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US20090306063 |
Oxadiazoanthracene Compounds For The Treatment Of Diabetes
The present invention provides oxadiazoanthracene derivatives of the formula (I),
wherein A, B, C, R, R 1 , R 2 , R 3 , R 4 and R 5 are as herein described, pharmaceutical compositions...
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US20090298816 |
PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE
Compounds of formula (I), wherein the substituents are as defined in claim 1 , and the agrochemically acceptable salts and all stereoisomers and tautomeric forms of the compounds of formula I can...
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US20090270379 |
QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
The present invention is directed to quinolone derivatives, useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said derivatives and...
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US20090253677 |
HIV Integrase Inhibitors
The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the...
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US20090233918 |
2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof:
wherein R 2 represents a hydrogen or the like; R 3 represents methyl...
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US20090192147 |
[a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
The invention relates to [a]-fused indole compounds of the Formula II,
or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein. The invention also...
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US20090163457 |
Compositions and methods for delivering a biologically active agent
The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations....
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US20090156577 |
7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES
The present invention relates to compounds having a structure according to Formula (I)
wherein n, m, z, R, R 2 , R 3 , R 4 , R 5 , R 6 , A, E, X, Y, a and b are as defined above; or an optical...
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US20090143356 |
Polycylclic Carbamoylpyridone Derivative Having HIV Integrase Inhibitory Acitvity
Is to provide a novel compound having an anti-viral activity, particularly a HIV integrase inhibitory activity, and a pharmaceutical composition, particularly an anti-HIV agent.
(wherein
...
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US20090143358 |
INHIBITORS OF ION CHANNELS
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly,...
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US20090069560 |
Process For Obtaining Levofloxacin Free From Salts
This invention relates to a process for obtaining levofloxacin free from salts. In this process the starting product used is the compound (V), alkaline hydrolysis of which within a water-(C 1 -C 4...
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US20090062266 |
OXAZOLIDINONE COMPOUNDS, AND COMPOSITIONS AND METHODS RELATED THERETO
The invention provides new oxazolidinone compounds of formula (I) wherein A is certain heterocycles optionally substituted; R 1 , R 2 , R 3 and R 4 are independently selected from —H and...
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US20090042873 |
TRICYCLIC N-HETEROARYL-CARBOXAMIDE DERIVATIVES CONTAINING A BENZIMIDAZOLE UNIT, METHOD FOR PREPARING SAME AND THEIR THERAPEUTIC USE
The invention concerns tricyclic N-heteroarylcarboxamide derivatives containing a benzimidazole unit of general formula (I):
Wherein A, P, Y, R 1 , R 2 and R 3 are as defined herein. The...
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US20090029980 |
C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents
The present invention relates to C-7 isoxazolyl quinoline/naphthyridine derivatives useful as antimicrobial compounds, pharmaceutical compositions comprising said derivatives and the use of said...
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US20080318940 |
Quinazolinone Derivatives as Vanilloid Antagonists
The invention relates to quinazolinone compounds of the formula
wherein the R groups are defined in the specification, processes for their preparation and their use as pharmaceuticals,...
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US20080300403 |
Method for Production of Quinolone-Containing Lyophilized Preparation
The present invention is directed to a lyophilized preparation which contains a synthetic quinolone antibacterial compound and, as a solo additive, a pH-adjusting agent, and which exhibits an...
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US20080293094 |
Novel Enzymatic Substrates Derived from Phenoxazinone and Their Use as Developer in Detection of Microorganisms with Peptidase Activity
The invention concerns novel enzymatic substrates of the general formula below:
wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A and X are as defined in claim 1 , reaction media containing...
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US20080287414 |
Mitotic Kinesin Inhibitors
The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin...
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US20080221091 |
Metalloprotease inhibitors containing a heterocyclic moiety
The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the...
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US20080221090 |
HCV NS5B Inhibitors
The invention encompasses compounds of Formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating...
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US20080214534 |
(1,10B-Dihydro-2-(Aminoalkyl-Phenyl)-5H-Pyrazolo[1,5-C][1,3]Benzoxazin-5-Yl)Phenyl Methanone Derivatives as Hiv Viral Replication Inhibitors
The present invention relates to 5H-pyrazolo[1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as inhibitors of the viral replication of the HIV virus, processes for their preparation as well...
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US20080146544 |
LISOFYLLINE ANALOGS AND METHODS FOR USE
The present invention provides analogs of a Lysofylline (LSF), and synthetic methods for the preparation of such analogs. The have the active side chain moiety (5-R-hydroxyhexyl) of LSF and can...
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US20080097095 |
Process for the Preparation of Levofloxacin Hemiydrate
The present invention relates to an improved process for the preparation of Levofloxacin hemihydrate by adjusting the moisture content of the solvent to about 12% to about 20% during crystallization.
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US20080090817 |
Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase
The invention provides N-cyclic sulfonamido compounds and salts of Formula I:
wherein A is as described in the specification and R 1 and R 2 combine to form a [3.3.1] or a [3.2.1] ring...
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US20080070907 |
Substituted chiral fused [1,2] imidazo [4,5-C] ring compounds and methods
Substituted fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines,...
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US20080045520 |
Substituted Pyrrolidine Derivative
The present invention contemplates provision of a quinolone antibacterial agent and a drug for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective...
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US20080027040 |
Oxazolidinone-Quinolone Hybrid Antibiotics
The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
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US20080004262 |
Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents
This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R 1 and R 2 are independently of each other hydrogen atom, C 1-6...
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