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US20150094466 SYNTHETIC VOACANGINE  
Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
US20130211073 SYNTHETIC VOACANGINE  
Synthetic voacangine, including in substantially enantiomerically enriched forms, and derivatives thereof are provided.
US20150193597 PHARMACEUTICAL PRODUCT AND COMMUNICATION TOOL  
A substance with pharmaceutical activity against a medical condition for use in a treatment of the medical condition in combination with a computer program product including instructions causing a...
US20120135961 USE OF OXAZOLIDINONE-QUINOLINE HYBRID ANTIBIOTICS FOR THE TREATMENT OF ANTHRAX AND OTHER INFECTIONS  
The present invention relates to the use of compounds, in which the pharmacophores of quinolone and oxazolidinone are chemically linked together through a linker that is stable under physiological...
US20110263553 STEROID ANALOGUES FOR NEUROPROTECTION  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
US20120277420 REFINED ROUTES TO CHLORIN BUILDING BLOCKS  
A method of making chlorins comprises the steps of reacting (e.g. condensing) a dipyrrin western half intermediate with an eastern half intermediate to form a tetrahydrobilene, and then cyclizing...
US20130090348 POLYMORPHIC FORMS OF RIFAXIMIN  
Provided for in the instant application are two additional polymorphic forms of rifaximin; namely substantially pure APO-I and APO-II. Also provided are processes for preparing substantially pure...
US20130288250 SIGNATURES OF CLINICAL OUTCOME IN GASTRO INTESTINAL STROMAL TUMORS AND METHOD OF TREATMENT OF GASTROINTESTINAL STROMAL TUMORS  
A method for in vitro predicting survival and/or metastatic outcome of gastrointestinal stromal tumors (GISTs), characterized in that it comprises the measure of the level, in a patient-derived...
US20120201747 System and Method for Diagnosis and Treatment  
This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy...
US20130289020 CXCR4 Receptor Antagonists  
Disclosed are compounds that are antagonists of the CXCR4 receptor.
US20120028907 METHODS FOR IDENTIFICATION OF TUMOR PHENOTYPE AND TREATMENT  
The disclosure relates to methods for identifying a tumor as an E2F-responsive gene over-expressing (ERGO) tumor, methods of determining the likelihood that an ERGO tumor patient will survive to a...
US20140045804 TREATMENT OF HYPOACTIVE SEXUAL DISORDER (HSDD)  
A topical cream to be applied to the clitoris and hood of the vaginal area to create an intense libido and drive for orgasm. The cream comprises a base cream having from about 9.5% to about 10%,...
US20110086818 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS  
The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while...
US20130216478 Non-Invasive Diagnostic Agents of Cancer and Methods of Diagnosing Cancer, Especially Leukemia and Lymphoma  
The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present...
US20140099662 PHOTOTOXICITY TEST METHOD  
The present invention provides a phototoxicity test method using human retinal pigment epithelial cells, and so on.
US20120184495 TARGETED NANO-PHOTOMEDICINES FOR PHOTODYNAMIC THERAPY OF CANCER  
The present invention relates to a photosensitizer-containing nanoparticle, comprising a photosensitizer covalently bonded throughout at least a part of said nanoparticle to the nanoparticle...
US20080161555 Purification of Tacrolimus on Supports of Vegetable Origin  
The invention relates to a process for the purification of tacrolimus comprising contacting crude tacrolimus with a silver salt dissolved in a water/organic solvent mixture and with a carrier of...
US20110244486 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES  
Methods, assays and compositions for the diagnosis and treatment of diabetes, in which the glutamate transporters and/or receptors expressed in pancreatic islet cells are used as therapeutic...
US20130252936 PYRAZOLOPYRIDAZINES AND METHODS FOR TREATING RETINAL-DEGENERATIVE DISEASES AND HEARING LOSS ASSOCIATED WITH USHER SYNDROME  
Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related...
US20120172590 METHODS FOR ISOLATING ALKALOIDS FROM PLANTS  
Methods are provided for isolating alkaloids from biomaterial, preferably plant biomaterial, wherein the biomaterial is extracted with a vegetable oil, in the concomitant presence of an alkaline...
US20110213145 Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners  
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with...
US20120136046 METHOD OF TREATING AGE RELATED DISORDERS  
The present invention relates to the use of fujimycin for the treatment of a disorder related to the chronological and/or replicative life-span of a cell, and to methods for increasing the...
US20110160175 18,21-Didesoxymacbecin Derivatives for the Treatment of Cancer  
The present invention relates to macbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and...
US20150258106 METHODS FOR ACUTE AND LONG-TERM TREATMENT OF SUBSTANCE ABUSE  
This invention is directed to a method of treating drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with noribogaine or a...
US20120232062 AZAINDAZOLES TO TREAT FLAVIVIRIDAE VIRUS INFECTION  
Azaindazole compounds are useful for treating Flaviviridae virus infection, including HCV infection.
US20150141410 GPR17 Receptor Modulators  
Chemical compounds are provided which act on GPR17 receptors and are useful in the treatment or amelioration of chronic and/or acute neurodegenerative diseases, such as multiple sclerosis,...
US20150190401 ENHANCED BRAIN BIOAVAILABILITY OF GALANTAMINE BY SELECTED FORMULATIONS AND TRANSMUCOSAL ADMINISTRATION OF LIPOPHILIC PRODRUGS  
The disclosure relates to selected administration routes for CNS (central nervous system) therapeutics and highly soluble salts, solutions, emulsions or powder formulations thereof, having optimal...
US20120101427 NOVEL PHOTOSENSITIZER FORMULATIONS FOR ORAL ADMINISTRATION  
The present invention provides novel drug formulations for oral administration for diverse medical applications including anticancer, antimetastatic, antibacterial, antifungal, antiprotozoic,...
US20150246060 Abiraterone Acetate Formulation and Methods of Use  
Pharmaceutical compositions, including unit dosage forms, comprising abiraterone acetate and methods for producing and using such compositions are described.
US20150231147 METHODS FOR ACUTE AND LONG-TERM TREATMENT OF DRUG ADDICTION  
This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with...
US20130004993 Green Chemical Process to Produce Natural Products  
Methods for producing and obtaining natural products from microbial amplification chambers are described. This approach utilizes the concept of green chemistry to synthesize and extract the marine...
US20150038472 USE OF THERAPEUTICALLY EFFECTIVE LIPIDS AND METHOD FOR PRODUCING ORGAN-/TISSUE-SPECIFIC THERAPEUTICALLY EFFECTIVE LIPIDS  
The use of therapeutically active lipids for organ/tissue-specific enrichment for the treatment of inflammatory, ischemic or degenerative disorders and/or for stimulating a regeneration is...
US20120202821 CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS  
Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation...
US20130072473 COMPOUNDS FOR TREATING PROTEIN FOLDING DISORDERS  
The present invention is directed to compounds of Formulae (I), (IIa-IIh), (IIIa-IIIe), (IVa-IVc), (Va-V1), (VIa-VII), (VII), (VIII) and (IX), pharmaceutical compositions thereof and methods of...
US20110008297 OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING  
Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
US20110137027 METHOD FOR PREPARING LACTAMES, COMPRISING A PHOTONITROSATION STEP, FOLLOWED BY A BECKMANN TRANSPOSITION STEP  
The invention relates to a method for preparing lactames, according to which a photonitrosation of a cycloallcane is carried out using nitrosyl chloride (NOCI). According to the invention, said...
US20140287039 Abiraterone Acetate Formulation  
Pharmaceutical compositions, including unit dosage forms, comprising fine particle abiraterone acetate with or without an antioxidant and or a sequestering agent as well as methods for producing...
US20120283217 MODULATORS OF AMYLOID-BETA PRODUCTION  
As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating...
US20120196847 6,6-Bicyclic Ring Substituted Heterobicyclic Protein Kinase Inhibitors  
Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the...
US20130310366 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF  
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and...
US20120270857 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF  
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and...
US20120219641 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF  
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and...
US20100298281 Steroid-Derived Cyclopamine Analogs and Methods for Using the Same in the Prevention or Treatment of Cancer  
The present invention relates to steroid-derived cyclopamine analogs and methods for using the same for inhibiting sonic hedgehog signaling and preventing or treating cancer. A method for...
US20150114261 HEAT RESISTANCE BIO-ADHESIVES  
An adhesive material produced by contacting a catechol with an amine may be stable under heated conditions and produce minimal outgassing under vacuum. The catechol may be an un-substituted...
US20130202525 MULTIFUNCTIONAL NANOPLATFORMS FOR FLUORESCENCE IMAGING AND PHOTODYNAMIC THERAPY DEVELOPED BY POST-LOADING PHOTOSENSITIZER AND FLUOROPHORE TO POLYACRYLAMIDE NANOPARTICLES  
A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same.
US20120214987 METHODS AND COMPOUNDS FOR PREPARING 3ALPHA-OXYGEN SUBSTITUTED STEROIDS  
The invention relates to processes for preparing 3α-O-linked steroids including 3α-O-linked-androst-5-ene steroids and 3α-O-linked-5a-androstane steroids. In one process a 3α,4α-epoxy...
US20110263534 PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS  
The present invention relates to phosphonated Rifamycins, and methods of making and using such compounds. These compounds are useful as antibiotics for prophylaxis and/or the treatment of bone and...
US20120101087 Generation of Combinatorial Synthetic Libraries and Screening for Novel Proadhesins and Nonadhesins  
The present invention relates to, in part, novel bisphenol compounds useful for the recognition, attachment and growth of unwanted biologics on natural and manmade surfaces. Another aspect of the...
US20130041307 APPLICATION OF BETA-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT  
The present invention provides methods to obtain biologically active compounds that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer,...
US20140243322 BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME  
Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on...