Matches 1 - 38 out of 38


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US20140288050 MODULATORS OF OPIOID RECEPTORS AND METHODS OF USE THEREOF  
Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain,...
US20120283248 COMPOSITION AND METHOD FOR TREATING COGNITIVE IMPAIRMENTS IN DOWN SYNDROM SUBJECTS  
Compounds having inverse agonist functional selectivity for GABAA receptors containing the α5 subunit for use as a medicament in the treatment of cognitive impairments in subjects suffering from...
US20140349992 COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF  
Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as...
US20120172350 HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF  
Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of...
US20110065694 Histamine H3 Inverse Agonists and Antagonists and Methods of Use Thereof  
Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of...
US20100317645 SUBSTITUTED DIAZEPINE SULFONAMIDES AS BOMBESIN RECEPTOR SUBTYPE-1 MODULATORS  
Certain novel substituted diazepine sulfonamides are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are...
US20140275042 TRICYCLIC AND TETRACYCLIC SYSTEMS ACTING UPON THE VASCULAR AND CENTRAL NERVOUS SYSTEMS  
Tricyclic and tetracyclic derivatives of benzodiazepine, pyridodiazepine, and pyrimidodiazepine fused with 1,4-dihydropyridine derivatives are disclosed. The present derivatives can be obtained...
US20130237530 BENZODIAZEPINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT  
This invention relates to benzodiazepine derivatives, compositions comprising therapeutically effective amounts of those benzodiazepine derivatives and methods of using those derivatives or...
US20090270612 Therapeutic Agent for Osteoporosis Using a Retinoid X Receptor-Related Compound  
It is an object of the present invention to provide a novel therapeutic agent for osteoporosis. HX531 is utilized, which is synthesized as a retinoid X receptor antagonist and has an activity in...
US20120276051 INHIBITORS OF HEPATITIS C VIRUS  
A class of compounds that inhibit Hepatitis C Virus (HCV) is disclosed, along with compositions containing the compound, and methods of using the composition for treating individuals infected with...
US20080045498 POLYCYCLIC VIRAL INHIBITORS  
Disclosed are compounds and compositions of Formula (A) and their uses for treating Flaviviridae family virus infections.
US20100204214 HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF  
Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of...
US20130302416 TRICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS  
New substituted tricyclic compounds of formula (I) are described, wherein R1, R2, X, Y, Z are herein defined, having protein kinase inhibiting activity. The invention includes methods to prepare...
US20120108574 Substituted Benzo-Imidazo-Pyrido-Diazepine Compounds  
The present invention relates to substituted benzo-imidazo-pyrido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions...
US20110245236 Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds  
The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical...
US20110166127 Substituted Benzo-Pyrimido-Tetrazolo-Diazepine Compounds  
The present invention relates to substituted benzo-pyrimido-tetrazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical...
US20110269714 Polycyclic Tetracycline Compounds  
The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein....
US20090197856 ANTIVIRAL COMPOUNDS  
Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae...
US20110301151 DIMERIC IAP INHIBITORS  
Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the...
US20120146012 Heterocyclic Radical or Diradical, The Dimers, Oligomers, Polymers, Dispiro Compounds and Polycycles Thereof, the Use Thereof, Organic Semiconductive Material and Electronic or Optoelectronic Component  
The present invention relates to heterocyclic radicals or diradicals, the dimers, oligomers, polymers, dispiro compounds and polycycles thereof, to the use thereof, to organic semiconductive...
US20120232057 CHIRAL FUSED [1,2]IMIDAZO[4,5-c] RING COMPOUNDS  
Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and...
US20090105227 Thienopyrroles As Antiviral Agents  
The present invention relates to tetracyclic thienopyrrole compounds of formula (I), wherein Ar, A, D1, D2, W, X, Y and Z are defined herein, and pharmaceutically acceptable salts thereof,...
US20110079733 FLUORESCENT, HETEROCYCLICALLY FUSED PERYLENES  
The reaction of aromatic nitriles with perylenetetracarboximides affords colorants which fluoresce strongly in the long-wave region and are of the formula in which one pair Q1 and Q2 or one pair...
US20090042866 Tetrahydrocarbazoles as Active Agents for Inhibiting VEGF Production by Translational Control  
The present invention relates to methods, compounds, and compositions for inhibiting angiogenesis. More particularly, the present invention relates to methods, compounds, and compositions for...
US20080269192 Chiral Fused [1,2]Imidazo[4,5-C] Ring Compounds  
Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and...
US20090062262 NON STEROIDAL GLUCOCORTICOID RECEPTOR MODULATORS  
The present invention relates to compounds having general Formula (I) or a pharmaceutically acceptable salt thereof. In this formula R1 is H or (1-4C)alkyl; R2 is —C(O)R15 or —S(O)2R15; R3 is H,...
US20120070409 TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR  
The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically...
US20060217370 Compounds useful for the treatment and prevention of pain and screening methods therefor  
The present invention relates to the composition of compounds having the generic structure: and to a method of treatment or prevention of pain using the above compounds.
US20120058989 ANTIBACTERIAL FLUOROQUINOLONE ANALOGS  
Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A,...
US20070249590 Substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds useful in treating kinase disorders  
The present invention is directed to substituted indolo[2,3-a]pyrrolo[3,4-c]carbazole compounds of formula (I): and forms thereof and their synthesis and use as protein kinase inhibitors and...
US20110014154 Aromatic Heterocyclic Fused Indolobenzadiazepine HCV NS5B Inhibitors  
The disclosure provides compounds of formula (I), including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and...
US20140011988 Dibenzo[B,F][1,4]Oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors  
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the...
US20140170111 FUSED TETRACYCLE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES  
The present invention relates to novel Fused Tetracycle Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, A′, B, G, R1, U, V, W, W′, X, X′, Y and Y′ are as...
US20100105666 TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS.  
Compounds of formula (I): wherein: R1 represents hydrogen, (C1-C6)alkyl, (C1-C6)aminoalkyl or (C1-C6)hydroxyalkyl,R2 represents hydrogen,or R1 and R2, together with the carbon atoms carrying them,...
US20160095938 CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS  
The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained...
US20160075720 MK2 INHIBITORS AND USES THEREOF  
The present invention provides compounds, compositions thereof, and methods of using the same.
US20150368261 CONJUGATES AND SMALL MOLECULES WHICH INTERACT WITH THE CD16A RECEPTOR  
The invention is related to medicine, in particular, to oncology and immunology. The novel compounds of the general formula 1 or 2, exhibiting affinity for CD16a receptor have been proposed. There...
US20120202799 Condensed Azepine Derivatives As Bromodomain Inhibitors  
Benzodiazepine compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.

Matches 1 - 38 out of 38