CRYSTALLINE FORMS OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER
Crystalline form, Form N-1, of [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,
1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester (Compound I) is provided....
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US20090227791 |
Active Esters of N-Substituted Piperazine Acetic Acids, Including Isotopically Enriched Versions Thereof
In some embodiments, this invention pertains to active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof. In some embodiments, this invention pertains...
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US20090221587 |
NOVEL INSECTICIDES
Compounds of formula (I), wherein the substituents are as defined in claim ( 1 ), and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula (I)...
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US20090214529 |
KINESIN INHIBITORS
This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat a kinesin Eg5 protein-mediated...
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US20090186886 |
Tricyclic 1,2,4-Triazine Oxides and Compositions for Therapeutic Use in Cancer Treatments
The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I
and to related analogues, to their preparation, and to their use as...
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US20090143356 |
Polycylclic Carbamoylpyridone Derivative Having HIV Integrase Inhibitory Acitvity
Is to provide a novel compound having an anti-viral activity, particularly a HIV integrase inhibitory activity, and a pharmaceutical composition, particularly an anti-HIV agent.
(wherein
...
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US20090131425 |
INHIBITORS OF PROTEIN KINASES
Compounds that inhibit Aurora-kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
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US20090111692 |
3-(Pyridin-2-Yl)-[1,2,4]-Triazines as Fungicides
The invention relates to 3-(pyridin-2-yl)-[1,2,4]-triazines of formula (I) and their use in the control of parasitic fungi and to herbicides that contain said compounds as an effective ingredient...
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US20090076011 |
DEUTERIUM-ENRICHED TIRAPAZAMINE
The present application describes deuterium-enriched tirapazamine, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
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US20080299076 |
Compunds and compositions that cause non-apoptotic cell death and uses thereof
The present invention relates to erastin analogs, particularly compounds of formulae I and II, including compounds 1-20, 22-24, 34, and 40. The invention also relates to pharmaceutical compositions...
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US20080292626 |
KINESIN INHIBITORS
This invention relates to the compounds of formula (I) shown below. Each variable in formula (I) is defined in the specification. These compounds can be used to treat a kinesin Eg5 protein-mediated...
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US20080275048 |
Substituted Diazabicycloalkane Derivates
Compounds of formula (I)
Z-Ar 1 —Ar 2 (I)
wherein Z is a diazabicyclic...
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US20080253988 |
Pyrrolo [1,2-D] [1,2-4] Triazine as Inhibitors of C-Jun N Terminal Kinases (Jnk) and P-38 Kinases
A compound of formula (I): wherein the substituents are as defined in the specification as inhibitor of C-Jun N terminal Kinases (JNK) and P-38 Kinases.
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US20080234276 |
Heterocyclic Triazines as Hypoxic Selective Protein Kinase Inhibitors
The invention relates to novel heterocyclic triazines which are useful as hypoxic selective cytotoxic agents that mediate and/or inhibit cell proliferation, for example, through the activity of...
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US20080221108 |
Anthranilic Acid Derivatives As Hm74A Receptor Agonists
Therapeutically active anthranilic acid derivatives of Formula (I) wherein R 1 , R 2 and W, are as defined in the specification, processes for the preparation of said derivatives, pharmaceutical...
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US20080200468 |
2-Substituted 5-Membered Heteroaryl Carboxylates as Hm74a Receptor Agonists
Therapeutically active heteroaryl carboxylic acid derivatives of Formula (I) wherein R 1 , R 2 , W, X, Y and Z are as defined in the specification, processes for the preparation of said...
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US20080194565 |
5-Phenyl-Pentanoic Acid Derivatives as Matrix Metalloproteinase Inhibitors for the Treatment of Asthma and Other Diseases
The present invention relates to C ompounds having the structure of Formula I: wherein n is an integer from 1 to 5; R 1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl,...
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US20080171741 |
HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS
A compound of Formula I
and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and...
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US20080139565 |
Anthranilic Acid Derivatives and Their Use in Treatment of Diseases of Lipid Metabolism, in Particular Dyslipidaemia
Therapeutically active anthranilic acid derivatives of Formula (I) wherein R 1 , R 2 , W, Y and Z are as defined in the specification, processes for the preparation of said derivatives,...
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US20080119456 |
Substituted Thiazoleacetic Acid as Crth2 Ligands
Compounds of formula (I) are useful for the treatment of disease responsive to modulation of CRTH2 receptor activity, such as asthma, rhinitis, allergic airway syndrome, and allergic...
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US20080058337 |
PYRROLOTRIAZINE KINASE INHIBITORS
The present invention provides compounds of formula I
and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of Trk receptors such as TrkA, TrkB...
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US20080045496 |
PYRROLOTRIAZINE KINASE INHIBITORS
The present invention provides compounds of formula I
and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of such as TrkA, TrkB, TrkC, Jak2,...
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