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US20090292119 |
METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS
The present invention provides improved methods for synthesizing novel benzothiazepine compounds. In particular, the invention relates to a new method that generally is used to make the substituted...
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US20090264407 |
Substituted Sulfonamide Compounds
Substituted sulfonamide compounds corresponding to formula I:
a process for their preparation, pharmaceutical compositions comprising such compounds, and the use of such substituted sulfonamide...
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US20090258856 |
IMIDAZOPYRIDAZINONE AND IMIDAZOPYRIDONE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula
wherein Y and R 1 to R 4 are defined as in claim 1 , the tautomers, enantiomers,...
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US20090253681 |
HIV Integrase Inhibitors
Compounds of Formula I are inhibitors of FHV integrase and inhibitors of FHV replication (I), wherein m, n, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 ; R 8 , R 9 and R 10 are defined herein. The...
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US20090227788 |
PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES
The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula:
by reacting a [2-(acylaminoethyl)thio]arene of formula
with an aldehyde or a multimer...
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US20090182140 |
Alicyclic Heterocyclic Compound
An alicyclic heterocyclic compound represented by the following formula or a pharmaceutically acceptable salt thereof:
wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a...
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US20090131402 |
Fused heterocyclic compound and use thereof
The present invention relates to a serotonin 5-HT 2C receptor activator containing a compound represented by the formula
wherein ring A is a 5- or 6-membered aromatic heterocycle optionally...
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US20090105211 |
INHIBITORS OF HEDGEHOG PATHWAY
The present invention is directed to a compound of Formula I
or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination...
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US20090075973 |
BENZO-FUSED HETEROCYCLES
The present invention provides benzo-fused heterocyclic compounds having the structure of formula I, as well as prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and...
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US20090062253 |
HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE
The present invention relates to compounds and methods useful as modulators of CB2 for the treatment or prevention of disease states including, but not limited to pain, autoimmune disease,...
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US20090042856 |
PYRIDAZINONE DERIVATIVES USED FOR THE TREATMENT OF PAIN
A pyridazinone derivative compound shown by the following formula (I): wherein R 1 is selected from hydrogen, etc.; R 2 is selected from substituted or unsubstituted aryl, etc.; R 3 is hydrogen,...
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US20090029965 |
Vasopressin V1a Antagonists
The present invention concerns compounds inter alia according to general formula 1 a . Compounds according to the invention are vasopressin V 1a receptor antagonists. Pharmaceutical compositions...
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US20080293690 |
[6,6] AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS
Novel compounds are provided which are GPR119 G protein-coupled receptor modulators. GPR119 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of...
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US20080234250 |
Heterocyclic Condensed Compounds Useful as Antidiuretic Agents
The invention concerns compounds according to general formulae 1, wherein G 1 is an amine. Compounds according to the invention are vasopressin V 2 receptor agonists. Pharmaceutical compositions...
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US20080207592 |
Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof
The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic.
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US20080194539 |
Phenyl Diazepane Carboxamides and Annelated Phenyl Piperazine Carboxamides Containing Oxygen and Used as Dopamine D3 Antagonists
The invention relates to annelated phenyl piperazine and phenyl diazepane carboxamides of general formula (I) containing oxygen.
The compounds are suitable for medical use.
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US20080154035 |
COUPLING METHOD BETWEEN INTRAMOLECULAR CARBON IN UNSATURATED HYDROCARBON COMPOUND USING ORGANO-INDIUM COMPOUND AS COUPLING AGENT
The present invention relates to a coupling method between intramolecular carbon using the intramolecular cyclization reaction in situ of an allyl-indium compound derived from an allyl derivative...
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US20080103300 |
PREPARATION OF QUINOXALINE COMPOUNDS
Certain methods that are useful in the preparation of amidophenyl-sulfonylamino-quinoxaline compounds CCK2 modulators are disclosed.
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US20080081803 |
Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
The present invention is directed to compounds of the formula I:
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, n and the broken lines are as defined herein which are useful as...
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US20080076918 |
QUINOXALINE COMPOUNDS
Certain amidophenyl-sulfonylamino-quinoxaline compounds are CCK2 modulators useful in the treatment of CCK2 mediated diseases.
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US20080039439 |
Alpha2C adrenoreceptor agonists
In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical...
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US20080027037 |
Cyclic compounds
1. A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof,
wherein X is ═CH— or ═N—, Y is —NH—, —NR 4 —, —S—, —O—, —CH═N—,...
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